Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis

2013 ◽  
Vol 5 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Fawad Javed ◽  
Hameeda B. Ahmed ◽  
Toshinari Mikami ◽  
Khalid Almas ◽  
Georgios E. Romanos ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Cytokine Profile ◽  
Crevicular Fluid

scholarly journals Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Isabela Silosi ◽  
Manole Cojocaru ◽  
Lili Foia ◽  
Mihail Virgil Boldeanu ◽  
Florin Petrescu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Serum Levels ◽  
Joint Disease ◽  
Control Serum ◽  
Healthy Control ◽  
Crevicular Fluid ◽  
And Control ◽  
Metalloproteinase 9

In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP. A total of fifty-six patients were included in the study. The subjects were categorized into four groups as follows: healthy-control (n=21), active RA (n=16), CP (n=14), and RA-CP association (n=12). Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique. The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control. Serum levels of MMP-9 were similar in RA and RA-CP associated patients. Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP. Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association. MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.

scholarly journals Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Zohaib Akram ◽  
Tariq Abduljabbar ◽  
Mohamed Ibrahim Abu Hassan ◽  
Fawad Javed ◽  
Fahim Vohra
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Meta Analysis ◽  
Cytokine Profile ◽  
Obese Patients ◽  
Necrosis Factor Alpha ◽  
Periodontal Inflammation ◽  
Mesh Terms ◽  
Meta Analyses ◽  
Crevicular Fluid

To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals. Eleven studies were included. Three studies showed comparable levels of leptin among obese and nonobese patients with CP. Four studies reported comparable levels of interleukin- (IL-) 6 and resistin whereas five studies reported comparable levels of adiponectin. Two studies reported similar levels of CRP in patients with periodontitis with and without obesity. One study showed higher levels of tumor necrosis factor-alpha in obese patients with CP. One study showed higher levels of IL-1βand IL-8 in obese patients with CP. The level of localized periodontal inflammation may have a greater influence on the GCF proinflammatory biomarker levels as compared to systemic obesity. Whether patients having chronic periodontitis with obesity have elevated proinflammatory GCF biomarkers levels compared to nonobese individuals remains debatable.

Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients

2013 ◽  
Vol 33 (10) ◽  
pp. 2607-2616 ◽  
Author(s):  
Başak Bıyıkoğlu ◽  
Nurcan Buduneli ◽  
Kenan Aksu ◽  
Ayşe Nalbantsoy ◽  
David F. Lappin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Interleukin 1Beta ◽  
Crevicular Fluid

scholarly journals The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients

2017 ◽  
Vol 65 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Ewa Dolińska ◽  
Anna Skurska ◽  
Małgorzata Pietruska ◽  
Violetta Dymicka-Piekarska ◽  
Robert Milewski ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid
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