scholarly journals In-Domain Control of a Heat Equation: An Approach Combining Zero-Dynamics Inverse and Differential Flatness

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jun Zheng ◽  
Guchuan Zhu

This paper addresses the set-point control problem of a one-dimensional heat equation with in-domain actuation. The proposed scheme is based on the framework of zero-dynamics inverse combined with flat system control. Moreover, the set-point control is cast into a motion planning problem of a multiple-input, multiple-output system, which is solved by a Green’s function-based reference trajectory decomposition. The validity of the proposed method is assessed through the analysis of the invertibility of the map generated by Green’s function and the convergence of the regulation error. The performance of the developed control scheme and the viability of the proposed approach are confirmed by numerical simulation of a representative system.

2020 ◽  
Vol 31 (23) ◽  
pp. 2583-2596
Author(s):  
John M. Boyle ◽  
Kelsey M. Hennick ◽  
Samuel G. Regalado ◽  
Jacob M. Vogan ◽  
Xiaozhu Zhang ◽  
...  

To better understand telomere length set point control in human stem cells, we generated knockout stem cell lines for TPP1 and contrasted their phenotypes with those of homozygous TPP1 L104A mutant stem cells. This comparison reveals that TPP1 L104A is not a hypomorphic allele but formally establishes TPP1 L104 as a dissociation of function mutant.


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