scholarly journals Effect of the Combined Extracts of Herba Epimedii and Fructus Ligustri Lucidi on Sex Hormone Functional Levels in Osteoporosis Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
RenHui Liu ◽  
Xue Kang ◽  
LiPing Xu ◽  
HongLei Nian ◽  
XinWei Yang ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Bone Histomorphometry ◽  
Hormone Receptors ◽  
Sex Hormone ◽  
Mineral Density ◽  
Oral Gavage ◽  
Treatment Of Osteoporosis ◽  
Fructus Ligustri Lucidi ◽  
Prevention And Treatment ◽  
Herba Epimedii

The combination of Herba Epimedii and Fructus Ligustri Lucidi has been used to treat osteoporosis for almost 50 years by Professor Shizeng Li, a famous doctor of traditional Chinese medicine (TCM). However, it is unclear whether the combination of the effective constituents of the two herbs may have a protective influence on the skeleton. In the present study, we investigated the effects of the combination extracts of Herba Epimedii and Fructus Ligustri Lucidi on rat model of osteoporosis induced by retinoic acid by gavage. With administrations of the combination extracts of the two herbs (50, 100, and 200 mg/kg/day) via oral gavage for 3 weeks, bone mineral density (BMD), femur histomorphometry, some sex hormones, and sex hormone receptors were measured. Results showed that the combined extracts could increase BMD, affect bone histomorphometry, coordinate the sex hormones at the level of hypothalamus-pituitary-gonad axis, and increase the protein and mRNA expressions of sex hormone receptors. The findings suggested that the combination extracts of Herba Epimedii and Fructus Ligustri Lucidi might be beneficial as an alternative medicine for the prevention and treatment of osteoporosis.

scholarly journals Endogenous Sex Hormones and Cardiovascular Disease in Men

2003 ◽  
Vol 88 (11) ◽  
pp. 5076-5086 ◽  
Author(s):  
Majon Muller ◽  
Yvonne T. van der Schouw ◽  
Jos H. H. Thijssen ◽  
Diederick E. Grobbee
Keyword(s):  
Cardiovascular Disease ◽  
Beneficial Effect ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Hormone Production ◽  
Adrenal Androgens ◽  
Prevention And Treatment ◽  
The Relationship ◽  
Circulating Levels ◽  
Endogenous Sex Hormones

Abstract Unlike women, men do not experience an abrupt reduction in endogenous sex hormone production. It has, however, become clear that an age-associated decrease in the levels of (bioactive) sex hormones does occur. Whether endogenous sex hormones have an impact on cardiovascular disease has for many years remained largely unknown, but during the last decade more attention has been drawn to the importance of testosterone, estrogens, and adrenal androgens in etiology, prevention, and treatment of male cardiovascular disease. The purpose of this article is to summarize the evidence currently available on the association between endogenous sex hormones and cardiovascular disease in males. Published studies dealing with the relationship between circulating levels of sex hormones and cardiovascular disease in males were reviewed. The studies reviewed in this article suggest that circulating endogenous sex hormones and estrogens have a neutral or beneficial effect on cardiovascular disease in men.

Sex Hormone Receptors in Vocal Fold Tissue: A Theory about the Influence of Sex Hormones in the Larynx

2011 ◽  
Vol 63 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Andrea Nacci ◽  
Bruno Fattori ◽  
Fabio Basolo ◽  
Maria E. Filice ◽  
Katia De Jeso ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Vocal Fold ◽  
Hormone Receptors ◽  
Sex Hormone

scholarly journals CHANGE OF MINERAL DENSITY OF BONE TISSUE IN WOMEN IN PRE - AND POSTMENPAUSA AND ITS CORRECTION

ASJ. ◽  
2021 ◽  
Vol 1 (56) ◽  
pp. 28-33
Author(s):  
O. Kalinkina ◽  
Yu. Tezikov ◽  
I. Lipatov
Keyword(s):  
Bone Mineral Density ◽  
Hormone Therapy ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Menopausal Hormone Therapy ◽  
Age Group ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Age Related ◽  
Prevention And Treatment

87 patients aged 40-69 years in the period of pre- and postmenopause were examined. In the analysis of age-related dynamics of bone mineral density (BMD) It was found that densitometry indicators corresponding to osteoporosis directly correlate with age and duration of the postmenopausal period. It is advisable in women of this age group with a decrease in bone mineral density, the combined appointment of menopausal hormone therapy (MGT) and non-hormonal therapy affecting bone metabolism (calcitonin). For the purpose of MGT in premenopausal women, the use of femostone 2/10 is effective, in postmenopausal women - femostone 1/10 and femostone 1/5, which does not cause withdrawal bleeding. If there are contraindications to menopausal hormone therapy, the prevention and treatment of osteoporosis should be guided by the appointment of nonhormonal drugs, in particular, calcitonin.

Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress

Endocrinology ◽  
2021 ◽  
Author(s):  
Nathalie Sumien ◽  
J Thomas Cunningham ◽  
Delaney L Davis ◽  
Rachel Engelland ◽  
Oluwadarasimi Fadeyibi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neurodegenerative Diseases ◽  
Sex Hormones ◽  
Intracellular Signaling ◽  
Hormone Receptors ◽  
Chromosome Complement ◽  
Sex Hormone ◽  
Stress Conditions ◽  
Signaling Cascades ◽  
Aging Men

Abstract Neurodegenerative diseases cause severe impairments in cognitive and motor function. With an increasing aging population and the onset of these diseases between 50-70 years, the consequences are bound to be devastating. While age and longevity are the main risk factors for neurodegenerative diseases, sex is also an important risk factor. Sex is multifaceted, encompassing sex chromosome complement, sex hormones (estrogens and androgens), and sex hormone receptors. Sex hormone receptors can induce various signaling cascades, ranging from genomic transcription to intracellular signaling pathways that are dependent on the health of the cell. Oxidative stress, associated with aging, can impact the health of the cell. Sex hormones can be neuroprotective under low oxidative stress conditions but not in high oxidative stress conditions. An understudied sex hormone receptor that can induce activation of oxidative stress signaling is the membrane androgen receptor (mAR). mAR can mediate NADPH oxidase (NOX) generated oxidative stress that is associated with several neurodegenerative diseases, such as Alzheimer’s disease. Further complicating this is that aging can alter sex hormone signaling. Prior to menopause, women experience more estrogens than androgens. During menopause, this sex hormone profile switches in women due to the dramatic ovarian loss of 17β-estradiol with maintained ovarian androgen (testosterone, androstenedione) production. Indeed, aging men have higher estrogens than aging women due to aromatization of androgens to estrogens. Therefore, higher activation of mAR-NOX signaling could occur in menopausal women compared to aged men, mediating the observed sex differences. Understanding these signaling cascades could provide therapeutic targets for neurodegenerative diseases.

scholarly journals Effect of Acupoint Catgut Embedding on Intestinal Flora in Rats with Ovariectomized Osteoporosis

2021 ◽  
Vol 46 (4) ◽  
pp. 307-318
Author(s):  
Na Shi ◽  
Chu-Qiong Zhang ◽  
Long Han ◽  
Gang Ouyang
Keyword(s):  
Pathogenic Bacteria ◽  
Statistical Significance ◽  
Intestinal Flora ◽  
Valeric Acid ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Prevention And Treatment ◽  
Group A ◽  
Group B ◽  
Group D

Objectives: By observing the effect of acupoint catgut embedding on the intestinal flora of ovariectomized osteoporotic rats, the correlation between the regulation of intestinal flora and the prevention and treatment of osteoporosis was discussed preliminarily. Methods: By observing the effect of acupoint catgut embedding on the intestinal flora of ovariectomized osteoporotic rats, the correlation between the regulation of intestinal flora and the prevention and treatment of osteoporosis was discussed preliminarily. Result: Compared with Group A and Group B, bone mineral density (BMD) of femur and tibia in Group C decreased significantly (p<0.05), indicating successful modeling. Compared with Group C, BMD of femur and tibia in Group D was significantly increased (p<0.05). Compared with Group A and Group B, content of serum estrogens, calcium, and PTHrP in Group C were significantly decreased (p<0.05 or p<0.01). Content of serum estrogen, calcium, and PTHrP in Group D were significantly higher than those in Group C (p<0.05 or p<0.01). Compared with Group A and Group B, the abundance of mollicutes, actinobacteria, acidobacteria, chloroflexi and fusobacteria in group C was significantly increased. The abundance of probiotics in Group D such as lactobacillales, (lactobacillaceae, lactobacillus), bacillales, and streptococcus was significantly higher than that in Group C (p<0.05). The content of SCFAs such as acetic acid, butyric acid, iso-valeric acid, valeric acid and caproic acid in Group D were significantly higher than those in Group C, with statistical significance (p<0.05). Conclusions: Acupoint catgut embedding can effectively improve BMD, increase content of estrogen, calcium, PTHrP and SCFAs. Furthermore, embedding can also improve the abundance of probiotics and reduce the abundance of pathogenic bacteria. The changes of intestinal flora were correlated with the changes of estrogen and calcium, which may be one of the mechanisms of acupoint catgut embedding in the prevention and treatment of osteoporosis.

Sex hormone receptors in varicose veins of women with premenstrual syndrome

Phlebologie ◽  
2008 ◽  
Vol 37 (02) ◽  
pp. 68-72 ◽  
Author(s):  
L. Dzieciuchowicz ◽  
M. Kotwicka ◽  
M. Gabriel ◽  
A. Szczęśniak-Chmielecka ◽  
B. Krasińska ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Sex Hormones ◽  
Hormone Receptors ◽  
Varicose Veins ◽  
Progesterone Receptors ◽  
Muscle Cells ◽  
Sex Hormone ◽  
Estrogen And Progesterone Receptors ◽  
Premenstrual Tension

SummaryThe pathogenesis of premenstrual tension syndrome is not fully understood. It has been hypothesized that the interaction between sex hormones and target organs is the key event in its pathogenesis. Aim: The purpose of the study was to examine the differences in the prevalence of smooth muscle cells with sex hormones receptors in varicose veins of women with and without premenstrual tension syndrome (PS). Patients, methods: Samples of great saphenous vein were obtained from 50 women during varicose vein surgery. They were divided into group I (20 women with clinically diagnosed PS) and group II (30 women without PS). Estrogen and progesterone receptors were detected with an immunohistochemical method. Superficial densities of smooth muscle cells positive to estrogen and progesterone receptors were analyzed with densitometric program IM-AN and automatic image analyzer Magicall. The results were compared with t-Student test. Results: There were no differences in superficial density of smooth muscle cells positive to estrogen receptors between the groups. In contradiction to this, superficial density of smooth muscle cells positive to progesterone receptors was higher in group with PS than in patients without, 343 (±171) and 240 (±123), respectively. The difference was statistically significant (p < 0.05). Conclusion: The amount of cells with sex hormone receptors, not the level of hormones, could play a role in PS pathology. Our results show that progesterone is more important than estrogen in effector organs.

scholarly journals Combined Extracts of Herba Epimedii and Fructus Ligustri Lucidi Rebalance Bone Remodeling in Ovariectomized Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Yuheng Chen ◽  
Xiaoxi Li ◽  
Xiufeng Tang ◽  
Yingying Gao ◽  
Ping Yu ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Molecular Mechanisms ◽  
Ovariectomized Rats ◽  
Tartrate Resistant Acid Phosphatase ◽  
Protective Effects ◽  
Mineral Density ◽  
Fructus Ligustri Lucidi ◽  
Maximal Load ◽  
Ovx Rats ◽  
Herba Epimedii

This study aimed to investigate the osteoprotective effect and the possible molecular mechanisms of the combined extracts of Herba Epimedii and Fructus Ligustri Lucidi on postmenopausal osteoporosis (PMOP). Forty-eight female SD rats were sham-operated (Sham, n = 8) or ovariectomized (OVX, n = 40). Then after a week, OVX rats were divided randomly into five groups (n = 8 in each group): OVX, extracts of Herba Epimedii (HE, 0.35 g/kg), extracts of Fructus Ligustri Lucidi (FLL, 0.35 g/kg), combined extracts of HE and FLL (HE & FLL, 0.20 g/kg HE plus 0.15 g/kg FLL), and Raloxifene hydrochloride (RH, 6.25 mg/kg) groups. All groups were administered once daily for 12 weeks. Indicators related to bone remodeling were detected, including estradiol (E2), bone mineral density (BMD), maximal load, ultimate deflection, micro-CT properties, tartrate-resistant acid phosphatase (TRACP) and alkaline phosphatase (ALP) levels in serum and bone, and the protein and mRNA expression of bone turnover markers (RANKL, M-CSF, Wnt5a, Atp6v0d2, OPG, IGF-1, TGF-β1, and Bmp-2). Results showed that the combined extracts could increase serum E2 levels and BMD, enhance bone strength, reserve bone microstructure degeneration, promote bone formation, and inhibit bone resorption through upregulating the mRNA and protein expression of OPG, IGF-1, TGF-β1, and Bmp-2, while downregulating RANKL, M-CSF, Wnt5a, and Atp6v0d2. These findings demonstrated that the combined extracts of Herba Epimedii and Fructus Ligustri Lucidi with bone protective effects on OVX rats might be an alternative medicine for the treatment of PMOP.

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