scholarly journals Gender Differences in Cerebral Regional Homogeneity of Adult Healthy Volunteers: A Resting-State fMRI Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Chunsheng Xu ◽  
Chuanfu Li ◽  
Hongli Wu ◽  
Yuanyuan Wu ◽  
Sheng Hu ◽  
...  
Keyword(s):  
Gender Differences ◽  
Cerebral Cortex ◽  
Healthy Volunteers ◽  
Resting State ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Regional Homogeneity ◽  
Female Group ◽  
Precentral Gyrus ◽  
Sensorimotor Network

Objective.We sought to use the regional homogeneity (ReHo) approach as an index in the resting-state functional MRI to investigate the gender differences of spontaneous brain activity within cerebral cortex and resting-state networks (RSNs) in young adult healthy volunteers.Methods.One hundred and twelve healthy volunteers (56 males, 56 females) participated in the resting-state fMRI scan. The ReHo mappings in the cerebral cortex and twelve RSNs of the male and female groups were compared.Results.We found statistically significant gender differences in the primary visual network (PVN) (P<0.004, with Bonferroni correction) and left attention network (LAtN), default mode network (DMN), sensorimotor network (SMN), executive network (EN), and dorsal medial prefrontal network (DMPFC) as well (P<0.05, uncorrected). The male group showed higher ReHo in the left precuneus, while the female group showed higher ReHo in the right middle cingulate gyrus, fusiform gyrus, left inferior parietal lobule, precentral gyrus, supramarginal gyrus, and postcentral gyrus.Conclusions.Our results suggested that men and women had regional specific differences during the resting-state. The findings may improve our understanding of the gender differences in behavior and cognition from the perspective of resting-state brain function.

Distinguishing hypochondriasis and schizophrenia using regional homogeneity: a resting-state fMRI study and support vector machine analysis

2021 ◽  
pp. 1-29
Author(s):  
Kangyu Jin ◽  
Zhe Shen ◽  
Guoxun Feng ◽  
Zhiyong Zhao ◽  
Jing Lu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Resting State ◽  
Parietal Lobe ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Regional Homogeneity ◽  
Middle Temporal Gyrus ◽  
Support Vector ◽  
Fmri Study

Abstract Objective: A few former studies suggested there are partial overlaps in abnormal brain structure and cognitive function between Hypochondriasis (HS) and schizophrenia (SZ). But their differences in brain activity and cognitive function were unclear. Methods: 21 HS patients, 23 SZ patients, and 24 healthy controls (HC) underwent Resting-state functional magnetic resonance imaging (rs-fMRI) with the regional homogeneity analysis (ReHo), subsequently exploring the relationship between ReHo value and cognitive functions. The support vector machines (SVM) were used on effectiveness evaluation of ReHo for differentiating HS from SZ. Results: Compared with HC, HS showed significantly increased ReHo values in right middle temporal gyrus (MTG), left inferior parietal lobe (IPL) and right fusiform gyrus (FG), while SZ showed increased ReHo in left insula, decreased ReHo values in right paracentral lobule. Additionally, HS showed significantly higher ReHo values in FG, MTG and left paracentral lobule but lower in insula than SZ. The higher ReHo values in insula were associated with worse performance in MCCB in HS group. SVM analysis showed a combination of the ReHo values in insula and FG was able to satisfactorily distinguish the HS and SZ patients. Conclusion: our results suggested the altered default mode network (DMN), of which abnormal spontaneous neural activity occurs in multiple brain regions, might play a key role in the pathogenesis of HS, and the resting-state alterations of insula closely related to cognitive dysfunction in HS. Furthermore, the combination of the ReHo in FG and insula was a relatively ideal indicator to distinguish HS from SZ.

Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation: A resting-state fMRI study

2012 ◽  
Vol 13 (6) ◽  
pp. 720-727 ◽  
Author(s):  
Xi-Jian Dai ◽  
Hong-Han Gong ◽  
Yi-Xiang Wang ◽  
Fu-Qing Zhou ◽  
You-Jiang Min ◽  
...  
Keyword(s):  
Gender Differences ◽  
Sleep Deprivation ◽  
Resting State ◽  
Healthy Subjects ◽  
Resting State Fmri ◽  
Regional Homogeneity ◽  
Fmri Study ◽  
Normal Sleep

ALTERED BRAIN ACTIVITY IN PATIENTS WITH DIABETIC RETINOPATHY USING REGIONAL HOMOGENEITY: A RESTING-STATE fMRI STUDY

2019 ◽  
Vol 25 (4) ◽  
pp. 320-327 ◽  
Author(s):  
Xu-Lin Liao ◽  
Qing Yuan ◽  
Wen-Qing Shi ◽  
Biao Li ◽  
Ting Su ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Resting State ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Regional Homogeneity ◽  
Fmri Study

scholarly journals Intrinsic Functional Relations Between Human Cerebral Cortex and Thalamus

2008 ◽  
Vol 100 (4) ◽  
pp. 1740-1748 ◽  
Author(s):  
Dongyang Zhang ◽  
Abraham Z. Snyder ◽  
Michael D. Fox ◽  
Mark W. Sansbury ◽  
Joshua S. Shimony ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Resting State ◽  
Brain Activity ◽  
Critical Role ◽  
Resting State Fmri ◽  
Intrinsic Activity ◽  
Bold Imaging ◽  
Functional Relations ◽  
State Activity ◽  
Human Thalamus

The brain is active even in the absence of explicit stimuli or overt responses. This activity is highly correlated within specific networks of the cerebral cortex when assessed with resting-state functional magnetic resonance imaging (fMRI) blood oxygen level–dependent (BOLD) imaging. The role of the thalamus in this intrinsic activity is unknown despite its critical role in the function of the cerebral cortex. Here we mapped correlations in resting-state activity between the human thalamus and the cerebral cortex in adult humans using fMRI BOLD imaging. Based on this functional measure of intrinsic brain activity we partitioned the thalamus into nuclear groups that correspond well with postmortem human histology and connectional anatomy inferred from nonhuman primates. This structure/function correspondence in resting-state activity was strongest between each cerebral hemisphere and its ipsilateral thalamus. However, each hemisphere was also strongly correlated with the contralateral thalamus, a pattern that is not attributable to known thalamocortical monosynaptic connections. These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting-state fMRI BOLD imaging to elucidate thalamocortical relationships.

scholarly journals Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ye-Lei Tang ◽  
Gong-Jun Ji ◽  
Yang Yu ◽  
Jue Wang ◽  
Zhong-Jin Wang ◽  
...  
Keyword(s):  
Behavioral Problems ◽  
Orbitofrontal Cortex ◽  
Resting State ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Regional Homogeneity ◽  
Healthy Children ◽  
Rolandic Epilepsy ◽  
Performance Intelligence Quotient ◽  
Local Synchronization

Children with rolandic epilepsy (RE) are often associated with cognitive deficits and behavioral problems. Findings from neurophysiological and neuroimaging studies in RE have now demonstrated dysfunction not only in rolandic focus, but also in distant neuronal circuits. Little is known, however, about whether there is distributed abnormal spontaneous brain activity in RE. Using resting-state functional magnetic resonance imaging (RS-fMRI), the present study aimed to determine whether children with RE show abnormal local synchronization during resting state and, if so, whether these changes could be associated with the behavioral/clinical characteristics of RE. Regional homogeneity (ReHo) in children with RE(n=30)and healthy children(n=20)was computed on resting-state functional MRI data. In comparison with healthy children, children with RE showed increased ReHo in the central, premotor, and prefrontal regions, while they showed decreased ReHo in bilateral orbitofrontal cortex and temporal pole. In addition, the ReHo value in the left orbitofrontal cortex negatively was corrected with performance intelligence quotient in the children with RE. The aberrant local synchronization, not strictly related to primary site of the typical rolandic focus, indicates the neuropathophysiological mechanism of RE. The study findings may shed new light on the understanding of neural correlation of neuropsychological deficiencies in the children with RE.

NEUROIMAGING OF IDIOPATHIC REM SLEEP BEHAVIOR DISORDER

2015 ◽  
Vol 86 (11) ◽  
pp. e4.95-e4
Author(s):  
Michal Rolinski ◽  
Ludovica Griffanti ◽  
Konrad Szewczyk-Krolikowski ◽  
Ricarda Menke ◽  
Timothy Quinnell ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Resting State ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Resting State Fmri ◽  
Precentral Gyrus ◽  
Sleep Behavior ◽  
Sensorimotor Network

IntroductionResting-state functional magnetic resonance imaging (rs-fMRI) studies have previously shown significantly impaired connectivity in patients within the early motor phase of Parkinson's disease. Is it possible to detect the same imaging signature of Parkinson's in RBD subjects, before a clinical diagnosis of Parkinson's disease is established?MethodsTwenty-six patients with polysomnography-proven RBD and twenty-two age- and sex-matched healthy controls were recruited into the study. All subjects underwent a comprehensive structural and resting-state MRI protocol.ResultsVoxel-based morphometry analysis did not yield any significant grey matter differences between the two groups. Similarly, no significant differences of fractional anisotropy were found using white matter tract analysis. Rs-fMRI revealed decreased coactivation within the basal ganglia network (involving the caudate, putamen, globus pallidus bilaterally) and the sensorimotor network (precentral gyrus) of patients with RBD. A small area of increased coactivation was found in the default mode network of patients with RBD.ConclusionsOur findings support the presence of basal ganglia dysfunction in patients with RBD, likely representing the prodromal stages of Parkinson's disease. Clinical and neuroimaging follow up is necessary to assess the clinical utility of resting state fMRI to predict the onset of Parkinson's disease in RBD subjects.

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