scholarly journals Synthesis of Novel Fluorescent Sensors Based on Naphthalimide Fluorophores for the Highly Selective Hg2+-Sensing

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yordkhuan Tachapermpon ◽  
Pornthip Piyanuch ◽  
Narupon Prapawattanapol ◽  
Kanjarat Sukrat ◽  
Kullatat Suwatpipat ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fluorescent Sensors ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
One Pot ◽  
H Nmr ◽  
Sensitivity And Selectivity ◽  
New Sensors ◽  
Interfering Ions ◽  
C Nmr

With an aim to develop the new sensors for optical detection of Hg2+ions, two novel fluorometric sensors were designed and successfully prepared using 2-(3-(2-aminoethylsulfanyl)propylsulfanyl)ethanamine and one or twoN-methylnaphthalimide moieties (1and2). Sensor1was obtained viaN-alkylation,N-imidation and a one-pot nucleophilic aromatic substitution, andN-formylation of the amine, while sensor2was prepared viaN-alkylation,N-imidation, and nucleophilic aromatic substitution. The characterization, including1H NMR,13C NMR, and mass spectrometry, was then performed for1and2. The Hg2+-binding behaviors of the sensors were investigated in terms of sensitivity and selectivity by fluorescence spectroscopy. Sensor1especially provided the reversible and highly Hg2+-selective ON-OFF fluorescence behavior by discriminating various interfering ions such as Pb2+, Co2+, Cd2+, Mn2+, Fe2+, K+, Na+, and in particular Cu2+and Ag+with a detection limit of 22 ppb toward Hg2+ions.

Novel One-Pot Synthesis of Xanthones via Sequential Fluoride Ion-Promoted Fries-Type Rearrangement and Nucleophilic Aromatic Substitution

Synlett ◽  
2013 ◽  
Vol 24 (19) ◽  
pp. 2575-2580 ◽  
Author(s):  
Takashi Matsumoto ◽  
Yuuki Fujimoto ◽  
Ryohei Itakura ◽  
Hiroki Hoshi ◽  
Hikaru Yanai ◽  
...  
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Fluoride Ion ◽  
Aromatic Substitution ◽  
One Pot ◽  
One Pot Synthesis

Crystal structure of 3-chlorobenzo[b]thiophene-2-carbonyl chloride

2009 ◽  
Vol 2009 (7) ◽  
pp. 437-439 ◽  
Author(s):  
Sara Tarighi ◽  
Alireza Abbasi ◽  
Sara Zamanian ◽  
Alireza Badiei ◽  
Mahmood Ghoranneviss
Keyword(s):  
Crystal Structure ◽  
Mass Spectrometry ◽  
Cinnamic Acid ◽  
Thionyl Chloride ◽  
Structure Determination ◽  
X Ray ◽  
Packing Structure ◽  
H Nmr ◽  
Carbonyl Chloride ◽  
C Nmr

3-Chlorobenzo[b]thiophene-2-carbonyl chloride was synthesised from cinnamic acid and thionyl chloride. The single crystal X-ray structure determination confirmed the earlier proposed structure and the product was further characterised by 1H NMR, 13C NMR and mass spectrometry. The X-ray structure determination revealed two sets of symmetry related molecules along the b-axis that are loosely connected by relatively weak CH…π ( 3.626, 3.628 Å) interactions, giving rise to two infinite chains. The packing structure is dominated by Van der Waals forces between these chains. No significant π–π interactions are found in the crystal structure.

Development of highly selective fluorescent sensors for detection of glycolipids in vesicles and visualization of glutamate for neuronal imaging

2020 ◽  
Author(s):  
◽  
Ming Xu
Keyword(s):  
Fluorescence Enhancement ◽  
Chemical Sensor ◽  
Fluorescent Sensor ◽  
Hydrophobic Effect ◽  
Fluorescent Sensors ◽  
Nucleophilic Aromatic Substitution ◽  
Sensor System ◽  
Aromatic Substitution ◽  
Glutamate Binding ◽  
A Cell

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Fluorescent sensors are very useful tools for exploring chemical biology and advanced medical research. Herein, we propose four different fluorescent sensor systems for the recognition of some important biological molecules. The first sensor system is a multi-component fluorescent sensor complex for the sensing of glycolipids. The glycolipid sensor system is a novel design that takes advantage of supramolecular self-assembly. Results show that it can bind with both the sugar headgroup and hydrocarbon tail of glycolipids, and turn on the fluorescence of the sensor system. The second sensor is a cell-impermeable fluorescent sensor system for the recognition and extraction of glycolipids from vesicles. To avoid the fluorescence enhancement caused by the hydrophobic effect from cell membrane, we designed a series of cell-impermeable sensor complexes. In addition, these complexes were fully explored by vesicle studies. Another fluorescent sensor is NS600 which was developed for detecting and imaging glutamate in neurons. This sensor system that utilizes a nucleophilic aromatic substitution for glutamate binding, and produces a 270-fold fluorescence enchantment upon glutamate binding. Also, it overcomes drawbacks of previous glutamate sensors including low signal response and poor sensitivity. It enables a clear and accurate visualization of glutamate in cultural neurons. The last sensor is NS570, a cell-impermeable glutamate sensor which could be loaded into synaptic vesicles by vesicle cycling. This sensor is a reversible chemical sensor that gives a 2600-fold fluorescence enhancement upon the titration with glutamate and can be used to monitor the release of neuronal glutamate in real time.

An efficient synthesis of 3-alkyl-2-diversity-substituted benzofuro[3,2-d]pyrimidin-4(3H)-one derivatives

2019 ◽  
Vol 43 (5-6) ◽  
pp. 201-204 ◽  
Author(s):  
Hong-Mei Wang ◽  
Tian-Shuai Wang ◽  
Sheng-Jie He ◽  
Zong-Yun Chen ◽  
Yang-Gen Hu
Keyword(s):  
Mass Spectrometry ◽  
Sodium Ethoxide ◽  
Catalytic Amount ◽  
Alkyl Halides ◽  
Efficient Synthesis ◽  
Pyrimidine Derivatives ◽  
Excess Carbon ◽  
H Nmr ◽  
Aliphatic Esters ◽  
C Nmr

Benzofuro[3,2- d]pyrimidine derivatives are prepared using aza-Wittig reactions of iminophosphoranes with n-butyl isocyanate at 40–50 °C to give carbodiimide intermediates, which are reacted with nitrogen-oxygen-containing nucleophiles to give 3-alkyl-2-amino (aryloxy/alkoxy)-benzofuro[3,2- d]pyrimidin-4(3 H)-ones in satisfactory yields in the presence of a catalytic amount of sodium ethoxide or K2CO3. The iminophosphorane also reacts directly with excess carbon disulfide, followed by n-propylamine; further reaction with alkyl halides or halogenated aliphatic esters in the presence of anhydrous K2CO3 produces the corresponding 2-alkylthio-3-n-propyl-benzofuro[3,2- d]pyrimidin-4(3 H)-ones in good yields. Their structures of the products are confirmed by 1H NMR, 13C NMR, mass spectrometry, infrared and elemental analysis.

scholarly journals Chloro- and BF2bdk-substituted dithienylethene: Synthesis, photophysical properties, and optical switching behavior

2020 ◽  
pp. 174751982095141
Author(s):  
Zhiqiang Lu ◽  
Wenbo Yang ◽  
Yanhui Bai ◽  
Mo Wang ◽  
Zixu Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Optical Switching ◽  
High Resolution Mass Spectrometry ◽  
Photophysical Properties ◽  
Red Light ◽  
Switching Behavior ◽  
Polar Solvents ◽  
H Nmr ◽  
Resolution Mass ◽  
C Nmr

A novel chloro- and BF2bdk-substituted dithienylethene derivative, in which a chlorine atom and a difluoroboron β-diketonate (BF2bdk) group are appended at the termini of the dithienylethene core, is developed. The structure was confirmed by 1H NMR, 13C NMR, and high-resolution mass spectrometry (electrospray ionization). It displayed solvent-dependent photophysical properties, and blue/red light-triggered optical switching behavior in nonpolar or less polar solvents.

Synthesis, Generic Dyeing of Nindigo Derivatives on Unmodified Polypropylene; First Time Application in Dyeing Technology

2019 ◽  
Vol 19 (11) ◽  
pp. 7105-7111 ◽  
Author(s):  
Raju Penthala ◽  
Rangaraju Satish Kumar ◽  
Hyorim Kim ◽  
Gisu Heo ◽  
Young-A Son
Keyword(s):  
Mass Spectrometry ◽  
Polypropylene Fiber ◽  
Blue Color ◽  
Substituted Anilines ◽  
Simple Route ◽  
H Nmr ◽  
Dispersing Agent ◽  
Didodecyldimethylammonium Bromide ◽  
First Time ◽  
C Nmr

Hydrophobic nindigo dyes were designed and successfully synthesized from indigo by reacting with substituted anilines in a simple route. Four nindigo dyes were fruitfully analyzed by 1H NMR 13C NMR, electronic and mass spectrometry. Here, we have firstly introduced these nindigo dyes into dyeing area for the dyeing of unmodified polypropylene fiber in aqueous medium. Dyeing experiments has been performed by using didodecyldimethylammonium bromide dispersing agent to make dye-dispersant complex for enhancing the dispersion of dyes. All the dyes were displayed profound blue color hue on polypropylene. The dyeing efficiency and dye fixation order of the nindigo dyes are 3d > 3c ≥ 3b > 3a. Compound 3d having higher the hydrophobic character (logP ═ 7.04), so greater the dye ability on the polypropylene fiber and exhibiting deep coloration.

Assignment techniques for 29Si NMR spectra of pertrimethylsilylated products. 29Si satellites in 13C NMR spectra measured with selective 29Si decoupling

1985 ◽  
Vol 50 (9) ◽  
pp. 2060-2064 ◽  
Author(s):  
Jaan Past ◽  
Jüri Puskar ◽  
Jan Schraml ◽  
Endel Lippmaa
Keyword(s):  
Nmr Spectra ◽  
29Si Nmr ◽  
13C Nmr Spectra ◽  
Difference Spectroscopy ◽  
Experimental Scheme ◽  
H Nmr ◽  
Correct Assignment ◽  
Sensitivity And Selectivity ◽  
29Si Nmr Spectra ◽  
C Nmr

It is shown that measurement of 29Si satellites in proton decoupled 13C NMR spectra with selective 29Si decoupling allows correct assignment of lines in 29Si NMR spectra of pertrimethylsilylated products. The experimental scheme, where selective decoupling and FID phase alternation are used (difference spectroscopy), has sufficient sensitivity and selectivity, provided the 29Si lines are well separated. The main advantage of the method is that it can be applied to compounds with unresolved 1H NMR spectra or with no protons in γ position to the silicon atom.

scholarly journals Synthesis, antioxidant activity, and density functional theory study of catechin derivatives

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 54136-54141 ◽  
Author(s):  
Jing Wang ◽  
Han Tang ◽  
Bo Hou ◽  
Pan Zhang ◽  
Qi Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Density Functional Theory ◽  
Antioxidant Activity ◽  
Density Functional ◽  
Density Functional Theory Study ◽  
Functional Theory ◽  
H Nmr ◽  
C Nmr

Catechin derivatives were synthesized, and their structures were characterized by 1H-NMR, 13C-NMR, and mass spectrometry.

scholarly journals Microwave-Assisted Hydrogenation of Codeine in Aqueous Media

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
F. Taktak ◽  
I. Bulduk
Keyword(s):  
Aqueous Solution ◽  
Aqueous Media ◽  
One Pot ◽  
H Nmr ◽  
Microwave Assisted ◽  
Analysis Technique ◽  
Purity Analysis ◽  
Ft Ir ◽  
Elemental Analysis Technique ◽  
C Nmr

An efficient one-pot microwave-assisted hydrogenation of codeine was achieved in aqueous solution. This technique is simple, fast, environmentally friendly, and highly efficient. Structure of produced dihydrocodeine was approved by using FT-IR, 1H NMR, 13C NMR, EIMS, and elemental analysis technique. Its purity analysis was performed by using HPLC and assay analysis was performed by using potentiometric titration methods.

5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part IV. One-pot Synthesis of 1H-Pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione Derivatives Using Controlled Microwave Heating

2011 ◽  
Vol 66 (8) ◽  
pp. 843-849
Author(s):  
Raafat M. Shaker ◽  
Kamal U. Sadek ◽  
Ebtisam A. Hafez ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Heating ◽  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
C Nmr

An efficient and direct procedure for the synthesis of pyrrolo[2,3-d]pyrimidine-2,4-dione derivatives using controlled microwave heating has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

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