scholarly journals T, B, and NKT Cells in Systemic Inflammation in Obstructive Sleep Apnoea

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Joanna Domagała-Kulawik ◽  
Iwona Osińska ◽  
Aleksandra Piechuta ◽  
Piotr Bielicki ◽  
Tomasz Skirecki
Keyword(s):  
Immune Response ◽  
T Cells ◽  
B Cells ◽  
Obstructive Sleep Apnoea ◽  
Systemic Inflammation ◽  
Sleep Apnoea ◽  
Metabolic Complications ◽  
Study Objective ◽  
Obstructive Sleep ◽  
Complication Score

Background. Obstructive sleep apnoea syndrome (OSAS) brings risk of serious complications. The study objective was to assess elements of the cellular immune response in the course of OSAS.Methods. Peripheral blood (PB) lymphocytes: T, B, NK, NKT-like, Th, Tc, and HLA DR+ T cells were evaluated by flow cytometry of 48 OSA patients; the concentration of adiponectin, interleukin 1β, and TNFαwas measured by ELISA method. TheOSA complication scorewas developed and used for statistical analysis.Results. The proportion of B cells and Th/Tc ratio were significantly lower in the BP of OSA patients when compared with control subjects (median 7.9 versus 10.9%, 0.9 versus 1.5,p<0.05). The proportion of Tc, NK, NKT-like, and HLADR positive T cells were elevated in OSA patients when compared with healthy subjects (36.4 versus 26.8, 15.5 versus 8.5, 5.7 versus 3.0, and 8.4 versus 4.5%,p<0.05, resp.) and were more pronounced in patients with metabolic syndrome. The grade ofOSA complication scorecorrelated with systemic inflammation markers and the proportion of B cells. The value of adiponectin/BMI ratio correlated significantly with SpO2(r=0.31,p<0.05), CRP (r=-0.35,p<0.05), TNFαconcentration (r=-0.36,p<0.05), and proportion of B cells (r=0.32,p<0.05).Conclusion. Lymphocytes B, Tc, NK, NKT-like, and adiponectin are involved in systemic immune response in OSA patients possibly predisposing them to cardiovascular and metabolic complications.

Exercise capacity, obesity and systemic inflammation in severe obstructive sleep apnoea

2017 ◽  
Author(s):  
Carmen C. Stroescu ◽  
Stefan Dumitrache-Rujinski ◽  
Ionela Erhan ◽  
Carmen Gigea ◽  
Irina Pele ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Obstructive Sleep Apnoea ◽  
Systemic Inflammation ◽  
Sleep Apnoea ◽  
Obstructive Sleep

scholarly journals The Recent View on the Obstructive Sleep Apnoea Syndrome in Children – Short Résumé

2012 ◽  
Vol 12 (3) ◽  
pp. 11-18 ◽  
Author(s):  
A Sujanska ◽  
P Durdik ◽  
P Banovcin
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Major Public Health Problem ◽  
Metabolic Complications ◽  
Adenotonsillar Hypertrophy ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep

Abstract The authors present a recent overview of the common clinical manifestations, management, diagnostic criteria and currently accepted treatment approaches of children with obstructive sleep apnoea syndrome (OSAS). Paediatric OSAS has become widely recognized as a frequent disorder and as a major public health problem. Diagnosis of this problem is usually based on physical examination, history and clinical evaluation confirmed by the polysomnography (PSG). PSG is considering as a gold-standard test for establishing the presence and severity of sleep disordered breathing (SDB) in children. According to current understanding, OSAS is a dynamic process in which increased upper airway collapsibility is present resulting from a combination of structural and neuromotor abnormalities, rather than from structural abnormalities alone. In children the OSAS has completely different clinical features and requires different management strategy. Snoring, difficult breathing and apnoea during sleep, restless sleep, frequent awakening and behavioural disturbances are the typical symptoms usually present in children with OSAS. Nowadays, the classic presentation of child with OSAS as underweight child with adenotonsillar hypertrophy is being replaced by younger overweight or obese patients usually without the hypertrophied adenoids and tonsils. Recently it has been reported that delayed diagnosis of OSAS can lead to neurobehavioural consequences and even serious cardiorespiratory morbidity, metabolic complications, as well as an increase in insulin resistance, high blood pressure and the development of OSAS in adulthood. OSAS must be diagnosed and managed aggressively with having these new repercussions. Evidence suggests that the surgical intervention with removal of the tonsils and/or adenoids will lead to significant improvements in the most incomplicated cases, as recently reported from a meta-analysis. SDB and especially OSAS should be taken into serious consideration by pediatricians to prevent comorbidities in adulthood.

NKT cells in systemic inflammation in the obstructive sleep apnoea syndrome (OSAS)

2015 ◽  
Author(s):  
Joanna Domagala-Kulawik ◽  
Iwona Osinska ◽  
Aleksandra Piechuta ◽  
Piotr Bielicki ◽  
Tomasz Skirecki
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Systemic Inflammation ◽  
Nkt Cells ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep

scholarly journals Circulating Soluble Urokinase-Type Plasminogen Activator Receptor in Obstructive Sleep Apnoea

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 77 ◽  
Author(s):  
Renata Marietta Bocskei ◽  
Martina Meszaros ◽  
Adam Domonkos Tarnoki ◽  
David Laszlo Tarnoki ◽  
Laszlo Kunos ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Obstructive Sleep Apnoea ◽  
Systemic Inflammation ◽  
Sleep Apnoea ◽  
Sleep Studies ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Obstructive Sleep ◽  
Plasminogen Activator Receptor ◽  
And Control

Background and Objectives: Obstructive sleep apnoea (OSA) is associated with heightened systemic inflammation and a hypercoagulation state. Soluble urokinase-type plasminogen activator receptor (suPAR) plays a role in fibrinolysis and systemic inflammation. However, suPAR has not been investigated in OSA. Materials and Methods: A total of 53 patients with OSA and 15 control volunteers participated in the study. Medical history was taken and in-hospital sleep studies were performed. Plasma suPAR levels were determined by ELISA. Results: There was no difference in plasma suPAR values between patients with OSA (2.198 ± 0.675 ng/mL) and control subjects (2.088 ± 0.976 ng/mL, p = 0.62). Neither was there any difference when patients with OSA were divided into mild (2.134 ± 0.799 ng/mL), moderate (2.274 ± 0.597 ng/mL) and severe groups (2.128 ± 0.744 ng/mL, p = 0.84). There was no significant correlation between plasma suPAR and indices of OSA severity, blood results or comorbidities, such as hypertension, diabetes, dyslipidaemia or cardiovascular disease. Plasma suPAR levels were higher in women when all subjects were analysed together (2.487 ± 0.683 vs. 1.895 ± 0.692 ng/mL, p < 0.01), and also separately in controls (2.539 ± 0.956 vs. 1.411 ± 0.534 ng/mL, p = 0.02) and patients (2.467 ± 0.568 vs. 1.991 ± 0.686 ng/mL, p < 0.01). Conclusions: Our results suggest that suPAR does not play a significant role in the pathophysiology of OSA. The significant gender difference needs to be considered when conducting studies on circulating suPAR.

scholarly journals Coagulation and Fibrinolysis in Obstructive Sleep Apnoea

2021 ◽  
Vol 22 (6) ◽  
pp. 2834
Author(s):  
Andras Bikov ◽  
Martina Meszaros ◽  
Esther Irene Schwarz
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Systemic Inflammation ◽  
Sleep Apnoea ◽  
Future Research ◽  
Common Disease ◽  
Upper Airways ◽  
Obstructive Sleep ◽  
Cardiovascular Morbidity And Mortality ◽  
Increased Risk ◽  
Coagulation And Fibrinolysis

Obstructive sleep apnoea (OSA) is a common disease which is characterised by repetitive collapse of the upper airways during sleep resulting in chronic intermittent hypoxaemia and frequent microarousals, consequently leading to sympathetic overflow, enhanced oxidative stress, systemic inflammation, and metabolic disturbances. OSA is associated with increased risk for cardiovascular morbidity and mortality, and accelerated coagulation, platelet activation, and impaired fibrinolysis serve the link between OSA and cardiovascular disease. In this article we briefly describe physiological coagulation and fibrinolysis focusing on processes which could be altered in OSA. Then, we discuss how OSA-associated disturbances, such as hypoxaemia, sympathetic system activation, and systemic inflammation, affect these processes. Finally, we critically review the literature on OSA-related changes in markers of coagulation and fibrinolysis, discuss potential reasons for discrepancies, and comment on the clinical implications and future research needs.

scholarly journals Upper airway and systemic inflammation in obstructive sleep apnoea

2016 ◽  
Vol 48 (4) ◽  
pp. 1108-1117 ◽  
Author(s):  
Eugenio Vicente ◽  
Jose M. Marin ◽  
Santiago J. Carrizo ◽  
Carlos S. Osuna ◽  
Ricardo González ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Obstructive Sleep Apnoea ◽  
Systemic Inflammation ◽  
Upper Airway ◽  
Study Groups ◽  
Sleep Apnoea ◽  
Inflammatory Biomarkers ◽  
Simultaneous Increase ◽  
Healthy Controls ◽  
Obstructive Sleep

Obstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study investigated whether local and systemic inflammatory biomarkers are related in patients with OSA. An uncontrolled extension to the study assessed the response to effective treatment.We recruited 89 patients with OSA (apnoea/hypopnoea index (AHI) ≥5 events·h−1), 28 snorers and 26 healthy controls. Pharyngeal lavage (PHAL) and plasma samples were collected at baseline and after a 1-year follow-up. Inflammatory cells were evaluated by flow cytometry; interleukin (IL)-6, IL-8 and tumour necrosis factor-α were evaluated by immunoassay.In PHAL, CD4+T-cells, IL-6 and IL-8 were higher in OSA patients than in snorers or healthy controls (p<0.05). The AHI correlated with CD4+, IL-6 and IL-8 in PHAL (all p-values <0.05). There were no differences in the inflammatory biomarkers in plasma between the study groups and no relationship between plasma and PHAL biomarkers. Biomarkers decreased significantly in PHAL but not in plasma after 1 year of therapy with continuous positive airway pressure or surgery.In patients with OSA, increased levels of inflammatory biomarkers were found in PHAL, which were reduced with effective treatment. No simultaneous increase in plasma inflammatory biomarkers was found.

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