scholarly journals The Role of Oxidative Stress and Autophagy in Atherosclerosis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Ida Perrotta ◽  
Saveria Aquila
Keyword(s):  
Potential Role ◽  
Menopausal Status ◽  
Oxygen Species ◽  
Artery Wall ◽  
Complex Interplay ◽  
Biological Investigation ◽  
Cellular Events ◽  
Vascular Smcs ◽  
Subendothelial Space

Atherosclerosis is a multifactorial, multistep disorder of large- and medium-sized arteries involving, in addition to age, gender and menopausal status, a complex interplay between lifestyle and genetic risk factors. Atherosclerosis usually begins with the diffusion and retention of atherogenic lipoproteins into the subendothelial space of the artery wall where they become oxidized by local enzymes and accumulate, leading to the formation of a cushion called atheroma or atheromatous or fibrofatty plaque, composed of a mixture of macrophages, lymphocytes, smooth muscle cells (SMCs), cholesterol cleft, necrotic debris, and lipid-laden foam cells. The pathogenesis of atherosclerosis still remains incompletely understood but emerging evidence suggests that it may involve multiple cellular events, including endothelial cell (EC) dysfunction, inflammation, proliferation of vascular SMCs, matrix (ECM) alteration, and neovascularization. Actually, a growing body of evidence indicates that autophagy along with the chronic and acute overproduction of reactive oxygen species (ROS) is integral to the development and progression of the disease and may represent fruitful avenues for biological investigation and for the identification of new therapeutic targets. In this review, we give an overview of ROS and autophagy in atherosclerosis as background to understand their potential role in this vascular disease.

scholarly journals Towards a Consensus on Alzheimer’s Disease Comorbidity?

2021 ◽  
Vol 10 (19) ◽  
pp. 4360
Author(s):  
Iska Avitan ◽  
Yudit Halperin ◽  
Trishna Saha ◽  
Naamah Bloch ◽  
Dana Atrahimovich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Potential Role ◽  
Oxygen Species ◽  
Degenerative Diseases ◽  
Comorbid Diseases

Alzheimer’s disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.

scholarly journals The signalling role of ROS in the regulation of seed germination and dormancy

2019 ◽  
Vol 476 (20) ◽  
pp. 3019-3032 ◽  
Author(s):  
Christophe Bailly
Keyword(s):  
Seed Germination ◽  
Oxygen Species ◽  
Direct Oxidation ◽  
Cellular Events ◽  
Seed Physiology ◽  
Spatiotemporal Regulation ◽  
Wide Range ◽  
Living Organisms ◽  
Hormone Signalling

Abstract Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have been reported to play a pivotal role in the regulation of seed germination and dormancy but their mechanisms of action are still far from being fully understood. In this review, we sum-up the major findings that have been carried out this last decade in this field of research and which altogether shed a new light on the signalling roles of ROS in seed physiology. ROS participate in dormancy release during seed dry storage through the direct oxidation of a subset of biomolecules. During seed imbibition, the controlled generation of ROS is involved in the perception and transduction of environmental conditions that control germination. When these conditions are permissive for germination, ROS levels are maintained at a level which triggers cellular events associated with germination, such as hormone signalling. Here we propose that the spatiotemporal regulation of ROS production acts in concert with hormone signalling to regulate the cellular events involved in cell expansion associated with germination.

The production of reactive oxygen and nitrogen species by skeletal muscle

2007 ◽  
Vol 102 (4) ◽  
pp. 1664-1670 ◽  
Author(s):  
Malcolm J. Jackson ◽  
Deborah Pye ◽  
Jesus Palomero
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Potential Role ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Redox Biology ◽  
Controlled Systems ◽  
Potential Source

Skeletal muscle has been recognized as a potential source for generation of reactive oxygen and nitrogen species for more than 20 years. Initial investigations concentrated on the potential role of mitochondria as a major source for generation of superoxide as a “by-product” of normal oxidative metabolism, but recent studies have identified multiple subcellular sites, where superoxide or nitric oxide are generated in regulated and controlled systems in response to cellular stimuli. Full evaluation of the factors regulating these processes and the functions of the reactive oxygen species generated are important in understanding the redox biology of skeletal muscle.

Potential Role of Heparanase in Atherosclerosis

Physiology ◽  
1989 ◽  
Vol 4 (1) ◽  
pp. 9-12
Author(s):  
JH Campbell ◽  
GR Campbell
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
T Lymphocytes ◽  
Potential Role ◽  
Activated Macrophages ◽  
Artery Wall ◽  
Degrading Enzymes ◽  
Matrix Degrading Enzymes

The mechanism by which a change in smooth muscle phenotype is effected in the artery wall during atherogenesis may be via release of extracellular matrix-degrading enzymes, particularly heparanase, from activated macrophages and T lymphocytes.

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