scholarly journals Acupuncture Point Laterality: Investigation of Acute Effects of Quchi (LI11) in Patients with Hypertension Using Heart Rate Variability

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Gerhard Litscher ◽  
Wei-Ping Cheng ◽  
Guang-Yu Cheng ◽  
Lu Wang ◽  
Jian Zhao ◽  
...  

Hypertension is one of the major risk factors for cardiovascular disease worldwide. Over 70% of the patients use antihypertensive drugs, so nonpharmacological treatments in addition to the medication are important. Our goal was to investigate acupuncture treatment on the Quchi acupoint using heart rate (HR) and heart rate variability (HRV) and to find out whether there is a laterality in acute effects. Sixty hypertensive patients (36 female, 24 male; mean age ± SD 55.8 ± 9.7 years) were randomly assigned to two manual needle acupuncture groups (group A: left Quchi (LI11) acupoint, group B: right Quchi acupoint). There was a significant (P<0.05) decrease in HR immediately after inserting and stimulating the needle at the left and the right Quchi acupuncture point. In contrast, total HRV increased immediately after inserting the needle, but this increase was significant only towards the end of the stimulation phase and after removing the needle. There were some differences between stimulation of the left and right Quchi acupoint, but they remained insignificant. This study provides evidence that there is a beneficial effect on heart rate variability in patients with hypertension and that there are some effects of laterality of the acupoint Quchi.

2016 ◽  
Vol 6 (4) ◽  
pp. 28-41
Author(s):  
Daniel Cesar Shirane ◽  
Fernanda Pereira Maiolini ◽  
Dalmo Antônio Ribeiro Moreira

Objetivo: O objetivo é analisar a variabilidade da frequência cardíaca em universitários saudáveis, após ingestão de bebida energética. Materiais e Métodos: Estudo prospectivo, uni-cego que incluiu indivíduos de coração normal. Todos submeteram-se à monitorização eletrocardiográfica por 5 minutos, antes da ingestão de 250 ml do energético Red Bull® (grupo A – GA) ou de placebo (grupo B – GB), numa relação 3:1, num período de 10 minutos. Após 45 minutos, um outro ECG foi realizado. Os indivíduos dos GA e GB permaneceram em repouso, sentados. Foi obtida a VFC antes e após a administração das substâncias, nos domínios do tempo (DT) e da frequência (DF). Foram excluídos consumidores de energéticos, aqueles que tivessem ingerido álcool ou cafeína nas 24 h antes da investigação. Resultados: Foram incluídos 30 indivíduos no grupo A (16H, 14M, média de idade 22±3a, variando entre 17 e 36 a) e 10 no grupo B (6H, 4M, média de idade 20±5a).  Não se observou variação da frequência cardíaca antes e após nos GA e GB (70±10 vs 71±8 no GA [p=0,941] e, 69±8 vs. 70±9 no GB[p=0,881]). Houve incremento significativo da atividade vagal no GA, em comparação ao GB, tanto no DT (SDNN e RMSSD), como no DF (HF). O Red Bull® interferiu pouco no sistema simpático e na relação LF/HF nos GA e GB. Conclusões: O Red Bull® na dose empregada, aumentou a VFC por incremento do tônus parassimpáticos; não causou alteração no equilíbrio autonômico (relação LF/HF); esses achados confirmam os efeitos da cafeína sobre a VFC demonstrado em outros estudos.Palavras-chave: Variabilidade da Frequência Cardíaca; Bebida Energética; ArritmiasABSTRACTObjective: The objective is to analyze the heart rate variability in college students after energy drink intake. Materials and Methods. Prospective study, uni-blind which included normal individuals. All the students underwent electrocardiographic monitoring for 5 minutes before ingestion of 250 ml of Red Bull® (group A - GA) or placebo (Group B - GB) in a 3: 1 ratio, in a 10-minute period. After 45 minutes, another ECG was performed. Individuals at GA and GB remained at rest, sitting. HRV was obtained before and after administration of the substances in the time domain (TD) and frequency domain (FD). Those students categorized as frequent consumers of energy drinks and those who have been drinking alcohol or caffeine in the 24 hours prior to investigation were excluded from the study.Results: Thirty  subjects were included in group A (16M, 14F, mean age 22 ± 3a, ranging between 17 and 36 a) and 10 in group B (6 H, 4M, mean age 20 ± 5a). There was no change in heart rate before and after ingestions in  GA and GB (70 ± 10 vs 71 ± 8 in GA [p = 0.941] and 69 ± 8 vs. 70 ± 9 in GB [p = 0.881]). There was a significant increase in vagal activity in GA compared to GB, both in TD (SDNN and RMSSD) as well as in the FD (HF). The Red bull® little interfered with the sympathetic system and the LF / HF ratio in GA and GB. Conclusions: The Red Bull increased HRV by increase in parasympathetic tone; caused no change in autonomic balance (LF / HF ratio); these findings confirm the effects of caffeine on HRV shown in other studies.Keywords: Heart Rate Variability; Energy Drinks; Arrhythmias


1986 ◽  
Vol 251 (1) ◽  
pp. H121-H126 ◽  
Author(s):  
M. Manohar

Right atrial, right ventricular, and pulmonary artery pressures, along with change in pleural pressure, were determined with catheter-tipped micromanometers in two groups of ponies at rest, as well as during moderate (trot; heart rate = 180 beats . min-1) and severe (gallop; heart rate = 220 beats . min-1) exercise performed on a treadmill. Group A (n = 8) ponies served as controls, and group B ponies (n = 6) had laryngeal hemiplegia (LH) induced by sectioning the left recurrent laryngeal nerve 20-29 days before the study. It was observed that LH ponies could not gallop for more than 45-90 s. With both levels of exertion, pressures in the right atrium, right ventricle, and pulmonary artery increased very significantly in normal ponies. The change in pleural pressure of galloping ponies was 30.4 +/- 2.9 cmH2O, and the respiratory (and stride) frequency was 138 +/- 4 breaths . min-1. During severe exercise in normal ponies, the systolic, mean, and diastolic pressures in the pulmonary artery were 107 +/- 7, 63.5 +/- 4.2, and 46 +/- 4 mmHg, despite the fact that no alveolar hypoxia could be detected. In LH ponies pulmonary artery pressures rose to levels observed in normal ponies, but during galloping, the change in pleural pressure (delta Ppl) (92 +/- 6 cmH2O) was three times that in normal ponies, and there was no synchronization of respiratory (86 +/- 6 breaths . min-1) frequency to stride frequency (142 +/- 3 strides . min-1). Despite these respiratory adjustments (decreased frequency and increased delta Ppl), arterial PO2 decreased and arterial PCO2 increased in galloping LH ponies.(ABSTRACT TRUNCATED AT 250 WORDS)


2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Guangjun Wang ◽  
Yuying Tian ◽  
Shuyong Jia ◽  
Wenting Zhou ◽  
Weibo Zhang

The specificity of acupuncture points (acupoints) is one of the key concepts in traditional acupuncture theory, but the question of whether there is adequate scientific evidence to prove or disprove specificity has been vigorously debated in recent years. Laterality, or the tendency for acupoints on the right or left side of the body to produce different physiological effects, is an important aspect of acupoint specificity. Data is particularly scarce regarding the laterality of the same channel, same-named acupoint located on opposite sides of the body. The aim of this study was to investigate whether Neiguan (PC6) has laterality. A total of eighteen healthy female volunteers were recruited for this study. Electrocardiograms were recorded and heart rate variability was analyzed before, during, and after PC6 was stimulated on either the left or the right side. The results show that during acupuncture, there were significant differences in the standard deviation of RR intervals (STDRR), root mean square of successive differences between RR intervals (RMSSD), and total power between the left PC6 stimulation group and the right PC6 stimulation group, which indicates that PC6 may have laterality.


Author(s):  
Dimple Arora

Background: Neural factors such as temperature, hormones, etc. are regulated by cardiovascular functions, in which neural factors mainly affect the autonomic-nervous system (ANS), which plays a major role in the maintenance & regulation of cardiac functions. Aims & Objectives: To analyze of the effect of aerobic exercise versus yoga in young adults on parameters of heart rate variability (HRV) Methodology: This was a cross-sectional study carried out in a physiology department of a medical college over the six month span in which male & female adults with written & informed consent were involved in the study, so 70 volunteers were enrolled in the Yoga Group (Group A) & 70 volunteers in the Aerobic Exercise Group (Group B) during the six months period. Both of them have been regularly trained & adequately exercised for a span of 24 weeks by a yoga instructor & physical trainer. They noticed all the base line parameters. The study of HRV was derived from an ECG unit. The parameters were compared at baseline (by paired t-test) in both groups before & after 24 weeks in Group B & Group A by unpaired t-test & were determined with latest SPSS version software. Results: The male-female ratio was comparable in both the groups as 2.5 : 1 & 1.9 : 1 groups (p>0.05). There was a substantial difference in changes over 12 weeks (p>0.05). The high-frequency HRV increased in the yoga community, where the reduction in the exercise group was statistically significant (p <0.05) & the decrease in the low frequency HRV & LF/HF ration was statistically significant (p <0.05) after 12 weeks of intervention. Conclusion: From our research, it can be inferred that the Yoga group substantially raises the high frequency HRV & reduces the low frequency HRV, so that the parasympathetic activity is more determined in the Yoga group compared to the aerobic exercise group. Keyword: HRV, Parasympathetic activity, Yoga, Aerobic exercise, ECG


Author(s):  
Yun-Te Chang ◽  
Wei-Chun Huang ◽  
Chin-Chang Cheng ◽  
Meng-Wei Ke ◽  
Jung-Shun Tsai ◽  
...  

Catecholamines have both anti-inflammatory and vasoactive properties. A decreased cardiac response to catecholamines has been associated with a high risk of death in sepsis and septic shock. The aim of this study was to investigate the effects of epinephrine (EPI) on heart rate variability and autonomic balance, as well as cytokine levels, in a rat sepsis model. Thirty-six male Sprague-Dawley rats were assigned to 4 experimental groups and 2 control groups of 6 rats each. The rats in the experimental groups were inoculated with a lipopolysaccharide (LPS, endotoxin) to establish a sepsis model. Group A received only LPS; group B received LPS, antecedent EPI and the nonselective beta-blocker propranolol; group C received LPS and antecedent EPI; and group D received LPS, antecedent EPI and the selective beta1-blocker esmolol. One control group received EPI and the other received saline placebo. Heart rate variability was analyzed and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) levels were measured. Measurements were carried out at baseline and 0, 0.5, 2, and 4 hours after LPS inoculation. There were significant differences in heart rate variability and cytokine levels between the groups, indicating that LPS infusion caused autonomic imbalance. Antecedent EPI significantly decreased the level of TNF-α in group C compared with group A in which TNF-α level peaked at 2 hours and then declined. Propranolol (group B) but not esmolol (group D) administration resulted in elevated TNF-α levels, comparable to those observed in group A. In conclusion, antecedent administration of EPI in a rat sepsis model inhibits the production of TNF-α possibly via the β2-adrenoreceptor.


2010 ◽  
Vol 19 (2) ◽  
pp. 173-183 ◽  
Author(s):  
Fani Giagkoudaki ◽  
Eleftherios Dimitros ◽  
Evangelia Kouidi ◽  
Asterios Deligiannis

Objective:To investigate the effects of an exercise-training program on heart-rate-variability (HRV) indices in individuals with Down syndrome (DS).Design:Controlled clinical trial.Participants:10 people with DS, age 24.2 ± 5.1 y (group A), and 10 age-matched healthy sedentary individuals (group B).Method:At baseline all subjects underwent a clinical examination and an ambulatory 24-h Holter monitoring for the evaluation of cardiac autonomic-nervous-system (ANS) activity by time- and frequency-domain analysis.Intervention:After initial evaluation, group A followed a 6-mo exercise-training program and thereafter underwent the same HRV analysis.Results:At the beginning of the study, group A showed a higher LF:HF ratio than group B, indicating impaired sympathovagal balance, likely because of lesser vagal modulation. Moreover, both time- and frequency-domain indices in group A were significantly lower than in group B. At the end of the study, exercise training was found to improve the sympathovagal balance, mainly by increasing vagal activity, in group A.Conclusion:The results indicate that individuals with DS have ANS dysfunction that can be improved by exercise’s increasing the parasympathetic modulation.


2016 ◽  
Vol 6 (2) ◽  
pp. 161
Author(s):  
Shamima Sultana ◽  
Shelina Begum ◽  
Sultana Ferdousi

<p><strong>Background:</strong> Essential hypertension is associated with altered autonomic function. Essential hypertension is treated with drugs which modify the sympatho-parasympathetic balance. Losartan (angioteosin II receptor blocker) and atenolol (beta blocker) is commonly used antihypertensive drugs.</p><p><strong>Objective:</strong> To evaluate the effect of antihypertensive drugs on heart rate variability (HRV) in patients with essential hypertension.</p><p><strong>Methods:</strong> This prospective observational study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from July 2012 to June 2013 on 120 newly diagnosed hypertensive patients without any medication (group B, age 30-55 years). They were selected from the Out Patients Department (OPD) of cardiology, BSMMU, Dhaka. Age, sex and BMI matched 60 apparently healthy norrnotensive subjects were also studied as control (group A). Based on treatment, these study subjects were divided into two groups (BI and B2). Group B1<sub>a</sub> included 60 patients received Josartan 50 mg daily and B<sub>2a</sub> included 60 patients received atenolol 50mg daily. They were observed once before the treatment (B<sub>1a</sub> &amp; B<sub>2a</sub>), after 3 months medication (B<sub>1b</sub> &amp; B<sub>2b</sub>) and after 6 months medication (B<sub>1c</sub> &amp; B<sub>2c</sub>). For assessing HRV, Mean heart rate, Mean R-R interval, Max/Min R-R interval, SDNN, RMSSD were recorded by a polyrite. Data were compared among before treatment, after 3 months treatment and after 6 months treatment. For statistical analysis ANOVA, independent sample't' test and paired sample 't' test were performed. <strong></strong></p><p><strong>Results:</strong> Mean resting pulse rate, mean heart rate, systolic blood pressure, diastolic blood pressure were significantly higher and mean R-R interval, Max/Min R-R interval, SDNN, RMSSD were significantly lower in newly diagnosed hypertensive patients in comparison with that of healthy normoten­sive subjects and after treatment. Jn both groups SDNN, RMS SD, mean R-R interval were found significantly higher after 6 months of treatment compared to their values after 3 months treatment. Again these values were found close to the values in normotensive subjects. In addition, mean heart rate was found significantly lower in atenolol treated patients than those of controls. Again in atenolol group these values were found significanLly higher than the corresponding values in losartan treated patients after 6 months treatment. <strong></strong></p><p><strong>Conclusion:</strong> Reduced cardiac vagal tone occurs in newly diagnosed hypertensive patients which is improved by both losartan and atenolol and in particular atenolol was found more effective.</p>


2020 ◽  
Vol 8 (11) ◽  
pp. 1118-1124
Author(s):  
Neha Saboo ◽  
◽  
Sudhanshu Kacker

Introduction: Prediabetes is the budding stage of type 2 diabetic mellitus and imposes the elevated risk for cardiovascular diseases (CVDs) with significant morbidity and mortality. Non pharmacological strategies such as yoga therapy have marked impact in the mitigation of prediabetes. In this backdrop, the present study was conducted to study the effect of six months yoga intervention on heart rate variability in patients diagnosed with prediabetes. Further, it has been used as tool for the maintenance of autonomic nervous system and to reduce the progression of diabetes. Material and Method: The study was conducted on 250 prediabetic adults aged ranging from 30-50 years attending the OPD of Jaipuria Hospital and from different yoga centers. Then the effect of yoga intervention on frequency domain parameters of heart rate variability such as Low frequency (LF),High frequency (HF), Ratio of LFto HF. The patients were divided into two groups as follows, Group A (n=125) were subjected to intervention with yoga exercises and Group B (n=125) were not advised for any yoga exercises. Data analysis was done by Oneway ANOVA for comparison between the groups and significance was analysed post hoc analysis followed by Tukeys and Schaffes tests. Results : In group A, yoga intervention leads to significant (p <0.001) decrease in LF component with an substantial elevation in HF component and the LF/HFratio shifted towards the parasympathetic dominance as compared to group Bat baseline, 3 and6 months. Conclusion: Thus the study reveals that yoga intervention for six months significantly shifted ANS system towards the parasympathetic dominance in prediabetic patients. Thus, routine yoga session could alleviate the cardiometabolic risk factors in individuals affected with prediabetes.


2019 ◽  
Vol 1 (4) ◽  
pp. 133-139
Author(s):  
Yasser Hamdy ◽  
Mohammed Mahmoud Mostafa ◽  
Ahmed Elminshawy

Background: Functional tricuspid valve regurgitation secondary to left-sided valve disease is common. DeVega repair is simple, but residual regurgitation with subsequent impairment of the right ventricular function is a concern. This study aims to compare tricuspid valve repair using DeVega vs. ring annuloplasty and their impact on the right ventricle in the early postoperative period and after six months. Methods: This is a prospective cohort study of 51 patients with rheumatic heart disease who underwent tricuspid valve repair for secondary severe tricuspid regurgitation. Patients were divided into two groups: group A; DeVega repair (n=34) and group B; ring annuloplasty repair (n=17). Patients were assessed clinically and by echocardiography before discharge and after six months for the degree of tricuspid regurgitation, right ventricular diameter and tricuspid annular plane systolic excursion (TAPSE). Results: Preoperative echocardiographic assessment showed no difference in left ventricular end-systolic diameter, end-diastolic diameter, ejection fraction and right ventricular diameter, however; group A had significantly better preoperative right ventricular function measured by TAPSE (1.96 ± 0.27 vs1.75 ± 0.31 cm; p=0.02). Group B had significantly longer cardiopulmonary bypass time (127.65 ± 13.56 vs. 111.74 ± 18.74 minutes; p= 0.003) and ischemic time (99.06 ± 11.80 vs. 87.15 ± 16.01 minutes; p= 0.009). Pre-discharge, there was no statistically significant difference in the degree of tricuspid regurgitation, but the right ventricular diameter was significantly lower in group B (2.66 ± 0.41 and 2.40 ± 0.48 cm; p=0.049). After six months of follow up, the degree of tricuspid regurgitation (p= 0.029) and the right ventricular diameter were significantly lower in the ring annuloplasty group (2.56 ± 0.39 and 2.29 ± 0.44 cm; p=0.029). Although there was a statistically significant difference in preoperative TAPSE, this difference disappeared after six months. Conclusion: Both DeVega and ring annuloplasty techniques were effective in the early postoperative period, ring annuloplasty was associated with lesser residual regurgitation and better right ventricular remodeling in severe functional tricuspid regurgitation than DeVega procedure after 6-months of follow up.


2021 ◽  
pp. 112067212110233
Author(s):  
Marcelina Sobczak ◽  
Magdalena Asejczyk ◽  
Malwina Geniusz

Objectives: The main goal of this research was to determine the differences between the values of intraocular pressure (IOP) in the supine and sitting positions, and to assess the effect of age and cardiovascular parameters. Methods: Seventy-two healthy adults were enrolled and classified into age groups: 20–30 years (group A), 31–40 years (group B), and 41–71 years (group C). Corneal biometry and cardiovascular parameters, such as heart rate (HR), were measured. IOP measurements were taken in the sitting position (IOPS) and in the supine position (IOPL) using the iCare® Pro tonometer. Results: A significant difference between the IOPS and IOPL in the entire cohort was found ( p < 0.001). Regarding the age subgroups, a significant difference ( p < 0.001) between the IOPS and IOPL was obtained in group A (2.6 ± 1.6 mmHg) and group C (1.5 ± 1.3 mmHg). There were no significant differences in the IOPS between groups. The highest IOP values were obtained for group A. The correlations between HR and IOPS are statistically significant for group A and group B, and for HR and IOPL-S for group B only. Multivariate analysis showed that HR has a significant influence on the difference in IOP in the two body positions. Conclusion: A statistically significant difference between the effect of age and the values of IOPS and IOPL was shown. Cardiovascular parameters showed some relevant statistical dependencies, but with a rather marginal significance in young people. The influence of body position for the measurement of IOP for healthy subjects does not seem to matter, despite the fact that there are some dependencies that are statistically significant.


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