Effects of Exercise Training on Heart-Rate-Variability Indices in Individuals With Down Syndrome
Objective:To investigate the effects of an exercise-training program on heart-rate-variability (HRV) indices in individuals with Down syndrome (DS).Design:Controlled clinical trial.Participants:10 people with DS, age 24.2 ± 5.1 y (group A), and 10 age-matched healthy sedentary individuals (group B).Method:At baseline all subjects underwent a clinical examination and an ambulatory 24-h Holter monitoring for the evaluation of cardiac autonomic-nervous-system (ANS) activity by time- and frequency-domain analysis.Intervention:After initial evaluation, group A followed a 6-mo exercise-training program and thereafter underwent the same HRV analysis.Results:At the beginning of the study, group A showed a higher LF:HF ratio than group B, indicating impaired sympathovagal balance, likely because of lesser vagal modulation. Moreover, both time- and frequency-domain indices in group A were significantly lower than in group B. At the end of the study, exercise training was found to improve the sympathovagal balance, mainly by increasing vagal activity, in group A.Conclusion:The results indicate that individuals with DS have ANS dysfunction that can be improved by exercise’s increasing the parasympathetic modulation.