scholarly journals Yersinia enterocoliticaInfection Simulating Lymphoproliferative Disease, after Liver Transplant

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
E. Jakobovich ◽  
B. Koplewitz ◽  
E. Marva ◽  
E. Granot
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Physical Examination ◽  
Liver Function Tests ◽  
Lymphoproliferative Disease ◽  
Mesenteric Lymph Nodes ◽  
Postoperative Course ◽  
Mesenteric Lymph ◽  
Elevated Sedimentation Rate ◽  
Autoimmune Conditions

We describe a 14-year-old girl, who was 13 y after liver transplantation for biliary atresia with an unremarkable postoperative course. She presented with fever of up to 40°C, extreme fatigue, malaise, anorexia, and occasional vomiting. On physical examination the only finding was splenomegaly. Lab results showed hyperglobulinemia and an elevated sedimentation rate. Liver function tests were normal except for mild elevation ofγGTP. Abdominal U/S and CT demonstrated an enlarged spleen with retroperitoneal and mesenteric lymph nodes enlargement. An exhaustive evaluation for infectious causes, autoimmune conditions, and malignancy was negative. A full recovery after 5 months prompted testing for self-limited infectious etiologies.Yersinia enterocoliticainfection was diagnosed.

Alkaline phosphatase isoforms in serum after liver allograft surgery

1994 ◽  
Vol 40 (7) ◽  
pp. 1272-1277 ◽  
Author(s):  
J Randolph-Habecker ◽  
J A Lott ◽  
R J Tesi
Keyword(s):  
Liver Transplantation ◽  
Alkaline Phosphatase ◽  
Liver Function Tests ◽  
Clinical Findings ◽  
High Molecular Mass ◽  
Reference Ranges ◽  
Liver Allograft ◽  
Postoperative Course ◽  
End Stage Liver Disease ◽  
End Stage

Abstract Orthotopic liver transplantation (OLT) is now the only available treatment for end-stage liver disease; the major postoperative complications of OLT are rejection and infection. Fractionation of alkaline phosphatase (ALP) isoforms in serum by isoelectric focusing can be used to identify patients with complications. Reference ranges for liver-function tests (LFT) and liver ALP isoforms were established for post-OLT patients with stable postoperative courses and compared with those of patients with complications. We found canalicular, hepatocyte, and high-molecular-mass ALP to be statistically higher in nearly all patients with complications as compared with patients who had a stable postoperative course; these tests may identify patients requiring a liver biopsy. When used in conjunction with LFT and other clinical findings, ALP isoforms could aid in the monitoring of complications and treatment and in the adjustment of immunosuppressive therapy in stable OLT cases.

Optimizing the Management of Abnormal Liver Function Tests after Orthotopic Liver Transplant: A Systems-Based Analysis of Health Care Utilization

2017 ◽  
Vol 83 (10) ◽  
pp. 1152-1156 ◽  
Author(s):  
Tara A. Russell ◽  
Stephanie A. K. Angarita ◽  
Amy Showen ◽  
Vatche Agopian ◽  
Ronald W. Busuttil ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Viral Hepatitis ◽  
Orthotopic Liver Transplantation ◽  
Liver Function Tests ◽  
Acute Cellular Rejection ◽  
Diagnostic Workup ◽  
Not Otherwise Specified ◽  
Bed Days ◽  
Cellular Rejection

Elevated liver function tests (eLFTs) are a major cause of unplanned readmissions (UR) after orthotopic liver transplantation. Diagnostic workup for eLFTs requires multiple invasive and noninvasive procedures, often done in the inpatient setting to expedite diagnosis, yet consequently resulting in increased costs. In this study, we evaluated eLFT readmissions at a single institution with respect to resource utilization. From 3/2013 to 12/2015, 388 patients underwent orthotopic liver transplantation, resulting in 463 UR totaling 5833 bed days; 87 (18.8%) UR and 929 (15.9%) bed days were for eLFTs. During eLFT-UR all patients underwent repeat laboratory testing, 75 (86.2%) liver ultrasound, 66 (75.8%) liver biopsy, and 17 (19.5%) endoscopic retrograde cholangiopancreatography. Discharge diagnoses were acute cellular rejection (40.2%), transaminitis not otherwise specified (17.2%), biliary complications (16.1%), recurrent hepatitis (11.5%), vascular complications (5.8%), viral hepatitis (5.8%), and steatohepatitis (3.5%). The greatest bed-day utilization was secondary to acute cellular rejection (60.8%) and biliary complications (13.7%). More than 35 per cent of eLFT-UR were due to transaminitis not otherwise specified, steatohepatitis, recurrent or viral hepatitis, none of which necessitate inpatient treatment. In addition, >25 per cent of eLFT-UR bed days were attributed to diagnostic workup. Identifying patients who can undergo expedited outpatient workup and require only outpatient management will result in significantly decreased readmissions, bed days, and hospital costs.

Quantitative liver function tests in donors and recipients of living donor liver transplantation

2006 ◽  
Vol 12 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Christoph Jochum ◽  
Mechthild Beste ◽  
Volker Penndorf ◽  
Marjan Sharifi Farahani ◽  
Giuliano Testa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Liver Function Tests ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Function Tests

Impaired liver function tests in patients treated with antithymocyte globulin: Implication for liver transplantation

1997 ◽  
Vol 14 (3-4) ◽  
pp. 125-129 ◽  
Author(s):  
Amos Toren ◽  
Yaron Ilan ◽  
Reuven Or ◽  
Joseph Kapelushnik ◽  
Arnon Nagler
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Antithymocyte Globulin ◽  
Liver Function Tests ◽  
Impaired Liver Function ◽  
Function Tests ◽  
Impaired Liver

scholarly journals Treatment of subacute hepatitis B with lamivudine: A pilot study in Serbia

2009 ◽  
Vol 66 (3) ◽  
pp. 199-202 ◽  
Author(s):  
Dragan Delic ◽  
Zorica Nesic ◽  
Milica Prostran ◽  
Ivan Boricic ◽  
Neda Svirtlih
Keyword(s):  
Liver Transplantation ◽  
Pilot Study ◽  
Hepatitis B ◽  
Liver Function ◽  
Fulminant Hepatic Failure ◽  
Liver Function Tests ◽  
Hbv Infection ◽  
Subacute Hepatitis ◽  
Life Saving ◽  
Acute Hepatitis B

Background/Aim. The incidence of acute hepatitis B viral (HBV) infection in adults has increased in recent years in Serbia. Most icteric patients with acute hepatitis B resolve their infection and do not require treatment. Fulminant hepatitis B is a severe form of acute infection complicated by encephalopathy and liver failure. Subgroups of fulminant hepatitis B including hyperacute, acute and subacute are defined by the interval between jaundice and encephalopathy. Fulminant hepatic failure or subacute hepatitis B infection we observed in about 1% of all cases. In cases of fulminant hepatic failure or subacute form of HBV infection orthotopic liver transplantation can be life-saving operation, but in our country this procedure is difficult to achieve. Lamivudine has been established as a safe and effective antiviral agent for the treatment of chronic HBV hepatitis. Methods. In our pilot study performed at the Institute of Infectious and Tropical Diseases in Belgrade, Serbia in the period between 2002 and 2006 we treated 10 patients with clinically verified subacute HBV infection with lamivudine, 100 mg orally per day. Results. The most of the treated patients (9/10; 90%) survived subacute form of hepatitis B. After a few weeks of the treatment serum aminotransferase levels and other liver-function tests were normalized. Also, after a four-month lamivudine treatment all the patients lost HBsAg. Lamivudine was discontinued after six months in all the patients. In addition, six months after lamivudine was discontinued the patients remained well with normal results on liver-function tests. Conclusion. The obtained results suggest significant efficacy of lamivudine in patients with subacute hepatitis B. Also, we suggest that lamivudine therapy should be administered early in progression of subacute disease since it could be life-saving treatment in some patients, especially in the countries (like Serbia) where orthotopic liver transplantation is difficult to achieve.

Could metabolic liver function tests predict mortality on waiting list for liver transplantation? A study on 560 patients

2010 ◽  
Vol 25 (5) ◽  
pp. 755-765 ◽  
Author(s):  
Marie Ecochard ◽  
Olivier Boillot ◽  
Olivier Guillaud ◽  
Sabine Roman ◽  
Mustapha Adham ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Liver Function Tests ◽  
Waiting List ◽  
Function Tests ◽  
Metabolic Liver Function

A young man with bleeding esophageal varices

2018 ◽  
Vol 1 (1) ◽  
pp. 14-16
Author(s):  
Soonthorn Chonprasertsuk
Keyword(s):  
Risk Factors ◽  
Portal Hypertension ◽  
Liver Function ◽  
Physical Examination ◽  
Esophageal Varices ◽  
Liver Function Tests ◽  
Noncirrhotic Portal Hypertension ◽  
Liver Histopathology ◽  
Function Tests ◽  
Bleeding Esophageal Varices

The noncirrhotic portal hypertension is an uncommon cause of bleeding esophageal varices. This condition must be suspected in patients with preserved liver function. We report a 25-year old man with SLE disease who presented with hematemesis. He had no history or risk factors for an underlying liver condition. A huge splenomegaly was detected by physical examination. The EGD found three large varices with red wale sign, whereas liver function tests were unremarkable. The noncirrhotic portal hypertension was diagnosed and confirmed by liver histopathology.

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