Quantitative liver function tests in donors and recipients of living donor liver transplantation

2006 ◽  
Vol 12 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Christoph Jochum ◽  
Mechthild Beste ◽  
Volker Penndorf ◽  
Marjan Sharifi Farahani ◽  
Giuliano Testa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Liver Function Tests ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Function Tests

scholarly journals Effect of Portal Venous Pressure on Liver Function of Donors in Living Donor Liver Transplantation

2019 ◽  
Vol 24 ◽  
pp. 401-406 ◽  
Author(s):  
Ahmed H. Khalil ◽  
Mohammed Khattab ◽  
Karim A. Hosny ◽  
Mostafa Elshazly ◽  
Ayman Salah Eldin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Venous Pressure ◽  
Portal Venous Pressure ◽  
Donor Liver ◽  
Donor Liver Transplantation

scholarly journals Preoperative nutrition and postoperative liver function: a correlation study of pediatric living donor liver transplantation

2018 ◽  
Vol 5 (2) ◽  
pp. 157-164
Author(s):  
Ye-Feng Lu ◽  
Yan Wang ◽  
Ming-Zhu Huang ◽  
Xue-Fei Ren ◽  
Lei-Qing Gao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Transplantation ◽  
Liver Function ◽  
Nutritional Status ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Nutritional Assessment ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Laboratory Examinations

AbstractObjectiveThere is little information focusing on the nutritional issue of pediatric recipients before they receive living donor liver transplantation. This study illustrates the relationship between nutritional status and graft liver function and provides a reference regarding nutritional interventions in future studies.MethodsWe prospectively collected data from 30 pediatric living donor liver transplant recipients from January 1, 2016, to June 30, 2016. The information included demographic data, preoperative nutritional assessment, and postoperative laboratory examinations. The nutritional assessment included the serum concentration of vitamin D, bone density, trace element, and weight Z value. The laboratory examinations included white blood cell count, neutrophil percentage, hemoglobin, blood platelet, total protein, albumin, total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase (AST), alkaline phosphatase, gamma-glutamyl transpeptidase, creatinine, bile acid, blood glucose (Glu), prothrombin time, international normalized ratio, tacrolimus concentration, and graft-to-recipient weight ratio (GRWR). The data were collected on Days 1, 2, 3, 4, 5, 6, 7, 14, 30, and 60 after liver transplantation.ResultsThe recipients consisted of 15 (50%) males and 15 (50%) females. The median age was 7 months (4–48 months). The mean height and weight were 69.07±9.98 cm and 8.09±2.63 kg, respectively. According to the univariate analysis, the gender, diagnosis, blood type, and GRWR did not significantly impact the liver function after the operation. The posttransplantation AST levels and Glu showed significant differences in terms of the nutritional status, withP<0.05. The multivariate correlation analysis showed that the serum concentrations of vitamin D and AST were midrange positively correlated, withP<0.05.ConclusionsThe nutritional status of patients with biliary atresia is relatively poor. There is a definite midrange positive correlation between nutrition and graft liver function that might play a relatively important role in the recovery of the graft.

scholarly journals Major influence of liver function itself but not of immunosuppression determines glucose tolerance after living-donor liver transplantation

2006 ◽  
Vol 12 (4) ◽  
pp. 535-543 ◽  
Author(s):  
Martin Stockmann ◽  
Thomas Konrad ◽  
Sabine Nolting ◽  
Diana Hünerbein ◽  
Klaus-Dieter Wernecke ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Glucose Tolerance ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Major Influence ◽  
Donor Liver ◽  
Donor Liver Transplantation

scholarly journals Graft-to-Recipient Weight Ratio Associated With Tacrolimus Metabolism Following Pediatric Living Donor Liver Transplantations

2019 ◽  
Vol 24 (2) ◽  
pp. 138-147
Author(s):  
Kensuke Shoji ◽  
Isao Miyairi ◽  
Eisuke Inoue ◽  
Akinari Fukuda ◽  
Seisuke Sakamoto ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Early Period ◽  
Weight Ratio ◽  
Pediatric Liver Transplantation ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Pediatric Liver

OBJECTIVES Tacrolimus (TAC) is an important immunosuppressant in liver transplantation. Since TAC is mainly metabolized by the liver enzymes CYP3A4 and 5, liver function is crucial for its pharmacokinetics (PK). Liver function is dynamic after liver transplantation; hence the PK of TAC metabolism after pediatric liver transplantation is not well understood. We aimed to investigate the time-dependent changes in TAC metabolism and to find factors influencing TAC PK after pediatric liver transplantation. METHODS We retrospectively reviewed the characteristics of the donors and recipients in pediatric living donor liver transplantation and used the TAC concentration-dose (CD) ratio as a surrogate marker of TAC metabolism. RESULTS Included were 326 patients with a median age of 13 months. After the liver transplantation, the CD ratio gradually decreased, then plateaued around day 21 to 28. A linear regression analysis demonstrated that a lower graft-to-recipient weight ratio (GRWR) and higher prothrombin time–international normalized ratio (PT-INR) were independently associated with a higher CD ratio in the early period after liver transplantation. However, association between GRWR and TAC CD ratio disappeared around 6 to 12 months after a liver transplantation possibly owing to graft regeneration. CONCLUSIONS Tacrolimus metabolism improved within the first month after liver transplantation, and the small graft size was associated with lower TAC metabolism in the early period after pediatric living donor liver transplantation.

Evaluation of liver function before living donor liver transplantation and liver resection

2008 ◽  
Vol 149 (17) ◽  
pp. 779-786 ◽  
Author(s):  
Tamás Mándli ◽  
János Fazakas ◽  
Gábor Ther ◽  
Mónika Árkosy ◽  
Balázs Füle ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Resection ◽  
Liver Function ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Liver Volume ◽  
Hepatobiliary Scintigraphy ◽  
Remnant Liver ◽  
Donor Liver ◽  
Donor Liver Transplantation

Liver resection is the curative therapeutic option for hepatocellular carcinoma, biliary tumors, metastases of colorectal and other extrahepatic tumors, living donor liver transplantation and other benign liver diseases. Aim of study: To summarize the evaluation methods of liver function before living donor liver transplantation and liver resection. Method: We summarize the literature about the evaluation of liver function. Results: Perioperative mortality is determined mostly by the extent of preoperative evaluation focused on the liver. After resection the remnant liver parenchyma must cope with the challenge caused by increased metabolism, portal overflow, decreased vascular bed and biliary tract and oxidative stress following the operation. If the remnant liver is unable to grow up to this challenge, acute liver failure occurs. This maintains the necessity of determining the hepatic functional reserve and the hepatic remnant volume. Child–Pugh classification is widely spread to predict outcome. Dynamic functional tests such as indocyanin green retention test, galactosyl human serum albumin scintigraphy and aminopyrin breath tests can be used to evaluate hepatic reserve. To determine remnant liver volume modern imaging processes such as CT volumetry and hepatobiliary scintigraphy are available. Conclusion: After the detailed evaluation resection can be limited to an extent which is oncologically radical enough (1% remnant liver tissue/kg) and spares parenchyma which can ensure survival yet. With careful preoperative examination mortality can be reduced even to reach zero.

Sign in / Sign up

Export Citation Format

Share Document