scholarly journals Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Ana L. Guadarrama-López ◽  
Roxana Valdés-Ramos ◽  
Beatríz E. Martínez-Carrillo
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Vitamin D ◽  
Innate Immune System ◽  
Inflammatory Diseases ◽  
Innate Immune ◽  
Important Public Health ◽  
Chronic Inflammatory Diseases ◽  
Treatment And Prevention

Chronic diseases have become one of the most important public health problems, due to their high costs for treatment and prevention. Until now, researchers have considered that the etiology of Type 2 diabetes mellitus (T2DM) is multifactorial. Recently, the study of the innate immune system has offered an explanation model of the pathogenesis of T2DM. On the other hand, there is evidence about the beneficial effect of polyunsaturated fatty acids (PUFA) n-3 and n-6 in patients with chronic inflammatory diseases including diabetes. Furthermore, high vitamin D plasmatic concentrations have been associated with the best performance of pancreaticβcells and the improving of this disease. In conclusion, certain fatty acids in the adequate proportion as well as 25-hydroxivitamin D can modulate the inflammatory response in diabetic people, modifying the evolution of this disease.

scholarly journals Vitamin D and inflammation in the prevention of type 2 diabetes: public health relevance

2012 ◽  
Vol 3 (4) ◽  
pp. 243
Author(s):  
Alaa Badawi ◽  
Eman Sadoun ◽  
Mohamed H. Al Thani
Keyword(s):  
Public Health ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Immune System ◽  
Innate Immune System ◽  
Population Level ◽  
Innate Immune ◽  
Low Grade ◽  
Low Grade Inflammation

The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. To reduce the disease risk and burden at the population level, preventative strategies should be developed with minimal cost and effort and with no side-effects. Low-grade inflammation resulting from imbalances in the innate immune system has been associated with an array of chronic disorders that predispose to the later development of T2DM (e.g., obesity, metabolic syndrome, and insulin resistance). As a result, inflammation may contribute to the pathogenesis of T2DM. Therefore, attenuation of this inflammatory response via modulating the innate immune system could lead to improved insulin sensitivity and delayed disease onset. Dietary supplementation with vitamin D may represent a novel strategy toward the prevention and control of T2DM at the population level due to its anti-inflammatory and antioxidant properties. This review examines current knowledge linking T2DM to chronic low-grade inflammation and the role of vitamin D in modulating this relationship. The concept that vitamin D, via attenuating inflammation, could be employed as a novel preventive measure for T2DM is evaluated in the context of its relevance to health care and public health practices.

scholarly journals Vitamin D and inflammation in the prevention of type 2 diabetes: public health relevance

2012 ◽  
Vol 3 (4) ◽  
pp. 243-255 ◽  
Author(s):  
Alaa Badawi ◽  
Eman Sadoun ◽  
Mohamed H. Al Thani
Keyword(s):  
Public Health ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Immune System ◽  
Innate Immune System ◽  
Population Level ◽  
Innate Immune ◽  
Low Grade ◽  
Low Grade Inflammation

The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. To reduce the disease risk and burden at the population level, preventative strategies should be developed with minimal cost and effort and with no side-effects. Low-grade inflammation resulting from imbalances in the innate immune system has been associated with an array of chronic disorders that predispose to the later development of T2DM (e.g., obesity, metabolic syndrome, and insulin resistance). As a result, inflammation may contribute to the pathogenesis of T2DM. Therefore, attenuation of this inflammatory response via modulating the innate immune system could lead to improved insulin sensitivity and delayed disease onset. Dietary supplementation with vitamin D may represent a novel strategy toward the prevention and control of T2DM at the population level due to its anti-inflammatory and antioxidant properties. This review examines current knowledge linking T2DM to chronic low-grade inflammation and the role of vitamin D in modulating this relationship. The concept that vitamin D, via attenuating inflammation, could be employed as a novel preventive measure for T2DM is evaluated in the context of its relevance to health care and public health practices.

NOD1 receptor is up-regulated in diabetic human and murine myocardium

2014 ◽  
Vol 127 (12) ◽  
pp. 665-677 ◽  
Author(s):  
Patricia Prieto ◽  
María Teresa Vallejo-Cremades ◽  
Gemma Benito ◽  
Pilar González-Peramato ◽  
Daniel Francés ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
Murine Models

We demonstrate that the myocardium from murine models of diabetes and the myocardium of patients with Type 2 diabetes overexpress the receptor of the innate immune system NOD1. This up-regulation occurred in cardiomyocytes and was associated with an increased apoptotic profile.

scholarly journals Is Type 2 Diabetes an Autoimmune-Inflammatory Disorder of the Innate Immune System?

Endocrinology ◽  
2005 ◽  
Vol 146 (10) ◽  
pp. 4189-4191 ◽  
Author(s):  
Leonard D. Kohn ◽  
Brian Wallace ◽  
Frank Schwartz ◽  
Kelly McCall
Keyword(s):  
Type 2 Diabetes ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
Inflammatory Disorder

scholarly journals Prevalence of Cognitive Impairment in Recently Diagnosed Type 2 Diabetes Patients: Are Chronic Inflammatory Diseases Responsible for Cognitive Decline?

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141325 ◽  
Author(s):  
Pilar Lavielle ◽  
Juan O. Talavera ◽  
Nancy Reynoso ◽  
Marissa González ◽  
Rita A. Gómez-Díaz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Diabetes Patients

scholarly journals Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

2018 ◽  
Vol 72 (3) ◽  
pp. 152-159
Author(s):  
Aleksejs Zavorins ◽  
Jūlija Voicehovska ◽  
Jānis Ķīsis ◽  
Aivars Lejnieks
Keyword(s):  
Endoplasmic Reticulum ◽  
Immune System ◽  
Cardiovascular Diseases ◽  
Innate Immune System ◽  
Inflammatory Diseases ◽  
Innate Immune ◽  
Inflammatory Skin Disease ◽  
Chronic Inflammatory Diseases ◽  
Central Regions ◽  
The Face

Abstract Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.

Abstract #421 Association of Vitamin D Levels with the Severity of Fibrosis in NAFLD Patients with Type 2 Diabetes

2019 ◽  
Vol 25 ◽  
pp. 199-200
Author(s):  
Prathyusha Chitrapu ◽  
Shilpa Jain ◽  
Aaron Thrift ◽  
Maya Balakrishnan ◽  
Ruchi Gaba
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Levels
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