scholarly journals An Alternative to Current Therapies of Functional Dyspepsia: Self-Administrated Transcutaneous Electroacupuncture Improves Dyspeptic Symptoms

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ting Ji ◽  
Xueliang Li ◽  
Lin Lin ◽  
Liuqin Jiang ◽  
Meifeng Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Therapeutic Potential ◽  
Treatment Options ◽  
Treatment Method ◽  
Gastric Accommodation ◽  
Dyspeptic Symptoms ◽  
New Treatment

Functional dyspepsia is of high prevalence with little treatment options. The aim of this study was to develop a new treatment method using self-management transcutaneous electroacupuncture (TEA) for functional dyspepsia (FD). Twenty-eight patients with FD were enrolled and underwent a crossover clinical trial with 2-week TEA at ST36 and PC6 and 2-week sham-TEA at nonacupuncture sham-points. Questionnaires were used to assess symptoms of dyspepsia and quality of life. Physiological testing included gastric emptying and electrogastrography. It was found that (1) TEA but not sham-TEA significantly improved dyspeptic symptoms and 4 domains in quality of life; improvement was also noted in self-rated anxiety and depression scores; (2) gastric emptying was significantly and substantially increased with 2-week TEA but not sham-TEA; and (3) gastric accommodation was also improved with TEA but not sham-TEA, reflected as increased ingested nutrient volumes at the levels of satiety and maximum tolerance. These findings suggest a therapeutic potential of self-administrated TEA method for functional dyspepsia, possibly attributed to improvement in gastric motility.

scholarly journals New treatment options of chronic urticaria

2021 ◽  
Vol 97 (5) ◽  
pp. 266-272
Author(s):  
Bernadett Hidvégi ◽  
◽  
Lilla Mihályi
Keyword(s):  
Quality Of Life ◽  
Chronic Urticaria ◽  
Treatment Options ◽  
Multifactorial Disease ◽  
2Nd Generation ◽  
New Treatment

Chronic urticaria is a multifactorial disease with increasing prevalence, that significantly deteriorates the quality of life of patients. Authors describe the pathomechanism of the disease, and they present the currently available treatment options and the promising future therapies as well. The therapeutic basis of chronic urticaria is the modern, 2nd generation antihistamines in a dosage of even four times higher than the regular one. In therapy resistant cases omalizumab or cyclosporin is advised. There is a growing demand for new medications because the number of those patients , who are non-responders or do not respond adequately to these therapies, is definitely increasing.

scholarly journals ACUPUNCTURE EFFECTIVENESS AS A COMPLEMENTARY THERAPY IN FUNCTIONAL DYSPEPSIA PATIENTS

2013 ◽  
Vol 50 (3) ◽  
pp. 202-207 ◽  
Author(s):  
Flavia Altaf da Rocha LIMA ◽  
Lincoln Eduardo Villela Vieira de Castro FERREIRA ◽  
Fabio Heleno de Lima PACE
Keyword(s):  
Quality Of Life ◽  
Drug Therapy ◽  
Functional Dyspepsia ◽  
Conventional Treatment ◽  
Epigastric Pain ◽  
Gastrointestinal Symptoms ◽  
Gastric Accommodation ◽  
Group I ◽  
Group Ii

Context Functional dyspepsia represents a frequent gastrointestinal disorder in clinical practice. According to the Roma III criteria, functional dyspepsia can be classified into two types as the predominant sympton: epigastric pain and postprandial discomfort. Even though the pathophysiology is still uncertain, the functional dyspepsia seems to be related to multiple mechanisms, among them visceral hypersensitivity, changes in the gastroduodenal motility and gastric accommodation and psychological factors. Objective Evaluate the effectiveness of acupuncture as a complementary to conventional treatment in functional dyspepsia patients. Methods Randomized clinical trial in which were enrolled patients with functional dyspepsia patients in according with Rome III criteria. One group was submitted to drug therapy and specific acupuncture (GI) and the other to drug therapy and non-specific acupuncture (GII). The gastrointestinal symptoms, presence of psychiatric disorders and quality of life were evaluated, at the end and three months after treatment. Results After 4 weeks of treatment there was improvement of gastrointestinal symptoms in Group I (55 ± 12 vs 29 ± 8.8; P = 0.001) and Group II (50.5 ± 10.2 vs 46 ± 10.5; P = 0.001). Quality of life was significantly better in Group I than group II (93.4 ± 7.3 vs 102.4 ± 5.1; P = 0.001). Anxiety (93.3% vs 0%; P = 0.001) and depression (46.7% vs 0%; P = 0.004) were significantly lower in Group I than group II. When comparing the two groups after 4 weeks of treatment, gastrointestinal symptoms (29 ± 8.8 vs 46 ± 10.5; P<0.001) and quality of life (102.4 ± 5.1 vs 96 ± 6.1; P = 0.021) were significantly better in Group I than group II. Three months after the treatment, gastrointestinal symptoms remained better only in Group I, when compared to the pre-treatment values (38 ± 11.3 vs 55 ± 12; P = 0.001). Conclusion In patients with functional dyspepsia the complementary acupuncture treatment is superior to conventional treatment. Further studies with more patients are needed to confirm these findings.

scholarly journals The Effects ofBanha-sasim-tangon Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Jae-Woo Park ◽  
Seok-Jae Ko ◽  
Gajin Han ◽  
Inkwon Yeo ◽  
Bongha Ryu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Dyspepsia ◽  
Gastric Motility ◽  
Slow Waves ◽  
Double Blind ◽  
Early Satiety ◽  
Gastric Slow Waves ◽  
Quality Of Life Scale ◽  
Dyspeptic Symptoms

Introduction. Functional dyspepsia (FD) is highly prevalent, and no standard treatments exist for this condition. Herbal prescriptions are widely used to treat FD. In traditional Korean medicine,Banha-sasim-tang(BST) is a famous herbal prescription for dyspepsia. This study aimed to evaluate the efficacy of BST and to examine the relationship between gastric slow waves and dyspeptic symptoms.Materials and Methods. In total, 100 FD patients were recruited; BST or placebo was administered for 6 weeks. The gastrointestinal symptom scale, FD-related quality of life scale, and frequency or power variables regarding gastric slow waves were measured at 0, 6, and 14 weeks.Results. There were no significant differences in the overall dyspeptic symptoms or quality of life between the BST and placebo groups. However, early satiety was significantly improved in the BST group (P=0.009, at 6 weeks by intention-to-treat analysis). Abnormal gastric dysrhythmias and power ratios were also significantly improved by BST.Conclusion. BST had no significant effects on FD. However, early satiety appeared to improve after BST administration. Electrogastrography may be a useful technique for assessing changes in gastric motility dysfunction after interventions for FD. Further investigation focused on specific symptoms or subtypes of FD is required.

Targeting the Interleukin-12/23 Cytokine Family in the Treatment of Psoriatic Disease

2008 ◽  
Vol 12 (6_suppl) ◽  
pp. S1-S10 ◽  
Author(s):  
Neil H. Shear ◽  
Jörg Prinz ◽  
Kim Papp ◽  
Richard G.B. Langley ◽  
Wayne P. Gulliver
Keyword(s):  
Quality Of Life ◽  
Treatment Options ◽  
Dose Finding ◽  
Phase Iii ◽  
Interleukin 12 ◽  
Finding Study ◽  
Ortho Biotech ◽  
Phase Iii Trials ◽  
New Treatment

Psoriasis is a complex systemic immune inflammatory disease whose burden of disease includes poorer quality of life, a high prevalence of serious comorbidities, and a potentially decreased life span—hence the continued need to search for new treatment options. ABT-874 (Abbott Laboratories, Saint-Laurent, QC,) and ustekinumab (CNTO 1275, Ortho Biotech, Toronto, ON) are two monoclonal antibodies against interleukins 12 and 23 (IL-12/23), key mediators of T-cell differentiation in the pathogenesis of psoriasis. The results of a 12-week, phase II, dose-finding study of ABT-874 have been encouraging. More recently, level 1 evidence has emerged for ustekinumab in two placebo-controlled phase III trials, PHOENIX 1 and PHOENIX 2; therapeutic responses to ustekinumab have been maintained up to 76 weeks of follow-up, and quality of life has significantly improved with ustekinumab. Both agents produced few and mild adverse events, and the rates of serious infections and cancers were very low and similar to those of placebo. These promising results strongly confirm the central role of IL-12/23 in psoriasis and its importance as a therapeutic target.

scholarly journals Impact of Sleep Disorders, Quality of Life and Gastric Emptying in Distinct Subtypes of Functional Dyspepsia in Japan

2014 ◽  
Vol 20 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Hiroshi Yamawaki ◽  
Seiji Futagami ◽  
Mayumi Shimpuku ◽  
Hitomi Sato ◽  
Taiga Wakabayashi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gastric Emptying ◽  
Sleep Disorders ◽  
Functional Dyspepsia

scholarly journals Acupuncture for Functional Dyspepsia: A Single Blinded, Randomized, Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yulian Jin ◽  
Qing Zhao ◽  
Kehua Zhou ◽  
Xianghong Jing ◽  
Xiaochun Yu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Group ◽  
Functional Dyspepsia ◽  
Mental Status ◽  
Serum Gastrin ◽  
Slow Waves ◽  
Control Group ◽  
Gastric Slow Waves ◽  
Dyspeptic Symptoms

In order to investigate the therapeutic potential of acupuncture on patients with functional dyspepsia (FD), patients were randomized to receive acupuncture at classic acupoints with manipulations (treatment group) versus acupuncture at nonacupoints without manipulation (control group) once every other day, three times a week, for one month and were followed up for three months. The primary outcomes included dyspeptic symptoms, quality of life, and mental status. The secondary outcomes included the fasting serum gastrin concentration, and frequency and propagation velocity of gastric slow waves. Sixty patients with FD were included, among whom, four dropped out. After one month's treatment, patients with FD showed significant improvements in primary (in both groups) and secondary (in the eight patients of the treatment group) outcomes as compared with baseline (P=0.0078to <0.0001); treatment group has better outcomes in all primary outcome measures (P<0.0001except for SDS (P=0.0005)). Improvements on dyspeptic symptoms persist during follow-up (better in the treatment group). Acupuncture with manual manipulation had better effects on improving dyspeptic symptoms, mental status, and quality of life in patients with FD. These effects may be related to the increased frequency and propagation speed of gastric slow waves and serum gastrin secretion.

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