scholarly journals Long Term Followup of Photorefractive Keratectomy with Adjuvant Use of Mitomycin C

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Vasilios F. Diakonis ◽  
Vardhaman P. Kankariya ◽  
George D. Kymionis ◽  
Georgios Kounis ◽  
George Kontadakis ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Mitomycin C ◽  
Cell Density ◽  
Endothelial Cell Density ◽  
Photorefractive Keratectomy ◽  
Visual Outcomes ◽  
One Year ◽  
The One ◽  
Postoperative Interval

Purpose.To study the long term refractive and visual outcomes of photorefractive keratectomy (PRK) with intraoperative application of mitomycin C (MMC).Methods.This study included 37 eyes who received myopic PRK; after photoablation, a sponge soaked in 0.02% MMC solution was applied in all corneas for 2 minutes. Efficacy, safety, predictability, and stability of PRK MMC were evaluated. Endothelial cell density was evaluated at the last postoperative interval.Results.Mean preoperative spherical equivalent (SEQ) was−6.03±1.87 D (diopters) and reduced to−0.09±0.53 D at the last postoperative examination. Mean followup was44.73±18.24months. All the eyes were in the ±1.00 D of attempted versus achieved SEQ at the one-year follow-up interval. Furthermore, 95% of the eyes did not lose lines or gained 1 to 2 lines of CDVA, while 5% lost 1 line. At the third postoperative month, 89% of the eyes either were clear or had trace haze, while 4 eyes had mild haze; by the 12-month postoperative interval, none of the eyes demonstrated haze. Mean endothelial cell density (ECD) at the last postoperative interval was2658±153 cells/mm2.Conclusions.PRK, with intraoperative use of MMC, demonstrates stable refractive and visual outcomes up to 44 months after surgery.

Cases With Long-Term High Corneal Endothelial Cell Density Maintained After Corneal Transplantation

Cornea ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kanae Kayukawa ◽  
Koji Kitazawa ◽  
Koichi Wakimasu ◽  
Sanjay V. Patel ◽  
John Bush ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Corneal Transplantation ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Corneal Endothelial Cell Density

Endothelial cell density after photorefractive keratectomy for moderate myopia using a 213 nm solid-state laser system

2007 ◽  
Vol 33 (11) ◽  
pp. 1866-1870 ◽  
Author(s):  
Nikolaos S. Tsiklis ◽  
George D. Kymionis ◽  
Aristofanis I. Pallikaris ◽  
Vasilios F. Diakonis ◽  
Harilaos S. Ginis ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Solid State ◽  
Cell Density ◽  
Laser System ◽  
Solid State Laser ◽  
Endothelial Cell Density ◽  
Photorefractive Keratectomy ◽  
State Laser

scholarly journals A survey of corneal changes caused by daily wear silicone hydrogel contact lenses

2015 ◽  
Vol 08 (06) ◽  
pp. 1550044 ◽  
Author(s):  
Beata Kettesy ◽  
Julianna Vardai ◽  
Andras Berta ◽  
Laszlo Modis ◽  
Adam Kemeny-Beke
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Contact Lens ◽  
Contact Lenses ◽  
Corneal Thickness ◽  
Endothelial Cell Density ◽  
Silicone Hydrogel ◽  
Group 2 ◽  
One Year ◽  
Group 1

Purpose: The examination of the effects of second generation lotrafilcon B silicone hydrogel (SiH) lenses on the cornea when worn for three years of daily wear. Material and Methods: 55 healthy patients were divided into two groups: current hydrogel contact lens wearers refitted with lotrafilcon B lenses (Group 1; 28 patients) and neophyte contact lens wearers (Group 2; 27 patients). Each patient's subjective eye comfort was measured with a self-administered questionnaire. The corneas were analyzed using contact specular microscope to measure corneal thickness and the endothelium before the SiH lenses were fitted after four weeks, one month, six months, one year, two years, and three years of lens wear. Results: Subjective complaints of patients in Group 1 were reduced; however patients in Group 2 experienced discomfort during the first two to four weeks of use. In Group 1, objective examinations identified a decrease in endothelial cell density. In Group 2, the endothelial cell density increased slightly in the first two years but decreased after three years. The results indicate that lotrafilcon B slows down the deleterious effects of contact lenses. The coefficient of variation significantly decreased after six months in Group 1 (0.47 vs 0.44; p = 0.049), whereas, in Group 2, the hexagonal cells improved significantly after one month (27.78 vs 28.25; p = 0.025). Conclusion: Based on the subjects involved and the period of time under examination, it can be concluded that high-Dk SiH lenses support the physiological metabolism and functions of the cornea by improving oxygen provision.

scholarly journals Visual Outcomes of Ultrathin-Descemet Stripping Endothelial Keratoplasty versus Descemet Stripping Endothelial Keratoplasty

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Konstantinos Droutsas ◽  
Myrsini Petrelli ◽  
Dimitrios Miltsakakis ◽  
Konstantinos Andreanos ◽  
Anastasia Karagianni ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Endothelial Cell ◽  
Cell Density ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Endothelial Cell Density ◽  
Endothelial Keratoplasty ◽  
Descemet Stripping Endothelial Keratoplasty ◽  
Visual Outcomes ◽  
The Impact

Purpose. To examine the impact of graft thickness (GT) on postoperative visual acuity and endothelial cell density after ultrathin-Descemet stripping automated endothelial keratoplasty (UT-DSAEK) versus conventional DSAEK. Methods. The medical records of all patients who underwent DSAEK at our institute during a 2-year period were reviewed. After excluding subjects with low visual potential, 34 eyes were divided into two groups based on the postoperative GT as measured with anterior segment optical coherence tomography (AS-OCT): an UT-DSAEK group (GT ≤ 100 μm, n=13 eyes) and a DSAEK group (GT > 100 μm, n=21 eyes). The groups were compared with regard to best-corrected visual acuity (BCVA), subjective refraction, central corneal thickness (CCT), GT, and endothelial cell density (ECD). Results. Preoperative BCVA (logMAR) was 1.035 ± 0.514 and 0.772 ± 0.428 for UT-DSAEK and DSAEK, respectively (P=0.072). At 6 months postoperatively, BCVA was 0.088 ± 0.150 following UT-DSAEK and 0.285 ± 0.158 following DSAEK (P=0.001). Conclusion. DSAEK grafts with a thickness under 100 μm offered better visual outcomes during the early postoperative period.

scholarly journals Change in Corneal Endothelial Cell Density after Baerveldt Shunt Implantation in Glaucoma Patients

2021 ◽  
Vol 73 (4) ◽  
pp. 252-258
Author(s):  
Ngamkae Ruangvaravate
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Linear Mixed Model ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Shunt Implantation ◽  
Corneal Endothelial Cell Density ◽  
One Year ◽  
Over Time

Objective: To evaluate changes in corneal endothelial cells density (EDC) at 1 one, six, and twelve months after Baerveldt shunt implantation. Materials and Methods: This prospective study included 24 patients who underwent Baerveldt shunt implantation for refractory glaucoma, and who had one full year of post-surgical follow-up. Best corrected visual acuity (BCVA), intraocular pressure (IOP), number of glaucoma medications, central corneal thickness (CCT), corneal endothelial cell density (EDC), and morphology in central, inferior, and superotemporal (stEDC) areas were recorded at baseline, and 1, 6, and 12 months after surgery. Distance between the tip of tube to corneal endothelium (TTC) was measured using optical coherence tomography at one month after surgery. Results: Twenty-four eyes from 24 patients were analyzed. Sixty-two percent were primary open-angle glaucoma, and 73.1% of patients had previous trabeculectomy. Mean BCVA was not significantly changed. The mean IOP at six months (12.2±4.35 mmHg) and at one year (11.1±4.31 mmHg) was significantly lower than baseline (20.1±9.24 mmHg) (p<0.001 and p<0.001 respectively). Median (min, max) number of anti-glaucoma medications significantly decreased from 4 (1, 6) at baseline to 1 (0, 3) and 1 (0, 3) at six months and one year after surgery (p<0.001 and p<0.001, respectively). Mean baseline stEDC was 1,527±644 cells/mm2. From linear mixed model, stEDC showed the most significantly decreasing slope (y=1365.54 – 18.6125t, p=0.014), and CCT showed a significant increase over time (y=533.65 + 1.8853t). Pearson’s correlation coefficient between TTC and stEDC change at one year was not statistically significant (-0.403, p=0.172). Conclusion: After Baerveldt shunt implantation, EDC loss over time was found in the area closest to where the tube was placed in addition to increasing CCT. Distance from tip of tube to cornea is not the only factor that can cause EDC loss after shunt implantation. Additional study to identify other possible mechanisms is warranted.

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