scholarly journals Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
John-Bruce D. Green ◽  
Phillip W. Carter ◽  
Yingqing Zhang ◽  
Dipa Patel ◽  
Priyanka Kotha ◽  
...  
Keyword(s):  
Particle Size ◽  
Clinical Importance ◽  
Automated System ◽  
Size Distributions ◽  
Mixing Conditions ◽  
Particle Size Distributions ◽  
Complex Formulation ◽  
Wide Range ◽  
Key Variables ◽  
Kinetics Of

Detailing the kinetics of particle formation for pharmaceutically relevant solutions is challenging, especially when considering the combination of formulations, containers, and timescales of clinical importance. This paper describes a method for using commercial software Automate with a stream-selector valve capable of sampling container solutions from within an environmental chamber. The tool was built to monitor changes in particle size distributions via instrumental particle counters but can be adapted to other solution-based sensors. The tool and methodology were demonstrated to be highly effective for measuring dynamic changes in emulsion globule distributions as a function of storage and mixing conditions important for parenteral nutrition. Higher levels of agitation induced the fastest growth of large globules (≥5 μm) while the gentler conditions actually showed a decrease in the number of these large globules. The same methodology recorded calcium phosphate precipitation kinetics as a function of [Ca2+] and pH. This automated system is readily adaptable to a wide range of pharmaceutically relevant systems where the particle size is expected to vary with time. This instrumentation can dramatically reduce the time and resources needed to probe complex formulation issues while providing new insights for monitoring the kinetics as a function of key variables.

Dissolution kinetics of colemanite in HCl solutions by measuring particle size distributions

2017 ◽  
Vol 53 (1) ◽  
pp. 198-205 ◽  
Author(s):  
Hikmet Sis ◽  
Ismail Bentli ◽  
Nizamettin Demirkiran ◽  
Ahmet Ekmekyapar
Keyword(s):  
Particle Size ◽  
Dissolution Kinetics ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Kinetics Of

scholarly journals Ice Cloud Particle Size Distributions and Pressure-Dependent Terminal Velocities from In Situ Observations at Temperatures from 0° to −86°C

2013 ◽  
Vol 70 (12) ◽  
pp. 4123-4154 ◽  
Author(s):  
Andrew J. Heymsfield ◽  
Carl Schmitt ◽  
Aaron Bansemer
Keyword(s):  
Particle Size ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Cloud Particle ◽  
Ice Clouds ◽  
Ice Cloud ◽  
Cloud Models ◽  
Wide Range ◽  
Functional Forms ◽  
Ice Water

Abstract The primary goal of this study is to derive ice particle terminal velocities from micron to centimeter sizes and for atmospheric pressures covering the range 200–1000 hPa from data spanning a wide range of locations, temperatures, and altitudes and to parameterize the results for use in cloud through cloud models. The study uses data from 10 field programs spanning the temperature range −86° to 0°C and encompassing a total of about 800 000 km of cloud horizontal pathlengths and includes measurements of ice particle size distributions (PSDs) and direct measurements of the ice water content (IWC). The necessary ice particle variables are derived using variables that are interconnected rather than varying independently from observations reported in the literature. A secondary goal of the study is to quantify the properties of ice cloud particle ensembles over a wide range of temperatures to further the understanding of how ice particle ensembles and ice clouds develop. Functional forms for the PSDs and mass– and area–dimensional relationships are developed from the observations and summarized in a table. The PSDs are found to be nearly exponential at temperatures from about −40° to −10°C although deviations from exponentiality are noted outside of this range. It is demonstrated that previous pressure-dependent corrections to ice fall speeds lead to overestimated terminal velocities for particles smaller than 1 mm, particularly so for sizes below 100 μm, with consequent effects on modeled lifetimes of cold ice clouds.

254. A Comparison of the Particle Size Distributions for Aerosols Generated During Wet Grinding and Dry Deburring of Beryllium

1999 ◽  
Author(s):  
K.K. Ellis ◽  
R. Buchan ◽  
M. Hoover ◽  
J. Martyny ◽  
B. Bucher-Bartleson ◽  
...  
Keyword(s):  
Particle Size ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Wet Grinding

Measurements of Mineral Particle Size Distributions by a Buoyancy Weighing Method

2010 ◽  
Vol 126 (10/11) ◽  
pp. 577-582 ◽  
Author(s):  
Katsuhiko FURUKAWA ◽  
Yuichi OHIRA ◽  
Eiji OBATA ◽  
Yutaka YOSHIDA
Keyword(s):  
Particle Size ◽  
Mineral Particle ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Weighing Method
Sign in / Sign up

Export Citation Format

Share Document