Tarnishing kinetics of powders with lognormal particle size distributions

1980 ◽  
Vol 76 (0) ◽  
pp. 2229 ◽  
Author(s):  
John H. Taplin
Keyword(s):  
Particle Size ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Kinetics Of

scholarly journals Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
John-Bruce D. Green ◽  
Phillip W. Carter ◽  
Yingqing Zhang ◽  
Dipa Patel ◽  
Priyanka Kotha ◽  
...  
Keyword(s):  
Particle Size ◽  
Clinical Importance ◽  
Automated System ◽  
Size Distributions ◽  
Mixing Conditions ◽  
Particle Size Distributions ◽  
Complex Formulation ◽  
Wide Range ◽  
Key Variables ◽  
Kinetics Of

Detailing the kinetics of particle formation for pharmaceutically relevant solutions is challenging, especially when considering the combination of formulations, containers, and timescales of clinical importance. This paper describes a method for using commercial software Automate with a stream-selector valve capable of sampling container solutions from within an environmental chamber. The tool was built to monitor changes in particle size distributions via instrumental particle counters but can be adapted to other solution-based sensors. The tool and methodology were demonstrated to be highly effective for measuring dynamic changes in emulsion globule distributions as a function of storage and mixing conditions important for parenteral nutrition. Higher levels of agitation induced the fastest growth of large globules (≥5 μm) while the gentler conditions actually showed a decrease in the number of these large globules. The same methodology recorded calcium phosphate precipitation kinetics as a function of [Ca2+] and pH. This automated system is readily adaptable to a wide range of pharmaceutically relevant systems where the particle size is expected to vary with time. This instrumentation can dramatically reduce the time and resources needed to probe complex formulation issues while providing new insights for monitoring the kinetics as a function of key variables.

Dissolution kinetics of colemanite in HCl solutions by measuring particle size distributions

2017 ◽  
Vol 53 (1) ◽  
pp. 198-205 ◽  
Author(s):  
Hikmet Sis ◽  
Ismail Bentli ◽  
Nizamettin Demirkiran ◽  
Ahmet Ekmekyapar
Keyword(s):  
Particle Size ◽  
Dissolution Kinetics ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Kinetics Of

254. A Comparison of the Particle Size Distributions for Aerosols Generated During Wet Grinding and Dry Deburring of Beryllium

1999 ◽  
Author(s):  
K.K. Ellis ◽  
R. Buchan ◽  
M. Hoover ◽  
J. Martyny ◽  
B. Bucher-Bartleson ◽  
...  
Keyword(s):  
Particle Size ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Wet Grinding

Measurements of Mineral Particle Size Distributions by a Buoyancy Weighing Method

2010 ◽  
Vol 126 (10/11) ◽  
pp. 577-582 ◽  
Author(s):  
Katsuhiko FURUKAWA ◽  
Yuichi OHIRA ◽  
Eiji OBATA ◽  
Yutaka YOSHIDA
Keyword(s):  
Particle Size ◽  
Mineral Particle ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Weighing Method

Certain Problems with the Application of Stochastic Diffusion Processes for the Description of Chemical Engineering Phenomena. Diffusional Change of Solid Particle Size

1996 ◽  
Vol 61 (4) ◽  
pp. 536-563
Author(s):  
Vladimír Kudrna ◽  
Pavel Hasal
Keyword(s):  
Particle Size ◽  
Solid Particle ◽  
Chemical Engineering ◽  
Diffusion Processes ◽  
Granular Systems ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Diffusion Term ◽  
Population Balances ◽  
And Diffusion

To the description of changes of solid particle size in population, the application was proposed of stochastic differential equations and diffusion equations adequate to them making it possible to express the development of these populations in time. Particular relations were derived for some particle size distributions in flow and batch equipments. It was shown that it is expedient to complement the population balances often used for the description of granular systems by a "diffusion" term making it possible to express the effects of random influences in the growth process and/or particle diminution.

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