scholarly journals We Are Ageing

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Genovefa D. Kolovou ◽  
Vana Kolovou ◽  
Sophie Mavrogeni
Keyword(s):  
Oxidative Stress ◽  
Growth Hormone ◽  
Dna Damage ◽  
Growth Factor ◽  
Glucose Metabolism ◽  
Caloric Restriction ◽  
Environmental Exposure ◽  
Target Of Rapamycin ◽  
Insulin Like Growth Factor ◽  
Dna Damage And Repair

Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.

Lifespan extension by reduction of the growth hormone‐insulin‐like growth factor‐1 axis: relation to caloric restriction

2003 ◽  
Vol 17 (9) ◽  
pp. 1108-1109 ◽  
Author(s):  
Isao Shimokawa ◽  
Yoshikazu Higami ◽  
Tomoshi Tsuchiya ◽  
Hiroshi Otani ◽  
Toshimitsu Komatsu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Caloric Restriction ◽  
Lifespan Extension ◽  
Insulin Like Growth Factor

scholarly journals EFFECT of Aloe vera EXTRACT TO THE INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) LEVELS FROM VISCERAL FAT TISSUE IN Rattus norvegicus WISTAR DIABETES MELLITUS

2015 ◽  
Vol 2 (1) ◽  
pp. 174
Author(s):  
Lulut Dwi Nurmamulyosari ◽  
Muhammad Rifqi Hariri ◽  
Abdul Gofur ◽  
Dwi Listyorini ◽  
Hendra Susanto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Growth Factor ◽  
Visceral Fat ◽  
Rattus Norvegicus ◽  
Aloe Vera ◽  
Insulin Like Growth Factor ◽  
Fat Tissue ◽  
C 30

<p>Diabetes mellitus is a metabolic disorder indicated by hyperglycaemia due to lack of insulin production, insulin activity, or both. It causes oxidative stress that may damage the receptor of Growth Hormone Releasing Hormone (GHRH) in the pituitary. As the result, Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF­1) production are decreased and glucose uptakes to the cell is inhibited. Aloe vera has a high antioxidant activity. It is possible to counter oxidative stress in unregulated the production of IGF-1. This study aimed to determine the effect of A. vera extracts to the level of IGF-1 from visceral fat tissue Rattus norvegicus wistar diabetes mellitus. This study used 24 R. norvegicus wistar male. R. norvegicus STZ-induced diabetes mellitus <br />R. norvegicus were grouped into positive control (C+), 30 mg/day, 60 mg/day, 120 mg/day. Fasting blood glucose test was performed to determine the successful induction of diabetes mellitus (DM) three days after induced. Non-DM rats (NDM) were grouped into negative control (C-), 30 mg/day, 60 mg/day, and 120 mg/ day. Each group was consisting of three replications. Each animal, except the controls, were treated 3 ml suspension of A. vera extract for 14 days by gavage. IGF-1 levels were measured using indirect ELISA. The result showed that the extract of A. vera significantly influenced the IGF-1 levels in DM group. The dose of 60 and 120 mg/day significantly raised the level of IGF-1 compared to C+. In NDM group the dose of 60 mg/ day significantly raised the level of IGF-1 compared to C-.</p><p><br /><strong>Keywords</strong>: Aloe vera, Rattus norvegicus, IGF-1, visceral fat, diabetes mellitus</p>

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