scholarly journals Cytohistopathological Study of Salivary Gland Lesions in Bundelkhand Region, Uttar Pradesh, India

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Anita Omhare ◽  
Sanjeev Kumar Singh ◽  
Jitendra Singh Nigam ◽  
Ankit Sharma
Keyword(s):  
Salivary Gland ◽  
Low Cost ◽  
Uttar Pradesh ◽  
Diagnostic Technique ◽  
High Specificity ◽  
Turnaround Time ◽  
Malignant Tumours ◽  
Female Ratio ◽  
Specificity And Sensitivity ◽  
Benign Tumours

Background. FNAC is a useful method for evaluating suspicious salivary glands lesions due to its low cost, minimum morbidity, rapid turnaround time, high specificity, and sensitivity. Aim. To know the frequency of the salivary gland lesions and cytohistological correlation in the Jhansi region, Uttar Pradesh, India. Material and Methods. In present study 124 cases were included and cytohistological correlation was made in 86 cases only. FNA was performed by using a 23/24-gauge needle without local anaesthesia. Air dried and 95% ethyl alcohol fixed wet smears were stained with Giemsa stain and Papanicolaou stain, respectively. Paraffin embedded tissue sections were stained with Haematoxylin and Eosin. Results. Parotid gland was the most commonly involved salivary gland. The commonest age group was 20 to 29 years, 30 to 39 years, and 60 to 69 years for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. The overall male to female ratio was 1.17 : 1. The diagnostic accuracy of FNAC was 100%, 93.3%, and 88.2% for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. Conclusion. The high accuracy, sensitivity, and specificity of FNAC confirm that preoperative cytology is a useful, quick, reliable diagnostic technique for rapid diagnosis and suitable for developing countries.

scholarly journals Spectrum of primary salivary gland tumors with special emphasis on their management and outcome at a rural tertiary care centre

2020 ◽  
Vol 7 (3) ◽  
pp. 818
Author(s):  
Dwaipayan Samaddar ◽  
Jaya B. Samaddar ◽  
Ahmad M. Aziz
Keyword(s):  
Salivary Gland ◽  
Tertiary Care ◽  
Study Data ◽  
Salivary Gland Tumors ◽  
P Value ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Medical College ◽  
Benign Tumours

Background: Salivary gland tumors (SGT) are uncommon tumors of diverse histopathology accounting for <2% of all neoplasms. Early diagnosis differentiates between benign and malignant SGT and less extensive surgical procedure can be performed. The objective is to study the spectrum of primary SGT with special emphasis on their distribution, treatment and outcome at a rural tertiary care centre.Methods: A prospective observational study was conducted on 30 consecutive primary SGT patients attending the Departments of Surgery and Otorhinolaryngology of North Bengal Medical College and Hospital over a period of one and half years. All patients were clinically evaluated, investigated, treated accordingly and followed up during the period of study. Data was collected and compiled in Excel sheet and analysed using GraphPad Software and GraphPad QuickCalcs 2018 (San Diego, CA). A p value <0.05 was considered statistically significant.Results: Maximum patients (83.3%) were in the age range of 31-60 years. The male to female ratio was 1:4 for benign tumours and 1:1 for malignant tumours. Malignant cases were 66.67%. Involvement of parotid gland was the commonest (43.3%) and mostly presented with swelling (73.3%). Pleomorphic salivary adenoma was the commonest benign tumor (33.3%) and mucoepidermoid carcinoma was the commonest malignant tumor (16.7%). Permanent facial palsy was observed in 2 (9.5%) and recurrence in 4 patients (19%).Conclusions: SGT are rare and present in various modes. Malignant cases were singularly more in this study.

scholarly journals Minor Salivary Gland Tumours of Upper Aerodigestive Tract: A Clinicopathological Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Grażyna Wyszyńska-Pawelec ◽  
Michał Gontarz ◽  
Jan Zapała ◽  
Mariusz Szuta
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Relative Survival ◽  
Aerodigestive Tract ◽  
Malignant Tumours ◽  
Upper Aerodigestive Tract ◽  
Female Ratio ◽  
Salivary Gland Tumours ◽  
Results Of Treatment ◽  
Radial Forearm

The aim of this retrospective study of 56 patients with minor salivary gland tumours (MSGTs) of the upper aerodigestive tract is to present demographic features, distribution of tumours as well as methods and results of treatment performed in our institution over a 10-year period. Of 221 patients with salivary gland tumours, 56 patients with MSGT were selected. There were 36 female and 20 male patients aged from 8 to 81 years. Male-to-female ratio was 1 : 2 in the group of benign MSGT and 1 : 1.7 in the group of malignant tumours. The palate was the most frequent site of MSGT (45.6%), followed by buccal mucosa (19.3%). Of all MSGTs 63.2% were malignant, and 36.8% were benign. Adenoid cystic carcinoma was the most common neoplasm (31.6%), followed by pleomorphic adenoma (29.8%). Surgery was the method of choice in the treatment of patients with MSGT. Postoperative defects were reconstructed by prosthetic obturators, local flaps, and free radial forearm flap. Relative survival for patients with malignant MSGT was 88% at three years and 71.5% at five years. MSGTs are more frequent in females and predominantly affect the palate. Malignant MSGTs are more common than benign.

scholarly journals A rapid and affordable point of care test for antibodies against SARS-CoV-2 based on hemagglutination and artificial intelligence interpretation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vanessa Redecke ◽  
Kazuki Tawaratsumida ◽  
Erin T. Larragoite ◽  
Elizabeth S. C. P. Williams ◽  
Vicente Planelles ◽  
...  
Keyword(s):  
Test Performance ◽  
Learning Algorithm ◽  
Point Of Care ◽  
Method Comparison ◽  
High Specificity ◽  
Turnaround Time ◽  
Analysis Tool ◽  
Point Of Care Test ◽  
Specificity And Sensitivity ◽  
A Cell

AbstractDiagnostic tests that detect antibodies (AB) against SARS-CoV-2 for evaluation of seroprevalence and guidance of health care measures are important tools for managing the COVID-19 pandemic. Current tests have certain limitations with regard to turnaround time, costs and availability, particularly in point-of-care (POC) settings. We established a hemagglutination-based AB test that is based on bi-specific proteins which contain a dromedary-derived antibody (nanobody) binding red blood cells (RBD) and a SARS-CoV-2-derived antigen, such as the receptor-binding domain of the Spike protein (Spike-RBD). While the nanobody mediates swift binding to RBC, the antigen moiety directs instantaneous, visually apparent hemagglutination in the presence of SARS-CoV-2-specific AB generated in COVID-19 patients or vaccinated individuals. Method comparison studies with assays cleared by emergency use authorization demonstrate high specificity and sensitivity. To further increase objectivity of test interpretation, we developed an image analysis tool based on digital image acquisition (via a cell phone) and a machine learning algorithm based on defined sample-training and -validation datasets. Preliminary data, including a small clinical study, provides proof of principle for test performance in a POC setting. Together, the data support the interpretation that this AB test format, which we refer to as ‘NanoSpot.ai’, is suitable for POC testing, can be manufactured at very low costs and, based on its generic mode of action, can likely be adapted to a variety of other pathogens.

Histopathological Profile of Non-Haematological Paediatric Neoplasms in Hadoti Region of Rajasthan

2020 ◽  
Vol 7 (43) ◽  
pp. 2453-2457
Author(s):  
Praveen Kumar Bairwa ◽  
Neelu Vashist ◽  
Deepti Sukheeja
Keyword(s):  
Epidemiological Data ◽  
Developed Countries ◽  
Bone Tumours ◽  
Age Group ◽  
Malignant Tumours ◽  
Female Ratio ◽  
Paediatric Tumours ◽  
Haematological Neoplasms ◽  
Benign Tumours ◽  
Male To Female

BACKGROUND Malignancy is a major cause of childhood death in developed countries. In developing countries like India, paediatric tumours are rising day by day. Proper management of paediatric tumours needs epidemiological data in various geographical areas. The present study was carried out to classify and find out the histopathological profile of solid tumours of childhood and infancy in 0 - 14 years age group from 1st January 2015 to 31st December 2017. METHODS We studied histopathology reports of 173 paediatric tumours over a period of 3 years. All the biopsy cases of solid neoplasms in the age group 0 - 14 years were included. RESULTS In our study of 173 paediatric tumours, 133 (76.87 %) were benign and 40 (23.12 %) were malignant. Maximum incidence of malignant paediatric tumours was seen in the age group of 0 - 14 years [12.13 % (21 out of 173)], with male to female ratio of (1:1.3). Amongst the benign tumours, vascular tumours were most common [27.74 % (48 of 173 cases)], with highest incidence of haemangioma [68.75 % (33 of 48 cases)]. Amongst the malignant tumours, most common were bone tumours [6.35 % (11 of 173 cases)] and amongst bone tumours, Ewing’s sarcoma accounted for 63.63 % cases (7 of 11 cases). CONCLUSIONS The incidence of paediatric neoplasms in Hadoti region of Rajasthan is 0.75 % and the majority (54.33 %) of neoplasms occurred in 10 - 14 yrs. age group. KEYWORDS Histopathology, Paediatric, Non-Haematological Neoplasms

scholarly journals Histopathological Spectrum of Non Traumatic Scalp Swellings in a Tertiary Teaching Hospital of Western Uttar Pradesh, India

2021 ◽  
Author(s):  
Kamna Gupta ◽  
Meenakshi Tyagi ◽  
Alok Mohan ◽  
Rajnish Kumar ◽  
Roopanshi Mittal
Keyword(s):  
Cell Carcinoma ◽  
Teaching Hospital ◽  
Malignant Lesion ◽  
Uttar Pradesh ◽  
Interdisciplinary Approach ◽  
Malignant Tumours ◽  
Female Ratio ◽  
Tertiary Teaching ◽  
Common Diagnosis ◽  
Tertiary Teaching Hospital

Introduction: Scalp is a region where pilosebaceous follicles are present in high density and a wide histopathological spectrum can be seen. Aetiology of a scalp swelling may be traumatic, inflammatory, allergic, infective or neoplastic. Malignant tumours are not uncommon in this region and the literature available is also limited. This makes the scalp an interesting site for study. Aim: The present study was to highlight the histopathological spectrum of non traumatic scalp swellings. Materials and Methods: The present study was a 10 year hospital-based observational ambispective study from February 2010 to January 2020, done in the department of Pathology in a tertiary teaching hospital in Western Uttar Pradesh, India. A total of 144 non traumatic scalp swellings were studied and analysed using Statistical Package for the Social Sciences (SPSS) version 19 software. Results: A total of 144 cases were studied. Male to female ratio was 1.4:1. Mean age was 40.94 years. Benign cases were 139 and five cases were malignant. Keratinous cyst was the common diagnosis (n=52), followed by lipoma (n=24). Most common malignant lesion was basal cell carcinoma (n=3), followed by squamous cell carcinoma (n=2). Conclusion: Scalp swellings vary from keratinous cysts to malignancies. The study of scalp swellings is a must so that a variety of histopathological manifestations can be widely understood and interdisciplinary approach can be implemented in the diagnosis and management.

scholarly journals Correlation of fine needle aspiration cytology and histopathology of neck swellings

2018 ◽  
Vol 4 (3) ◽  
pp. 648
Author(s):  
C. S. Asha ◽  
B. R. Suchit Roy
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Predictive Value ◽  
Age Groups ◽  
Invasive Procedure ◽  
High Specificity ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Predictive Values ◽  
Specificity And Sensitivity

<p class="abstract"><strong>Background:</strong> Neck swellings are a common clinical finding affecting all age groups. FNAC is a minimally invasive procedure helpful in the diagnosis of various neck swellings. The purpose of this study is to determine the accuracy of FNAC in the diagnosis of neck swellings by comparing it with the histopathology which is taken as the gold standard.</p><p class="abstract"><strong>Methods:</strong> A prospective study which included 90 patients who attended ENT and surgery departments of Government Medical College, Trivandrum with neck swellings from July 2006-2007. FNAC of the swelling was done and the FNAC results were compared with the histopathology results. The specificity, sensitivity, positive and negative predictive values and accuracy of FNAC were calculated.  </p><p class="abstract"><strong>Results:</strong> Of the 90 patients, thyroid swelling formed the major group followed by lymph node, salivary gland and miscellaneous swellings. Thyroid swellings had a female predominance while the other three groups namely lymph node, salivary gland and miscellaneous groups showed a male preponderance. When the neck swellings namely thyroid, salivary gland, lymph node and miscellaneous group were taken into consideration as a whole, the sensitivity of FNAC for detecting malignancy was 64.3%. The specificity, positive predictive value, negative predictive value and accuracy were 97.4%, 81.8%, 93.7% and 92% respectively.</p><p class="abstract"><strong>Conclusions:</strong> FNAC can be rated as a safe, simple, reliable, cost effective and rapid diagnostic tool with high specificity and sensitivity for the initial evaluation of neck swellings.</p>

scholarly journals Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA

Micromachines ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1409
Author(s):  
Sze Shin Low ◽  
Daizong Ji ◽  
Wai Siong Chai ◽  
Jingjing Liu ◽  
Kuan Shiong Khoo ◽  
...  
Keyword(s):  
Electrochemical Biosensor ◽  
Sequence Similarity ◽  
Low Cost ◽  
High Specificity ◽  
Disease Diagnosis ◽  
Electrochemical Biosensors ◽  
High Sequence Similarity ◽  
Aberrant Expression ◽  
Specificity And Sensitivity ◽  
Different Types

MicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing crucial regulating roles in human body. Therefore, miRNAs have received extensive attention from various disciplines as the aberrant expression of miRNAs are tightly related to different types of diseases. Furthermore, the exceptional stability of miRNAs has presented them as biomarker with high specificity and sensitivity. However, small size, high sequence similarity, low abundance of miRNAs impose difficulty in their detection. Hence, it is of utmost importance to develop accurate and sensitive method for miRNA biosensing. Electrochemical biosensors have been demonstrated as promising solution for miRNA detection as they are highly sensitive, facile, and low-cost with ease of miniaturization. The incorporation of nanomaterials to electrochemical biosensor offers excellent prospects for converting biological recognition events to electronic signal for the development of biosensing platform with desired sensing properties due to their unique properties. This review introduces the signal amplification strategies employed in miRNA electrochemical biosensor and presents the feasibility of different strategies. The recent advances in nanomaterial-based electrochemical biosensor for the detection of miRNA were also discussed and summarized based on different types of miRNAs, opening new approaches in biological analysis and early disease diagnosis. Lastly, the challenges and future prospects are discussed.

scholarly journals Maxillofacial tumors and tumor-like lesions : a retrospective analysis

2018 ◽  
Vol 8 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Md Amirul Islam ◽  
M Ahmed Hossain ◽  
Sabrina Binte Rahman ◽  
Md Ali Kawser ◽  
Md Shamsur Rahman
Keyword(s):  
Dentigerous Cyst ◽  
Maxillofacial Surgery ◽  
Descriptive Study ◽  
Oral And Maxillofacial Surgery ◽  
Malignant Tumours ◽  
Cross Sectional ◽  
Female Ratio ◽  
Odontogenic Tumours ◽  
Benign Tumours ◽  
Tumor Like Lesions

Background: This paper reviews the types, prevalence and demographic distribution of maxillofacial tumors, cysts and tumor-like lesions in a Bangladeshiteaching Hospital.An observational descriptive study (January’ 2014 to December’ 2016) was performed at Oral and Maxillofacial Surgery depart- ment, Dental Unit,TMSS Medical College and Hospital. This study presents 55 cases of maxillofacial tumour & tumour like lesions collected over 3 years at a tertiary oral care centre in Bogra, Bangla- desh.Objectives:To find out the distribution & pattern of maxillofacial tumours and to find out the age, sex, site, clinical presentation and thehistological types of these tumors Method: A cross sectional descriptive study where the Histopathological types of the maxillofacial tumours were analyzed to indicate the numbers that occurred and also the pattern of occurrence according to age, gender, site and clinical presentation.Result: There were 55 maxillofacial tumour & tumour like lesions of which 44 (80.01%) were Benign tumours & 11 (19.81%) were malignant tumours. Among Eighteen histo- pathologic types were found of which Squamous cell carcinoma (18.18%), Ameloblastoma (16.36%), Odontogenic keratocystic tumour (10.90%), Dentigerous cyst (7.27%)& Radicular cyst (7.27%) were predominant. The male to female ratio was 1.29:1. Patients were between 10 years and 72 years with most patients (27.27%) in 51 to 60 years of life. Case presented with symptoms such as swelling (41.96%), pain (28.82%) and loosetooth (17.12%).Conclusion: Both malignant and benign tumours are seen. In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 34.54% of all tumors.Tumour & tumour like lesions of the oral & maxillofacial region with late presentation still remains the main challenging factor in the early detection & management. Surgery was the main modality used for treat- ment while some patients had no treatment due to self discharge and late presentation.Update Dent. Coll. j: 2018; 8 (1): 22-28

scholarly journals DEMOGRAPHIC STUDY OF SALIVARY GLAND SWELLING

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Akshay Akulwar ◽  
Akshay Bavikatte
Keyword(s):  
Salivary Gland ◽  
Connective Tissue Diseases ◽  
Benign Neoplasm ◽  
Undifferentiated Carcinoma ◽  
Facial Nerve Paralysis ◽  
X Rays ◽  
Malignant Tumours ◽  
Nerve Paralysis ◽  
Mikulicz Disease ◽  
Benign Tumours

Introduction: Salivary glands, major and minor, comprise a complex anatomic and physiologic “organ” system-producing enzyme, lubrication, mixing agent and immune factors. Salivary gland swellings can be broadly classified into inflammatory, non- inflammatory and neoplastic swellings like calculi, benign tumours such as pleomorphic adenoma, oncocytoma, warthin’s tumour or malignant tumours like adenocarcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.  Connective tissue diseases like haemangioma, lymphangia, neurofibroma  and  other auto immune diseases like Sjogren’s syndrome, Mikulicz disease etc. Appropriate therapeutic management may be planned earlier, whether it is local excision for a benign neoplasm, radical surgery for a malignant one or any other alternate treatment. With non-neoplastic lesions, metastasis and lymph proliferative disorders, conservative management, chemotherapy or radiotherapy might be respectively preferable. Material and Methods: 40 cases of salivary gland swelling are studied, which were analyzed and conclusion drawn. The statistics have been compared with different standard studies conducted on same subject by various authors around world. Associated medical conditions like diabetes, hypertension and anemia were managed and controlled before surgery with the patient’s advice. As a part of general work up of surgery in all patients, hemoglobin level, bleeding time, clotting time, urine, sugar albumin, microscopy, chest screening, ECG, Blood urea, serum Creatinine, RBS was estimated. Specific investigations like FNAC, X-rays of Mandible were done for all patients in the study group. Demographic profile of all the study population was recorded. Results: Age of the patients varied from 9 years to 80 years. Average age   of the patient was 40.6 years. The case of lowest age group i.e., 9 years was of non-inflammatory swelling   and the case of highest age i.e., 80 years was of tumor swelling. Out of 40 cases 15(35%) cases was of male and 25(65%) cases of female. In this study, all cases presented with, symptoms of swelling (100%), 65% (26) presented with pain. 55 % (22) presented with tenderness. Three cases were with deep lobe involvement (11.4%), 19 cases of ear lobe elevation (47.5%). Facial nerve paralysis occurred in one case (2.8%). Conclusion: Diagnosis of the salivary gland tumors must be considered in any patient presenting with salivary gland swelling. Salivary gland swelling occur more commonly in 3rd and 4th decades of life and seen most common in females. Keywords: salivary gland, tumour, benign, malignant

scholarly journals Increase in the incidence of parotid gland tumors in the years 2005–2014

2017 ◽  
Vol 71 (2) ◽  
pp. 29-34 ◽  
Author(s):  
Grażyna Stryjewska-Makuch ◽  
Bogdan Kolebacz ◽  
Małgorzata A. Janik ◽  
Agnieszka Wolnik
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Head And Neck ◽  
Cancer Incidence ◽  
Malignant Tumours ◽  
Parotid Glands ◽  
Upward Trend ◽  
Salivary Gland Tumours ◽  
Benign Tumours ◽  
Parotid Gland Tumours

Introduction: Salivary gland tumours account for 3-6% of tumours of the head and neck. About 80% of salivary gland tumors occur in parotid glands, 10-17% of which are malignant The aim of the study was to assess whether there is an upward trend in cancer incidence within the parotid glands, with particular emphasis on cancers. Materials and methods: 322 patients underwent surgery and 328 parotid gland tumours were removed in the years 2005-2014 at the Department of Laryngology and Laryngological Oncology of the Upper Silesian Medical Centre in Katowice-Ochojec. Clinical, histopathological and statistical analyses of the removed parotid gland tumours were performed. Results and discussion: A significant increase in the incidence of benign tumours, especially mixed and Warthin tumours, was demonstrated. There was no significant increase in the number of malignant tumours over the analysed period of time.

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