scholarly journals The Altered Water System: Excess Levels of Free Radicals Contribute to Carcinogenesis by Altering Arginine Vasopressin Production and Secretion and Promoting Dysregulated Water Homeostasis in Concert with Other Factors

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Amy Marie Beutler ◽  
Bradford N. Strand
Keyword(s):  
Free Radicals ◽  
Tumor Growth ◽  
Arginine Vasopressin ◽  
Large Body ◽  
Water System ◽  
Review Article ◽  
Radical Species ◽  
Water Homeostasis ◽  
Cycle Arrest ◽  
Pituitary Adrenal Axis

A large body of evidence accumulated during the last decade has revealed diverse roles of dysregulated water homeostasis in tumorigenesis. In particular, many tumors hypersecrete arginine vasopressin (AVP) causing hypoosmolar conditions associated with different cancers. Excess levels of free radicals and nonosmotic stimuli may act as signals in water homeostasis and induce the production and secretion of AVP. Hypoosmolar conditions cause alterations in the expression of many genes. Other alterations in hydration patterns may induce mutations and increase the levels of protein kinases to contribute to oncogenesis. Furthermore, AVP regulates the hypothalamic-pituitary-adrenal axis and angiogenesis, and its overproduction may contribute to tumor growth and metabolism. This review article describes a mechanism by which oxygen radical species and other free radicals act as signaling molecules that, in concert with increased AVP production and secretion, pleiotropically affect tumor growth and metabolism, resulting in dysregulated proliferation, cell cycle arrest, apoptosis, and genomic instability.

scholarly journals  -Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth

2011 ◽  
Vol 33 (2) ◽  
pp. 413-419 ◽  
Author(s):  
J. J. Johnson ◽  
S. M. Petiwala ◽  
D. N. Syed ◽  
J. T. Rasmussen ◽  
V. M. Adhami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Xenograft Tumor ◽  
Cycle Arrest ◽  
Xenograft Tumor Growth

Centrally Administered Murine-Leptin Stimulates the Hypothalamus-Pituitary- Adrenal Axis through Arginine-Vasopressin

2000 ◽  
Vol 71 (6) ◽  
pp. 366-374 ◽  
Author(s):  
Isao Morimoto ◽  
Shigeki Yamamoto ◽  
Keiko Kai ◽  
Takashi Fujihira ◽  
Emiko Morita ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Adrenal Axis ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals The role of the liver in the production of free radicals during halothane anaesthesia in the rat. Quantification of N-tert-butyl-alpha-(4-nitrophenyl)nitrone (PBN)-trapped adducts in bile from halothane as compared with carbon tetrachloride

1991 ◽  
Vol 277 (3) ◽  
pp. 795-800 ◽  
Author(s):  
H M Hughes ◽  
I M George ◽  
J C Evans ◽  
C C Rowlands ◽  
G M Powell ◽  
...  
Keyword(s):  
Free Radicals ◽  
Spin Trap ◽  
Halothane Anaesthesia ◽  
Perfused Liver ◽  
Radical Species ◽  
Tert Butyl ◽  
Biliary Elimination ◽  
Ccl4 Administration ◽  
Liver Preparation

Halothane or CCl4 was co-administered with the spin trap N-tert-butyl-alpha-(4-nitrophenyl)nitrone (PBN) to rats fitted with bile duct cannuli or to isolated perfused liver preparations. Rats maintained under halothane anaesthesia generated significant amounts of free radicals, and 5-9 nmol was excreted in bile over 1 h. No adducts were detected in urine or plasma. The hepatic origin of these free radicals was confirmed by studies on isolated perfused livers where the addition of halothane to the perfusate resulted in the biliary elimination of the same PBN-trapped radical adducts. Similarly, following CCl4 administration, the same radical species were eliminated in bile in the whole animal and the perfused liver preparation. In the perfused liver, over 3 h the total biliary elimination of radicals derived from halothane or CCl4 (administered at equimolar concentrations) was approximately the same (5-7 nmol); however, the elimination of halothane-derived radicals was more rapid over the first 1 h.

scholarly journals A Novel Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest via p27 Stabilization

2008 ◽  
Vol 283 (17) ◽  
pp. 11565-11574 ◽  
Author(s):  
Chunmei Wang ◽  
Nan Li ◽  
Xingguang Liu ◽  
Yuanyuan Zheng ◽  
Xuetao Cao
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Inhibitory Protein ◽  
Cycle Arrest

Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest

2012 ◽  
Vol 108 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Zhiqiang Xu ◽  
Neel Joshi ◽  
Ashima Agarwal ◽  
Sonika Dahiya ◽  
Patrice Bittner ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Nucleolin Expression

scholarly journals New pyrazolo‐[3,4‐ d ]‐pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

2010 ◽  
Vol 24 (8) ◽  
pp. 2881-2892 ◽  
Author(s):  
Alessandra Rossi ◽  
Silvia Schenone ◽  
Adriano Angelucci ◽  
Martina Cozzi ◽  
Valentina Caracciolo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Kinase Inhibitors ◽  
Src Kinase ◽  
Pyrimidine Derivative ◽  
Growth Reduction ◽  
Cycle Arrest ◽  
Human Medulloblastoma
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