scholarly journals New pyrazolo‐[3,4‐ d ]‐pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

2010 ◽  
Vol 24 (8) ◽  
pp. 2881-2892 ◽  
Author(s):  
Alessandra Rossi ◽  
Silvia Schenone ◽  
Adriano Angelucci ◽  
Martina Cozzi ◽  
Valentina Caracciolo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Kinase Inhibitors ◽  
Src Kinase ◽  
Pyrimidine Derivative ◽  
Growth Reduction ◽  
Cycle Arrest ◽  
Human Medulloblastoma

scholarly journals A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo

Oncogene ◽  
2006 ◽  
Vol 26 (13) ◽  
pp. 1829-1839 ◽  
Author(s):  
L Bagella ◽  
A Sun ◽  
T Tonini ◽  
G Abbadessa ◽  
G Cottone ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Small Molecule ◽  
Growth Reduction ◽  
Cycle Arrest ◽  
Cdk2 Activity

Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells

2007 ◽  
Vol 18 (9) ◽  
pp. 981-995 ◽  
Author(s):  
Daniel Nowak ◽  
Simone Boehrer ◽  
Simone Hochmuth ◽  
Bettina Trepohl ◽  
Wencke Hofmann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Kinase Inhibitors ◽  
Src Kinase ◽  
Lymphoma Cells ◽  
Cycle Arrest ◽  
Mediate Cell

scholarly journals IL-22-Mediated Tumor Growth Reduction Correlates with Inhibition of ERK1/2 and AKT Phosphorylation and Induction of Cell Cycle Arrest in the G2-M Phase

2006 ◽  
Vol 177 (11) ◽  
pp. 8266-8272 ◽  
Author(s):  
Georg F. Weber ◽  
Florian C. Gaertner ◽  
Wolfgang Erl ◽  
Klaus-Peter Janssen ◽  
Birgit Blechert ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Growth Reduction ◽  
Akt Phosphorylation ◽  
Cycle Arrest ◽  
M Phase

scholarly journals Novel Benzenesulfonate Scaffolds with a High Anticancer Activity and G2/M Cell Cycle Arrest

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1790
Author(s):  
Katarzyna Malarz ◽  
Jacek Mularski ◽  
Michał Kuczak ◽  
Anna Mrozek-Wilczkiewicz ◽  
Robert Musiol
Keyword(s):  
Cell Cycle ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Anticancer Agents ◽  
Kinase Inhibitors ◽  
P53 Protein ◽  
Structural Similarity ◽  
M Cell ◽  
Cycle Arrest ◽  
Small Series

Sulfonates, unlike their derivatives, sulphonamides, have rarely been investigated for their anticancer activity. Unlike the well-known sulphonamides, esters are mainly used as convenient intermediates in a synthesis. Here, we present the first in-depth investigation of quinazoline sulfonates. A small series of derivatives were synthesized and tested for their anticancer activity. Based on their structural similarity, these compounds resemble tyrosine kinase inhibitors and the p53 reactivator CP-31398. Their biological activity profile, however, was more related to sulphonamides because there was a strong cell cycle arrest in the G2/M phase. Further investigation revealed a multitargeted mechanism of the action that corresponded to the p53 protein status in the cell. Although the compounds expressed a high submicromolar activity against leukemia and colon cancers, pancreatic cancer and glioblastoma were also susceptible. Apoptosis and autophagy were confirmed as the cell death modes that corresponded with the inhibition of metabolic activity and the activation of the p53-dependent and p53-independent pathways. Namely, there was a strong activation of the p62 protein and GADD44. Other proteins such as cdc2 were also expressed at a higher level. Moreover, the classical caspase-dependent pathway in leukemia was observed at a lower concentration, which again confirmed a multitargeted mechanism. It can therefore be concluded that the sulfonates of quinazolines can be regarded as promising scaffolds for developing anticancer agents.

scholarly journals  -Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth

2011 ◽  
Vol 33 (2) ◽  
pp. 413-419 ◽  
Author(s):  
J. J. Johnson ◽  
S. M. Petiwala ◽  
D. N. Syed ◽  
J. T. Rasmussen ◽  
V. M. Adhami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Xenograft Tumor ◽  
Cycle Arrest ◽  
Xenograft Tumor Growth

c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells

2006 ◽  
Vol 80 (2) ◽  
pp. 123-131 ◽  
Author(s):  
Peng Zhang ◽  
Hong Li ◽  
Mo-Li Wu ◽  
Xiao-Yan Chen ◽  
Qing-You Kong ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Molecular Event ◽  
Cycle Arrest ◽  
Human Medulloblastoma

scholarly journals A Novel Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest via p27 Stabilization

2008 ◽  
Vol 283 (17) ◽  
pp. 11565-11574 ◽  
Author(s):  
Chunmei Wang ◽  
Nan Li ◽  
Xingguang Liu ◽  
Yuanyuan Zheng ◽  
Xuetao Cao
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Inhibitory Protein ◽  
Cycle Arrest

Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest

2012 ◽  
Vol 108 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Zhiqiang Xu ◽  
Neel Joshi ◽  
Ashima Agarwal ◽  
Sonika Dahiya ◽  
Patrice Bittner ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Nucleolin Expression
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