scholarly journals Pomegranate Fruit as a Rich Source of Biologically Active Compounds

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Sreeja Sreekumar ◽  
Hima Sithul ◽  
Parvathy Muraleedharan ◽  
Juberiya Mohammed Azeez ◽  
Sreeja Sreeharshan
Keyword(s):  
Protective Role ◽  
Normal Breast ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Osteoblastic Cell ◽  
Published Data ◽  
Active Compounds ◽  
Medicinal Properties ◽  
Pomegranate Fruit

Pomegranate is a widely used plant having medicinal properties. In this review, we have mainly focused on the already published data from our laboratory pertaining to the effect of methanol extract of pericarp of pomegranate (PME) and have compared it with other relevant literatures onPunica. Earlier, we had shown its antiproliferative effect using human breast (MCF-7, MDA MB-231), and endometrial (HEC-1A), cervical (SiHa, HeLa), and ovarian (SKOV3) cancer cell lines, and normal breast fibroblasts (MCF-10A) at concentration of 20–320 μg/mL. The expressions of selected estrogen responsive genes (PR, pS2, and C-Myc) were downregulated by PME. Unlike estradiol, PME did not increase the uterine weight and proliferation in bilaterally ovariectomized Swiss-Albino mice models and its cardioprotective effects were comparable to that of 17β-estradiol. We had further assessed the protective role of PME on skeletal system, using MC3T3-E1 cells. The results indicated that PME (80 μg/mL) significantly increased ALP (Alkaline Phosphatase) activity, supporting its suggested role in modulating osteoblastic cell differentiation. The antiosteoporotic potential of PME was also evaluated in ovariectomized (OVX) rodent model. The results from our studies and from various other studies support the fact that pomegranate fruit is indeed a source of biologically active compounds.

scholarly journals Expanding the chemical space of hydrophobic pharmacophores: the role of hydrophobic substructures in the development of novel transcription modulators

MedChemComm ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1082-1092 ◽  
Author(s):  
Shinya Fujii
Keyword(s):  
Hydrophobic Interactions ◽  
Chemical Space ◽  
Pharmacokinetic Profile ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

Interactions between biologically active compounds and their targets often involve hydrophobic interactions, and hydrophobicity also influences the pharmacokinetic profile.

scholarly journals The Potential Role of Cinnamon in Human Health

Forests ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 648
Author(s):  
Natalia Błaszczyk ◽  
Angelina Rosiak ◽  
Joanna Kałużna-Czaplińska
Keyword(s):  
Potential Role ◽  
Folk Medicine ◽  
Antibacterial Properties ◽  
Analytical Techniques ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Tropical Plant ◽  
Digestive Disorders

Cinnamon is an unusual tropical plant belonging to the Lauraceae family. It has been used for hundreds of years as a flavor additive, but it has also been used in natural Eastern medicine. Cinnamon extracts are vital oils that contain biologically active compounds, such as cinnamon aldehyde, cinnamic alcohol, cinnamic acid, and cinnamate. It has antioxidant, anti-inflammatory, and antibacterial properties and is used to treat diseases such as diabetes and cardiovascular disease. In folk medicine, cinnamon species have been used as medicine for respiratory and digestive disorders. Their potential for prophylactic and therapeutic use in Parkinson’s and Alzheimer’s disease has also been discovered. This review summarizes the available isolation methods and analytical techniques used to identify biologically active compounds present in cinnamon bark and leaves and the influence of these compounds in the treatment of disorders.

Medicinal properties of Inglish Oak (Quercus robur l.)

2020 ◽  
Author(s):  
V.V. Grevtsova ◽  
◽  
V.S. Peshenkina V.S. ◽  
V.A. Voronshihin
Keyword(s):  
Quercus Robur ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
English Oak ◽  
Medicinal Properties

provides an overview of the medicinal properties of English oak (Quercus robur L.) and biologically active compounds synthesized by it.

Biologically active compounds from bryophytes

2007 ◽  
Vol 79 (4) ◽  
pp. 557-580 ◽  
Author(s):  
Yoshinori Asakawa
Keyword(s):  
Biological Activity ◽  
Aromatic Compounds ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Lead Compounds ◽  
Structure Activity ◽  
Medicinal Properties

Liverworts produce a great variety of lipophilic terpenoids, aromatic compounds, and acetogenins. Many of these constituents have characteristic scents, pungency, and bitterness, and display a quite extraordinary array of bioactivities and medicinal properties. These expressions of biological activity are summarized and discussed, and examples are given of the potential of certain lead compounds for structure-activity studies and synthesis.

scholarly journals Role Of Copper For Human Organism

2011 ◽  
Vol 2 ◽  
Author(s):  
Sedrak Ghazaryan
Keyword(s):  
Biologically Active Compounds ◽  
Biologically Active ◽  
Human Organism ◽  
Biological Aspect ◽  
Active Compounds

The review focuses on a very peculiar aspect of the application of copper containing biologically active compounds of different chemical classes as have shown at the last scientific researches in the field of Cu (II) chelates, chelates possess have a higher activity of the same sort, than their mother compounds.The presented material shows essentially important qualities of Cu (II) containing compounds in biological aspect and has an interest for chemists, biochemists and pharmacologists.

Nickel(0)-Catalyzed Linear-Selective Hydroarylation of Unactivated Alkenes and Styrenes with Arylboron Acids

2018 ◽  
Author(s):  
Honggui Lv ◽  
Li-Jun Xiao ◽  
Dongbing Zhao ◽  
Qi-Lin Zhou
Keyword(s):  
Butyric Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Highly Efficient ◽  
Organoboronic Acids

Herein, we realized the first linear-selective hydroarylation of unactivated alkenes and styrenes with organoboronic acids by introducing directing groupon alkenes. Our method is highly efficient and scalable, and provides a modular route to assemble structurally diverse alkylarenes, especially for γ-aryl butyric acid derivatives, which have been widely utilized as chemical feedstocks to access multiple marketed drugs, and biologically active compounds.<br>

SOME DIRECTIONS IN THE MODIFICATION OF AZOLES

2020 ◽  
Vol 5 (443) ◽  
pp. 85-91
Author(s):  
Ibrayev M.K., ◽  
◽  
Takibayeva A.T., ◽  
Fazylov S.D., ◽  
Rakhimberlinova Zh.B., ◽  
...  
Keyword(s):  
13C Nmr Spectroscopy ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Synthesis Conditions ◽  
Alkaloid Cytisine ◽  
Azole Ring ◽  
Cyclic Compounds ◽  
New Compounds ◽  
Derivatives Of

This article presents studies on the targeted search for new derivatives of azoles, such as benzthiazole, 3,5-dimethylpyrazole, 1,3,4-oxadiazole-2-thione, 1,3,4-thiadiazole. The possibility of combining in one molecule of the azole ring with other cyclic compounds: the alkaloid cytisine, morpholine, furan and some arenes has been studied. To obtain new compounds, the reactions of bromination, acylation, and interaction with isothiocyanates were studied. Optimal synthesis conditions were studied for all reactions. It was found that the reaction of 4-bromo-3,5-dimethylpyrazole with isothiocyanates, in contrast to the previously written derivatives of anilines, takes a longer time and requires heating the reaction mixture. The combination of a pirasol fragment with halide substituents often results in an enhanced therapeutic effect. The synthesized 2-bromine-N-(6-rodanbenzo[d]thiazole-2-yl)acetamide, due to the alkylbromide group, is an important synth in the synthesis of new benzthiazole derivatives. Its derivatives combine in one molecule the rest of rhodanbenzthiazole with alkaloid cytisine and biogenic amine morpholine and are potentially biologically active compounds, since the molecule structure contains several pharmacophoric fragments: benzthiazole and alkaloid (amine) heterocycles, rhodane and urea groups. The mechanism of formation of 1,3,4-oxadiazole-2-tyons from hydrazides under action on them by carbon disulfide was studied and assumed. It was shown that dithiocarbamates in acidic medium decompose with the release of hydrogen sulfide and the formation of highly reactive isothiocyanate group. Then, intra-molecular cyclization occurs, with the formation of end products - 1,3,4-oxadiazole-2-thions. The structures of the synthesized compounds were studied by 1H and 13C NMR spectroscopy. All synthesized substances are potentially biologically active compounds, since they contain several pharmacophore fragments in their structure.

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