scholarly journals Effects of Subchronic Exposure of Diclofenac on Growth, Histopathological Changes, and Oxidative Stress in Zebrafish (Danio rerio)

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Eva Praskova ◽  
Lucie Plhalova ◽  
Lucie Chromcova ◽  
Stanislava Stepanova ◽  
Iveta Bedanova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glutathione Reductase ◽  
Danio Rerio ◽  
Fish Growth ◽  
Histopathological Changes ◽  
Glutathione S Transferase ◽  
Environmental Concentration ◽  
Subchronic Exposure ◽  
Effect Concentration ◽  
And Oxidative Stress

The aim of this study was to investigate effects of subchronic exposure to sublethal levels of diclofenac on growth, oxidative stress, and histopathological changes inDanio rerio. The juvenile growth tests were performed onDanio rerioaccording to OECD method number 215. Fish at the age of 20 days were exposed to the diclofenac environmental concentration commonly detected in the Czech rivers (0.02 mg L−1) and the range of sublethal concentrations of diclofenac (5, 15, 30, and 60 mg L−1) for 28 days. A significant decrease (P<0.01) in the fish growth caused by diclofenac was observed in the concentrations of 30 and 60 mg L−1. The identified value of LOEC (lowest observed effect concentration) was 15 mg L−1of diclofenac and NOEC (no observed effect concentration) value was 5 mg L−1of diclofenac. We did not find histopathological changes and changes of selected parameters of oxidative stress (glutathione S-transferase, glutathione reductase) in tested fish. The environmental concentration of diclofenac in Czech rivers did not have any effect on growth, selected oxidative stress parameters (glutathione S-transferase, glutathione reductase), or histopathological changes inDanio reriobut it could have an influence on lipid peroxidation.

scholarly journals The enantioselective toxicity and oxidative stress of dinotefuran on zebrafish (Danio rerio)

2021 ◽  
Vol 226 ◽  
pp. 112809
Author(s):  
Lulu Ran ◽  
Ya Yang ◽  
Xia Zhou ◽  
Xiaoxia Jiang ◽  
Deyu Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Danio Rerio ◽  
And Oxidative Stress

scholarly journals Nitrite Toxicity to Danio rerio: Effects of Subchronic Exposure on Fish Growth

2008 ◽  
Vol 77 (3) ◽  
pp. 455-460 ◽  
Author(s):  
E. Voslářová ◽  
V. Pištěková ◽  
Z. Svobodová ◽  
I. Bedáňová
Keyword(s):  
Danio Rerio ◽  
Significant Inhibition ◽  
Fish Growth ◽  
Long Term Effects ◽  
Exponential Relationship ◽  
Subchronic Exposure ◽  
Control Growth ◽  
Nitrite Toxicity ◽  
Fish Weight

The aim of this study was to investigate the long-term effects of subchronic exposure to sublethal levels of nitrite, ranging from 15 to 130 mg l-1 NO2-, on growth in aquarium fish Danio rerio. The juvenile growth test according to OECD 215 was used in the experiments. Fish weight was measured at the beginning of the experiment and then using the same method, fish weight was observed 28 days after fish stocking. Compared to the control, growth suppression was detected from the concentration of 73 mg l-1 NO2- (P < 0.05) and a significant inhibition of fish body growth was shown from 130 mg l-1 NO2- (P < 0.01). An exponential relationship between nitrite concentrations and specific growth rate (R2 = 0.896) was detected.

Association of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress markers in preterm labor

2010 ◽  
Vol 43 (13-14) ◽  
pp. 1124-1128 ◽  
Author(s):  
M.D. Mustafa ◽  
Rahul Pathak ◽  
Tanzeel Ahmed ◽  
Rafat S. Ahmed ◽  
A.K. Tripathi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Preterm Labor ◽  
Gene Polymorphisms ◽  
Oxidative Stress Markers ◽  
Glutathione S Transferase ◽  
Stress Markers ◽  
T1 Gene ◽  
And Oxidative Stress

The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae

Chemosphere ◽  
2019 ◽  
Vol 225 ◽  
pp. 705-712 ◽  
Author(s):  
Biran Zhu ◽  
Wei He ◽  
Shengchao Hu ◽  
Ren Kong ◽  
Lihua Yang
Keyword(s):  
Oxidative Stress ◽  
Danio Rerio ◽  
Sio2 Nanoparticles ◽  
And Oxidative Stress

scholarly journals Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 443 ◽  
Author(s):  
Sumbal Iqbal ◽  
Fawad Ali Shah ◽  
Komal Naeem ◽  
Humaira Nadeem ◽  
Sadia Sarwar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neuronal Injury ◽  
Binding Affinities ◽  
Glutathione S Transferase ◽  
In Vivo Experiments ◽  
Tnf Α ◽  
And Oxidative Stress ◽  
Necrosis Factor

Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series of novel succinamide derivatives and to further investigate the neuroprotective potential of these compounds against scopolamine-induced neuronal injury by in silico, morphological, and biochemical approaches. The characterization of all the succinamide derivatives was carried out spectroscopically via proton NMR (1H-NMR), FTIR and elemental analysis. Further in vivo experiments showed that scopolamine induced neuronal injury, characterized by downregulated glutathione (GSH), glutathione S-transferase (GST), catalase, and upregulated lipid peroxidation (LPO). Moreover, scopolamine increased the expression of inflammatory mediators such as cyclooxygenase2 (COX2), nuclear factor kappa B (NF-kB), tumor necrosis factor (TNF-α), further associated with cognitive impairment. On the other hand, treatment with succinamide derivatives ameliorated the biochemical and immunohistochemical alterations induced by scopolamine, further supported by the results obtained from molecular docking and binding affinities.

Glyphosate Adversely Affects Danio rerio Males: Acetylcholinesterase Modulation and Oxidative Stress

Zebrafish ◽  
2017 ◽  
Vol 14 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Fernanda Moreira Lopes ◽  
Sergiane Souza Caldas ◽  
Ednei Gilberto Primel ◽  
Carlos Eduardo da Rosa
Keyword(s):  
Oxidative Stress ◽  
Danio Rerio ◽  
And Oxidative Stress

DNA damage and oxidative stress induced by endosulfan exposure in zebrafish (Danio rerio)

Ecotoxicology ◽  
2012 ◽  
Vol 21 (5) ◽  
pp. 1533-1540 ◽  
Author(s):  
Bo Shao ◽  
Lusheng Zhu ◽  
Miao Dong ◽  
Jun Wang ◽  
Jinhua Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Danio Rerio ◽  
And Oxidative Stress

Biochemical impact of soccer: an analysis of hormonal, muscle damage, and redox markers during the season

2014 ◽  
Vol 39 (4) ◽  
pp. 432-438 ◽  
Author(s):  
João Renato Silva ◽  
António Rebelo ◽  
Franklim Marques ◽  
Laura Pereira ◽  
André Seabra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glutathione Reductase ◽  
Muscle Damage ◽  
Muscle Function ◽  
Biochemical Markers ◽  
Reductase Activity ◽  
Recovery Period ◽  
Soccer Players ◽  
Professional Soccer ◽  
And Oxidative Stress

This study aimed to analyze changes in performance, muscle function, and stress-related biochemical markers in professional soccer players (n = 14) at 4 timepoints (3 for performance and 4 for stress-related biochemical markers) during the soccer season [Formula: see text] preseason (E1), midseason (E2), end of the season (E3) [Formula: see text] and after the end of the recovery period (E4). Performance in 5- and 30-m sprints, countermovement jump, and agility, and maximal isokinetic knee extension and knee flexion strength were measured (E1 to E3). We observed increased in-season levels of myoglobin (E2 > E1 and E4; p < 0.05), a higher testosterone/cortisol ratio (T/C), and increased levels of creatine kinase (CK), C-reactive protein, superoxide dismutase (SOD), protein sulfhydryls (–SH), and malondialdehyde (E2 and E3 > E1 and E4; p < 0.05). Lower cortisol concentrations (E3 < E1 and E4; p < 0.05) and glutathione reductase activity (E3 < E2 and E4; p < 0.05) were observed at the end of the season. T/C, CK, SOD, –SH, and malondialdehyde decreased during the off-season, and cortisol and glutathione reductase increased (E3 < E4; p < 0.05). Agility increased in E2 and E3 (p < 0.01). Significant correlations were found during the season between hormonal and muscle function parameters (r = 0.56–0.86; p < 0.05). In addition, in E2, significant associations were observed between match-accumulated time (MATE2; minutes played by each player during the competition period), performance, and hormonal and redox parameters (r = 0.456–0.615; p < 0.05). In conclusion, this study shows that soccer players face significant changes in biomarkers of physiologic strain (muscle damage and oxidative stress-related markers) during the season, but values return to normal during the off-season. Additionally, MAT influences physical, hormonal, and oxidative stress-related parameters in professional soccer players.

scholarly journals The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Tuğba Gürpınar ◽  
Nuran Ekerbiçer ◽  
Nazan Uysal ◽  
Turgay Barut ◽  
Figen Tarakçı ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Histopathological Changes ◽  
Melatonin Treatment ◽  
Adult Rats ◽  
Significant Difference ◽  
Immunohistochemical Methods ◽  
And Oxidative Stress

Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.

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