scholarly journals The Analysis of the Disease Spectrum in China

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Xin Zhang ◽  
Xiaoping Zhou ◽  
Xinyi Huang ◽  
Shumei Miao ◽  
Hongwei Shan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Age Of Onset ◽  
Malignant Tumors ◽  
Scientific Basis ◽  
Policy Formulation ◽  
Noncommunicable Diseases ◽  
Dependent Diabetes Mellitus ◽  
Daily Cost ◽  
Disease Spectrum ◽  
Average Daily Cost

Analysis of the related risks of disease provides a scientific basis for disease prevention and treatment, hospital management, and policy formulation by the changes in disease spectrum of patients in hospital. Retrospective analysis was made to the first diagnosis, age, gender, daily average cost of hospitalized patients, and other factors in the First Affiliated Hospital of Nanjing Medical University during 2006–2013. The top 4 cases were as follows: cardiovascular disease, malignant tumors, lung infections, and noninsulin dependent diabetes mellitus. By the age of disease analysis, we found a younger age trend of cardiovascular disease, and the age of onset of cancer or diabetes was somewhat postponed. The average daily cost of hospitalization and the average daily cost of the main noncommunicable diseases were both on the rise. Noncommunicable diseases occupy an increasingly important position in the constitution of the disease, and they caused an increasing medical burden. People should pay attention to health from the aspects of lifestyle changing. Hospitals should focus on building the appropriate discipline. On the other hand, an integrated government response is required to tackle key risks. Multiple interventions are needed to lower the burden of these diseases and to improve national health.

scholarly journals Heterogeneity of the Clinical Presentation of the MEN1 LRG_509 c.781C>T (p.Leu261Phe) Variant Within a Three-Generation Family

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 512
Author(s):  
Aleksandra Gilis-Januszewska ◽  
Anna Bogusławska ◽  
Kornelia Hasse-Lazar ◽  
Beata Jurecka-Lubieniecka ◽  
Barbara Jarząb ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Malignant Tumors ◽  
Genetic Disorder ◽  
Family Members ◽  
Pancreatic Neuroendocrine Tumor ◽  
Index Patient ◽  
Generation Family

Multiple neuroendocrine neoplasia type 1 (MEN1) is a rare genetic disorder with an autosomal dominant inheritance, predisposing carriers to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localization, age of onset, and clinical aggressiveness, even between affected members within the same family. We describe a heterogenic phenotype of the MEN1 variant c.781C>T (LRG_509t1), which was previously reported only once in a family with isolated hyperparathyroidism. A heterozygous missense variant in exon 4 of the gene was identified in the sequence of the MEN1 gene, i.e., c.781C>T, leading to the amino acid change p.Leu261Phe in a three-generation family. In the screened family, 5/6 affected members had already developed hyperparathyroidism. In the index patient and two other family members, an aggressive course of pancreatic neuroendocrine tumor (insulinoma and non-functioning neuroendocrine tumors) with dissemination was diagnosed. In the index patient, late diagnosis and slow progression of the disseminated neuroendocrine tumor have been observed (24 years of follow-up). The very rare variant of MEN1, LRG_509t1 c.781C>T /p.Leu261Phe (LRG_509p1), diagnosed within a three-generation family has a heterogenic clinical presentation. Further follow-up of the family members should be carried out to confirm the spectrum and exact time of clinical presentation.

scholarly journals Life expectancy and mortality in 363 cities of Latin America

2021 ◽  
Author(s):  
Usama Bilal ◽  
◽  
Philipp Hessel ◽  
Carolina Perez-Ferrer ◽  
Yvonne L. Michael ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Latin America ◽  
Life Expectancy ◽  
Latin American ◽  
Causes Of Death ◽  
Urban Environments ◽  
Noncommunicable Diseases ◽  
Modifiable Factors ◽  
Specific Mortality ◽  
Latin American Countries

AbstractThe concept of a so-called urban advantage in health ignores the possibility of heterogeneity in health outcomes across cities. Using a harmonized dataset from the SALURBAL project, we describe variability and predictors of life expectancy and proportionate mortality in 363 cities across nine Latin American countries. Life expectancy differed substantially across cities within the same country. Cause-specific mortality also varied across cities, with some causes of death (unintentional and violent injuries and deaths) showing large variation within countries, whereas other causes of death (communicable, maternal, neonatal and nutritional, cancer, cardiovascular disease and other noncommunicable diseases) varied substantially between countries. In multivariable mixed models, higher levels of education, water access and sanitation and less overcrowding were associated with longer life expectancy, a relatively lower proportion of communicable, maternal, neonatal and nutritional deaths and a higher proportion of deaths from cancer, cardiovascular disease and other noncommunicable diseases. These results highlight considerable heterogeneity in life expectancy and causes of death across cities of Latin America, revealing modifiable factors that could be amenable to urban policies aimed toward improving urban health in Latin America and more generally in other urban environments.

scholarly journals Analysis of The Factors Affecting China's Food Security and The Countermeasures

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Fang Liu ◽  
◽  
Shuai Liu ◽  
Keyword(s):  
Food Security ◽  
Agricultural Land ◽  
Scientific Basis ◽  
Policy Formulation ◽  
Social Stability ◽  
Land Resources ◽  
Factors Affecting ◽  
Global Food Security ◽  
National Food Security ◽  
Global Food

Food security is the foundation of a country's social stability and economic development. This paper compares the global food security with China's food situation, summarizes the main problems of China's food security, and explores the factors that affect China's food security, including the shortage of agricultural land resources, the inability to meet the needs of food production, the rapid growth of food demand, the aggravation of the imbalance of food supply and the threat from the international market. Based on this, the paper puts forward suggestions of relevant policy to ensure national food security, in order to provide a scientific basis for the policy formulation of relevant government departments.

scholarly journals Cardiovascular Disease Prevention and Implications of Coronavirus Disease 2019: An Evolving Case Study in the Crescent City

2020 ◽  
Vol 9 (13) ◽  
Author(s):  
Alexander C. Razavi ◽  
Tanika N. Kelly ◽  
Jiang He ◽  
Camilo Fernandez ◽  
Paul K. Whelton ◽  
...  
Keyword(s):  
Public Health ◽  
Cardiovascular Disease ◽  
Access To Health Care ◽  
Cardiovascular Health ◽  
Case Fatality ◽  
Noncommunicable Diseases ◽  
Lifestyle Behaviors ◽  
Public Health Perspective ◽  
Access To Health ◽  
The Impact

Abstract Medicine and public health have traditionally separated the prevention and treatment of communicable and noncommunicable diseases. The coronavirus disease 2019 ( COVID ‐19) pandemic has challenged this paradigm, particularly in the setting of cardiovascular disease ( CVD ). Overall, individuals with underlying CVD who acquire severe acute respiratory syndrome coronavirus 2 experience up to a 10‐fold higher case‐fatality rate compared with the general population. Although the impact of the pandemic on cardiovascular health continues to evolve, few have defined this association from a frontline, public health perspective of populations disproportionately affected by CVD and COVID ‐19. Louisiana is ranked within the bottom 5 states for cardiovascular health, and it is home to several parishes that have experienced among the highest COVID ‐19 case‐fatality rates nationally. Herein, we review CVD prevention and implications of COVID ‐19 in New Orleans, LA, a city holding a sobering yet resilient history with previous public health disasters. In particular, we discuss potential pandemic‐driven changes in access to health care, preventive pharmacotherapy, and lifestyle behaviors, all of which may adversely affect CVD prevention and management, while amplifying racial disparities. Through this process, we highlight proposed recommendations for how CVD prevention efforts can be improved in the midst of the current COVID ‐19 pandemic and future public health crises.

Epidemiology and Risk Factors of Bipolar Disorder and Schizophrenia in the Conceptualization of the Disease Spectrum

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
C. Höschl ◽  
P. Stopková
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Age Of Onset ◽  
Prenatal Development ◽  
Type I ◽  
Perinatal Complications ◽  
Birth Seasonality ◽  
Genetic Studies ◽  
Disease Spectrum ◽  
Disorder Type

Both disorders are worldwide, lifelong, and recurrent illnesses with periods of exacerbation and partial or full remissions. Lifetime prevalence of schizophrenia and bipolar disorder type I is around 1%. Women and men are affected at proximately equal rates and the typical age of onset is similar. Both disorders also share risk factors showing evidence for impaired prenatal development, such as birth seasonality, abnormal dermatoglyphs and higher incidence of perinatal complications. However, there is evidence for differences in prevalence in geographical isolates, in presence of minor physical abnormalities and possibly also in influence of psychosocial factors, urbanicity and use of cannabis. However, based only on similar epidemiological parameters, it is not possible to assume any degree of continuity between bipolar disorder and schizophrenia. The main evidence for partially shared pathophysiology is given by genetic studies.

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