Fruits and Vegetables Diet Improves Some Selected Haemorheological Parameters Predisposing to Cardiovascular Disease in non Insulin Dependent Diabetes Mellitus NIDDM Subjects

2012 ◽  
Vol 15 (14) ◽  
pp. 694-697 ◽  
Author(s):  
B.A. Salau ◽  
M.M. Adeyanju ◽  
K.T. Odufuwa ◽  
O. Osilesi
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Fruits And Vegetables ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

The Effect of Microalbuminuria on Glycaemic Control, Serum Lipids and Haemostasis Parameters in Non-Insulin-Dependent Diabetes Mellitus

1993 ◽  
Vol 30 (5) ◽  
pp. 439-444 ◽  
Author(s):  
S H J Donders ◽  
F A T Lustermans ◽  
J W J van Wersch
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Glycaemic Control ◽  
Blood Lipids ◽  
Density Lipoprotein ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Niddm Patients

Microalbuminuria is an important risk factor for cardiovascular disease in non-insulin-dependent diabetes mellitus (NIDDM) patients although the pathogenic mechanism between microalbuminuria and cardiovascular disease has not yet been established. Microalbuminuria in insulin-dependent diabetes mellitus (IDDM) patients has been related to abnormalities in haemostasis, poor glycaemic control, disadvantageous alterations in the lipid spectrum and elevated concentrations of lipoprotein(a), another independent risk factor for cardiovascular disease. In this study the interrelations between microalbuminuria and metabolic control, lipoprotein(a), other blood lipids and several haemostasis parameters were studied in 96 NIDDM patients (50 women, 46 men). Forty-three patients showed microalbuminuria. No significant differences were found in blood lipids (Lp(a), serum cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol and triglycerides), glycaemic control (HbA1c) and several haemostasis parameters (factor VII, VIII, fibrin monomer, thrombin-antithrombin III, D-dimer, tissue plasminogen activator antigen and plasminogen activator inhibitor-1) between the micro- and normoalbuminuric subgroups. In the microalbuminuric subgroup increased concentrations for plasminogen and α2-antiplasmin were measured. In general, the presence of microalbuminuria was not associated with significant alterations in glycaemic control, blood lipids or haemostasis parameters in this group of 96 NIDDM patients. Further investigation is required to explain the excess cardiovascular mortality in patients with an elevated urinary albumin excretion rate.

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