scholarly journals Reduced Bone and Body Mass in Young Male Rats Exposed to Lead

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Fellipe Augusto Tocchini de Figueiredo ◽  
Raquel Fernanda Gerlach ◽  
Márcia Andreia Mesquita Silva da Veiga ◽  
Flavio Venancio Nakadi ◽  
Junia Ramos ◽  
...  
Keyword(s):  
Whole Blood ◽  
Young Male ◽  
Blood Lead ◽  
Male Rats ◽  
Control Groups ◽  
Growing Rats ◽  
Bone Lead ◽  
Exposure Biomarker ◽  
Significant Difference ◽  
Gf Aas

The aim of this study was to see whether there would be differences in whole blood versus tibia lead concentrations over time in growing rats prenatally. Lead was given in the drinking water at 30 mg/L from the time the dams were pregnant until offspring was 28- or 60-day-old. Concentrations of lead were measured in whole blood and in tibia after 28 (28D) and 60 days (60D) in control (C) and in lead-exposed animals (Pb). Lead measurements were made by GF-AAS. There was no significant difference (P>0.05) in the concentration of whole blood lead between Pb-28D (8.0±1.1 μg/dL) and Pb-60D (7.2±0.89 μg/dL), while both significantly varied (P<0.01) from controls (0.2 μg/dL). Bone lead concentrations significantly varied between the Pb-28D (8.02±1.12 μg/g) and the Pb-60D (43.3±13.26 μg/g) lead-exposed groups (P<0.01), while those exposed groups were also significantly higher (P<0.0001) than the 28D and 60D control groups (Pb < 1 μg/g). The Pb-60D group showed a 25% decrease in tibia mass as compared to the respective control. The five times higher amount of lead found in the bone of older animals (Pb-60D versus Pb-28D), which reinforces the importance of using bone lead as an exposure biomarker.

scholarly journals Diltiazem did not induce gingival overgrowth in rats: a clinical, histological and histometric analysis

2005 ◽  
Vol 19 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Fernanda de Oliveira Bello Corrêa ◽  
Gabriela Giro ◽  
Daniela Gonçalves ◽  
Luis Carlos Spolidorio ◽  
Silvana Regina Perez Orrico
Keyword(s):  
Body Weight ◽  
Treatment Duration ◽  
Young Male ◽  
Male Rats ◽  
Channel Blockers ◽  
Connective Tissues ◽  
Control Groups ◽  
Duration Of Treatment ◽  
Gingival Overgrowth ◽  
Significant Difference

The administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.

EFFECT OF LIPOTROPIC AGENTS UPON THE NET SYNTHESIS OF CHOLESTEROL IN THE RAT

1960 ◽  
Vol 38 (1) ◽  
pp. 757-761
Author(s):  
Sailen Mookerjea ◽  
C. C. Lucas
Keyword(s):  
Choline Chloride ◽  
Young Male ◽  
Significant Degree ◽  
Male Rats ◽  
Vitamin B ◽  
Normal Range ◽  
Liver Lipids ◽  
Significant Difference

The content of cholesterol in the bodies of young male rats fed a basal hypolipotropic diet has been compared with that of other rats pair-fed on similar diets supplemented with choline chloride, methionine, or vitamin B12, respectively. Increased efficiency of utilization of the food and variable lipotropic effects were observed, but no significant difference was found in the total amounts of cholesterol at the end of the 3-week test periods. The lipotropic agents do not influence to any significant degree the net biosynthesis of cholesterol in rats fed this type of diet but they do affect the distribution, tending to keep the liver lipids, including cholesterol, in the normal range.

EFFECT OF LIPOTROPIC AGENTS UPON THE NET SYNTHESIS OF CHOLESTEROL IN THE RAT

1960 ◽  
Vol 38 (7) ◽  
pp. 757-761
Author(s):  
Sailen Mookerjea ◽  
C. C. Lucas
Keyword(s):  
Choline Chloride ◽  
Young Male ◽  
Significant Degree ◽  
Male Rats ◽  
Vitamin B ◽  
Normal Range ◽  
Liver Lipids ◽  
Significant Difference

The content of cholesterol in the bodies of young male rats fed a basal hypolipotropic diet has been compared with that of other rats pair-fed on similar diets supplemented with choline chloride, methionine, or vitamin B12, respectively. Increased efficiency of utilization of the food and variable lipotropic effects were observed, but no significant difference was found in the total amounts of cholesterol at the end of the 3-week test periods. The lipotropic agents do not influence to any significant degree the net biosynthesis of cholesterol in rats fed this type of diet but they do affect the distribution, tending to keep the liver lipids, including cholesterol, in the normal range.

scholarly journals Impact of Buprenorphine on Learning and Memory Ability Related to the Acetylcholinesterase Change in the Hippocampus of Rats

2021 ◽  
Vol 11 (5) ◽  
pp. 13111-13114
Keyword(s):  
Memory Impairment ◽  
Ache Activity ◽  
Memory Function ◽  
Male Rats ◽  
Control Groups ◽  
Treatment Groups ◽  
Activity Inhibition ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
The Impact

Buprenorphine (BUP), a “synthetic opioid”, may cause memory impairment. This investigation aimed to study the impact of BUP on memory function related to acetylcholinesterase (AChE) activity inhibition in male rats. 24 male Wistar rats were randomly divided into three groups; control (C) and two treatment groups BUP (0.3 and 1) (n=8, for each group). BUP (0.3 and 1 mg/kg) was administrated subcutaneously once a day for 30 days. Normal saline 0.9% was injected in to control groups. In the end, animals were anesthetized and decapitated, and their hippocampus was dissected to assess AChE activity. There were no significant differences between the activities of AChE in the hippocampus in BUP-treated animals compared with controls. Besides, the activities of AChE in the BUP 0.3 group and BUP 1 group did not indicate a significant difference. These findings did not confirm the effect of BUP at doses of 0.3 and 1 mg/kg on memory function associated with the AChE activity inhibition.

scholarly journals The Effect of Anti Masquito Electric Gas that Consist Allethrin That Influence The Weight and Colour of Rats Liver

2017 ◽  
Vol 6 (2) ◽  
pp. 6
Author(s):  
Nurmawanti Nurmawanti ◽  
Ayly Soekanto
Keyword(s):  
Male Rats ◽  
Control Group ◽  
Control Groups ◽  
Control Group Design ◽  
Significant Difference ◽  
Post Test ◽  
Group 3 ◽  
The Subject ◽  
Group 2 ◽  
Group 1

The aim of this research is to know the influence of anti mosquito electric gas that consisted Allethrin to the weight and colour of the rats liver. This research used an experimental method with the post test only  control group design.  The subject of this research is male rats weight of 150 grams each and total there was 24 rats that were divided to 4 groups. The first one, the  control groups (PO) was not given any of the gas, the second one, group 1 (P1) was given the gas for 4 hours everday, the third one, group  2 (P2), was given for 6 hours and last, group 3  (P3) was given 8 hours everyday. After later, on  30 Th day, the rats were terminated and being put in a surgery to remove their liver. This data was analyzed using SPPS for windows version 16. To see the differences in weight between the groups, it was analyzed using anova, and  to obtain the discoloration of the rats liver was analyzed using Kruskal Wallis Test. From the statistic tests, it show that there is significant difference in weight and color of liver in the group that α ≤ 0,05. According Anova Test, it shows that there is a significant difference α = 0,034 and from Kruskal Wallis test α = 0,013. In the conclusion anti mosquito electric gas that consist Allethrin affects the weight and the color of rats liver.

scholarly journals Effect of Nicotine Administration on Body Weight and Liver Enzymes in Male Rats

2021 ◽  
Vol 8 (5) ◽  
Author(s):  
Faraj Hato Johni
Keyword(s):  
Body Weight ◽  
Veterinary Medicine ◽  
Liver Enzymes ◽  
Treated Group ◽  
Male Rats ◽  
Control Group ◽  
Control Groups ◽  
Nicotine Administration ◽  
Significant Difference

The study was conducted in Basrah University – veterinary medicine college, used about (60) sixty male rats divided into two groups randomly, control group and nicotine treated group with 0.5 mg / kg / BW, the result showed no significant difference in growth rats compared to control group also significant increase of liver enzymes compared to the control groups.

scholarly journals Comparison of the specificity of cardiac troponin I and creatine kinase MB in isoproterenol-induced cardiotoxicity model in rats

2015 ◽  
Vol 84 (4) ◽  
pp. 343-350
Author(s):  
Eliška Kolmanová ◽  
Ladislava Bartošová ◽  
Elian Khazneh ◽  
Tomáš Parák ◽  
Pavel Suchý
Keyword(s):  
Creatine Kinase ◽  
Troponin I ◽  
Plasma Concentrations ◽  
Male Rats ◽  
Cardiac Markers ◽  
Control Groups ◽  
Creatine Kinase Mb ◽  
Significant Difference ◽  
And Control ◽  
Isoproterenol Hydrochloride

The aim of this study was to implement the determination of cardiac markers in preclinical research at our department. For this purpose, the pathophysiological model of acute cardiotoxicity induced by high doses of isoproterenol was used. Isoproterenol hydrochloride was intraperitoneally administrated to 42 Wistar male rats at a dose of 50 mg/kg body weight. Cardiac injury was determined by assessing the concentrations of the cardiac markers (cTnI - cardiospecific troponin I and CKMB - cardiac isoenzyme creatine kinase) in the blood at predetermined time-intervals (2, 4, 6, 12, 24 and 36 h), and confirmed by ECG. Isoproterenol hydrochloride caused an elevation in the plasma concentrations of both markers. The results showed a significant difference (P< 0.01) in the concentrations of cTnI between the experimental and control groups at 2, 4, 6 and 24 h with a maximum peak between the fourth and sixth hour. However, the difference in the concentrations of CKMB between the experimental and control groups was non-significant. This experiment confirmed that cTnI is more cardiospecific than CKMB. It also revealed the possibility to use this marker in preclinical testing.

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

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