scholarly journals Effect of Modulated Alternating and Direct Current Iontophoresis on Transdermal Delivery of Lidocaine Hydrochloride

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Gaurav Bhatia ◽  
Ajay K. Banga
Keyword(s):  
Stratum Corneum ◽  
Direct Current ◽  
Transdermal Delivery ◽  
Alternating Current ◽  
Lidocaine Hydrochloride ◽  
Tape Stripping ◽  
Porcine Skin ◽  
Skin Receptor ◽  
Time Periods ◽  
Iontophoretic Delivery

The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/v solution of lidocaine hydrochloride. Tape stripping was done to quantify the amount of drug permeated into stratum corneum and skin extraction studies were performed to determine the amount of drug in stripped skin. Receptor was sampled and analyzed over predefined time periods. The amount of lidocaine delivered across porcine skin after modulated direct current iontophoresis for 2 h was1069.87±120.03 μg/sq·cm compared to744.81±125.41 μg/sq·cm after modulated alternating current iontophoresis for 2 h. Modulated direct current iontophoresis also enhanced lidocaine delivery by twelvefold compared to passive delivery as91.27±18.71 μg/sq·cm of lidocaine was delivered after passive delivery. Modulated iontophoresis enhanced the delivery of lidocaine hydrochloride across porcine skin compared to the passive delivery. Modulated alternating current iontophoresis for duration of 2 h at frequency of 1 kHz was found to be comparable to the continuous direct current iontophoresis for 1 h.

Effect of gel properties on transdermal iontophoretic delivery of diclofenac sodium

e-Polymers ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. 25-32 ◽  
Author(s):  
S. Arunkumar ◽  
H.N. Shivakumar ◽  
B.G. Desai ◽  
Purnima Ashok
Keyword(s):  
Transdermal Delivery ◽  
Passive Control ◽  
Diclofenac Sodium ◽  
Matrix Material ◽  
Penetration Enhancers ◽  
Porcine Skin ◽  
Gel Properties ◽  
Iontophoretic Delivery

AbstractThe aim of the study was to develop hydrogels and investigate the suitability for transdermal delivery of diclofenac sodium (DS) using constant voltage iontophoresis (CVI). Four batches of hydrogels of DS were developed using hydroxylethyl cellulose (HEC) as matrix material and terpenes as penetration enhancers. The hydrogels displayed a viscosity of ~1500 cps at a shear rate of 250 s-1 that was unlikely to change on minute shift in pH or temperature so that the iontophoretic transport would be unaffected. Moreover, the hydrogels were found to possess adequate conductivity at pH 7.4 to enable iontophoretic delivery of DS. In vitro studies indicated that passive transport of DS across porcine skin from hydrogels was comparable (p>0.05) to aqueous solution. The lead hydrogel (F1), containing geraniol was found to enhance the iontophoretic flux of DS by 5.16 fold at 1.5 V compared to passive control. In vivo studies in rats indicated that CVI on application of F1 significantly suppressed (p<0.001) carrageenan induced edema compared to passive treatment throughout the study.

scholarly journals The Tape-Stripping Technique as a Method for Drug Quantification in Skin

2008 ◽  
Vol 11 (1) ◽  
pp. 104 ◽  
Author(s):  
Jose Juan Escobar-Chavez ◽  
V. Merino-Sanjuán ◽  
M. López-Cervantes ◽  
Z. Urban-Morlan ◽  
E. Piñón-Segundo ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Penetration Depth ◽  
Transdermal Delivery ◽  
Tape Stripping ◽  
Drug Penetration ◽  
Human Stratum Corneum ◽  
Investigative Techniques

Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques. Tape stripping of human stratum corneum is widely used as a method for studying the kinetics and penetration depth of drugs. This paper shows the applications of the tape stripping technique to quantify drug penetration through the skin, underlining its versatile application in the area of topical and transdermal drugs.

Microneedle-Assisted Percutaneous Transport of Magnesium Sulfate

2020 ◽  
Vol 17 (2) ◽  
pp. 140-147
Author(s):  
Karna B. Ghimirey ◽  
Kevin Ita
Keyword(s):  
Confocal Microscopy ◽  
Stratum Corneum ◽  
Magnesium Sulfate ◽  
Inductively Coupled Plasma ◽  
Optical Emission ◽  
Magnesium Concentration ◽  
Porcine Skin ◽  
Time Curve ◽  
Student’S T

Objective: In vitro diffusion experiments were performed to assess the permeation of magnesium sulfate across pig skin. Method: The mean thickness of the dermatomed porcine skin was 648 ± 12 µm. Magnesium concentration was measured using inductively coupled plasma-optical emission spectroscopy. Transdermal flux of magnesium sulfate across MN-treated and untreated porcine skin was obtained from the slope of the steady-state linear portion of cumulative amount versus time curve. Results: Statistical analysis of the results was done with Student’s t-test. The transdermal flux of magnesium sulfate across microneedle-treated porcine skin was 134.19 ± 2.4 µg/cm2/h and transdermal flux across untreated porcine skin was 4.64 ± 0.05 µg/cm2/h. Confocal microscopy was used to visualize the microchannels created by a solid microneedle roller (500 µm). Conclusion: From our confocal microscopy studies, it was evident that the 500 μm long microneedles disrupted the stratum corneum and created microchannels measuring 191 ± 37 µm. The increase in transdermal flux across the microneedle-treated skin was statistically significant compared to that of controls, i.e., without the application of microneedles. With the application of microneedles, the transdermal flux of magnesium permeated over 12 h was approximately 33-fold higher in comparison to passive diffusion across an intact stratum corneum.

scholarly journals Size-Tunable Paclitaxel Nanoparticles Stabilized by Anionic Phospholipids for Transdermal Delivery Applications

2020 ◽  
Vol 15 (3) ◽  
pp. 1934578X1990068
Author(s):  
Noriyuki Uchida ◽  
Masayoshi Yanagi ◽  
Hiroki Hamada
Keyword(s):  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Skin Tissue ◽  
Composite Nanoparticles ◽  
Rat Skin ◽  
Cooling Process ◽  
Anionic Phospholipid ◽  
Anionic Phospholipids ◽  
Subsequent Heating

Composite nanoparticles composed of an anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and paclitaxel (PTX) were successfully prepared by mixing them in water followed by a subsequent heating/cooling process. The size of DPPG-PTX nanoparticle could be easily tuned by ultrasonic fragmentation. Upon addition of small-sized fluorescently labeled paclitaxel (FLPTX) nanoparticles with DPPG (DPPG-FLPTX) to rat skin tissue, part of the FLPTX molecules permeated to the stratum corneum.

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

Comparison of alternating current with direct current electroshock across the closed chest

1962 ◽  
Vol 10 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Bernard Lown ◽  
Jose Neuman ◽  
Raghavan Amarasingham ◽  
Barouh V. Berkovits
Keyword(s):  
Direct Current ◽  
Alternating Current ◽  
Closed Chest

CONCEPTS OF ELECTRONICALLY-CONTROLLED ELECTROMECHANICAL/MECHANOELECTRICAL STEER-, AUTODRIVE- AND AUTOABSORBABLE WHEELS FOR ENVIRONMENTALLY-FRIENDLY TRI-MODE SUPERCARS

1994 ◽  
Vol 04 (04) ◽  
pp. 501-516 ◽  
Author(s):  
BOGDAN T. FIJALKOWSKI ◽  
JAN W. KROSNICKI
Keyword(s):  
Direct Current ◽  
Integrated Circuit ◽  
Environmentally Friendly ◽  
Alternating Current ◽  
Switching Frequency ◽  
Neuro Fuzzy ◽  
Interior Permanent Magnet ◽  
Application Specific Integrated Circuit ◽  
Computer Processor ◽  
Application Specific

Concepts of the electronically-controlled electromechanical/mechanoelectrical Steer-, Autodrive- and Autoabsorbable Wheels (SA2W) with their brushless Alternating Current-to-Alternating Current (AC-AC), Alternating Current-to-Direct Current-Alternating Current (AC-DC-AC) and/or Direct Current-to-Alternating Current (DC-AC)/Alternating Current-to-Direct Current (AC-DC) macroelectronic converter commutator (macro-commutator) wheel-hub motors/generators with the Application Specific Integrated Matrixer (ASIM) macroelectronic converter commutators (ASIM macrocommutators) and Application Specific Integrated Circuit (ASIC) microelectronic Neuro-Fuzzy (NF) computer (processor) controllers (ASIC NF microcontrollers) for environmentally-friendly tri-mode supercars (advanced ultralight hybrids) have been conceived by the first author and designed by both authors with the Cracow University of Technology’s Automotive Mechatronics Research and Development (R&D) Team. These electromechanical/mechanoelectrical wheel-hub motors/generators, respectively, for instance, can be composed of the outer rotor with the Interior Permanent Magnet (IPM) poles and the inner stator that has the three-phase armature winding. The macroelectronic converter commutator establishes the AC-AC cycloconverter, AC-DC rectifier-DC-AC inverter and/or DC-AC inverter/AC-DC rectifier ASIM macrocommutator. The microelectronic NF computer (processor) controller establishes the ASIC microcomputer-based NF microcontroller. By adopting continuous semiconductor bipolar electrical valves in the high-power ASIM, it has been able to increase the commutation (switching) frequency and reduce harmonic losses of the electromechanical/mechanoelectrical wheel-hub motors/generators, respectively.

Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition

2013 ◽  
Vol 233 ◽  
pp. 49-56 ◽  
Author(s):  
Qiang Chen ◽  
Luis Cordero-Arias ◽  
Judith A. Roether ◽  
Sandra Cabanas-Polo ◽  
Sannakaisa Virtanen ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Electrophoretic Deposition ◽  
Direct Current ◽  
Composite Coatings ◽  
Alternating Current
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