scholarly journals The Role of CTLA-4 Exon-1 49 A/G Polymorphism and Soluble CTLA-4 Protein Level in Egyptian Patients with Behçet's Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Sahar M. Abdel Galil ◽  
Hoda A. Hagrass
Keyword(s):  
Frequency Distribution ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Allele Frequency Distribution ◽  
Behcet's Disease ◽  
Egyptian Patients ◽  
Pcr Rflp ◽  
Exon 1

This study analyzed the association of the A/G SNP at position +49 of exon-1 in the CTLA-4 gene to the susceptibility and clinical manifestations of Behcet’s disease (BD). It was performed on 60 Egyptian BD patients and 95 age- and sex-matched healthy controls. The genotypes for the +49 A/G polymorphism of the CTLA-4 gene were determined by PCR-RFLP, while the serum level of CTLA-4 protein was measured by ELISA. CTLA-4 +49 A allele (P<0.001,OR=3.084, and CI (95%) = 1.90–4.99) and A/A genotype (P<0.001,OR=6.643, and CI (95%) = 2.58–17.10) frequency distribution was significantly more increased in patients than in the controls, with no significant differences between males and females with regard to the genotype or allele frequency distribution. A/A genotype was associated with a more reduced expression of sCTLA-4 protein in patients than in the controls (1.76±0.19versus1.91±0.30, resp;P<0.0007). In addition, it is associated with the occurrence of ocular and vasculitic manifestations of BD in the patient group. The CTLA-4 gene could be considered as a susceptibility and a disease-modifying gene to BD in Egyptian population that needs further confirmatory studies on larger cohorts.

scholarly journals Behcet’s Disease: An In-depth Review About Pathogenesis, Gastrointestinal Manifestations And Management

2021 ◽  
Author(s):  
Anthony Nguyen ◽  
Shubhra Upadhyay ◽  
Muhammad Ali Javaid ◽  
Abdul Moiz Qureshi ◽  
Shahan Haseeb ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Vascular Disorder ◽  
Robust Algorithms ◽  
Behcet's Disease ◽  
Relapsing Remitting

Background: Behcet’s Disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age groups. There are many variations of BD, however, intestinal BD is not only more common but has many signs and symptoms. Summary: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. Key messages: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations and creating robust algorithms.

scholarly journals MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet’s disease

2021 ◽  
Author(s):  
Omayma Abdelaleem ◽  
Olfat Shaker
Keyword(s):  
Risk Factor ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Recessive Model ◽  
Additive Models ◽  
Ocular Involvement ◽  
Behcet's Disease ◽  
Egyptian Population ◽  
Egyptian Patients

IntroductionBackground: The current study designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Behçet’s disease (BD) in Egyptian population.Material and methodsMethods: A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155(rs767649) using real-time polymerase chain reaction.ResultsResults: the results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared with controls (adjusted OR = 22.156, 95% CI (4.728-103.818); P < 0.001 and adjusted OR = 40.358, 95% CI (8.928 -182.440); P < 0.001, respectively). Also, rs2910164 G allele conferred a higher risk of developing BD (adjusted OR = 3.665, 95% CI (2.013-6.671); P < 0.001). MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance(All P < 0.001), while, the miR-155(rs767649) polymorphism was a risk factor in recessive model only (P = 0.021). GG and CG genotypes of rs2910164 were associated with higher BDCAI activity and ocular involvement compared with CC genotype (P = 0.005 and P =0.004, respectively). Genotype AT of rs767649 was related to higher BDCAI activity (P = 0. 026) compared with TT or AA genotypes.ConclusionsConclusion: The miR-146a (rs2910164) and miR-155(rs767649) were likely to play an important role in Egyptian population to develop BD and also influence disease severity.

HLA Class I in Egyptian patients with Behçet’s disease: new association with susceptibility, protection, presentation and severity of manifestations

2018 ◽  
Vol 48 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Mohanad M. Elfishawi ◽  
Fatema Elgengehy ◽  
Ghada Mossallam ◽  
Sally Elfishawi ◽  
Mostafa Alfishawy ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Hla Class I ◽  
Class I ◽  
Behcet's Disease ◽  
Egyptian Patients ◽  
New Association

scholarly journals Acute Agitation as an Initial Manifestation of Neuro-Behçet’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Yuki Otsuka ◽  
Tetsuya Yumoto ◽  
Hiromi Ihoriya ◽  
Namiko Matsumoto ◽  
Kota Sato ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Parietal Lobe ◽  
Psychiatric Symptoms ◽  
Behçet's Disease ◽  
Physical Restraint ◽  
Clinical Manifestations ◽  
Initial Manifestation ◽  
Behcet's Disease ◽  
Acute Agitation

Managing acutely agitated or violent patients in the emergency department (ED) represents a significant challenge. Acute agitation as an initial manifestation of neuro-Behcet’s disease (NBD) is an extremely rare clinical entity. A 44-year-old male, who had been complaining about a severe headache and fever for several days, was admitted to our ED due to acutely presented incontinence and agitation. On admission, physical restraint and sedation with sevoflurane and propofol were required for his combative and violent behavior. Cerebrospinal fluid examination revealed increased cell count. Fluid attenuated inversion recovery magnetic resonance imaging showed a high intensity signal in the left parietal lobe and bilateral occipital lobe. As infectious meningoencephalitis was suspected, empirical therapy was immediately started. He recovered uneventfully without neurological defect in seven days. Based on positive human leukocyte antigen B-51 and clinical manifestations, the diagnosis of NBD was made and remitted by steroid therapy. Although acute NBD commonly presents with focal neurological symptoms, psychiatric symptoms could be considered the first manifestation. A focused and thorough examination coupled with appropriate management strategies can assist emergency clinicians safely and effectively manage these patients.

scholarly journals Micro RNA 499 gene expression and interleukin 17 in Egyptian patients with Behçet’s disease

2020 ◽  
Vol 42 (2) ◽  
pp. 135-139
Author(s):  
Dina F. Elessawi ◽  
Nashwa K. Radwan ◽  
Neveen M. Nosseir ◽  
Mohamed S. Tawfik
Keyword(s):  
Gene Expression ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Micro Rna ◽  
Interleukin 17 ◽  
Behcet's Disease ◽  
Egyptian Patients

scholarly journals The effect of vitamin D on clinical manifestations and activity of Behçet’s disease

2017 ◽  
Vol 1 ◽  
pp. 15-20 ◽  
Author(s):  
Nurşad Aslan ◽  
Kamile Demirci ◽  
Tuba Güler ◽  
Fulya Dörtbaş ◽  
Ebru Kale
Keyword(s):  
Vitamin D ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Behcet's Disease

scholarly journals Colonic perforation as an unusual manifestation of Behcet's disease

2011 ◽  
Vol 68 (11) ◽  
pp. 992-995
Author(s):  
Aleksandra Tomic-Lucic ◽  
Snezana Jovanovic ◽  
Milan Petronijevic ◽  
Mirjana Veselinovic
Keyword(s):  
Behçet’S Disease ◽  
Transverse Colon ◽  
Behcet’S Disease ◽  
Clinical Symptoms ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Unusual Manifestation ◽  
Behcet's Disease ◽  
Abdominal Symptoms ◽  
Emergent Laparotomy

Introduction. Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as litle as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who underwent both surgical and conversative treatment due to perforation of the colon. Case report. A 34-year-old patient was admitted to the hospital with fever, aphthous ulcerations on oral mucosa and genitals and bilateral uveitis. On the basis of clinical symptoms and the International Criteria developed in 1990 Behcet's disease was diagnosed. During the next few days the patient developed erythema nodosum, diarrheic syndrome and acute abdominal symptoms due to perforation of the transverse colon. An emergent laparotomy was undertaken involving resection of a perforated segment of the colon, and bipolar colostomy on the left side of abdomen. Following the surgery the patient was treated except for antibiotics with three successive pulse doses of methylprednisolone (500 mg/daily) and cyclophosphamide (15 mg/kg). The treatment was continued by gradual decrease in the close of the corticosteroid (perorally) and by cyclophosphamide first with monthly doses (5 monthly pulse doses of 15 mg/kg cyclophosphoamide), and then with 3-month doses (totally 6 doses) up to totally 12 g. Conclusion. The therapy with pulse doses of methylprednisolone combined with pulse doses of cyclophosphamide was very effective in the reported case with the complex clinical manifestations leading to resolution of gastrointenstinal, ocular and orogenital lesions.

Behcet’s disease: is there a gender influence on clinical manifestations?

2011 ◽  
Vol 15 (3) ◽  
pp. 306-314 ◽  
Author(s):  
Fereydoun DAVATCHI ◽  
Farhad SHAHRAM ◽  
Cheyda CHAMS-DAVATCHI ◽  
Bahar SADEGHI ABDOLLAHI ◽  
Hormoz SHAMS ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Behcet's Disease ◽  
Gender Influence
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