IL-18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients

2014 ◽  
Vol 43 (10) ◽  
pp. 746-753 ◽  
Author(s):  
Hala H. A. Hazzaa ◽  
Weam A. M. Rashwan ◽  
Enas A. S. Attia
2011 ◽  
Vol 38 (4) ◽  
pp. 295-301 ◽  
Author(s):  
A. A. Özçimen ◽  
K. Dilek ◽  
Ü. Bingöl ◽  
H. Sarıcaoğlu ◽  
A. Sarandöl ◽  
...  

2009 ◽  
Vol 30 (2) ◽  
pp. 285-289 ◽  
Author(s):  
Mortaza Bonyadi ◽  
Zohreh Jahanafrooz ◽  
Mohsen Esmaeili ◽  
Susan Kolahi ◽  
Alireza Khabazi ◽  
...  

Author(s):  
Omayma Abdelaleem ◽  
Olfat Shaker

IntroductionBackground: The current study designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Behçet’s disease (BD) in Egyptian population.Material and methodsMethods: A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155(rs767649) using real-time polymerase chain reaction.ResultsResults: the results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared with controls (adjusted OR = 22.156, 95% CI (4.728-103.818); P < 0.001 and adjusted OR = 40.358, 95% CI (8.928 -182.440); P < 0.001, respectively). Also, rs2910164 G allele conferred a higher risk of developing BD (adjusted OR = 3.665, 95% CI (2.013-6.671); P < 0.001). MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance(All P < 0.001), while, the miR-155(rs767649) polymorphism was a risk factor in recessive model only (P = 0.021). GG and CG genotypes of rs2910164 were associated with higher BDCAI activity and ocular involvement compared with CC genotype (P = 0.005 and P =0.004, respectively). Genotype AT of rs767649 was related to higher BDCAI activity (P = 0. 026) compared with TT or AA genotypes.ConclusionsConclusion: The miR-146a (rs2910164) and miR-155(rs767649) were likely to play an important role in Egyptian population to develop BD and also influence disease severity.


2014 ◽  
Vol 35 (3) ◽  
pp. 471-477 ◽  
Author(s):  
Suleyman Serdar Koca ◽  
Murat Kara ◽  
Firat Deniz ◽  
Metin Ozgen ◽  
Caner Feyzi Demir ◽  
...  

2018 ◽  
Vol 48 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Mohanad M. Elfishawi ◽  
Fatema Elgengehy ◽  
Ghada Mossallam ◽  
Sally Elfishawi ◽  
Mostafa Alfishawy ◽  
...  

2020 ◽  
Vol 42 (2) ◽  
pp. 135-139
Author(s):  
Dina F. Elessawi ◽  
Nashwa K. Radwan ◽  
Neveen M. Nosseir ◽  
Mohamed S. Tawfik

2009 ◽  
Vol 70 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Ryuichi Tomiyama ◽  
Akira Meguro ◽  
Masao Ota ◽  
Yoshihiko Katsuyama ◽  
Tadayuki Nishide ◽  
...  

2016 ◽  
Vol 45 (6) ◽  
pp. 531-542 ◽  
Author(s):  
Asmaa Kamal ◽  
Sherif M. Gamal ◽  
Fatema T. Elgengehy ◽  
Alkhateeb K. Alkemary ◽  
Ibrahem Siam

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