scholarly journals Development and Optimization of Osmotically Controlled Asymmetric Membrane Capsules for Delivery of Solid Dispersion of Lycopene

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nitin Jain ◽  
Rashmi Sareen ◽  
Neeraj Mahindroo ◽  
K. L. Dhar
Keyword(s):  
Drug Release ◽  
Osmotic Pressure ◽  
Correlation Coefficient ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Dip Coating ◽  
Asymmetric Membrane ◽  
Independent Variables ◽  
Coating Method ◽  
Dip Coating Method

The aim of the present investigation is to develop and statistically optimize the osmotically controlled asymmetric membrane capsules of solid dispersion of lycopene. Solid dispersions of lycopene withβ-cyclodextrin in different ratios were prepared using solvent evaporation method. Solubility studies showed that the solid dispersion with 1 : 5 (lycopene : β-cyclodextrin) exhibited optimum solubility (56.25 mg/mL) for osmotic controlled delivery. Asymmetric membrane capsules (AMCs) were prepared on glass mold pins via dip coating method. Membrane characterization by scanning electron microscopy showed inner porous region and outer dense region. Central composite design response surface methodology was applied for the optimization of AMCs. The independent variables were ethyl cellulose (X1), glycerol (X2), and NaCl (X3) which were varied at different levels to analyze the effect on dependent variables (percentage of cumulative drug release (Y1) and correlation coefficient of drug release (Y2)). The effect of independent variables on the response was significantly influential. The F18was selected as optimized formulation based on percentage of CDR (cumulative drug release) of 85.63% and correlation coefficient of 0.9994. The optimized formulation was subjected to analyze the effect of osmotic pressure and agitational intensity on percentage of CDR. The drug release was independent of agitational intensity but was dependent on osmotic pressure of dissolution medium.

Porous Gel Coatings Obtained by Phase Separation in ORMOSIL System

2000 ◽  
Vol 628 ◽  
Author(s):  
Kazuki Nakanishi ◽  
Souichi Kumon ◽  
Kazuyuki Hirao ◽  
Hiroshi Jinnai
Keyword(s):  
Phase Separation ◽  
Reaction Time ◽  
Volume Fraction ◽  
Sol Gel ◽  
Reaction Times ◽  
Dip Coating ◽  
Coating Solution ◽  
Coating Method ◽  
Gel Phase ◽  
Dip Coating Method

ABSTRACTMacroporous silicate thick films were prepared by a sol-gel dip-coating method accompanied by the phase separation using methyl-trimethoxysilane (MTMS), nitric acid and dimethylformamide (DMF) as starting components. The morphology of the film varied to a large extent depending on the time elapsed after the hydrolysis until the dipping of the coating solution. On a glass substrate, the films prepared by early dipping had inhomogeneous submicrometer-sized pores on the surface of the film. At increased reaction times, relatively narrow sized isolated macropores were observed and their size gradually decreased with the increase of reaction time. On a polyester substrate, in contrast, micrometer-sized isolated spherical gel domains were homogeneously deposited by earlier dippings. With an increase of reaction time, the volume fraction of the gel phase increased, then the morphology of the coating transformed into co-continuous gel domains and macropores, and finally inverted into the continuous gel domains with isolated macropores. The overall morphological variation with the reaction time was explained in terms of the phase separation and the structure freezing by the forced gelation, both of which were induced by the evaporation of methanol during the dipping operation.

scholarly journals Preparation of Polypropylene/PVDF Composite Membrane by Dip-Coating Method

2021 ◽  
Vol 1115 (1) ◽  
pp. 012028
Author(s):  
P T P Aryanti ◽  
G Trilaksono ◽  
A Hotmaida ◽  
M A Afifah ◽  
F P Pratiwi ◽  
...  
Keyword(s):  
Composite Membrane ◽  
Dip Coating ◽  
Coating Method ◽  
Dip Coating Method

Characterization of UHMWPE- HAp coating produced by dip coating method on Ti6Al4V alloy

2021 ◽  
pp. 127091
Author(s):  
Gözde Çelebi Efe ◽  
Elif Yenilmez ◽  
İbrahim Altinsoy ◽  
Serbülent Türk ◽  
Cuma Bindal
Keyword(s):  
Dip Coating ◽  
Ti6al4v Alloy ◽  
Coating Method ◽  
Dip Coating Method

scholarly journals Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies

2021 ◽  
Vol 14 (2) ◽  
pp. 132
Author(s):  
Siriporn Okonogi ◽  
Adchareeya Kaewpinta ◽  
Sakornrat Khongkhunthian ◽  
Pisaisit Chaijareenont
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Tooth Bleaching ◽  
Polymer Mixture ◽  
Release Mechanism ◽  
Burst Release ◽  
Order Kinetic ◽  
Carbamide Peroxide ◽  
Periodontal Tissues

Burst release of carbamide peroxide (CP) from traditional hydrogels causes severe inflammation to periodontal tissues. The present study explores the development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based gel in which CP was loaded with a view to controlling CP release. CP solid dispersions were prepared, using white soft paraffin or polyvinylpyrrolidone-white soft paraffin mixture as a carrier, prior to formulating nanoemulsions. It was found that carrier type and the ratio of CP to carrier affected drug crystallinity. Nanoemulsions formulated from the optimized CP solid dispersions were used to prepare CP-NG. It was found that the ratio of drug to carrier in CP solid dispersions affected the particle size and zeta potential of the nanoemulsions as well as drug release behavior and tooth bleaching efficacy of CP-NG. Drug release from CP-NG followed a first-order kinetic reaction and the release mechanism was an anomalous transport. Drug release rate decreased with an increase in solid dispersion carriers. CP-NG obtained from the solid dispersion with a 1:1 ratio of CP to the polymer mixture is suitable for sustaining drug release with high tooth bleaching efficacy and without reduction of enamel microhardness. The developed CP-NG is a promising potential tooth bleaching formulation.

scholarly journals The Effect of Film Thickness and Content on Film Formation from PS/ Nanocomposites Prepared by Dip-Coating Method

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
M. Selin Sunay ◽  
Onder Pekcan ◽  
Saziye Ugur
Keyword(s):  
Film Thickness ◽  
Elevated Temperatures ◽  
Film Formation ◽  
Fluorescence Emission ◽  
Dip Coating ◽  
Atomic Force ◽  
Annealing Step ◽  
Coating Method ◽  
Fluorescence Emission Intensity ◽  
Dip Coating Method

Steady-state fluorescence (SSF) technique in conjunction with UV-visible (UVV) technique and atomic force microscope (AFM) was used for studying film formation from TiO2covered nanosized polystyrene (PS) latex particles (320 nm). The effects of film thickness and TiO2content on the film formation and structure properties of PS/TiO2composites were studied. For this purpose, two different sets of PS films with thicknesses of 5 and 20 μm were prepared from pyrene-(P-) labeled PS particles and covered with various layers of TiO2using dip-coating method. These films were then annealed at elevated temperatures above glass transition temperature () of PS in the range of 100–280°C. Fluorescence emission intensity, from P and transmitted light intensity, were measured after each annealing step to monitor the stages of film formation. The results showed that film formation from PS latexes occurs on the top surface of PS/TiO2composites and thus developed independent of TiO2content for both film sets. But the surface morphology of the films was found to vary with both TiO2content and film thickness. After removal of PS, thin films provide a quite ordered porous structure while thick films showed nonporous structure.

Preparation and properties of polyurethane coatings modified by polysilazane

2019 ◽  
Vol 32 (6) ◽  
pp. 611-619 ◽  
Author(s):  
Xiaoli Liu ◽  
Zhen Ge ◽  
Wenguo Zhang ◽  
Yunjun Luo
Keyword(s):  
Mechanical Property ◽  
Photoelectron Spectroscopy ◽  
Composite Coatings ◽  
Composite Films ◽  
Dip Coating ◽  
Water Contact ◽  
Research Attention ◽  
Elongation At Break ◽  
Coating Method ◽  
Dip Coating Method

Due to their unique physicochemical properties, polysilazanes exhibit excellent performance when combined with some resin matrixes, which had drawn great research attention. In this article, polyurethane (PU) was firstly prepared by polytetrahydrofuran glycol, isophorone diisocyanate, and 1,4-butanediol as main materials. Then, the prepared PU was blended with polysilazane by mixing the two solutions together, which was cured to films via dip-coating method at room temperature. The structure, thermal stability, and surface properties of the composite coatings were investigated by Fourier-transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and X-ray photoelectron spectroscopy. The results demonstrated that after modification with polysilazane, the heat resistance, hydrophobicity, and mechanical property of the PU coatings were improved. When the content of polysilazane was 6 wt%, the mechanical property of the composite films was optimized, with a maximum tensile strength of 25.7 MPa and elongation at break of 797%. Meanwhile, the water contact angle of the composite film was 107° and the water absorption reached a minimum of 2.1%, which showed improved hydrophobicity and water resistance.

scholarly journals Tuning Deposition of Magnetic Metallic Nanoparticles from Periodic Pattern to Thin Film Entrainment by Dip Coating Method

Langmuir ◽  
2014 ◽  
Vol 30 (30) ◽  
pp. 9028-9035 ◽  
Author(s):  
J. Dugay ◽  
R. P. Tan ◽  
A. Loubat ◽  
L.-M. Lacroix ◽  
J. Carrey ◽  
...  
Keyword(s):  
Thin Film ◽  
Metallic Nanoparticles ◽  
Dip Coating ◽  
Periodic Pattern ◽  
Coating Method ◽  
Dip Coating Method
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