scholarly journals Coating Solid Dispersions on Microneedles via a Molten Dip‐Coating Method: Development and In Vitro Evaluation for Transdermal Delivery of a Water‐Insoluble Drug

2014 ◽  
Vol 103 (11) ◽  
pp. 3621-3630 ◽  
Author(s):  
Yunzhe Ma ◽  
Harvinder S. Gill
Keyword(s):  
Transdermal Delivery ◽  
Method Development ◽  
Solid Dispersions ◽  
Dip Coating ◽  
In Vitro Evaluation ◽  
Coating Method ◽  
Water Insoluble Drug ◽  
Dip Coating Method

scholarly journals Development and Optimization of Osmotically Controlled Asymmetric Membrane Capsules for Delivery of Solid Dispersion of Lycopene

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nitin Jain ◽  
Rashmi Sareen ◽  
Neeraj Mahindroo ◽  
K. L. Dhar
Keyword(s):  
Drug Release ◽  
Osmotic Pressure ◽  
Correlation Coefficient ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Dip Coating ◽  
Asymmetric Membrane ◽  
Independent Variables ◽  
Coating Method ◽  
Dip Coating Method

The aim of the present investigation is to develop and statistically optimize the osmotically controlled asymmetric membrane capsules of solid dispersion of lycopene. Solid dispersions of lycopene withβ-cyclodextrin in different ratios were prepared using solvent evaporation method. Solubility studies showed that the solid dispersion with 1 : 5 (lycopene : β-cyclodextrin) exhibited optimum solubility (56.25 mg/mL) for osmotic controlled delivery. Asymmetric membrane capsules (AMCs) were prepared on glass mold pins via dip coating method. Membrane characterization by scanning electron microscopy showed inner porous region and outer dense region. Central composite design response surface methodology was applied for the optimization of AMCs. The independent variables were ethyl cellulose (X1), glycerol (X2), and NaCl (X3) which were varied at different levels to analyze the effect on dependent variables (percentage of cumulative drug release (Y1) and correlation coefficient of drug release (Y2)). The effect of independent variables on the response was significantly influential. The F18was selected as optimized formulation based on percentage of CDR (cumulative drug release) of 85.63% and correlation coefficient of 0.9994. The optimized formulation was subjected to analyze the effect of osmotic pressure and agitational intensity on percentage of CDR. The drug release was independent of agitational intensity but was dependent on osmotic pressure of dissolution medium.

scholarly journals In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Salim Levent Aktug ◽  
Salih Durdu ◽  
Selin Kalkan ◽  
Kultigin Cavusoglu ◽  
Metin Usta
Keyword(s):  
Antimicrobial Properties ◽  
Dip Coating ◽  
In Vitro Bioactivity ◽  
Thermal Cracks ◽  
Coating Method ◽  
Micro Arc Oxidation ◽  
Edx Analyses ◽  
Dip Coating Method ◽  
Bioceramic Coatings

AbstractCa-based porous and rough bioceramic surfaces were coated onto zirconium by micro-arc oxidation (MAO). Subsequently, the MAO-coated zirconium surfaces were covered with an antimicrobial chitosan layer via the dip coating method to develop an antimicrobial, bioactive, and biocompatible composite biopolymer and bioceramic layer for implant applications. Cubic ZrO2, metastable Ca0.15Zr0.85O1.85, and Ca3(PO4)2 were detected on the MAO surface by powder-XRD. The existence of chitosan on the MAO-coated Zr surfaces was verified by FTIR. The micropores and thermal cracks on the bioceramic MAO surface were sealed using a chitosan coating, where the MAO surface was porous and rough. All elements such as Zr, O, Ca, P, and C were homogenously distributed across both surfaces. Moreover, both surfaces indicated hydrophobic properties. However, the contact angle of the MAO surface was lower than that of the chitosan-based MAO surface. In vitro bioactivity on both surfaces was investigated via XRD, SEM, and EDX analyses post-immersion in simulated body fluid (SBF) for 14 days. In vitro bioactivity was significantly enhanced on the chitosan-based MAO surface with respect to the MAO surface. In vitro microbial adhesions on the chitosan-based MAO surfaces were lower than the MAO surfaces for Staphylococcus aureus and Escherichia coli.

scholarly journals In Vitro Biological and Antimicrobial Properties of Chitosan-based Bioceramic Coatings on Zirconium

2021 ◽  
Author(s):  
Salim Levent Aktug ◽  
Salih Durdu ◽  
Selin Kalkan ◽  
Kultigin Cavusoglu ◽  
Metin Usta
Keyword(s):  
Antimicrobial Properties ◽  
Dip Coating ◽  
Thermal Cracks ◽  
Coating Method ◽  
Micro Arc Oxidation ◽  
Edx Analyses ◽  
Dip Coating Method ◽  
The One ◽  
Bioceramic Coatings

Abstract Ca-based porous and rough bioceramic surfaces were coated on zirconium by micro arc oxidation (MAO). Subsequently, an antibacterial chitosan layer was covered on the MAO-coated zirconium surfaces by dip coating method to develop an antibacterial, bioactive and biocompatible composite biopolymer and bioceramic layer for implant applications. The cubic-ZrO2, meta-stable Ca0.15Zr0.85O1.85, and Ca3(PO4)2 were detected on the MAO surface by powder-XRD. The existence of chitosan on the MAO-coated Zr surfaces was verified by FTIR. The micro-pores and thermal cracks on the bioceramic MAO surface were sealed by chitosan coating, while the MAO surface is porous and rough. All elements such as Zr, O, Ca, P and C were homogenously distributed through both surfaces. Moreover, both surfaces indicated hydrophobic properties. However, the contact angle value of the MAO surface was lower than the one of chitosan-based MAO surface. In vitro bioactivity on both surfaces was investigated by XRD, SEM and EDX analyses at post-immersion in simulated body fluid (SBF) up to 14 days. In vitro bioactivity was significantly enhanced on the chitosan-based MAO surface with respect to the MAO surface. In vitro bacterial adhesions on the chitosan-based MAO surfaces were lower compared to the MAO surfaces for Staphylococcus aureus and Escherichia coli.

In Vitro Behavior of Magnesium Apatite Coatings in Organic Modified Simulated Body Fluid

2011 ◽  
Vol 299-300 ◽  
pp. 508-511
Author(s):  
Guo Chao Qi ◽  
Feng Jun Shan ◽  
Qiang Li ◽  
Jing Yuan Yu ◽  
Qu Kai Zhang
Keyword(s):  
Simulated Body Fluid ◽  
Photoelectron Spectroscopy ◽  
Body Fluid ◽  
Sol Gel ◽  
Dip Coating ◽  
X Ray ◽  
Coating Method ◽  
Sbf Solution ◽  
Dip Coating Method

Magnesium apatite (MA, (Ca9Mg)(PO4)6(OH)2) and Hydroxyapatite (HA) coatings were synthesized on Ti6Al4V substrates by a sol-gel dip coating method. Glucose and bovine serum albumin (BSA) were added to the standard simulated body fluid (SBF) separately to form organic-containing simulated body fluids. MA and HA coatings were immersed in standard and organic modified SBF for time periods of 4, 7, 14, 21 and 28 days at 37±1°C. The surface dissolution and deposition behavior of the coatings after soaking were examined with Scanning Electron Microscopy (SEM) and X-ray Photoelectron Spectroscopy (XPS). The results show that glucose in SBF has no apparent effect on the deposition of new apatite from the solution. BSA in SBF shows retardation effect on the deposition of apatite by forming a protein dominant globular layer. This layer inhibits the further deposition of apatite from SBF solution.

scholarly journals Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4907
Author(s):  
Ozlem Ipek Kalaoglu-Altan ◽  
Havva Baskan ◽  
Timo Meireman ◽  
Pooja Basnett ◽  
Bahareh Azimi ◽  
...  
Keyword(s):  
Wound Dressing ◽  
High Performance ◽  
High Surface ◽  
High Surface Area ◽  
Human Keratinocytes ◽  
Dip Coating ◽  
Wound Dressings ◽  
Coating Method ◽  
Dip Coating Method

Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good handling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications.

Porous Gel Coatings Obtained by Phase Separation in ORMOSIL System

2000 ◽  
Vol 628 ◽  
Author(s):  
Kazuki Nakanishi ◽  
Souichi Kumon ◽  
Kazuyuki Hirao ◽  
Hiroshi Jinnai
Keyword(s):  
Phase Separation ◽  
Reaction Time ◽  
Volume Fraction ◽  
Sol Gel ◽  
Reaction Times ◽  
Dip Coating ◽  
Coating Solution ◽  
Coating Method ◽  
Gel Phase ◽  
Dip Coating Method

ABSTRACTMacroporous silicate thick films were prepared by a sol-gel dip-coating method accompanied by the phase separation using methyl-trimethoxysilane (MTMS), nitric acid and dimethylformamide (DMF) as starting components. The morphology of the film varied to a large extent depending on the time elapsed after the hydrolysis until the dipping of the coating solution. On a glass substrate, the films prepared by early dipping had inhomogeneous submicrometer-sized pores on the surface of the film. At increased reaction times, relatively narrow sized isolated macropores were observed and their size gradually decreased with the increase of reaction time. On a polyester substrate, in contrast, micrometer-sized isolated spherical gel domains were homogeneously deposited by earlier dippings. With an increase of reaction time, the volume fraction of the gel phase increased, then the morphology of the coating transformed into co-continuous gel domains and macropores, and finally inverted into the continuous gel domains with isolated macropores. The overall morphological variation with the reaction time was explained in terms of the phase separation and the structure freezing by the forced gelation, both of which were induced by the evaporation of methanol during the dipping operation.

scholarly journals Preparation of Polypropylene/PVDF Composite Membrane by Dip-Coating Method

2021 ◽  
Vol 1115 (1) ◽  
pp. 012028
Author(s):  
P T P Aryanti ◽  
G Trilaksono ◽  
A Hotmaida ◽  
M A Afifah ◽  
F P Pratiwi ◽  
...  
Keyword(s):  
Composite Membrane ◽  
Dip Coating ◽  
Coating Method ◽  
Dip Coating Method

Characterization of UHMWPE- HAp coating produced by dip coating method on Ti6Al4V alloy

2021 ◽  
pp. 127091
Author(s):  
Gözde Çelebi Efe ◽  
Elif Yenilmez ◽  
İbrahim Altinsoy ◽  
Serbülent Türk ◽  
Cuma Bindal
Keyword(s):  
Dip Coating ◽  
Ti6al4v Alloy ◽  
Coating Method ◽  
Dip Coating Method

scholarly journals The Effect of Film Thickness and Content on Film Formation from PS/ Nanocomposites Prepared by Dip-Coating Method

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
M. Selin Sunay ◽  
Onder Pekcan ◽  
Saziye Ugur
Keyword(s):  
Film Thickness ◽  
Elevated Temperatures ◽  
Film Formation ◽  
Fluorescence Emission ◽  
Dip Coating ◽  
Atomic Force ◽  
Annealing Step ◽  
Coating Method ◽  
Fluorescence Emission Intensity ◽  
Dip Coating Method

Steady-state fluorescence (SSF) technique in conjunction with UV-visible (UVV) technique and atomic force microscope (AFM) was used for studying film formation from TiO2covered nanosized polystyrene (PS) latex particles (320 nm). The effects of film thickness and TiO2content on the film formation and structure properties of PS/TiO2composites were studied. For this purpose, two different sets of PS films with thicknesses of 5 and 20 μm were prepared from pyrene-(P-) labeled PS particles and covered with various layers of TiO2using dip-coating method. These films were then annealed at elevated temperatures above glass transition temperature () of PS in the range of 100–280°C. Fluorescence emission intensity, from P and transmitted light intensity, were measured after each annealing step to monitor the stages of film formation. The results showed that film formation from PS latexes occurs on the top surface of PS/TiO2composites and thus developed independent of TiO2content for both film sets. But the surface morphology of the films was found to vary with both TiO2content and film thickness. After removal of PS, thin films provide a quite ordered porous structure while thick films showed nonporous structure.

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