scholarly journals A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Eiko Saito ◽  
Shinji Sato ◽  
Shinichi Nogi ◽  
Noriko Sasaki ◽  
Naofumi Chinen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lymph Node ◽  
Systemic Sclerosis ◽  
Primary Biliary Cirrhosis ◽  
Interleukin 6 ◽  
Lymph Node Biopsy ◽  
Biliary Cirrhosis ◽  
Node Biopsy ◽  
Limited Systemic Sclerosis ◽  
Generalized Lymphadenopathy

A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. Because of gradually worsening arthritis, tocilizumab was administered and arthritis improved markedly. Interestingly, lymphadenopathy and PBC improved simultaneously. This suggested that interleukin-6 might play an important role in reactive lymphadenopathy and PBC associated with RA/lSSc.

scholarly journals Primary Biliary Cirrhosis Associated with Systemic Sclerosis: Diagnostic and Clinical Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Cristina Rigamonti ◽  
Dimitrios P. Bogdanos ◽  
Maria G. Mytilinaiou ◽  
Daniel S. Smyk ◽  
Eirini I. Rigopoulou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Systemic Sclerosis ◽  
General Population ◽  
Primary Biliary Cirrhosis ◽  
Early Identification ◽  
Case Reports ◽  
Biliary Cirrhosis ◽  
Antimitochondrial Antibodies ◽  
Favorable Prognosis ◽  
Limited Systemic Sclerosis

Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The mechanisms responsible for the co-occurrence of these diseases are largely unknown. Genetic, epigenetic, environmental, and infectious factors appear to be important for the pathogenesis of the disease, but the hierarchy of events are not well defined. Patients with SSc and PBC have an increased morbidity and mortality compared with the general population, but whether the presence of both diseases in an affected individual worsens the prognosis and/or outcome of either disease is not clear. Some case reports suggested that the presence of SSc in PBC patents is associated with a more favorable prognosis of the liver disease, whereas others report an increased mortality in patients with PBC and SSc compared to patients with PBC alone. This paper discusses the features of patients with PBC-associated SSc. Our aims are to clarify some of the pathogenetic, diagnostic, and clinical challenges that are currently faced in the routine management of these patients. We also intend to provide some practical hints for practitioners that will assist in the early identification of patients with PBC-associated SSc.

GENERALIZED LYMPHADENOPATHY AND HEPATOSPLENOMEGALY INDUCED BY DIPHENYLHYDANTOIN

PEDIATRICS ◽  
1961 ◽  
Vol 28 (6) ◽  
pp. 943-945
Author(s):  
Mehdi Bajoghli
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Drug Therapy ◽  
Biopsy Specimen ◽  
Lymphoid Hyperplasia ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Generalized Lymphadenopathy

A 6-year-old child developed generalized lymphadenopathy and hepatosplenomegaly 2 weeks after diphenylhydantoin therapy was begun. The patient recovered 4 weeks after discontinuance of the drug therapy. There was eosinophilia in blood and in bone marrow, and a lymph node biopsy specimen showed reticulum and lymphoid hyperplasia.

Results of initial lymph node biopsy in homosexual men with generalized lymphadenopathy.

1986 ◽  
Vol 4 (2) ◽  
pp. 165-169 ◽  
Author(s):  
A M Levine ◽  
P R Meyer ◽  
P S Gill ◽  
R L Burkes ◽  
M Krailo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Laboratory Data ◽  
Clinical Parameter ◽  
Lymph Node Biopsy ◽  
Homosexual Men ◽  
Laboratory Findings ◽  
Node Biopsy ◽  
Significant Difference ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

Persistent, generalized lymphadenopathy (PGL) is considered part of the acquired immunodeficiency syndrome (AIDS)-related complex. The clinical course is usually benign, although some patients may evolve to AIDS. Characteristic features on lymph node biopsy have been described. Recently, large series of PGL have been reported in which many study patients have not undergone initial diagnostic biopsy. The value of such biopsy has been questioned. We report the clinical, pathologic, and laboratory findings in six homosexual men initially considered as potential candidates for study of the natural history of PGL. They were excluded by initial lymph node biopsy, which revealed small-cleaved lymphoma in two, focal Kaposi's sarcoma in two, disseminated mycobacterium tuberculosis in one, and histoplasma encapsulatum in one. The clinical and laboratory data from these six patients were compared with those from 34 patients with biopsy-proven PGL; no statistically significant difference in any prebiopsy clinical parameter was found. We conclude that initial lymph node biopsy may reveal changes other than reactive hyperplasia in homosexual men with generalized lymphadenopathy.

scholarly journals Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At‐Risk and Earliest Phases of Rheumatoid Arthritis

2016 ◽  
Vol 69 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Javier Rodríguez‐Carrio ◽  
Janine S. Hähnlein ◽  
Tamara H. Ramwadhdoebe ◽  
Johanna F. Semmelink ◽  
Ivy Y. Choi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Lymph Node ◽  
Lymphoid Cell ◽  
Lymph Node Biopsy ◽  
Innate Lymphoid Cell ◽  
Biopsy Specimens ◽  
Node Biopsy ◽  
Human Lymph Node

scholarly journals Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at‐risk phase of autoantibody positive rheumatoid arthritis

2016 ◽  
Vol 46 (12) ◽  
pp. 2812-2821 ◽  
Author(s):  
Tamara H. Ramwadhdoebe ◽  
Janine Hähnlein ◽  
Karen I. Maijer ◽  
Leonard J. Boven ◽  
Danielle M. Gerlag ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Lymph Node ◽  
Lymph Node Biopsy ◽  
Node Biopsy
Sign in / Sign up

Export Citation Format

Share Document