scholarly journals Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at‐risk phase of autoantibody positive rheumatoid arthritis

2016 ◽  
Vol 46 (12) ◽  
pp. 2812-2821 ◽  
Author(s):  
Tamara H. Ramwadhdoebe ◽  
Janine Hähnlein ◽  
Karen I. Maijer ◽  
Leonard J. Boven ◽  
Danielle M. Gerlag ◽  
...  
2016 ◽  
Vol 69 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Javier Rodríguez‐Carrio ◽  
Janine S. Hähnlein ◽  
Tamara H. Ramwadhdoebe ◽  
Johanna F. Semmelink ◽  
Ivy Y. Choi ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Eiko Saito ◽  
Shinji Sato ◽  
Shinichi Nogi ◽  
Noriko Sasaki ◽  
Naofumi Chinen ◽  
...  

A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. Because of gradually worsening arthritis, tocilizumab was administered and arthritis improved markedly. Interestingly, lymphadenopathy and PBC improved simultaneously. This suggested that interleukin-6 might play an important role in reactive lymphadenopathy and PBC associated with RA/lSSc.


Author(s):  
Arda Isik ◽  
Atilla Soran ◽  
Ariel Grasi ◽  
Noran Barry ◽  
Efe Sezgin

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