scholarly journals Oxidative Stress-Mediated Aging during the Fetal and Perinatal Periods

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Lucia Marseglia ◽  
Gabriella D’Angelo ◽  
Sara Manti ◽  
Teresa Arrigo ◽  
Ignazio Barberi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Periventricular Leukomalacia ◽  
Postnatal Period ◽  
Antioxidant Defenses ◽  
Free Radical Damage ◽  
Radical Generation ◽  
Radical Damage ◽  
In Pregnancy

Oxidative stress is worldwide recognized as a fundamental component of the aging, a process that begins before birth. There is a critical balance between free radical generation and antioxidant defenses. Oxidative stress is caused by an imbalance between the production of free radicals and the ability of antioxidant system to detoxify them. Oxidative stress can occur early in pregnancy and continue in the postnatal period; this damage is implicated in the pathophysiology of pregnancy-related disorders, including recurrent pregnancy loss, preeclampsia and preterm premature rupture of membranes. Moreover, diseases of the neonatal period such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and periventricular leukomalacia are related to free radical damage. The specific contribution of oxidative stress to the pathogenesis and progression of these neonatal diseases is only partially understood. This review summarizes what is known about the role of oxidative stress in pregnancy and in the pathogenesis of common disorders of the newborn, as a component of the early aging process.

scholarly journals Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants

2021 ◽  
Vol 15 ◽  
Author(s):  
Ferdinando Franzoni ◽  
Giorgia Scarfò ◽  
Sara Guidotti ◽  
Jonathan Fusi ◽  
Muzaffar Asomov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Central Nervous System ◽  
Nervous System ◽  
Free Radical ◽  
Natural Antioxidants ◽  
High Reactivity ◽  
Free Radical Damage ◽  
The Central Nervous System ◽  
Radical Damage

Free- radicals (Oxygen and Nitrogen species) are formed in mitochondria during the oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an increase of the oxidative stress. This condition affects above all the brain, that usually needs a large oxygen amount and in which there is the major possibility to accumulate “Reacting Species.” Antioxidant molecules are fundamental in limiting free-radical damage, in particular in the central nervous system: the oxidative stress, in fact, seems to worsen the course of neurodegenerative diseases. The aim of this review is to sum up natural antioxidant molecules with the greatest neuroprotective properties against free radical genesis, understanding their relationship with the Central Nervous System.

Study of antioxidant potential in leaves, stems, nuts of Juglans regia L.

2012 ◽  
Vol 1 (10) ◽  
pp. 79 ◽  
Author(s):  
G. Raja* ◽  
Ivvala Anand Shaker ◽  
Inampudi Sailaja ◽  
R. Swaminathan ◽  
S. Saleem Basha ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Juglans Regia ◽  
Radical Scavenging ◽  
Antioxidant Compounds ◽  
Free Radical Damage ◽  
Radical Damage

Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as lipid oxidative rancidity in foods. The role of antioxidants has protected effect against free radical damage that may cause many diseases including cancer. Primary sources of naturally occurring antioxidants are known as whole grains, fruits, and vegetables. Several studies suggest that regular consumption of nuts, mostly walnuts, may have beneficial effects against oxidative stress mediated diseases such as cardiovascular disease and cancer. The role of antioxidants has attracted much interest with respect to their protective effect against free radical damage that may cause many diseases including cancer. Juglans regia L. (walnut) contains antioxidant compounds, which are thought to contribute to their biological properties. Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of Leaves, Stems and Nuts extract of Juglans regia L. as evaluated using DPPH, ABTS, Nitric acid, hydroxyl and superoxide radical scavenging activity, lipid peroxidation and total oxidation activity were determined. The antioxidant activities of Leaves, Stems and Nuts extract of Juglans regia L. were concentration dependent in different experimental models and it was observed that free radicals were scavenged by the test compounds in all the models.

The role of iron in oxygen-free radical damage during kidney storage at hypothermia

Cryobiology ◽  
1985 ◽  
Vol 22 (6) ◽  
pp. 614 ◽  
Author(s):  
B. Fuller ◽  
C. Green ◽  
G. Healing ◽  
S. Marley ◽  
S. Simpkin ◽  
...  
Keyword(s):  
Free Radical ◽  
Oxygen Free Radical ◽  
Free Radical Damage ◽  
Radical Damage

Free-radical damage to the liver during its transplantation under conditions of oxidative stress

1995 ◽  
Vol 120 (5) ◽  
pp. 1093-1095
Author(s):  
V. I. Mil'chakov ◽  
I. I. Dement'eva ◽  
M. Yu. Andrianova ◽  
M. V. Palyulina
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Free Radical Damage ◽  
Radical Damage

scholarly journals The therapeutic implications of oxidative stress in patients receiving haemodialysis

1999 ◽  
Vol 3 (2) ◽  
Author(s):  
AV Crowe ◽  
GM Bell
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Chemical Species ◽  
Free Radical Damage ◽  
Therapeutic Implications ◽  
Oxygen Derived Free Radicals ◽  
Low Levels ◽  
Free Radical Activity ◽  
Antioxidant Mechanisms ◽  
Radical Damage

Oxygen-derived free radicals are highly reactive chemical species containing an unpaired electron. They are capable of reacting with lipids, proteins and nucleic acids and are thought to have a major role in the pathogenesis of a variety of diseases including atherosclerosis, diabetes and cancer. Antioxidants protect and limit free radical damage and it is the balance between free radical activity and antioxidant mechanisms that determine the potential for tissue damage [1,2]. Oxidative stress exists when there are either low levels of these antioxidants or increased production of reactive oxygen species (ROS).

Clinical Role of Antioxidants in the Treatment of Diseases

2019 ◽  
pp. 392-401 ◽  
Author(s):  
Kirti Rani
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Clinical Role ◽  
Free Radical Damage ◽  
Potential Benefits ◽  
Risk Of Cancer ◽  
Radical Damage ◽  
Wide Assortment

Antioxidants are our first line of defense against free radical damage and are critical for maintaining optimum healthcare. Although most of the present day research is focused on the potential benefits of antioxidant nutrients or supplements, it has become clear that the best protection against oxidative stress involves a wide assortment of interrelated antioxidants and antioxidant cofactors. Additionally, the combination of several suboptimal concentrations of these kinds of detoxifying supplements may have an additive or even synergistic role to decrease the risk of some of diseases which are caused by aging. Adequate intake of fruit and vegetables have essential antioxidants like B-carotene and vitamin C, which are reported for decreasing the risk of cancer and coronary heart disease (CHD).

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