scholarly journals Gastroprotective Effect of Freeze Dried Stripped Snakehead Fish (Channa striata Bloch.) Aqueous Extract against Aspirin Induced Ulcerogenesis in Pylorus Ligated Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mohammed Safwan Ali Khan ◽  
Abdul Manan Mat Jais ◽  
Javeed Hussain ◽  
Faiza Siddiqua ◽  
A. Gopala Reddy ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Gastric Juice ◽  
Aqueous Extract ◽  
Antiulcer Activity ◽  
Fresh Water Fish ◽  
Ulcer Index ◽  
Standard Drug ◽  
Freeze Dried ◽  
Wide Range ◽  
Channa Striata

Channa striata (Bloch.) is a fresh water fish belonging to the family Channidae. The stripped snakehead fish possesses wide range of medicinal properties. In view of traditional use of C. striata for wound healing, the present study was undertaken to investigate the beneficial effects of orally administered freeze dried aqueous extract of Channa striata (AECS) in experimentally induced gastric ulcers in Wistar rats. Aspirin induced ulcerogenesis in pyloric ligation model was used for the assessment of antiulcer activity and Ranitidine (50 mg/kg) was employed as the standard drug. The various gastric parameters like volume of gastric juice, pH, free and total acidities, ulcer index, and levels of antioxidant enzymes like catalase, superoxide dismutase, and lipid peroxidation marker malondialdehyde were determined. AECS at concentrations of 40% and 50% w/v significantly decreased the volume of gastric juice and increased the levels of catalase while considerable decrease in free and total acidities and increase in superoxide dismutase were observed with the treatment of standard drug and AECS (50% w/v). All the test doses of AECS markedly decreased ulcer index and malondialdehyde compared to the standard drug whereas AECS 30% w/v did not alter volume of gastric juice, pH, free and total acidities, catalase, and superoxide dismutase. From these findings, it can be concluded that AECS is devoid of acid neutralizing effects at lower doses and possesses antisecretory and antiulcer activities and this could be related to its antioxidant mechanism.

DEVELOPMENT OF ANTIULCER HERBOMINERAL FORMULATION ALCECARE

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (02) ◽  
pp. 54-59
Author(s):  
M Prasad ◽  
◽  
R Rajput ◽  
A. Kushwaha ◽  
R. Bharti
Keyword(s):  
Gastric Juice ◽  
Aqueous Extract ◽  
Seed Oil ◽  
Negative Control ◽  
Control Group ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Calculated Quantity

A herbomineral formulation was developed in suspension form by using the herb, mineral and different excipient and named “Alcecare”. The formulation was prepared by mixing calculated quantity of shatavari aqueous extract, fennel seed oil and praval bhasma to make smooth cream and then other excipients added to form a suspension for the evaluation of antiulcer activity in rats using aspirin model. The anti-ulcer activity of herbomineral formulation showed that the minimum ulcer index was observed with pantoprazole (1.98±0.29) which was nearly comparable with herbomineral formulation (2.85±0.47) and showed significant antiulcer activity compared to negative control with reducing the volume of gastric juice (5.99±0.25, 3.57±0.92, 4.22±0.67 of ulcerated control, standard and herbomineral formulation groups respectively). It was observed that developed herbomineral formulation possess significant antiulcer activity compared to control group and obtained results were nearly comparable with standard drug (pantoprazole).

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

scholarly journals ANTIULCER ACTIVITY OF CONTROLLED RELEASE FORMULATION CONTAINING AQUEOUS EXTRACT OF ACACIA CATECHU WILLD ON RODENT MODELS

2018 ◽  
Vol 10 (5) ◽  
pp. 25
Author(s):  
Basant Khare ◽  
Naina Dubey ◽  
Akash Sharma
Keyword(s):  
Controlled Release ◽  
Aqueous Extract ◽  
Maximum Activity ◽  
Antiulcer Activity ◽  
Rodent Models ◽  
Ulcer Index ◽  
Release Formulation ◽  
Acacia Catechu

Objective: To study the Antiulcer activity of aqueous extract of acacia catechu willd on rodent models by controlled release formulation.Methods: Microspheres were prepared by solvent evapoaration method and were evaluated for various parameters like SEM, stability and in vitro relese. And acacia catechu willd loaded microspheres were evaluated for in vivo study involving Gastric ulceration in rats was induced by Ethanol/HCl. Ulcer genic effect (Ulcer Index), pH and Total acidity, Histopathological studies.Results: Results indicated that Acacia catechu willd microspheres contains some active constituents like flavanoid which are responsible for its anti ulcer activity. Also it was observed aqueous extract loaded microspheres showed maximum activity was found (200 mg/kg) with standard Cimetidine (100 mg/kg) also, the results revealed that aqueous extract microspheres at 200 mg/kg had reduced ulcer incidence significantly, when compared to the control as evident by decrease in ulcer score in the model.Conclusion: Based on the result it can be concluded that microspheres loaded with aqueous extracts of Acacia catechu willd produced promising antiulcer activity and were safe.

scholarly journals Peptic Ulcer Healing Activity of Fruit Pulp Extract and Seed Oil of Adansonia digitata Linn

2019 ◽  
Vol 11 (05) ◽  
Author(s):  
Kajal Kamalso Malgave ◽  
Nilofar Shahnwaj Naikwade ◽  
Padma Laxmikant Ladda ◽  
Tabbasum S. Shikalgar ◽  
Sudhir S. Patil
Keyword(s):  
Secondary Metabolites ◽  
Seed Oil ◽  
Enzyme Level ◽  
Histopathological Study ◽  
Antiulcer Activity ◽  
Marker Enzyme ◽  
Fruit Pulp ◽  
Adansonia Digitata ◽  
Ulcer Index ◽  
Standard Drug

Adansonia digitata (AD) Linn has been used to cure PU in Ayurveda but its efficacy has not been validated. The current study was so carried out to evaluate the antiulcer activity of ethanolic extract of Adansonia digitata fruit pulp (ADFP), n hexane extract of Adansonia digitata seed oil (ADSO) and their combination (ADFP+ADSO) in rats. The effect of AD on gastric ulcer in pylorus ligation induced and ethanol induced models was studied using doses [ADFO (500 mg/kg), ADSO (300 mg/kg) and combination of ADFP and ADSO] for 10 days. Omeprazole (10 mg/kg) were used as the standard drug. Depending on the model, outcomes measures were gastric volume, pH, free acidity, total acidity, ulcer index, percentage inhibition of ulcer index, protein, pepsin, mucus, antioxidant marker enzyme level (Superoxide dismutase, Catalase, Lipid peroxidation), morphological and Histopathological study. The result obtained with combination was set up near to the standard drug and consequence showed that the combination of ADFP and ADSO was found to be more effective than the individual extract of AD. The outcomes were statistically evaluated with the one-way ANOVA followed by the test of Dennett’s‘t’. The secondary-metabolites such as flavonoids, proteins, saponins, tannins, phenols, terpenoids, alkaloids and Fatty acids (palmitic acid, oleic acid, linoleic acid) are potent as antioxidant, antiulcer and anti-inflammatory. The finding of this reading confirmed that AD has antiulcer activity due to 1 or more of the secondary-metabolites present in it. Therefore, this study validates its antiulcer use in Ayurveda. Future investigation on separation of specific phytochemicals and elucidate MOA are needed.

scholarly journals Activities of Some Antioxidant Enzymes in Some Tissues of Acetaminophen-Induced Hepatotoxic Albino Rats Treated with Anacardium Occidentale Stem Bark Aqueous Extract

2020 ◽  
Vol 1 (4) ◽  
Author(s):  
Philip O. Amira ◽  
Adebayo S. Daramola ◽  
Mike O. Sanni
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Free Radicals ◽  
Aqueous Extract ◽  
Antioxidant System ◽  
Stem Bark ◽  
The Body ◽  
Anacardium Occidentale ◽  
Albino Rats ◽  
Wide Range

Liver is a vital organ present in vertebrates, which has a wide range of functions including aiding of digestion, detoxification and protein biosynthesis. But the ability of the liver to perform these functions can be compromised by numerous substances it is daily exposed to, including certain medicinal agents which when taken in over doses. Liver damage, just like many other diseased conditions can lead to oxidative stress, especially when the body’s antioxidant system is overwhelmed by the free radicals thus generated. A major component of this antioxidant system are the natural antioxidant enzymes superoxide dismutase and catalase manufactured in the body, which provide an important defense against free radicals usually generated in diseased conditions. Most synthetic anti-hepatotoxicity drugs available present serious side effects and are generally out of reach of the common man. Consequently, the effect of administration of aqueous extract of Anacardium occidentale stem bark on the activities of superoxide dismutase and catalase in some tissues of acetaminophen-induced hepatotoxic rats was investigated. There was a significant (p < 0.05) reduction in the activities of superoxide dismutase and catalase in the serum, liver, kidney and heart of the hepatotoxic rats. However, treatment of hepatotoxic rats with aqueous extract of Anacardium occidentale stem bark led to a significant (p < 0.05) increase in the activities of superoxide dismutase and catalase in the serum, liver, kidney and heart of acetaminophen-induced hepatotoxic rats.

Comparative Evaluation of Antiulcer Activity of Ficus religiosa (Stem Bark) Extracts Prepared by Different Methods of Extraction

2020 ◽  
Vol 6 (4) ◽  
pp. 351-359
Author(s):  
Sunita Panchawat ◽  
Joohee Pradhan
Keyword(s):  
Extraction Method ◽  
Soxhlet Extraction ◽  
Stem Bark ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Ficus Religiosa ◽  
Standard Drug ◽  
Hydroalcoholic Extract ◽  
Acute Toxicity Study ◽  
Assisted Extraction

Background: The stem bark of Ficus religiosa L. (Family-Moraceae) is traditionally used to treat gonorrhea, diarrhea, dysentery, leucorrhea, menorrhagia, vaginal and other urogenical disorders, ulcers and gastrohelcosis. Objective: The study was aimed at comparing antiulcer activity (ethanol induced gastric ulcer) for stem bark extracts of Ficus religiosa Linn. prepared by different extraction methods viz. soxhlet, ultrasonication and microwave assisted extraction. Methods: The powdered drug material was extracted by soxhlet (time 48 hours., temperature 60°C and solvent 60% ethanol), Ultrasonic (90 min., 50°C and acetone as solvent)and Microwave (3 min., 60°C and acetone as solvent) assisted extraction method. The acute toxicity study was carried out in adult female albino rats by “fix dose” method of OECD guideline no. 420 for selection of doses. Antiulcerogenic effect of prepared extracts (200mg/kg) was evaluated by ethanol induced ulcer method using omeprazole (40 mg/kg) as standard drug and absolute alcohol 99.5% as necrotizing agent. Result and Conclusion: Acute toxicity study did not show any significant toxicity signs and extracts were said to be practically non-toxic at tested dose level of 2000 mg/kg, b.w. The best antiulcer activity was shown by the hydroalcoholic extract prepared by soxhlet extraction method. Administration of ethanol produced significant ulcer index (41.00 ± 1.75) in the control group. Standard drug omeprazole (40 mg/kg) produced percentage protection of 70.31%. Among all three extracts, Ulcer index is significantly (p<0.001) protected by hydroalcoholic extract (Soxhlet Extraction Method) with percentage protection 52.02%.

Pharmacological Evaluation of Anti-ulcer Activity of Caesalpinia crista in Rats

2017 ◽  
Vol 10 (4) ◽  
pp. 3772-3779
Author(s):  
Kintu Patel ◽  
Bhagyabhumi Patel ◽  
Alkesh Patel ◽  
Samir Shah
Keyword(s):  
Inflammatory Cells ◽  
Control Group ◽  
Antiulcer Activity ◽  
Standard Group ◽  
Free Acidity ◽  
Rat Stomach ◽  
Ulcer Index ◽  
Standard Drug ◽  
Group Iii ◽  
Group I

In present study, we evaluated the antiulcer activity of the herbal preparation of Caesalpinia crista in rat models.  Experimental animals were divided into four groups. Rats of group I (disease control) treated with normal saline only, group II (standard group) treated with Omeprazole (2 mg/ kg; p.o.), group III and IV served as test groups and were treated with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. Peptic ulcer was induced by ligating the pyloric portion of rat stomach and was done 45 min after the respective treatment. After 4 hour of pylorus ligation, rats were sacrificed. Parameters like ulcer index, percent ulcer protection, total and free acidity were estimated for evaluation of anti-ulcer activity. Histopathological evaluation was also performed. The aqueous extract of Caesalpinia crista seeds reduced the volume of gastric juice, free acidity, total acidity and ulcer index. It increased the pH of the gastric acid. Histopathology of the rat stomach revealed the presence of lesions and infiltration of inflammatory cells in control group. Moreover, animals treated with test drug and standard drug did not reveal any microscopic lesions. These findings suggest that Caesalpinia crista seeds may have anti-secretory and anti-ulcer activity and may be helpful for ulcer therapy. 

scholarly journals Anti-ulcer activity of Cestrum nocturnum leaf in ethanol- and indomethacin-induced ulcer models

2017 ◽  
Vol 12 (3) ◽  
pp. 335
Author(s):  
Uzma Saleem ◽  
Ejaz Ul Haq ◽  
Bashir Ahmad ◽  
Mohammad Saleem
Keyword(s):  
Gastric Juice ◽  
Video Clip ◽  
Gastric Ph ◽  
Control Group ◽  
Antiulcer Activity ◽  
Standard Drug ◽  
Treatment Groups ◽  
Full Screen ◽  
Hexane Extracts ◽  
Dose Dependent Increase

<p class="Abstract">This study was planned to explore the antiulcer activity of the methanolic and <em>n</em>-hexane extracts of <em>Cestrum nocturnum</em> leaf against ethanol- and indomethacin-induced ulcer models in rats. The rats were administered orally vehicle in normal control group, methanolic and <em>n</em>-hexane extracts at doses 300, 500, 700 mg/kg, in treated groups and omeprazole 20 mg/kg, as standard drug. The gastric tissues/contents were examined to determine the ulcer index, antiulcer activity, gastric pH, gastric juice volume and acidity. Both extracts showed dose-dependent increase in antiulcer activity (%) in both ulcer models. Histopathology also supported these results. Gastric pH significantly increased while the gastric juice and acidity significantly decreased in the treatment groups of both ulcer models indicating the anti-secretory effect of extracts. It may be concluded that <em>C. nocturnum</em> protect gastric mucosa by decreasing gastric juice, acidity and increasing the gastric pH.</p><p><strong>Video Clip of Methodology</strong>:</p><p>6 min 58 sec:   <a href="https://www.youtube.com/v/q1ZJszfNJTc">Full Screen</a>   <a href="https://www.youtube.com/watch?v=q1ZJszfNJTc">Alternate</a></p>

scholarly journals Gastro-protective effects of methanol extract of Tephrosia calophylla

2018 ◽  
Vol 8 (6-s) ◽  
pp. 141-145
Author(s):  
C Ramesh ◽  
A. Prameela Rani
Keyword(s):  
Protected Area ◽  
Methanol Extract ◽  
Research Work ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Protective Effects ◽  
Ulcer Index ◽  
Standard Drug ◽  
Soxhlet Apparatus

Objective: The present research work was designed to investigate gastro protective potentials of methanol extract of Tephrosia calophylla. Methods: The aerial parts of Tephrosia calophylla were dried under shade, powdered and deffated with petroleum ether and then marc left over was subjected to methanol extraction using soxhlet apparatus. Antiulcer activity of methanol extract was determined against stress induced and aspirin induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. Results: Methanol extract of Tephrosia calophylla have significantly reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compare to vehicle control and there by significantly increased percentage inhibition of ulcers and protected area which was evident by significant rise in pH of gastric content. The effect of extracts was dose dependent and results were comparable to that of standard drug omeprazole. Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia calophylla possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats. Keywords: Tephrosia calophylla, Anti ulcer activity, Ethanol, Aspirin Ulcer index, pH, total acidity, Percentage inhibition and percentage of protected area.

scholarly journals Prostaglandin Analogous and Antioxidant Activity Mediated Gastroprotective Action ofTabernaemontana divaricata(L.) R. Br. Flower Methanolic Extract against Chemically Induced Gastric Ulcers in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Mohammed Safwan Ali Khan ◽  
Abdul Manan Mat Jais ◽  
Adiba Afreen
Keyword(s):  
Superoxide Dismutase ◽  
Total Protein ◽  
Methanolic Extract ◽  
Histopathological Examination ◽  
Basic Mechanism ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Mass Spectral ◽  
Antioxidant Mechanism

The present study was conducted to evaluate the antiulcerogenic effect and recognize the basic mechanism of action ofTabernaemontana divaricata(L.) R. Br. flowers.T. divaricataflower methanolic extract (TDFME) was screened for antiulcer activity versus aspirin and ethanol induced gastric ulcers at three doses—125, 250, and 500 mg/kg—orally using misoprostol as a standard. Besides histopathological examination, seven parameters, that is, ulcer index, total protein, nonprotein sulphhydryls, mucin, catalase, malondialdehyde, and superoxide dismutase levels, were estimated. In addition to HPLC profiling, GC-MS analysis and electrospray ionization—high resolution mass spectral (ESI-HRMS) analysis of crude TDFME were carried out in an attempt to identify known phytochemicals present in the extract on the basis ofm/zvalue. The results revealed a significant increase in the levels of catalase, superoxide dismutase, mucin, and nonprotein sulphhydryls, while they revealed a reduction in ulcer index, the levels of total protein, and malondialdehyde. Histopathological observations also demonstrated the protective effect. Though all the doses of TDFME exhibited gastroprotective function, higher doses were found to be more effective. Mass spectral analysis gave a few characteristicm/zvalues suggesting the presence of a few known indole alkaloids, while HPLC profiling highlighted the complexity of the extract. TDFME was found to exhibit its gastroprotective effect through antioxidant mechanism and by enhancing the production of gastric mucous.

Sign in / Sign up

Export Citation Format

Share Document