scholarly journals Comparative Hair Restorer Efficacy of Medicinal Herb on Nude (Foxn1nu) Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Shahnaz Begum ◽  
Mi Ra Lee ◽  
Li Juan Gu ◽  
Md. Jamil Hossain ◽  
Hyun Kyoung Kim ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Nude Mice ◽  
Hair Loss ◽  
Hair Growth ◽  
Growth Promotion ◽  
Hair Follicles ◽  
Growth Potential ◽  
Eclipta Alba ◽  
Growth Area ◽  
Brdu Labeling

Eclipta alba(L.) Hassk,Asiasarum sieboldii(Miq.) F. Maek (Asiasari radix), andPanax ginsengC. A. Mey (red ginseng) are traditionally acclaimed for therapeutic properties of various human ailments. Synergistic effect of each standardized plant extract was investigated for hair growth potential on nude mice, as these mutant mice genetically lack hair due to abnormal keratinization. Dried plant samples were ground and extracted by methanol. Topical application was performed on the back of nude mice daily up to completion of two hair growth generations. The hair density and length ofEclipta albatreated mice were increased significantlyP>0.001than control mice. Hair growth area was also distinctly visible inEclipta albatreated mice. On the other hand,Asiasari radixandPanax ginsengtreated mice developing hair loss were recognized from the abortive boundaries of hair coverage. Histomorphometric observation of nude mice skin samples revealed an increase in number of hair follicles (HFs). The presence of follicular keratinocytes was confirmed by BrdU labeling, S-phase cells in HFs. Therefore,Eclipta albaextract and/or phytochemicals strongly displayed incomparability of hair growth promotion activity than others. Thus, the standardizedEclipta albaextract can be used as an effective, alternative, and complementary treatment against hair loss.

scholarly journals Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1808 ◽  
Author(s):  
Gennaro Riccio ◽  
Eduardo Sommella ◽  
Nadia Badolati ◽  
Emanuela Salviati ◽  
Sara Bottone ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hair Loss ◽  
Hair Growth ◽  
Treatment Options ◽  
Pentose Phosphate ◽  
Hair Follicles ◽  
Common Side Effect ◽  
Safe Alternative ◽  
Polyphenolic Extract

Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Synthetic drugs protecting from CIA and endowed with hair growth stimulatory properties are prescribed with caution by oncologists. Hormones, growth factors, morphogens could unwontedly protect tumour cells or induce cancer cell proliferation and are thus considered incompatible with many chemotherapy regimens. Nutraceuticals, on the contrary, have been shown to be safe and effective treatment options for hair loss. We here show that polyphenols from Malus Pumila Miller cv Annurca are endowed with hair growth promoting activity and can be considered a safe alternative to avoid CIA. In vitro, Annurca Apple Polyphenolic Extract (AAE) protects murine Hair Follicles (HF) from taxanes induced dystrophy. Moreover, in virtue of its mechanism of action, AAE is herein proven to be compatible with chemotherapy regimens. AAE forces HFs to produce ATP using mitochondrial β-oxidation, reducing Pentose Phosphate Pathway (PPP) rate and nucleotides production. As consequence, DNA replication and mitosis are not stimulated, while a pool of free amino acids usually involved in catabolic reactions are spared for keratin production. Moreover, measuring the effect exerted on Poly Unsaturated Fatty Acid (PUFA) metabolism, we prove that AAE promotes hair-growth by increasing the intracellular levels of Prostaglandins F2α (PGF2α) and by hijacking PUFA catabolites toward β-oxidation.

scholarly journals Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

2021 ◽  
Vol 12 ◽  
Author(s):  
Jawaria Iltaf ◽  
Sobia Noreen ◽  
Muhammad Fayyaz ur Rehman ◽  
Shazia Akram Ghumman ◽  
Fozia Batool ◽  
...  
Keyword(s):  
In Silico ◽  
Hair Growth ◽  
De Novo ◽  
Growth Promotion ◽  
Hair Follicles ◽  
Binding Energies ◽  
Ficus Benghalensis ◽  
Rp Hplc

The screening of hair follicles, dermal papilla cells, and keratinocytes through in vitro, in vivo, and histology has previously been reported to combat alopecia. Ficus benghalensis has been used conventionally to cure skin and hair disorders, although its effect on 5α-reductase II is still unknown. Currently, we aim to analyze the phytotherapeutic impact of F. benghalensis leaf extracts (FBLEs) for promoting hair growth in rabbits along with in vitro inhibition of the steroid isozyme 5α-reductase II. The inhibition of 5α-reductase II by FBLEs was assessed by RP-HPLC, using the NADPH cofactor as the reaction initiator and Minoxin (5%) as a positive control. In silico studies were performed using AutoDock Vina to visualize the interaction between 5α-reductase II and the reported phytoconstituents present in FBLEs. Hair growth in female albino rabbits was investigated by applying an oral dose of the FBLE formulation and control drug to the skin once a day. The skin tissues were examined by histology to see hair follicles. Further, FAAS, FTIR, and antioxidants were performed to check the trace elements and secondary metabolites in the FBLEs. The results of RP-HPLC and the binding energies showed that FBLEs reduced the catalytic activity of 5α-reductase II and improved cell proliferation in rabbits. The statistical analysis (p < 0.05 or 0.01) and percentage inhibition (>70%) suggested that hydroalcoholic FBLE has more potential in increasing hair growth by elongating hair follicle’s anagen phase. FAAS, FTIR, and antioxidant experiments revealed sufficient concentrations of Zn, Cu, K, and Fe, together with the presence of polyphenols and scavenging activity in FBLE. Overall, we found that FBLEs are potent in stimulating hair follicle maturation by reducing the 5α-reductase II action, so they may serve as a principal choice in de novo drug designing to treat hair loss.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

scholarly journals Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-clinical Study Using Phototrichogram Analysis

Cosmetics ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 66
Author(s):  
Hyoung Chul Choi ◽  
Gae Won Nam ◽  
Noh Hee Jeong ◽  
Bu Young Choi
Keyword(s):  
Clinical Study ◽  
Hair Loss ◽  
Hair Growth ◽  
Blood Circulation ◽  
Growth Promotion ◽  
Test Group ◽  
Androgenetic Alopecia ◽  
Hair Density ◽  
Caesalpinia Sappan ◽  
Inula Helenium

Inula helenium (IH) is known to possess antifungal, anti-bacterial, anti-helminthic, and anti-proliferation activities. Caesalpinia Sappan (CS) is known to reduce inflammation and improve blood circulation. Based on their folkloric use, these plants are expected to be promising candidates for promoting hair growth and preventing hair loss. Moreover, these plants are rich sources of certain phytochemicals, which have been reported to promote hair growth. In this clinical trial, we investigate the efficacy of a scalp shampoo formulated by mixing extracts of IH and CS in preventing hair loss and promoting hair growth in patients with androgenetic alopecia. Using a phototrichogram (Folliscope 2.8, LeadM, Korea), we compared the hair density and total hair counts in patients receiving the scalp shampoo at baseline, and at 8, 16, and 24 weeks after use of the shampoo. We found a statistically significant increase in the total hair count in the test group (n = 23) after 16 and 24 weeks of using the scalp shampoo (2.17 n/cm2 ± 5.72, p < 0.05; and 4.30 n/cm2 ± 6.37, p < 0.01, respectively) as compared to the control subjects. Based on the results of this clinical study, we conclude that the IH and CS extract complex is a promising remedy for preventing hair loss and promoting hair growth.

scholarly journals Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 42170-42178 ◽  
Author(s):  
Yan Zhang ◽  
Jie-wen Wang ◽  
Fan-zhi Qu ◽  
Yu-meng Zhang ◽  
Guang-yue Su ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Hair Loss ◽  
Hair Growth ◽  
Growth Promotion ◽  
Promotion Effect

Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss.

scholarly journals Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

2018 ◽  
Vol 19 (9) ◽  
pp. 2703 ◽  
Author(s):  
Bu Choi
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Social Impact ◽  
Molecular Mechanisms ◽  
Growth Potential ◽  
Environmental Toxicants ◽  
Androgenic Alopecia ◽  
Three Stages ◽  
Growth Promoting ◽  
Underlying Mechanisms

The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.

HOW WIGS AND WOMEN’S BEAUTY SUPPLY PRODUCTS MOVE THROUGHOUT THE SUPPLY CHAIN

2018 ◽  
Vol 3 (10) ◽  
Author(s):  
Alexa Green ◽  
Felicia Jefferson
Keyword(s):  
Supply Chain ◽  
Epithelial Cells ◽  
Literature Review ◽  
Hair Loss ◽  
Outer Layer ◽  
Hair Growth ◽  
Review Paper ◽  
Hair Follicles ◽  
Key Factors ◽  
Sebaceous Glands

Everyone wants shine, softness, and hair strength, all key factors in having healthy hair. The purpose of this literature review is to provide information about healthy hair growth. Research states that the hair grows from follicles within the skin. Hair follicles are sacs where hair grows and where the sebaceous glands open. The follicles lined by cells derived from the epidermal. Keratin protects epithelial cells from damage and it makes up the outer layer of human skin. Even though there are many ways you can grow your hair, there are many ways you can lose your hair as well. This review paper also explains disorders that can cause hair loss.

scholarly journals Formulation and Evaluation of Herbal Hair Gel Containing Fenugreek Seed Extract for Nourishment and Hair Growth

2019 ◽  
pp. 92-103
Author(s):  
Suryawanshi Nishant C ◽  
Vijayendra Swamy S. M. ◽  
Nagoba Shivappa N. ◽  
Wanje Vaijanti V.
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Estrogen Therapy ◽  
Hair Follicles ◽  
Hormone Deficiency ◽  
Gelling Agent ◽  
Nutritional Deficiencies ◽  
Topical Formulation ◽  
Fenugreek Seed

The present study now a days many people face the major problem related to hair i.e. hair loss. There are many causes of hair loss physiological conditions, emotional or physical stress, nutritional deficiencies, hormonal disorders one of the due to hormone deficiency of estrogen. External administration of the estrogen could changes the hormonal cycle and increase cancer risk some natural alternative estrogen therapy can be found in the various plants containing natural products those having weak estrogen activity like Phyto-estrogen. Herbal drug has less side effects and more effective as comparative to synthetic drug. Phytoestrogen are competing with the estrogen by the binding to the estrogen receptor and produce estrogen effect, Phytoestrogen in the fenugreek seed. Family – Fabaceae Ethanolic extract of (Trigonella foenum-graecum) fenugreek seed prepared for the topical formulation of herbal hair gel formulation by using Carbopol 934 gelling agent, glycerin, pvp, methyl paraben, PEG, Triethanolamine Fenugreek was evaluated for its potency on hair growth activity by in vivo method. In vivo, study 2.5mg of fenugreek extract is used. That is applied on the shaved skin of mice to determine the length of hair and the different cyclic phase of hair follicles like anagen and s phases were will be grow after some time periods. From the study topical use of gel formulation were apply for 30 days .There are use of fenugreek extract containing gel formulation over the shaved skin of mice that shows the significant result by increase the hair growth. The prepared gel was characterized for their physicochemical constants, preliminary phyto-chemical analysis, quantitative analysis, Spread-ability, pH, viscosity, and stability study.

scholarly journals Role of Non Androgenic Factors in Hair loss and Hair Regrowth

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Nutritive Value ◽  
Transforming Growth Factor ◽  
Hair Follicles ◽  
The Body ◽  
Immune Recognition ◽  
Micronutrient Deficiencies ◽  
Poor Growth

Multiple nutritional, environmental and lifestyle factors can directly affect hair follicles, to weaken and make them sensitive to the action of androgens. Hair loss can be corrected and hair growth can be improved by addressing these non-androgenic factors. Patients having hair fall, thinning, loss of volume and poor growth can be precursors to androgenetic alopecia. Recent research has shown that androgens inhibit hair growth through release of Transforming Growth Factor (TGF) ß1. Further study of this mechanism reveals that generation of Reactive Oxygen Species (ROS) induced by androgens leads to release of TGF ß1 and use of ROS scavengers can block the release of TGF ß1, explaining beneficial role of antioxidants in hair growth. The binding of ROS to intracellular proteins also causes hair loss by altering the protein structure, changing their immune recognition and converting them to new antigens targeted by inflammatory and immune systems. Calorie restriction and individual micronutrient deficiencies lead to a new process of intracellular destruction or autophagy before cell apoptosis, which could explain cessation of hair growth. Telogen is not a resting phase but now defined as active conservation of follicles under unfavourable conditions. Thus any stress, trauma, metabolic change or insult causes telogen. Micronutrients zinc, copper, selenium maintains immunity, control inflammation and preserve antioxidant activity of the cells. Vitamins A, C, D have a role in phagocytosis and antibodies maintaining resistance. Vitamin D3 modulates the hair-inductive capacity of dermal papilla cells. Vitamin and micronutrient deficiencies are prevalent among all the population of the world. Nutritive value of the foods has reduced over the years by 30%. Endocrine Disrupting chemicals are creating further damage to the hormonal balance of the body. All these can be countered by use of antioxidants and a well-planned nutritional program which will ensure strengthening and regrowth of hair follicles, without the use of Finasteride.

scholarly journals Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Jan Wadstein ◽  
Erling Thom ◽  
Aida Gadzhigoroeva
Keyword(s):  
Replacement Therapy ◽  
Hair Loss ◽  
Hair Growth ◽  
Relative Concentration ◽  
Follicular Phase ◽  
Hair Follicles ◽  
Growth Disorders ◽  
Female Pattern Hair Loss ◽  
Functional Involvement ◽  
Pathogenetic Factor

Follicular proteoglycans are key players with structural, functional, and regulatory roles in the growth and cycling behaviour of the hair follicles. The expression pattern of specific proteoglycans is strongly correlated with follicular phase transitions, which further affirms their functional involvement. Research shows that bioactive proteoglycans, e.g., versican and decorin, can actively trigger follicular phase shift by their anagen-inducing, anagen-maintaining, and immunoregulatory properties. This emerging insight has led to the recognition of “dysregulated proteoglycan metabolism” as a plausible causal or mediating pathology in hair growth disorders in both men and women. In support of this, declined expression of proteoglycans has been reported in cases of anagen shortening and follicular miniaturisation. To facilitate scientific communication, we propose designating this pathology “follicular hypoglycania (FHG),” which results from an impaired ability of follicular cells to replenish and maintain a minimum relative concentration of key proteoglycans during anagen. Lasting FHG may advance to structural decay, called proteoglycan follicular atrophy (PFA). This process is suggested to be an integral pathogenetic factor in pattern hair loss (PHL) and telogen effluvium (TE). To address FHG and PFA, a proteoglycan replacement therapy (PRT) program using oral administration of a marine-derived extract (Nourkrin® with Marilex®, produced by Pharma Medico Aps, Aarhus, Denmark) containing specific proteoglycans has been developed. In clinical studies, this treatment significantly reduced hair fall, promoted hair growth, and improved quality of life in patients with male- and female-pattern hair loss. Accordingly, PRT (using Nourkrin® with Marilex®) can be recommended as an add-on treatment or monotherapy in patients with PHL and TE.

Sign in / Sign up

Export Citation Format

Share Document