scholarly journals Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Natascia Brondino ◽  
Simona Re ◽  
Annalisa Boldrini ◽  
Antonella Cuccomarino ◽  
Niccolò Lanati ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Therapeutic Agent ◽  
Short Term ◽  
Dementia Patients ◽  
Indian Medicine ◽  
Present Systematic Review ◽  
Potential Use

Dementia is a leading health problem worldwide, with Alzheimer’s disease (AD) representing up to 60% of all dementia cases. A growing interest has recently risen on the potential use of natural molecules in this condition. Curcumin is a polyphenolic compound traditionally used in Indian medicine. Severalin vitroandin vivostudies have found a protective effect of curcumin in AD. In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. To date there is insufficient evidence to suggest the use of curcumin in dementia patients. Of note, short-term use of curcumin appears to be safe. Several reasons could be responsible for the discrepancy betweenin vitroandin vivofindings and human trials, such as low bioavailability and poor study design.

scholarly journals Anticancer Effects of Disulfiram: A Systematic Review of in Vitro, Animal, and Human Studies

2021 ◽  
Author(s):  
ling wang ◽  
yang yu ◽  
cong zhou ◽  
run wan ◽  
Yumin Li
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Animal Models ◽  
Human Studies ◽  
Cochrane Library ◽  
Future Research ◽  
Tumor Inhibition ◽  
Anti Tumor Activity

Abstract Background and objectives: Cancer morbidity and mortality rates remain high, and thus, at present, considerable efforts are focused on finding drugs with higher sensitivity against tumor cells and fewer side effects. Several preclinical and clinical studies have examined the potential of repurposing disulfiram (DSF) as an anticancer treatment. This systematic review aimed to assess evidence regarding the antineoplastic activity of DSF in in vitro and in vivo models, as well as in humans.Methods: Two authors independently conducted this systematic review of English and Chinese articles from the PubMed, Embase, and the Cochrane Library databases up to July 2019. Eligible in vitro studies needed to include assessments of the apoptosis rate by flow cytometry using annexin V/propidium iodide, and studies in animal models and clinical trials needed to examine tumor inhibition rates, and progression-free survival (PFS) and overall survival (OS), respectively. Data were analyzed using descriptive statistics.Results: Overall, 35 studies, i.e., 21 performed in vitro, 11 based on animal models, and three clinical trials, were finally included. In vitro and animal studies indicated that DSF was associated with enhanced apoptosis and tumor inhibition rates. Human studies showed that DSF prolongs PFS and OS. The greatest anti-tumor activity was observed when DSF was used as combination therapy or as a nanoparticle-encapsulated molecule.Conclusions: This systematic review provides evidence regarding the anti-tumor activity of DSF in vitro, in animals, and in humans and indicates the optimal forms of treatment to be evaluated in future research.

The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Firoozeh Alavian ◽  
Sorayya Ghasemi
Keyword(s):  
Systematic Review ◽  
Gene Therapy ◽  
Data Extraction ◽  
Gene Therapies ◽  
Gene Therapy Approach ◽  
Therapy Studies ◽  
Present Systematic Review

Background: Glioblastoma multiforme (GBM) is the most common and fatal type of glioma. Nanoparticles (NPs) are using new approaches for the delivery of gene therapy in the treatment of GBM. Introduction: This article was designed to review the efficacy of NPs as the targeted carriers in the gene therapy aimed at apoptosis in GBM. Method: The appropriate keywords such as nanoparticle, glioblastoma, gene therapy, apoptosis, and the related words were used to search from PubMed, ISI Web of Science, and Scopus for relevant publications up to September 4, 2020, with no language restrictions. The present systematic review was performed based on PRISMA protocol and reviewed the articles evaluating the effects of nanoparticles, carriers of various gene therapies essentials, on GBM cells apoptosis in vitro and in vivo. The selected articles were considered using specific scores on the quality of the articles. Data extraction and quality valuation were performed by two reviewers. Result: Of 101 articles retrieved, forty-two met the inclusion criteria and were, therefore, subjected to the final deduction. The most widely used NP in GBM gene therapy studies is polyamidoamine (PAMAM). The most common gene therapy approach for apoptosis in GBM is using siRNAs. Conclusions: In conclusion, these studies validated that NPs could be a practical choices to enhance the efficiency and specific delivery in gene therapies for GBM cell apoptosis. However, the choice of NP type and gene therapy mechanism affect the GBM cell apoptotic efficiency.

scholarly journals Convolvulus pluricaulis as a Cognition Booster: Relevance to Alzheimer’s Disease

2016 ◽  
Vol 8 (02) ◽  
Author(s):  
Syed Bihaqi ◽  
Suhaib Rashaan ◽  
Manisha Tiwari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Agent ◽  
In Vivo Models ◽  
Mental Stimulation ◽  
Herbal Medicinal ◽  
Convolvulus Pluricaulis ◽  
Indian Medicine

The herbal medicinal plant, Convolvulus pluricaulis: a rasayana drug has been primarily advocated for use in mental stimulation and rejuvenation therapy. In ancient systems of Indian medicine, Ayurveda, the plant is also known by the name Shankhpushpi and has been shown to act as a prominent memory improving drug, a psychostimulant and tranquiliser. The plant displays its biological activity due to the presence of several alkaloids, flavanoids and coumarins as active chemicals. Previous reports by us and others have demonstrated beneficial effect of extracts of this plant in an in-vitro and in-vivo models of Alzheimer’s disease (AD). Justification of its potential for an ancient brain tonic has been provided recently by clinical studies on polyherbal formulation of this plant. This review attempts to compile information on Convolvulus Pluricaulis in order to establish this herbal drug as a potent natural therapeutic agent to combat AD related symptoms.

scholarly journals The mutagenicity and carcinogenicity of pesticides and hazards for human health: A systematic review

2019 ◽  
Vol 61 (2) ◽  
pp. 96-102 ◽  
Author(s):  
Nataliya A. Ilyushina ◽  
O. V. Egorova ◽  
G. V. Masal’Tsev ◽  
N. S. Averyanova ◽  
Yu. A. Revazova
Keyword(s):  
Systematic Review ◽  
Short Term ◽  
Rural Regions ◽  
Carcinogenic Activity ◽  
Concise Review ◽  
Epidemiological Surveys ◽  
Synergy Effects ◽  
Oncological Diseases

The article presents concise review of data obtained during last years at studying mutagenic and carcinogenic activity of pesticides in test-systems in vitro and in vivo Also, are covered the results of epidemiological surveys carried out in Russia and abroad related to discovery of association of effect of pesticides and development of oncological diseases in workers involved into agricultural manufacturing and in population of rural regions. The publications search was implemented using databases of Scopus, Medline, Google Scholar, RINTC. The issues are discussed concerning evaluation of mutagenic characteristics of effecting substances and preparative forms ofpesticides, application of short-term tests for evaluating carcinogenicity, possible synergy effects in case of combination of two and more effecting substances of various pesticide preparations.

Iranian herbal medicines against hydatid cyst protoscoleces: A Systematic Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Iraj Salimikia ◽  
Marzieh Hakami ◽  
Mohammad Kazem Shahmoradi
Keyword(s):  
Systematic Review ◽  
Hydatid Cyst ◽  
Web Of Science ◽  
Human Subjects ◽  
Herbal Medicines ◽  
Methanolic Extracts ◽  
Oil Plant ◽  
Present Systematic Review

Background: In recent years, more attention has been focused in the practice of both crude extract of medicinal plants, and the screening plant-derived compounds as substitute scolicidal agents during hydatid cyst surgery. The present study was designed to review the protoscolicidal effects of some Iranian herbal medicines against hydatid cyst protoscoleces. Methods: English databases, including PubMed, Google Scholar, Web of Science, EBSCO, Science Direct, and Scopus were searched for publications worldwide related to protoscolicidal effects of Iranian herbal medicines without date limitation so that identify all published articles (in vitro, in vivo, clinical and case-control) have studied. Keywords included “Protoscolicidal”, “Scolicidal”, “Herbal medicines”, “Extract”, “Essential oil”, “Plant”, “In vitro”, and “Iran”. Moreover, the language of data collection was limited to English. Results: In total, 40 papers up to 2020 were included in the present systematic review. The most studies were conducted on protoscolicidal activity of methanolic extracts (17 studies) followed by essential oils (15 studies), and aqueous extract (3 studies). The most commonly used part of herbs were leaves (21 herbs), seeds (8 herbs), and fruit (6 herbs), respectively. Moreover, the most prevalent herbal family was Lamiaceae (6 studies), followed by Apiaceae (5 studies) and Liliaceae (5 studies). Conclusion: Considering the high efficacy of Iranian herbal medicines against hydatid cyst protoscoleces, it can be concluded that Iranian herbal medicines have ability to consider as new alternative protoscolicidal agents during hydatid cyst surgery; however, more clinical studies are required to discover the precise protoscolicida activity of Iranian medicines in animal and human subjects.

scholarly journals Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

Biomedicines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 3 ◽  
Author(s):  
Abu Bakar ◽  
Pin-Chuan Yao ◽  
Valendriyani Ningrum ◽  
Cheng-Tzu Liu ◽  
Shih-Chieh Lee
Keyword(s):  
Systematic Review ◽  
Oral Mucositis ◽  
Wound Repair ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
In Vivo Studies ◽  
Potential Use ◽  
Anti Inflammation

The aim of this review was to provide an updated overview of studies on the medical-biological activities of Cinnamomum osmophloeum (C. osmophloeum) in vitro and in vivo and the potential therapeutic use of natural agents prepared from this plant for the alleviation of oral mucositis (OM). Reported articles were collected using web search engine tools. The systematic review was organized according to the preferred reporting items for reviews and meta-analyses (PRISMA) statement. Additional sources were identified through cross-referencing to identify the potential use of C. osmophloeum in the alleviation of OM. The results disclosed that C. osmophloeum is comprised of bioactive ingredients that could act diversely as a reagent in anti-inflammation, antibacterial, antioxidant, anti-hyperglycemic, antidyslipidemia, anti-cancer, renal disease therapy and anti-hyperuricemia capacities. Recent studies revealed that the overall effects on anti-inflammation, wound repair, and the antibacterial and antioxidant activities of its constituents would act as a potential remedy for oral mucositis. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation.

scholarly journals The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3283 ◽  
Author(s):  
Franziska Pohl ◽  
Paul Kong Thoo Lin
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Neurodegenerative Diseases ◽  
Neurological Disorders ◽  
Natural Antioxidants ◽  
Natural Extracts ◽  
The Impact ◽  
Potential Use

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase over the next decades due to increasing life expectancies. No cure is currently available for the treatment of these conditions; only drugs, which merely alleviate the symptoms. Oxidative stress has long been associated with neurodegeneration, whether as a cause or as part of the downstream results caused by other factors. Thus, the use of antioxidants to counter cellular oxidative stress within the nervous system has been suggested as a potential treatment option for neurological disorders. Over the last decade, significant research has focused on the potential use of natural antioxidants to target oxidative stress. However, clinical trial results have lacked success for the treatment of patients with neurological disorders. The knowledge that natural extracts show other positive molecular activities in addition to antioxidant activity, however, has led to further research of natural extracts for their potential use as prevention or treatment/management of neurodegenerative diseases. This review will cover several in vitro and in vivo research studies, as well as clinical trials, and highlight the potential of natural antioxidants.

scholarly journals Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 360 ◽  
Author(s):  
Vivek Kaushik ◽  
Juan Yakisich ◽  
Anil Kumar ◽  
Neelam Azad ◽  
Anand Iyer
Keyword(s):  
Clinical Trials ◽  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Targeted Drug Delivery ◽  
Ion Homeostasis ◽  
Anticancer Activities ◽  
In Vivo Models ◽  
Potential Use

Ion homeostasis is extremely important for the survival of both normal as well as neoplastic cells. The altered ion homeostasis found in cancer cells prompted the investigation of several ionophores as potential anticancer agents. Few ionophores, such as Salinomycin, Nigericin and Obatoclax, have demonstrated potent anticancer activities against cancer stem-like cells that are considered highly resistant to chemotherapy and responsible for tumor relapse. The preclinical success of these compounds in in vitro and in vivo models have not been translated into clinical trials. At present, phase I/II clinical trials demonstrated limited benefit of Obatoclax alone or in combination with other anticancer drugs. However, future development in targeted drug delivery may be useful to improve the efficacy of these compounds. Alternatively, these compounds may be used as leading molecules for the development of less toxic derivatives.

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