scholarly journals Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Xiuhui Li ◽  
Xi Zhang ◽  
Jianbo Ding ◽  
Yi Xu ◽  
Dan Wei ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Herbal Medicines ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Combination Group ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Significant Difference ◽  
Foot And Mouth ◽  
Reduning Injection

Background.This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional Chinese medicine (TCM) granule, in patients with severe hand, foot, and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial.Methods.355 severe HFMD patients were randomly assigned to receive conventional therapy alone, Reduning injection plus conventional therapy, or TCM enema plus conventional therapy for 7–10 days.Results.There was no significant difference in the incidence of major complications between the groups. Median time to fever clearance was 20 hours (95% CI: 6.0–25.0) for conventional therapy recipients, 18 hours (95% CI: 4.0–24.0) for Reduning combination-treated patients, and 6 hours (95% CI: 4.0–16.0) for TCM combination-treated patients. Only the difference in time to fever clearance between TCM combination group and conventional group reached statistical significance (P=0.048). Reduning combination group showed a significant reduction in sedative administration compared with conventional therapy group (P=0.008). No HFMD-related death and no important adverse events were observed.Conclusions.Reduning injection plus conventional therapy significantly reduced the concomitant use of sedatives, which may help decrease HFMD-related neurologic complications in children. TCM effectively reduced time to fever clearance and may become a complementary therapy for relieving the symptoms of severe HFMD.

scholarly journals Occurrence of vaccine abscesses in bovines after the administration of bivalent foot-and-mouth disease vaccine

2020 ◽  
Vol 21 ◽  
Author(s):  
Willy Kelvin CANDEIRA ◽  
Luciano Santos da FONSECA ◽  
Roberto Carlos Negreiros de ARRUDA ◽  
Layza Michelle de Azevedo FREITAS ◽  
Hilmanara Tavares da SILVA ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccine Formulation ◽  
Post Mortem ◽  
Subcutaneous Route ◽  
Significant Difference ◽  
Foot And Mouth ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT The aim of the present study is to identify the occurrence of abscesses in cattle after the administration of bivalent foot-and-mouth disease vaccine as adverse reaction to components in the new commercial vaccine formulation. Thirty bovines were divided into three groups composed of 10 animals, each. Groups 1 and 2 were vaccinated by researchers based on good vaccination practices criteria. Group 1 was intramuscularly administered with the vaccine, Group 2 received it through subcutaneous route and Group 3 was vaccinated by breeders through subcutaneous route. Animals were selected and observed in vivo in three different moments (7, 28 and 45 days after vaccination). Subsequently, they were observed during post mortem inspection in order to assess the occurrence of vaccine abscesses. Vaccine abscesses were recorded in 40% of bovines in Group 1, in 50% of the ones in Group 2 and in 60% of those in Group 3. There was no significant difference between experimental groups based on the Chi-square test and on Cramer's V analysis; there was no significant difference among experimental groups. Excess of carcass parts presenting vaccine abscesses during post mortem inspection resulted in the meat loss of 1.775 kg in Group 1, of 2.303 kg in Group 2 and of 3.268 kg in Group 3. In conclusion, despite changes in bivalent foot-and-mouth disease vaccine formulation, care should be taken at vaccination time to minimize the occurrence of vaccine abscesses and, consequently, meat losses at slaughter, as well as to reduce losses in beef production chain.

scholarly journals Effect of heat-clearing and detoxifying Chinese medicines combined with conventional therapy on mild hand, foot, and mouth disease with fever

Medicine ◽  
2020 ◽  
Vol 99 (23) ◽  
pp. e20473
Author(s):  
Shiyan Yan ◽  
Ying Lu ◽  
Guoliang Zhang ◽  
Xiuhui Li ◽  
Zhong Wang ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Chinese Medicines ◽  
Foot And Mouth

scholarly journals A meta-analysis and experiment assessing phage-based FMDV vaccine

2020 ◽  
Author(s):  
Peng Wu ◽  
Ningning Yang ◽  
Yueli Wang ◽  
Mingguo Xu ◽  
Yunfeng Zhang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Foot And Mouth Disease ◽  
Fixed Effect Model ◽  
Mouth Disease ◽  
Control Group ◽  
Phage Group ◽  
Mouth Disease Virus ◽  
Significant Difference ◽  
Foot And Mouth ◽  
And Control

AbstractFoot-and-mouth disease (FMD) is a pathological disease caused by the foot- and-mouth disease virus (FMDV), which mainly affects cloven-hoofed animals. This study was conducted to a meta-analysis and experiment on the effect of bacteriophages used in the development of FMDV vaccines. A systematic search was conducted for the collection of the protection effect for the phage-based FMDV vaccine using sensitive search strategies. The extracted data were analyzed using Rev-Man 5.4 software. This experiment used the T7 phage to express the capsid protein VP1 of the OHM-02 strain, and the recombinant VP1 phage was termed OHM-T7. Antibodies and cytokines levels were assessed after immunizing BALB/C mice with OHM-T7. The results showed that a total of 115 articles were retrieved, and 4 of them met the inclusion criteria. There was no heterogeneity with I2 = 0%, 20% or 43%. We used a fixed-effect model for meta-analysis, and the results showed a protective effect on FMDV between the phage group and control group (P<0.01) and between FMDV group and control group (P<0.01). Furthermore, when the phage group was compared to the FMDV group, there was also no significant difference (P>0.05). After successfully obtained the ohm-t7 strain and immunized the mice, it could induce high levels of IFN-γ levels in mice with little effect on IL-4 levels. OHM-T7 could be used to detect antibodies produced by mice immunized with different FMDV antigens and produce high levels of anti-FMD antibodies. In summary, these results showed the potential of phage-based FMDV vaccines in FMDV prevention.

scholarly journals Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xiuhui Li ◽  
Chi Zhang ◽  
Qingsheng Shi ◽  
Tong Yang ◽  
Qingxiong Zhu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Conventional Therapy ◽  
Therapy Group ◽  
Control Measure ◽  
Controlled Trial ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Major Complications ◽  
Fever Clearance Time ◽  
Foot And Mouth

Background. Herb-derived compound andrographolide sulfonate (called Xiyanping injection) recommended control measure for severe hand, foot, and mouth disease (HFMD) by the Ministry of Health (China) during the 2010 epidemic. However, there is a lack of good quality evidence directly comparing the efficacy of Andrographolide Sulfonate combination therapy with conventional therapy.Methods. 230 patients were randomly assigned to 7–10 days of Andrographolide Sulfonate 5–10 mg/Kg/day and conventional therapy, or conventional therapy alone.Results. The major complications occurred less often after Andrographolide Sulfonate (2.6% versus 12.1%; risk difference [RD], 0.94; 95% CI, 0.28–1.61;P=0.006). Median fever clearance times were 96 hours (CI, 80 to 126) for conventional therapy recipients and 48 hours (CI, 36 to 54) for Andrographolide Sulfonate combination-treated patients (χ2=16.57,P<0.001). The two groups did not differ in terms of HFMD-cause mortality (P=1.00) and duration of hospitalization (P=0.70). There was one death in conventional therapy group. No important adverse event was found in Andrographolide Sulfonate combination therapy group.Conclusions. The addition of Andrographolide Sulfonate to conventional therapy reduced the occurrence of major complications, fever clearance time, and the healing time of typical skin or oral mucosa lesions in children with severe HFMD.

scholarly journals The effect of vaccination regimen on the transfer of foot and mouth disease antibodies from the sow to her piglets

1984 ◽  
Vol 93 (1) ◽  
pp. 123-131 ◽  
Author(s):  
M. J. Francis ◽  
L. Black
Keyword(s):  
Neutralizing Antibodies ◽  
Foot And Mouth Disease ◽  
Neutralizing Antibody ◽  
Mouth Disease ◽  
Oil Emulsion ◽  
Fmd Virus ◽  
Significant Difference ◽  
Foot And Mouth ◽  
Antibody Titres ◽  
Antibody Class

SUMMARYFour groups of pregnant sows were inoculated with type O1 foot and mouth disease (FMD) oil emulsion vaccine at various times before farrowing and samples of the sow's serum, colostrum and milk, and piglet's serum, collected during the first week after farrowing, were analysed for FMD virus neutralizing activity.No FMD neutralizing antibodies were detectable in the piglets serum at birth but they were present 1·5 h after suckling and peak titres were reached 1–3 days later. There was no significant difference between the antibody titres of colostrum samples collected from different teats at farrowing. However, similar samples collected 3 days later showed significant (P < 0·005) fore to hind variation. The principal FMD virus neutralizing antibody class present in the sow's serum at farrowing and in their 3-day-old piglets was governed by the inoculation schedule employed. When the last vaccinations were given ≃ 30 days before farrowing (dbf) the predominant FMD virus neutralizing class was IgG. However, when the sows were vaccinated only ≃ 12 dbf the predominant class was IgM. A significant correlation was observed between the sow's serum titres and colostrum titres at farrowing (r = 0·90), and also between sows colostrum titres at farrowing and their 3-day-old piglets serum titres (r = 0·99).

scholarly journals Intestinal microbiota has important effect on severity of hand foot and mouth disease in children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chenguang Shen ◽  
Yi Xu ◽  
Jingkai Ji ◽  
Jinli Wei ◽  
Yujin Jiang ◽  
...  
Keyword(s):  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Intestinal Bacteria ◽  
Mouth Disease ◽  
Childhood Illness ◽  
Healthy Controls ◽  
Intestinal Microorganisms ◽  
Significant Difference ◽  
Foot And Mouth ◽  
The Relationship

Abstract Background The incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The relationship between different enterovirus genotypes and disease severity is not clearly understood. Given that enteroviruses are transmitted through the gastrointestinal tract, we hypothesized that variation in intestinal microorganisms of the host might play a role in the prognosis of HFMD. Methods We carried out a meta-transcriptomic-wide association study of fecal samples obtained from a cohort of children (254 patients, 227 tested positive for enterovirus, including 16 patients co-infectied with 2 kinds of enterovirus) with mild and severe HFMD and healthy controls. Results We found there was no significant difference in the amount of each virus type between the mild and severe cases. Genes of enterovirus 71 (EV71) and coxsackievirus A (CV-A) from the severe and mild cases did not show significant clustering. Clostridium sp. L2-50 and Bacteroides stercoris ATCC 43183 were enriched in the guts of children with severe HFMD and KEGG enrichment was found between mild and severe cases. Conclusions Intestinal microorganisms appear to interact with enterovirus to determine the progression of HFMD. Genes of Bacteroides and Clostridium may be used as predictive markers for a more efficient prognosis and intervention. The enrichment of intestinal bacteria genes with functions may facilitate the development of severe symptoms for HFMD patients.

scholarly journals An Easy Method for Identifying 315 Categories of Commonly-Used Chinese Herbal Medicines Based on Automated Image Recognition Using AutoML Platforms

2020 ◽  
Author(s):  
Wenting Chen ◽  
Jiayun Tong ◽  
Rui He ◽  
Peiting Chen ◽  
Zixin Chen ◽  
...  
Keyword(s):  
Image Recognition ◽  
Herbal Medicines ◽  
Model Performance ◽  
Easy Method ◽  
Chinese Herbal Medicines ◽  
Training Time ◽  
Chinese Herbal ◽  
Significant Difference ◽  
Model Training ◽  
The One

Abstract Background: The identification and authentication of Chinese herbal medicines (CHMs) are directly related to their safety and efficacy in clinical treatment. However, the limited number of qualified professionals with expertise fails to meet the demand of the vast CHMs market. To make the CHMs identification more convenient and accurate, this study aimed at assessing the feasibility of the state-of-art automated machine learning (AutoML) technology in CHMs image recognition.Methods: This study presented an experimental AutoML model built on the one-stop Huawei ModelArts platform instead of a handcrafted neural network. A rich and representative dataset of 31,460 images consisting of 315 categories of commonly-used CHMs was built and used for the model creation. Furthermore, the Huawei ModelArts model was compared with a model built on the Baidu EasyDL platform using the same dataset to investigate their ability to recognize CHMs images. Three professionals were also invited to recognize images of 315 categories of CHMs.Results: During the model evaluation, high accuracies of 99.2% and 98.4% were achieved by ModelArts and EasyDL, respectively. In the subsequent held-out tests, the accuracies of ModelArts and EasyDL models were 91.2% and 91.85%, respectively. Both models performed very well individually and no statistically significant difference was found in model performance between these two platforms. However, the model-training time was only approximately 41 minutes on ModelArts platform but 118 minutes on EasyDL. The mean accuracy of the manual recognition for 315 CHMs was 97.46±1.58%.Conclusion: Results revealed that AutoML technology is a fast and simple approach and has great practical potential in the field of CHMs image recognition. Since the Huawei ModelArts platform requires less training time, we recommend it as a priority.

scholarly journals Management of Severe Hand, Foot and Mouth Disease in Xiangyang, China from 2008-2013.

2020 ◽  
Author(s):  
Jian Liu ◽  
Jing Qi
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Nervous System ◽  
Early Stage ◽  
Foot And Mouth Disease ◽  
Stage Iv ◽  
Mouth Disease ◽  
Clinical Severity ◽  
Significant Difference ◽  
Foot And Mouth

Abstract Therapeutic strategies for severe hand, foot and mouth disease (HFMD) are currently either inconsequent or deficient in evidence. We retrospectively surveyed HFMD outbreaks in Xiangyang from June 2008 to December 2013. FHMD is staged form I to V according to clinical severity and the case with central nervous system involvement is defined as a severe one. Most severe cases were investigated to analyse risk factors for fatality and to compare the efficiency and outcome of some therapies by binary logistic regression. The overall HFMD cases included 637 (1.26%) severe cases, 38 fatal cases (0.75‰). Analysis indicates that age (<3 y), enterovirus 71 (+), autonomic nervous system dysregulation, pulmonary edema/hemorrhage, CRP (>40 mg/L) and cardiac troponin I (>0.04 ng/mL) are risk factors for fatality (all P < 0.05). Intravenous immunoglobulin (IVIG) and mechanical ventilation applied in early stage IV significantly improved HFMD progression (both P < 0.05) with odds ratios of 0.24 (95% CI: 0.10-0.57) and 0.01 (95% CI: 0.00-0.10), respectively. Methylprednisolone and milrinone administered in any stage, and all therapies applied in stage III made no significant difference on mortality (all P > 0.05). Precise recognition of the severe HFMD cases in early stage IV and timely IVIG and mechanical ventilation application may decrease mortality. Mechanical ventilation training programs and dispatching specialists to county-level or district hospitals when there is no chance for severe HFMD cases to be transferred to superior hospitals are two key successful administrative initiatives.

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