scholarly journals Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xiuhui Li ◽  
Chi Zhang ◽  
Qingsheng Shi ◽  
Tong Yang ◽  
Qingxiong Zhu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Conventional Therapy ◽  
Therapy Group ◽  
Control Measure ◽  
Controlled Trial ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Major Complications ◽  
Fever Clearance Time ◽  
Foot And Mouth

Background. Herb-derived compound andrographolide sulfonate (called Xiyanping injection) recommended control measure for severe hand, foot, and mouth disease (HFMD) by the Ministry of Health (China) during the 2010 epidemic. However, there is a lack of good quality evidence directly comparing the efficacy of Andrographolide Sulfonate combination therapy with conventional therapy.Methods. 230 patients were randomly assigned to 7–10 days of Andrographolide Sulfonate 5–10 mg/Kg/day and conventional therapy, or conventional therapy alone.Results. The major complications occurred less often after Andrographolide Sulfonate (2.6% versus 12.1%; risk difference [RD], 0.94; 95% CI, 0.28–1.61;P=0.006). Median fever clearance times were 96 hours (CI, 80 to 126) for conventional therapy recipients and 48 hours (CI, 36 to 54) for Andrographolide Sulfonate combination-treated patients (χ2=16.57,P<0.001). The two groups did not differ in terms of HFMD-cause mortality (P=1.00) and duration of hospitalization (P=0.70). There was one death in conventional therapy group. No important adverse event was found in Andrographolide Sulfonate combination therapy group.Conclusions. The addition of Andrographolide Sulfonate to conventional therapy reduced the occurrence of major complications, fever clearance time, and the healing time of typical skin or oral mucosa lesions in children with severe HFMD.

scholarly journals Effect of heat-clearing and detoxifying Chinese medicines combined with conventional therapy on mild hand, foot, and mouth disease with fever

Medicine ◽  
2020 ◽  
Vol 99 (23) ◽  
pp. e20473
Author(s):  
Shiyan Yan ◽  
Ying Lu ◽  
Guoliang Zhang ◽  
Xiuhui Li ◽  
Zhong Wang ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Chinese Medicines ◽  
Foot And Mouth

scholarly journals Seroprevalence of foot and mouth disease (FMD) among sedentary cattle in northern Plateau, Nigeria

2015 ◽  
Vol 1 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Yiltawe Simwal Wungak ◽  
Ishola Olayinka Olabisi ◽  
Babasola Oluseyi Olugasa ◽  
David Dazhia Lazarus ◽  
Hussaini Gulak Ularamu
Keyword(s):  
Risk Factors ◽  
Whole Blood ◽  
Animal Movement ◽  
Control Measure ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Adult Cattle ◽  
Mouth Disease Virus ◽  
Foot And Mouth

This study was aimed to determine the seroprevalence of foot and mouth disease (FMD) in cattle and identifying the potential risk factors associated with the disease among sedentary cattle in northern part of Plateau state, Nigeria. Two hundred and seventy cattle aged from 6 months to ?3 years old were randomly selected and identified and whole blood collected from the jugular vein using plain evacuated tubes. Whole blood was processed and separated and sera were screened for foot and mouth disease virus (FMDV) 3D non-structural proteins using blocking enzyme linked immunosorbent assay (ELISA). Overall, 55.9% (95%CI: 49.96-61.77) FMD seroprevalence was obtained from the study area. Seroprevalence was highest in Riyom (82.5%), followed by Barkin Ladi (66.2%), Jos South (55.5%) and Bassa (41.2%) (x2 = 17.21, P<0.05). Risk factors for age, management system and location were significant associated (P<0.05) with seroprevalence of FMD. However, there was no significant association with sex (P>0.05). The prevalence odd ratio of FMD was more in Riyom than in Jos South, Barkin Ladi and Bassa (P<0.05). Prevalence odd ratio of FMD was more in extensively managed system relative to intensively managed system, more in adult cattle aged >2 years old. This study has indicated that FMD is an important disease among sedentary cattle in Northern Plateau, however little is currently known about the economic impact of the disease on the local farmers and their livelihoods. As a control measure, efforts should be improved on animal movement during outbreaks while prophylactic control using vaccination should be considered as another option using vaccines containing virus representative of the region.Asian J. Med. Biol. Res. June 2015, 1(2): 169-174

scholarly journals Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Xiuhui Li ◽  
Xi Zhang ◽  
Jianbo Ding ◽  
Yi Xu ◽  
Dan Wei ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Herbal Medicines ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Combination Group ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Significant Difference ◽  
Foot And Mouth ◽  
Reduning Injection

Background.This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional Chinese medicine (TCM) granule, in patients with severe hand, foot, and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial.Methods.355 severe HFMD patients were randomly assigned to receive conventional therapy alone, Reduning injection plus conventional therapy, or TCM enema plus conventional therapy for 7–10 days.Results.There was no significant difference in the incidence of major complications between the groups. Median time to fever clearance was 20 hours (95% CI: 6.0–25.0) for conventional therapy recipients, 18 hours (95% CI: 4.0–24.0) for Reduning combination-treated patients, and 6 hours (95% CI: 4.0–16.0) for TCM combination-treated patients. Only the difference in time to fever clearance between TCM combination group and conventional group reached statistical significance (P=0.048). Reduning combination group showed a significant reduction in sedative administration compared with conventional therapy group (P=0.008). No HFMD-related death and no important adverse events were observed.Conclusions.Reduning injection plus conventional therapy significantly reduced the concomitant use of sedatives, which may help decrease HFMD-related neurologic complications in children. TCM effectively reduced time to fever clearance and may become a complementary therapy for relieving the symptoms of severe HFMD.

scholarly journals Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field

2010 ◽  
Vol 139 (2) ◽  
pp. 189-196 ◽  
Author(s):  
A. K. SANGULA ◽  
H. R. SIEGISMUND ◽  
G. J. BELSHAM ◽  
S. N. BALINDA ◽  
C. MASEMBE ◽  
...  
Keyword(s):  
Vaccine Strain ◽  
Control Measure ◽  
Sequence Divergence ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Complex Processes ◽  
Low Diversity ◽  
Foot And Mouth ◽  
Capsid Protein Vp1 ◽  
Virus Isolates

SUMMARYMost viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (π=0·0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.

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