scholarly journals Antiobesity Effect of Caraway Extract on Overweight and Obese Women: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Mahnaz Kazemipoor ◽  
Che Wan Jasimah Bt wan Mohamed Radzi ◽  
Majid Hajifaraji ◽  
Batoul Sadat Haerian ◽  
Mohammad Hossein Mosaddegh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Fat ◽  
Urine Specific Gravity ◽  
Controlled Clinical Trial ◽  
Body Fat Percentage ◽  
Obese Women ◽  
Fat Percentage ◽  
Anthropometric Indices ◽  
Physically Active ◽  
Waist To Hip Ratio

Caraway (Carum carviL.), a potent medicinal plant, is traditionally used for treating obesity. This study investigates the weight-lowering effects of caraway extract (CE) on physically active, overweight and obese women through a randomized, triple-blind, placebo-controlled clinical trial. Seventy overweight and obese, healthy, aerobic-trained, adult females were randomly assigned to two groups (n=35per group). Participants received either 30 mL/day of CE or placebo without changing their diet or physical activity. Subjects were examined at baseline and after 90 days for changes in body composition, anthropometric indices, and clinical and paraclinical variables. The treatment group, compared with placebo, showed a significant reduction of weight, body mass index, body fat percentage, and waist-to-hip ratio. No changes were observed in lipid profile, urine-specific gravity, and blood pressure of subjects. The results suggest that a dietary CE with no restriction in food intake, when combined with exercise, is of value in the management of obesity in women wishing to lower their weight, BMI, body fat percentage, and body size, with no clinical side effects. In conclusion, results of this study suggest a possible phytotherapeutic approach for caraway extract in the management of obesity. This trial is registered withNCT01833377.

scholarly journals Efficacy and Safety of Combined Extracts of Cornus officinalis and Ribes fasciculatum for Body Fat Reduction in Overweight Women

2020 ◽  
Vol 9 (11) ◽  
pp. 3629
Author(s):  
Eunkuk Park ◽  
Chang Gun Lee ◽  
Jeonghyun Kim ◽  
Jae-Heon Kang ◽  
Young Gyu Cho ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Fat ◽  
Safety Assessment ◽  
Subcutaneous Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Waist To Hip Ratio ◽  
Overweight Women ◽  
Cornus Officinalis ◽  
Fat Reduction

Obesity is a medical condition that presents excessive fat accumulation with high risk of serious chronic diseases. The aim of this clinical trial is to investigate the anti-obesity effects of Cornus officinalis (CO) and Ribes fasciculatum (RF) on body fat reduction in Korean overweight women. A total of 147 overweight female participants enrolled in double-blinded clinical trial for 12 weeks and 76 participants completed the clinical study. Participants were treated with four CO and RF mixture (COEC; 400 mg per tablet) or four placebo tablets once a day. Obesity associated parameters (body weight, body mass index (BMI), waist circumference, waist-to-hip ratio, body fat percentage and body fat mass) and safety assessment were analyzed. After 12 weeks of COEC treatment, primary outcomes such as body fat percentage (0.76% vs. 0.01%; p = 0.022) and mass (1.1 kg vs. 0.5 kg; p = 0.049) were significantly decreased. In addition, the results were statistically significant between the COEC and placebo groups, strongly indicated that COEC had anti-obesity effects on overweight women. Secondary outcomes—including body weight, waist and hip circumference, waist-to-hip ratio, body mass index and computed tomography measurement of visceral fat area, subcutaneous fat area, total abdominal fat area and visceral-to-subcutaneous fat ratio—were reduced in COEC-treated group, but no statistical differences were found between the COEC and placebo groups. The safety assessment did not differ between the two groups. These results suggest that treatment of COEC extract reduces body fat percentage and mass in Korean overweight women, indicating it as a protective functional agent for obesity.

scholarly journals The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ren Yoshitomi ◽  
Mao Yamamoto ◽  
Motofumi Kumazoe ◽  
Yoshinori Fujimura ◽  
Madoka Yonekura ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Gain ◽  
Green Tea ◽  
Body Fat ◽  
Controlled Clinical Trial ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Reduced Body ◽  
Blood Biochemical ◽  
Double Blinded

AbstractGreen tea, a widely consumed beverage in Asia, contains green tea catechins effective against obesity, especially epigallocatechin-3-O-gallate (EGCG), but must be consumed in an impractically huge amount daily to elicit its biological effect. Meanwhile, citrus polyphenols have various physiological effects that could enhance EGCG functionality. Here we investigated the antiobesity effect of a combination of EGCG and α-glucosyl hesperidin, a citrus polyphenol, at doses that have not been previously reported to exert antiobesity effects by themselves in any clinical trial. In a randomized, placebo-controlled, double-blinded, and parallel-group-designed clinical trial, 60 healthy Japanese males and females aged 30–75 years consumed green tea combined with α-glucosyl hesperidin (GT-gH), which contained 178 mg α-glucosyl hesperidin and 146 mg EGCG, for 12 weeks. Physical, hematological, blood biochemical, and urine examinations showed that GT-gH is safe to use. At week 12, GT-gH prevented weight gain and reduced body mass index (BMI) compared with the placebo. Especially in those aged < 50 years, triglyceride and body fat percentage decreased at week 6, visceral fat level and body fat percentage decreased at week 12; body weight, BMI, and blood LDL/HDL ratio also decreased. In conclusion, taking GT-gH prevents weight gain, and the antiobesity effect of GT-gH was more pronounced in people aged < 50 years.

scholarly journals Anthropometric Obesity Indices, Body Fat Percentage, and Grip Strength in Young Adults with different Physical Activity Levels

2019 ◽  
Vol 4 (3) ◽  
pp. 51
Author(s):  
Söğüt ◽  
Kaya ◽  
Altunsoy ◽  
Clark ◽  
Clemente ◽  
...  
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Grip Strength ◽  
Body Fat ◽  
Activity Level ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Physically Active ◽  
Obesity Indices ◽  
Activity Groups

The purposes of this study were to determine whether moderately physically active (MPA) and highly physically active (HPA) male (n = 96, age = 22.5 ± 1.7 years) and female (n = 85, age = 21.3 ± 1.6 years) young adults differed in their anthropometric obesity indices (AOIs), body fat percentage (BF%), and muscular strength, and also to examine the associations between physical activity level (PAL) and the abovementioned variables. Participants were measured for body height and weight, BF%, waist and hip circumferences, and maximal isometric grip strength. According to their PAL, estimated by the short version of the International Physical Activity Questionnaire, they were assigned to MPA and HPA subgroups. Regardless of gender, results indicated that participants in the MPA groups had significantly higher values of body weight, waist and hip circumference, BF%, and BMI than participants in the HPA groups. No significant differences were found between physical activity groups in terms of grip strength. The AOIs and BF% were found to be significantly and negatively correlated with the PAL in both genders. In conclusion, the findings of the study suggest that high habitual physical activity is associated with lower adiposity markers. However, the differences in the hand grip strength of the contrasting activity groups were negligible.

scholarly journals Association of Sugar-Sweetened Beverage Frequency with Adiposity: Evidence from the “Children of 1997” Birth Cohort

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1015
Author(s):  
Ting Zhang ◽  
Shiu Lun Au Yeung ◽  
Man Ki Kwok ◽  
Lai Ling Hui ◽  
Gabriel Matthew Leung ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Birth Cohort ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Z Score ◽  
Fat Percentage ◽  
Sugar Sweetened Beverage ◽  
Waist To Hip Ratio ◽  
Sweetened Beverage ◽  
Consumption Frequency

Background: Observationally, sugar-sweetened beverage (SSB) consumption is associated with adiposity in Western children but could be confounded. We examined the association of SSB frequency with adiposity in the non-Western setting of Hong Kong. Methods: We examined the associations of SSB consumption frequency at 11 and 13 years assessed by using a food frequency questionnaire with subsequent body mass index (BMI) z-score and overweight/obesity up to 18 years using generalized estimating equations, and with waist circumference, waist-to-hip ratio, and body fat percentage at 16–19 years using linear regression in a population-representative Chinese birth cohort “Children of 1997” (n = 3628). Results: At 11 and 13 years, 6.8% and 8.2% of children respectively consumed SSB daily. Neither SSB frequency at 11 nor at 13 years was associated with subsequent BMI z-score or overweight/obesity up to 18 years, or with waist circumference, waist-to-hip ratio, or body fat percentage at 16–19 years adjusted for age, sex, socioeconomic position, health status, physical activity and other food consumption, although bias to the null from under-reporting cannot be eliminated. Conclusion: Although we cannot definitively exclude a small association of SSB frequency with adiposity, lack of association of SSB frequency with adiposity in a non-Western setting with low SSB consumption suggests that the role of SSB in adiposity appears to be minor.

Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease

Heart ◽  
2014 ◽  
Vol 100 (20) ◽  
pp. 1613-1619 ◽  
Author(s):  
Phyo Kyaw Myint ◽  
Chun Shing Kwok ◽  
Robert N Luben ◽  
Nicholas J Wareham ◽  
Kay-Tee Khaw
Keyword(s):  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Waist To Hip Ratio ◽  
Predictors Of Mortality

Effects of Fed- Versus Fasted-State Aerobic Training During Ramadan on Body Composition and Some Metabolic Parameters in Physically Active Men

2012 ◽  
Vol 22 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Khaled Trabelsi ◽  
Kais el Abed ◽  
Stephen R. Stannard ◽  
Kamel Jammoussi ◽  
Khaled M. Zeghal ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Body Fat ◽  
Aerobic Training ◽  
Metabolic Parameters ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Physically Active ◽  
Fed State ◽  
Fasted State

The aim of this study was to evaluate the effects of aerobic training in a fasted versus a fed state during Ramadan on body composition and metabolic parameters in physically active men. Nineteen men were allocated to 2 groups: 10 practicing aerobic training in a fasted state (FAST) and 9 training in an acutely fed state (FED) during Ramadan. All subjects visited the laboratory for a total of 4 sessions on the following occasions: 3 days before Ramadan (Bef-R), the 15th day of Ramadan; the 29th day of Ramadan (End-R), and 21 days after Ramadan. During each session, subjects underwent anthropometric measurement, completed a dietary questionnaire, and provided fasting blood and urine samples. Body weight decreased in FAST and FED by 1.9% (p < .001) and 2.6% (p = .046), respectively. Body fat percentage decreased only in FAST by 6.2% (p = .016). FAST experienced an increase in the following parameters from Bef-R to End-R: urine specific gravity (0.64%, p = .012), urea (8.7%, p < .001), creatinine (7.5%, p < .001), uric acid (12.7%, p < .001), sodium (1.9%, p = .003), chloride (2.6%, p < .001), and high-density lipoprotein cholesterol (27.3%, p < .001). Of these parameters, only creatinine increased (5.8%, p = .004) in FED. Creatinine clearance values of FAST decreased by 8.9% (p < .001) and by 7.6% in FED (p = .01) from Bef-R to End-R. The authors conclude that aerobic training in a fasted state lowers body weight and body fat percentage. In contrast, fed aerobic training decreases only body weight. In addition, Ramadan fasting induced change in some metabolic parameters in FAST, but these changes were absent in FED.

scholarly journals Effects of run sprint interval training on healthy, inactive, overweight/obese women: A pilot study

FACETS ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 53-67 ◽  
Author(s):  
Taylor W. Rowley ◽  
Jennifer L. Espinoza ◽  
Jeremy D. Akers ◽  
David L. Wenos ◽  
Elizabeth S. Edwards
Keyword(s):  
Body Fat ◽  
Perceived Exertion ◽  
Disease Risk ◽  
Interval Training ◽  
Moderate Intensity ◽  
Body Fat Percentage ◽  
Sprint Interval Training ◽  
Obese Women ◽  
Fat Percentage ◽  
Perceived Enjoyment

This study examined the effects of a 12 week, treadmill-based, run sprint interval training (SIT) protocol compared with that of a moderate-intensity continuous training (MICT) protocol in healthy, inactive, overweight/obese women, on cardiovascular disease risk factors. After random assignment, the SIT group completed 4–10 × 30 s maximal sprints, with a 4 min active recovery between sprints, and the MICT group completed 30–60 min at moderate intensity (45–55% heart rate reserve (HRR)). The rate of perceived exertion (RPE) was recorded for each session, and perceived enjoyment was quantified every 3 weeks. Clinical and fitness testing were completed at baseline, 6 weeks, and 12 weeks. Twelve female participants (age: 34.1 ± 6.1; body mass index (BMI): 31.3 ± 6.8; VO2peak: 27.0 ± 6.2) completed the intervention. There were significant main effects for time for VO2peak ( p = 0.001), body fat percentage ( p = 0.001), and session RPE ( p = 0.006). VO2peak improved 20.7% in the SIT group ( n = 5) and 24.4% in the MICT group ( n = 7). Body fat percentage reduced by 1.7% in the SIT group and 2.6% in the MICT group. Perceived enjoyment was similarly high between the groups despite higher session RPE in the SIT group ( p = 0.441). SIT training on a motor-driven treadmill elicits similar improvements in oxygen utilization and body composition as moderate-intensity training in this population.

scholarly journals Network Mendelian randomization study: exploring the causal pathway from insomnia to type 2 diabetes

2022 ◽  
Vol 10 (1) ◽  
pp. e002510
Author(s):  
Wen Xiuyun ◽  
Lin Jiating ◽  
Xie Minjun ◽  
Li Weidong ◽  
Wu Qian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Fat ◽  
Mendelian Randomization ◽  
Body Fat Percentage ◽  
Causal Association ◽  
Fat Percentage ◽  
Waist To Hip Ratio ◽  
Increased Risk ◽  
Causal Pathway

IntroductionInsomnia is a novel pathogen for type 2 diabetes mellitus (T2DM). However, mechanisms linking insomnia and T2DM are poorly understood. In this study, we apply a network Mendelian randomization (MR) framework to determine the causal association between insomnia and T2DM and identify the potential mediators, including overweight (body mass index (BMI), waist-to-hip ratio, and body fat percentage) and glycometabolism (HbA1c, fasting blood glucose, and fasting blood insulin).Research design and methodsWe use the MR framework to detect effect estimates of the insomnia–T2DM, insomnia–mediator, and mediator–T2DM associations. A mediator between insomnia and T2DM is established if MR studies in all 3 steps prove causal associations.ResultsIn the Inverse variance weighted method, the results show that insomnia will increase the T2DM risk (OR 1.142; 95% CI 1.072 to 1.216; p=0.000), without heterogeneity nor horizontal pleiotropy, strongly suggesting that genetically predicted insomnia has a causal association with T2DM. Besides, our MR analysis provides strong evidence that insomnia is causally associated with BMI and body fat percentage. There is also suggestive evidence of an association between insomnia and the waist-to-hip ratio. At the same time, our results indicate that insomnia is not causally associated with glycometabolism. Higher BMI, waist-to-hip ratio, and body fat percentage levels are strongly associated with increased risk of T2DM.ConclusionsGenetically predicted insomnia has a causal association with T2DM. Being overweight (especially BMI and body fat percentage) mediates the causal pathway from insomnia to T2DM.

Sign in / Sign up

Export Citation Format

Share Document