scholarly journals Heat Shock Proteins and Regulatory T Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
E. W. Brenu ◽  
D. R. Staines ◽  
L. Tajouri ◽  
T. Huth ◽  
K. J. Ashton ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
Heat Shock ◽  
Regulatory T Cells ◽  
Heat Shock Proteins ◽  
Protein Function ◽  
Cellular Functions ◽  
Wide Range ◽  
Diseased State ◽  
Shock Proteins

Heat shock proteins (HSPs) are important molecules required for ideal protein function. Extensive research on the functional properties of HSPs indicates that HSPs may be implicated in a wide range of physiological functions including immune function. In the immune system, HSPs are involved in cell proliferation, differentiation, cytokine release, and apoptosis. Therefore, the ability of the immune system, in particular immune cells, to function optimally and in unison with other physiological systems is in part dependent on signaling transduction processes, including bidirectional communication with HSPs. Regulatory T cells (Tregs) are important T cells with suppressive functions and impairments in their function have been associated with a number of autoimmune disorders. The purpose of this paper is to examine the relationship between HSPs and Tregs. The interrelationship between cells and proteins may be important in cellular functions necessary for cell survival and expansion during diseased state.

scholarly journals Heat Shock Proteins: Connectors between Heart and Kidney

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1939
Author(s):  
Carolina Victória Cruz Junho ◽  
Carolina Amaral Bueno Azevedo ◽  
Regiane Stafim da Cunha ◽  
Ainhoa Rodriguez de Yurre ◽  
Emiliano Medei ◽  
...  
Keyword(s):  
Immune System ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Intracellular Signaling ◽  
Cardiorenal Syndrome ◽  
Redox Balance ◽  
Cellular Functions ◽  
Shock Proteins ◽  
Type 3

Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Regarding pathological situations as seen in cardiorenal syndrome (CRS), HSPs have been shown to be important mediators involved in the control of gene transcription and intracellular signaling, in addition to be an important connector with the immune system. CRS is classified as acute or chronic and according to the first organ to suffer the injury, which can be the heart (CRS type 1 and type 2), kidneys (CRS type 3 and 4) or both (CRS type 5). In all types of CRS, the immune system, redox balance, mitochondrial dysfunction, and tissue remodeling have been the subject of numerous studies in the literature in order to elucidate mechanisms and propose new therapeutic strategies. In this sense, HSPs have been targeted by researchers as important connectors between kidney and heart. Thus, the present review has a focus to present the state of the art regarding the role of HSPs in the pathophysiology of cardiac and renal alterations, as well their role in the kidney–heart axis.

scholarly journals Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)

2016 ◽  
Vol 3 ◽  
pp. 317-323 ◽  
Author(s):  
Tomasz Koliński ◽  
Natalia Marek-Trzonkowska ◽  
Piotr Trzonkowski ◽  
Janusz Siebert
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Regulatory T Cells ◽  
Heat Shock Proteins ◽  
Shock Proteins

Heat-shock proteins as activators of the innate immune system

2002 ◽  
Vol 23 (3) ◽  
pp. 130-135 ◽  
Author(s):  
Robert P.A Wallin ◽  
Andreas Lundqvist ◽  
Solveig H Moré ◽  
Arne von Bonin ◽  
Rolf Kiessling ◽  
...  
Keyword(s):  
Immune System ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Innate Immune System ◽  
Innate Immune ◽  
Shock Proteins

Polyclonal Responses of γδ T Cells to Heat Shock Proteins

2020 ◽  
pp. 557-569
Author(s):  
Willi Born ◽  
Mary Ann DeGroote ◽  
Fu Yang-Xin ◽  
Christina Ellis Roark ◽  
Kent Heyborne ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Γδ T Cells ◽  
Shock Proteins

Expression of heat shock proteins in medulloblastoma

2013 ◽  
Vol 12 (5) ◽  
pp. 452-457 ◽  
Author(s):  
George A. Alexiou ◽  
George Vartholomatos ◽  
Kalliopi Stefanaki ◽  
Amalia Patereli ◽  
Lefkothea Dova ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Significant Positive Correlation ◽  
Large Cell ◽  
Hsp70 Expression ◽  
Ki 67 ◽  
Positive Correlation ◽  
Wide Range ◽  
Shock Proteins ◽  
Multiplex Bead

Object Medulloblastoma (MB) is the most common malignant brain tumor in children. Heat shock proteins (HSPs) comprise a superfamily of proteins that serve as molecular chaperones and are overexpressed in a wide range of human cancers. The purpose of the present study was to investigate the expression of HSP27 (pSer82), HSP27 (pSer15), HSP40, HSP60, HSP70, HSP90-α, Akt, and phospho-Akt by multiplex bead array assay of MBs. The results of HSP and Akt expression were correlated with MB subtype; immunohistochemical expression of Ki-67 index, bcl-2, and p53; and patients' prognosis. Methods The authors retrospectively evaluated 25 children with MB who underwent surgery. Immunohistochemical analysis of Ki-67, p53, and bcl-2 expression was performed in all cases. By using multiplex bead array assay, a simultaneous detection of HSP27 (pSer82), HSP27 (pSer15), HSP40, HSP60, HSP70, HSP90-α, Akt, and phospho-Akt was performed. Results Medulloblastoma with extensive nodularity had significantly lower HSP27 (pSer15) expression (p = 0.039) but significantly higher HSP60 expression (p = 0.021) than classic MB. Large-cell MB had significantly higher HSP70 expression (p = 0.028) than classic MB. No significant difference was found between HSP27 (pSer82), HSP40, HSP90-α, Akt, or phospho-Akt expression and MB subtype. Large-cell MBs had significantly higher Ki-67 index compared with classic MBs (p = 0.033). When analyzing all MBs, there was a significant negative correlation between HSP27 (pSer15) and Ki-67 index (r = −0.475, p = 0.016); a significant positive correlation between HSP70 expression and Ki-67 index (r = 0.407, p = 0.043); and a significant positive correlation between HSP70 expression and bcl-2 index (r = 0.491, p = 0.023). Patients with large-cell MB had a worse survival than those with classic MB, but the difference did not reach statistical significance (p = 0.076). Conclusions A substantial expression of several HSPs in MB was observed. Given that HSPs represent an attractive strategy for anticancer therapy, further studies, involving larger series of patients, are obviously necessary to clarify the relationship of HSPs with tumor aggressiveness and prognosis.

V-delta2+ gamma/delta T cells directly recognize 70-kD heat shock proteins: relevance to MS

1996 ◽  
Vol 2 (5) ◽  
pp. 250-250
Author(s):  
M Salvetti ◽  
G Ristori ◽  
P Fiori ◽  
C Buttinelli ◽  
C Fieschi ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Shock Proteins

γδ T cells lyse autologous and allogenic oesophageal tumours: involvement of heat-shock proteins in the tumour cell lysis

2000 ◽  
Vol 48 (11) ◽  
pp. 653-659 ◽  
Author(s):  
M. Loui Thomas ◽  
Urmila C. Samant ◽  
Ramakant Krishnaji Deshpande ◽  
Shubhada Vivek Chiplunkar
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Tumour Cell ◽  
Γδ T Cells ◽  
Cell Lysis ◽  
Shock Proteins
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