scholarly journals Pulmonary Function after Weight Loss in Obese Women Undergoing Roux-en-Y Gastric Bypass: One-Year Followup

ISRN Obesity ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Marcela Cangussu Barbalho-Moulim ◽  
Gustavo Peixoto Soares Miguel ◽  
Eli Maria Pazzianotto Forti ◽  
Flávio do Amaral Campos ◽  
Fabiana Sobral Peixoto-Souza ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Gastric Bypass Surgery ◽  
Respiratory Muscle Strength ◽  
Obese Women ◽  
Lung Volumes ◽  
One Year

Introduction. Obesity is a condition that causes damage to the respiratory function. However, studies have demonstrated that weight loss due to bariatric surgery has resulted in a huge improvement on some lung volumes, but controversy still persists regarding the behavior of the respiratory muscle strength and IRV (inspiratory reserve volume). Objective. To evaluate the effect of weight loss, after 1 year of the Roux-en-Y gastric bypass surgery (RYGB), on the lung volumes and the respiratory muscle strength in obese women. Methods. 24 obese women candidates were recruited for RYGB. Lung volumes (spirometry) and respiratory muscle strength were evaluated in preoperative period and one year after surgery. Results. There was a significant increase in some lung volumes. However, when examining the components of the VC (vital capacity) separately, an increase in ERV (expiratory reserve volume) and reduction of IRV were observed. Moreover, a statistically significant reduction in the values of respiratory muscle strength was recorded: MIP (maximal inspiratory pressure) and MEP (maximal expiratory pressure). Conclusion. Weight loss induced by bariatric surgery provides an increase in some lung volumes of obese women, but reduction in IRV. Additionally, there was also a reduction in the respiratory muscle strength.

scholarly journals Effects of preoperative inspiratory muscle training in obese women undergoing open bariatric surgery: respiratory muscle strength, lung volumes, and diaphragmatic excursion

Clinics ◽  
2011 ◽  
Vol 66 (10) ◽  
pp. 1721-1727 ◽  
Author(s):  
Marcela Cangussu Barbalho-Moulim ◽  
Gustavo Peixoto Soares Miguel ◽  
Eli Maria Pazzianotto Forti ◽  
Flavio do Amaral Campos ◽  
Dirceu Costa
Keyword(s):  
Bariatric Surgery ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Inspiratory Muscle ◽  
Inspiratory Muscle Training ◽  
Respiratory Muscle Strength ◽  
Obese Women ◽  
Muscle Training ◽  
Lung Volumes ◽  
Open Bariatric Surgery

scholarly journals Association of Circulating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric Bypass Surgery

2019 ◽  
Vol 16 (4) ◽  
pp. 660 ◽  
Author(s):  
Yeon Lee ◽  
Yoonseok Heo ◽  
Ji-Ho Choi ◽  
Sunghyouk Park ◽  
Kyoung Kim ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Excess Weight Loss ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Preoperative Serum ◽  
One Year

Irisin is a myokine with potential anti-obesity properties that has been suggested to increase energy expenditure in obese patients. However, there is limited clinical information on the biology of irisin in humans, especially in morbidly obese patients undergoing bariatric surgery. We aimed to assess the association of circulating irisin concentrations with weight loss in obese patients undergoing bariatric surgery. This was a pilot, single-centre, longitudinal observational study. We recruited 25 morbidly obese subjects who underwent Roux-en-Y gastric bypass surgery (RYGBP), and blood samples from 12 patients were taken to measure serum irisin concentrations before, and one and nine months after surgery. Their clinical characteristics were measured for one year. The preoperative serum irisin concentration (mean 1.01 ± 0.23 μg/mL, range 0.73–1.49) changed bidirectionally one month after RYGBP. The mean concentration at nine months was 1.11 ± 0.15 μg/mL (range 0.92–1.35). Eight patients had elevated irisin levels compared with their preoperative values, but four did not. Elevations of irisin levels nine months, but not one month, after surgery, were associated with lower preoperative levels (p = 0.016) and worse weight reduction rates (p = 0.006 for the percentage excess weight loss and p = 0.032 for changes in body mass index). The preoperative serum irisin concentrations were significantly correlated with the percentage of excess weight loss for one year (R2 = 0.612; p = 0.04) in our study. Our results suggest that preoperative circulating irisin concentrations may be at least in part associated with a weight loss effect of bariatric surgery in morbidly obese patients. Further large-scale clinical studies are needed to ratify these findings.

Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery

2008 ◽  
Vol 19 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Christian L. Roth ◽  
Thomas Reinehr ◽  
Gerit-Holger Schernthaner ◽  
Hans-Peter Kopp ◽  
Stefan Kriwanek ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Women ◽  
Before And After ◽  
Severely Obese

scholarly journals Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252525
Author(s):  
Martin Aasbrenn ◽  
Mathilde Svendstrup ◽  
Theresia M. Schnurr ◽  
Dorte Lindqvist Hansen ◽  
Dorte Worm ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Abdominal Obesity ◽  
Bypass Surgery ◽  
Risk Allele ◽  
Gastric Bypass Surgery ◽  
Genetic Determinants ◽  
Risk Alleles ◽  
Baseline Bmi

Background Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery. Methods Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated. Results The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25). Discussion GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.

scholarly journals Microbial Adaptation Due to Gastric Bypass Surgery: The Nutritional Impact

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1199 ◽  
Author(s):  
Silke Crommen ◽  
Alma Mattes ◽  
Marie-Christine Simon
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Liver Fat ◽  
Microbial Composition ◽  
The Impact

Bariatric surgery leads to sustained weight loss and the resolution of obesity-related comorbidities. Recent studies have suggested that changes in gut microbiota are associated with the weight loss induced by bariatric surgery. Several studies have observed major changes in the microbial composition following gastric bypass surgery. However, there are inconsistencies between the reported alterations in microbial compositions in different studies. Furthermore, it is well established that diet is an important factor shaping the composition and function of intestinal microbiota. However, most studies on gastric bypass have not assessed the impact of dietary intake on the microbiome composition in general, let alone the impact of restrictive diets prior to bariatric surgery, which are recommended for reducing liver fat content and size. Thus, the relative impact of bariatric surgery on weight loss and gut microbiota remains unclear. Therefore, this review aims to provide a deeper understanding of the current knowledge of the changes in intestinal microbiota induced by bariatric surgery considering pre-surgical nutritional changes.

Impairment of lung volumes and respiratory muscle strength in adult patients with growth hormone deficiency

1995 ◽  
Vol 133 (6) ◽  
pp. 680-685 ◽  
Author(s):  
Bartolomeo Merola ◽  
Matteo Sofia ◽  
Salvatore Longobardi ◽  
Serafino Fazio ◽  
Assunta Micco ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Vital Capacity ◽  
Gh Deficiency ◽  
Adult Patients ◽  
Hormone Deficiency ◽  
Respiratory Muscle Strength ◽  
Lung Volumes ◽  
Lung Capacity

Merola B, Sofia M, Longobardi S, Fazio S, Micco A, Esposito V, Colao A, Biondi B, Lombardi G. Impairment of lung volumes and respiratory muscle strength in adult patients with growth hormone deficiency. Eur J Endocrinol 1995;133:680–5. ISSN 0804–4643 Little is known of the respiratory function in patients with growth hormone (GH) deficiency. The aim of the present study was to evaluate lung volumes and respiratory muscle strength in patients diagnosed as GH deficient in childhood. Ten patients diagnosed as GH deficient in childhood and ten healthy subjects entered the study. For each subject the evaluation of respiratory function followed the same standard approach, consisting of respiratory muscle strength assessment, recording of flowvolume curves, measurement of static lung volumes and lung diffusing capacity. Both maximal inspiratory and expiratory mouth pressures were decreased in GH deficiency. Vital capacity, N2 functional residual capacity and total lung capacity were significantly reduced when compared to healthy subjects. Conversely, the residual volume and diffusing lung capacity to CO did not show any significant change. No significant change of percentage forced expiratory volume in 1 s/forced vital capacity ratio was observed. The decrease of respiratory mouth pressures was not correlated to the decrease of lung volumes. In conclusion, the results of this study show that adult patients affected with childhood onset GH deficiency suffer from impairment of ventilatory function and a decrease of respiratory muscle pressures, probably due to reduction of respiratory muscle strength. Gaetano Lombardi, Via G Santacroce 40/1, 80 129 Naples, Italy

scholarly journals Chest Wall Mobility Is Related to Respiratory Muscle Strength and Lung Volumes in Healthy Subjects

2013 ◽  
Vol 58 (12) ◽  
pp. 2107-2112 ◽  
Author(s):  
F. d. C. Lanza ◽  
A. A. de Camargo ◽  
L. R. F. Archija ◽  
J. P. R. Selman ◽  
C. Malaguti ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Chest Wall ◽  
Healthy Subjects ◽  
Respiratory Muscle ◽  
Respiratory Muscle Strength ◽  
Lung Volumes ◽  
Wall Mobility
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