scholarly journals Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea

2013 ◽  
Vol 27 (7) ◽  
pp. 403-404 ◽  
Author(s):  
Raymond J Playford ◽  
Charlotte Pither ◽  
Rui Gao ◽  
Stephen J Middleton
Keyword(s):  
Gastric Bypass ◽  
Gastric Emptying ◽  
Small Volume ◽  
Dietary Intervention ◽  
Partial Gastrectomy ◽  
Dietary Modification ◽  
Glucosidase Inhibitor ◽  
Reactive Hypoglycemia ◽  
Alpha Glucosidase ◽  
Symptoms And Signs

Postprandial reactive hypoglycemia, early satiety and diarrhea are well-recognized side effects following full or partial gastrectomy or gastric bypass. It has only recently been realized, however, that patients with normal gastric anatomy may experience similar symptoms and signs due to primary accelerated gastric emptying (Middleton syndrome). In previous case studies, patients responded well to the use of dietary modification (frequent small-volume meals) alone. The authors describe two patients with this syndrome who continued to experience symptoms of reactive postprandial hypoglycemia despite dietary intervention but became asymptomatic following the addition of the alpha-glucosidase inhibitor acarbose.

scholarly journals Treatment with .ALPHA.-Glucosidase Inhibitor for Severe Reactive Hypoglycemia. A Case Report.

2000 ◽  
Vol 47 (4) ◽  
pp. 437-442 ◽  
Author(s):  
SHINICHI TENO ◽  
YUKO NAKAJIMA-UTO ◽  
KAZUTAKA NAGAI ◽  
MADOKA SHIMIZU-SAITOH ◽  
HIROYUKI OZU ◽  
...  
Keyword(s):  
Case Report ◽  
Glucosidase Inhibitor ◽  
Reactive Hypoglycemia ◽  
Alpha Glucosidase

Post-Gastric-Bypass Hypoglycemia Successfully Treated with Alpha-Glucosidase Inhibitor Therapy

2013 ◽  
Vol 19 (3) ◽  
pp. 511-514 ◽  
Author(s):  
Shavon Frankhouser ◽  
Aakif Ahmad ◽  
Gretchen Perilli ◽  
Benjamin Quintana ◽  
Marc Vengrove
Keyword(s):  
Gastric Bypass ◽  
Inhibitor Therapy ◽  
Glucosidase Inhibitor ◽  
Alpha Glucosidase

P1-25 THE ALPHA-GLUCOSIDASE INHIBITOR VOGLIBOSE REDUCES MYOCARDIAL INFARCT SIZE TROUGH PRODUCTION OF GLUCAGON-LIKE PEPTIDE-1 IN RABBITS

2007 ◽  
Vol 122 ◽  
pp. S68
Author(s):  
Masamitsu Iwasa ◽  
Hiroyuki Kobayashi ◽  
Shinji Yasuda ◽  
Narentuoya Bao Itta Kawamura ◽  
Takahiko Yamaki ◽  
...  
Keyword(s):  
Infarct Size ◽  
Myocardial Infarct ◽  
Myocardial Infarct Size ◽  
Glucosidase Inhibitor ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Alpha Glucosidase

scholarly journals Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women’s Health Initiative Randomized Trial

2020 ◽  
Vol 38 (13) ◽  
pp. 1419-1428 ◽  
Author(s):  
Rowan T. Chlebowski ◽  
Aaron K. Aragaki ◽  
Garnet L. Anderson ◽  
Kathy Pan ◽  
Marian L. Neuhouser ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dietary Fat ◽  
Dietary Intervention ◽  
Breast Cancer Incidence ◽  
Intervention Group ◽  
Dietary Modification ◽  
Fat Intake ◽  
Health Initiative

PURPOSE Observational studies of dietary fat intake and breast cancer have reported inconsistent findings. This topic was addressed in additional analyses of the Women’s Health Initiative (WHI) Dietary Modification (DM) clinical trial that evaluated a low-fat dietary pattern influence on breast cancer incidence. METHODS In the WHI DM trial, 48,835 postmenopausal women, ages 50-79 years, with no prior breast cancer, and a dietary fat intake of ≥ 32% of energy were randomly assigned at 40 US centers to a usual diet comparison group (60%) or dietary intervention group (40%). The goals were to reduce fat intake to 20% of energy and increase vegetable, fruit, and grain intake. Breast cancers were confirmed after central medical record review and serial National Death Index linkages to enhance mortality findings. RESULTS During 8.5 years of dietary intervention, breast cancer incidence and deaths as a result of breast cancer were nonsignificantly lower in the intervention group, while deaths after breast cancer were statistically significantly lower both during intervention and through a 16.1-year (median) follow-up. Now, after a long-term, cumulative 19.6-year (median) follow-up, the significant reduction in deaths after breast cancer persists (359 [0.12%] v 652 [0.14%] deaths; hazard ratio [HR], 0.85; 95% CI, 0.74 to 0.96; P = .01), and a statistically significant reduction in deaths as a result of breast cancer (breast cancer followed by death attributed to the breast cancer) emerged (132 [0.037%, annualized risk] v 251 [0.047%] deaths, respectively; HR, 0.79; 95% CI, 0.64 to 0.97; P = .02). CONCLUSION Adoption of a low-fat dietary pattern associated with increased vegetable, fruit, and grain intake, demonstrably achievable by many, may reduce the risk of death as a result of breast cancer in postmenopausal women.

Produksi Dan Ekstraksi Inhibitor Alfa Glukosidase Dari Isolat Aktinomiset Jp-3

2016 ◽  
Vol 17 (2) ◽  
pp. 123
Author(s):  
Sri Pujiyanto ◽  
Rejeki Siti Ferniah ◽  
Sunarno S
Keyword(s):  
Ethyl Acetate ◽  
Active Compound ◽  
Inhibitor Activity ◽  
Glucosidase Inhibitor ◽  
Glucosidase Inhibitors ◽  
Complex Carbohydrates ◽  
Diabetes Drug ◽  
Chloroform Methanol ◽  
Alpha Glucosidase

Alpha-glucosidase inhibitors are compounds that can prevent the digestion of complex carbohydrates into glucose, so potentially used as a diabetes drug. This study aims to examine the production and extraction of alpha-glucosidase inhibitor compound from Isolate Aktinomiset JP-3 from the sea. The supernatant obtained from the culture of the JP-3 isolate was extracted using various solvents to obtain the active compound. The solvents used were chloroform, methanol, and ethyl acetate. An assay of inhibitor activity of the α-glucosidase using p-nitrophenyl α-D-glucopyranoside substrate. The activity of the enzyme is measured based on the absorbance of p-nitrophenol produced from the breaking reaction of the substrate. The results showed that extraction of alpha-glucosidase inhibitor compound with ethyl acetate yielded extract with highest inhibitor activity. Keywords: alpha-glucosidase inhibitors, actinomycetes, diabetes, extraction, fractionation

Long-term effect of alpha-glucosidase inhibitor on late dumping syndrome

1998 ◽  
Vol 13 (12) ◽  
pp. 1201-1206 ◽  
Author(s):  
TAKENAO HASEGAWA ◽  
MASASHI YONEDA ◽  
KIMIHIDE NAKAMURA ◽  
KUNIYO OHNISHI ◽  
HIROYUKI HARADA ◽  
...  
Keyword(s):  
Term Effect ◽  
Dumping Syndrome ◽  
Glucosidase Inhibitor ◽  
Long Term Effect ◽  
Late Dumping Syndrome ◽  
Alpha Glucosidase
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