scholarly journals Rapid and Economic Access to Some NSAIDS-Based Bioactive Heterocycles

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
A. V. Chavan ◽  
R. R. Somani ◽  
P. P. Kalantri ◽  
D. T. Makhija
Keyword(s):  
Reaction Time ◽  
Microwave Synthesis ◽  
Microwave Energy ◽  
The Other ◽  
Microwave Assisted Synthesis ◽  
Simple Method ◽  
Short Reaction Time ◽  
Microwave Assisted ◽  
Target Molecules ◽  
Bioactive Heterocycles

The use of microwave energy for the synthesis is considered as one of the alternate strategies. The present work includes the synthesis of some newer 2,5-disubstituted-1,3,4-oxadiazole analogues using both conventional and alternate rapid methods.The conventional method involves the synthesis of the target molecules by using cyclodehydrating agent like POCl3, while the other method consists of using some catalytic reagents like PbO2. Also, the short reaction time provided by microwave synthesis makes it ideal for the reaction. Hence, this project describes an efficient and operationally simple method for the microwave-assisted synthesis of some bioactive heterocycles based on NSAIDs.

scholarly journals Microwave assisted synthesis of five membered nitrogen heterocycles

RSC Advances ◽  
2020 ◽  
Vol 10 (59) ◽  
pp. 36031-36041
Author(s):  
Gopinadh Meera ◽  
K. R. Rohit ◽  
Salim Saranya ◽  
Gopinathan Anilkumar
Keyword(s):  
Reaction Time ◽  
Nitrogen Heterocycles ◽  
Product Formation ◽  
Microwave Assisted Synthesis ◽  
Short Reaction Time ◽  
Microwave Assisted ◽  
High Yields

Microwave assisted synthesis of N-heterocycles with short reaction time, high yields and high product purities along with a decrease in the rate of by-product formation.

scholarly journals DABCO Catalyzed Synthesis of Xanthene Derivatives in Aqueous Media

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Pradeep Paliwal ◽  
Srinivasa Rao Jetti ◽  
Anjna Bhatewara ◽  
Tanuja Kadre ◽  
Shubha Jain
Keyword(s):  
Reaction Time ◽  
Aqueous Media ◽  
Environmentally Friendly ◽  
The Other ◽  
Short Reaction Time ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Conventional Methods

The reaction of 5,5-dimethylcyclohexane-1,3-dione with various heteroarylaldehydes afforded the corresponding heteroaryl substituted xanthene derivatives 1(a–f). The reaction proceeds via the initial Knoevenagel, subsequent Michael, and final heterocyclization reactions using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalyst in aqueous media. The synthesized heteroaryl substituted xanthenes 1(a–f) reacted with malononitrile to obtain different alkylidenes 2(a–f). Short reaction time, environmentally friendly procedure, avoiding of cumbersome apparatus, and excellent yields are the main advantages of this procedure which makes it more economic than the other conventional methods.

Size-Controlled Microwave-Assisted Synthesis of Water-Dispersible Cd(Se,S) Quantum Dots for Potential Biological Applications

2015 ◽  
Vol 1784 ◽  
Author(s):  
E. Calderón-Ortiz ◽  
S. Bailón-Ruiz ◽  
L. Alamo-Nole ◽  
J. Rodriguez-Orengo ◽  
O. Perales-Perez
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Reaction Time ◽  
Reaction Temperature ◽  
Quantum Confinement Effect ◽  
Reactive Oxygen Species Generation ◽  
Size Control ◽  
Average Crystallite Size ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

ABSTRACTNanomedicine is fostering significant advances in the development of platforms for early detection and treatment of diseases. Nanoparticles (NPs) like quantum dots (QDs) exhibit size-dependent optical properties for light-driven technologies, which might become important in bio-imaging, sensing and photo-dynamic therapy (PDT) applications. The present research addresses the synthesis of water-stable Cd-based QDs via a Microwave-Assisted synthesis approach using cadmium sulfate salt, and thioglycolic acid as Cd- and S-precursors, respectively. Selenide ions were available by reductive leaching of metallic Selenium in Sodium bisulfite solution. The size control and the tunability of the optical properties were achieved by a suitable control of the reaction temperature (in the 140°C- 190°C range) and reaction time (10 minutes-40 minutes). X-ray diffraction analyses suggested the development of a CdSe,S face cubic centered structure; the broadening of the diffraction peaks indicated the presence of very small nanocrystals in the samples. The average crystallite size was estimated at 5.50 nm ± 1.17nm and 3.72 nm ± 0.04 nm, for nanoparticles synthesized at 180°C after 40 minutes or 10 minutes of reaction, respectively. HRTEM images confirmed the crystalline nature and the small size of the synthesized nanocrystals. In turn, the exciton was red-shifted from 461nm to 549 nm when the reaction temperature was prolonged from 140°C to 190 °C, suggesting the crystal growth. The corresponding band gap values were approximately 2.2 eV, confirming the quantum confinement effect (bulk value 1.74eV). This red shift was also evidenced in PL measurements where the main emission peak was shifted from 507 nm to 564 nm when the samples were excited at 420 nm. A narrow size-tunable emission also was supported by the full width at half maximum (∼ 45 nm) for the synthesized nanocrystals. The reactive oxygen species generation capability of as-synthesized QDs was also investigated. The correlation between the particle size and the generation of (ROS) by the degradation of methylene blue was evident with a reduction of MB concentration from 10μM to 7.5μM and 6.7μM after 15 minutes of UV irradiation for reaction time of 10 min. and 40 min. respectively. No additional degradation was noticed after 60 minutes of irradiation.

scholarly journals Microwave Assisted Synthesis of 1,5-Benzothiazepines Using Greener Reaction Medium

2019 ◽  
Vol 31 (5) ◽  
pp. 993-996 ◽  
Author(s):  
Sanjay S. Kotalwar ◽  
Amol D. Kale ◽  
Ram B. Kohire ◽  
Vasant B. Jagrut
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Reaction Medium ◽  
Microwave Assisted Synthesis ◽  
Reaction Conditions ◽  
Renewable Sources ◽  
Microwave Assisted ◽  
High Yields

An efficient and eco-friendly synthesis of 1,5-benzothiazepines has been developed by the reaction of various 2-propen-1-ones with 2-aminothiophenol using microwave irradiation in greener reaction medium, glycerol. The clean reaction conditions, shorter reaction time, high yields and non-toxic, biodegradable reaction medium manufactured from renewable sources are unique features of this method.

Microwave-assisted Diels–Alder polycondensation of proton conducting poly(phenylene)s

2019 ◽  
Vol 10 (13) ◽  
pp. 1668-1685 ◽  
Author(s):  
Michael Adamski ◽  
Thomas J. G. Skalski ◽  
Shaoyi Xu ◽  
Miho Killer ◽  
Eric M. Schibli ◽  
...  
Keyword(s):  
Reaction Time ◽  
Microwave Synthesis ◽  
Diels Alder ◽  
Proton Conducting ◽  
Microwave Assisted ◽  
Fold Reduction ◽  
Sulfonated Poly

A 24-fold reduction in reaction time is achieved in the preparation of sulfonated poly(polyphenylene)s using microwave synthesis.

Microwave-assisted synthesis of porous organic cages CC3 and CC2

CrystEngComm ◽  
2019 ◽  
Vol 21 (31) ◽  
pp. 4534-4537 ◽  
Author(s):  
Jolie Lucero ◽  
Carla Osuna ◽  
James M. Crawford ◽  
Moises A. Carreon
Keyword(s):  
Microwave Synthesis ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

The microwave synthesis of two prototypical porous organic cages, denoted as CC3 and CC2 is demonstrated.

scholarly journals Microwave Assisted One Pot Synthesis of 3,4-Dihydropyrano[c]chromene Derivatives using [Emim]OH Ionic Liquid as Novel Catalyst

2019 ◽  
Vol 31 (4) ◽  
pp. 829-833
Author(s):  
D.S. Bhagat ◽  
S.G. Pande ◽  
M.V. Katariya ◽  
R.P. Pawar ◽  
P.S. Kendrekar
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
High Yield ◽  
Reaction Conditions ◽  
One Pot ◽  
Short Reaction Time ◽  
Aryl Aldehydes ◽  
Microwave Assisted ◽  
Novel Catalyst ◽  
Work Up

One-pot efficient protocol to the synthesis of 2-amino-5-oxo-4,5-dihydropyrano(3,2-c)chromene-3-carbonitrile derivatives via condensation of various aryl aldehydes, dicyanomethane and 4-hydroxycoumarin in presence of Emim hydroxide as an excellent homogeneous liquid catalyst. The key advantages of this methodology are mild reaction conditions, novel catalyst, short reaction time, eco-friendly, easy work-up procedure and high yield of isolation of derivatives.

scholarly journals High-Speed Reduction of Triarylpyrylium Salts Using Zn(BH4)2/SiO2as an Efficient and Regiospecific Reducing Reagent

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Arash Mouradzadegun ◽  
Ali Reza Kiasat ◽  
Somayeh Elahi
Keyword(s):  
Reaction Time ◽  
High Speed ◽  
The Other ◽  
Speed Reduction ◽  
Short Reaction Time

The regiospecific reduction of some triarylpyrylium salts in the presence of modified hydride donors was investigated. Among these reagents, Zn(BH4)2/SiO2performed the best results. The major advantages of this reagent are the cheapness, availability, simplicity in operation, very short reaction time and much improved regioselectivity in comparison with the other reducing reagents.

A Convenient One-Pot and Rapid Microwave-Assisted Synthesis of Biologically Active s-Triazolo[3,4-b][1,3,4]Thiadiazine and s-Triazolo[3,4-b][1,3,4]Thiadiazole Nanoarchitectonics

2020 ◽  
Vol 20 (5) ◽  
pp. 2917-2929
Author(s):  
Ahmed F. M. EL-Mahdy ◽  
Hassan A. H. EL-Sherief ◽  
Zeinab A. Hozien ◽  
Shiao-Wei Kuo
Keyword(s):  
Acetic Acid ◽  
Sulfuric Acid ◽  
Reaction Time ◽  
Catalytic Amount ◽  
Biologically Active ◽  
Microwave Assisted Synthesis ◽  
One Pot ◽  
Microwave Assisted ◽  
Work Up ◽  
Temperature Time

A rapid and efficient one-pot protocol has been developed for the synthesis of s-triazolo[3,4-b][1,3,4]thiadiazine and s-triazolo[3,4-b][1,3,4]thiadiazole nanoarchitectonics through the reaction of s-triazoles with ketones and nitriles in acetic acid containing a catalytic amount of sulfuric acid under microwave irradiation in excellent yields. With this catalytic reaction, the cheap sulfuric acid as well as other acids were examined as catalysts and the highly toxic and irritating haloketones and halonitriles were avoided to form. The effects of microwave power, temperature, time, solvent and catalyst were examined. This method achieved a better performance; e.g., higher yields, shorter reaction time and easier work-up as compared to other conventional methods. Therefore, the proposed method will be readily applicable to the synthesis of biologically important compounds containing s-triazolo[3,4-b][1,3,4]thiadiazine and s-triazolo[3,4-b][1,3,4]thiadiazole framework.

Microwave Synthesis and Properties of Thin Layer Pt Modified TiO2 Nanofibers Coating

2016 ◽  
Vol 721 ◽  
pp. 383-388
Author(s):  
Reinis Drunka ◽  
Jānis Grabis ◽  
Dzidra Jankovica ◽  
Aija Krūmiņa
Keyword(s):  
Thin Layer ◽  
Surface Area ◽  
Visible Light Irradiation ◽  
Microwave Synthesis ◽  
Raw Materials ◽  
Synthesis Method ◽  
Total Surface Area ◽  
Microwave Assisted Synthesis ◽  
Fiber Layer ◽  
Microwave Assisted

In the present work formation of macro-size TiO2 nanofiber layers in microwave synthesis were studied. Anatase nanopowder and 10M KOH solution were used as raw materials. Microwave assisted synthesis method permitted to obtain TiO2 nanofibres containing individual nanowires with a diameter of 5nm and a specific surface area up to 129m2/g. Macro size layer of TiO2 nanofibers was obtained on the surface of microwave vessel. Total surface area covered with TiO2 was about 390cm2. Modification with platinum allows to increase photocatalytical activity of TiO2 macro size fiber layer up to 94.4% in UV irradiation and up to 11.6% under visible light irradiation.

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