scholarly journals Preparation of Polysaccharide-Based Microspheres by a Water-in-Oil Emulsion Solvent Diffusion Method for Drug Carriers

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Yodthong Baimark ◽  
Yaowalak Srisuwan
Keyword(s):  
Electron Microscopy ◽  
Drug Loading ◽  
Drug Carriers ◽  
Water Soluble ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method ◽  
Scanning Electron

Polysaccharide-based microspheres of chitosan, starch, and alginate were prepared by the water-in-oil emulsion solvent diffusion method for use as drug carriers. Blue dextran was used as a water-soluble biomacromolecular drug model. Scanning electron microscopy showed sizes of the resultant microspheres that were approximately 100 μm or less. They were spherical in shape with a rough surface and good dispersibility. Microsphere matrices were shown as a sponge. Drug loading efficiencies of all the microspheres were higher than 80%, which suggested that this method has potential to prepare polysaccharide-based microspheres containing a biomacromolecular drug model for drug delivery applications.

Genipin-cross-linked silk fibroin microspheres prepared by the simple water-in-oil emulsion solvent diffusion method

2010 ◽  
Vol 203 (3) ◽  
pp. 603-608 ◽  
Author(s):  
Thanonchat Imsombut ◽  
Yaowalak Srisuwan ◽  
Prasong Srihanam ◽  
Yodthong Baimark
Keyword(s):  
Silk Fibroin ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method

scholarly journals Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Theeraphol Phromsopha ◽  
Yodthong Baimark
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Average Particle Size ◽  
Water Soluble ◽  
Diffusion Method ◽  
Average Particle ◽  
Blend Ratio ◽  
Oil Emulsion ◽  
Vis Spectroscopy ◽  
Water In Oil Emulsion

Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. Thein vitrodrug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

scholarly journals The NANOSPONGES: AN INNOVATIVE DRUG DELIVERY SYSTEM

2019 ◽  
pp. 60-67
Author(s):  
SIMRANJOT KAUR ◽  
SANDEEP KUMAR
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Active Ingredient ◽  
The Body ◽  
Target Site ◽  
Water Soluble ◽  
Diffusion Method ◽  
Solvent Diffusion ◽  
Emulsion Solvent Diffusion Method

For prolonged time there is a delusion for efficacious targeted drug delivery system, but the chemistry hold complex form had made situations thorny, but the development of new colloidal carrier called nanosponges (NSs) likely circumvent these problems. NSs are the nanoporous particles that can entangle a huge range of material and then be engulfed into a suitable formulation depend on the route of administration. They prevent the drug-protein degradation, lengthen the drug release in a controlled manner, and release the medicament to the target site. They can travel around the body and attach on the surface and liberate the drug in a controlled and predictable manner at the specific target site. They are fine aqueous solubility which makes them a bearer for low water-soluble drugs. Drugs having low bioavailability are best suited for this type of carrier system. Both lipophilic and hydrophilic drugs can be included in NSs. Particle size can change from smaller to bigger by varying the amount of crosslinker to the polymer. Various applications of NSs such as recovering bioavailability of active ingredient molecule and delivery of active ingredient into oral, topical, parenteral, and nasal route make them a superior candidate for targeted delivery of drugs. It can be used as a shipper for biocatalysts in the transport and release of enzymes, proteins, vaccines, and antibodies. They can be prepared by different methods such as emulsion solvent diffusion method, melt method, ultrasound-assisted method, Quasi emulsion solvent diffusion method. This analysis is focusing on the advantages, formulation, evaluation, application, and patent report of the NSs.

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