Morphology and thermal stability of cross-linked silk fibroin microparticles prepared by the water-in-oil emulsion solvent diffusion method

2011 ◽  
Vol 7 ◽  
pp. S112-S117 ◽  
Author(s):  
Yodthong Baimark
Keyword(s):  
Thermal Stability ◽  
Silk Fibroin ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method ◽  
Thermal Stability Of

Genipin-cross-linked silk fibroin microspheres prepared by the simple water-in-oil emulsion solvent diffusion method

2010 ◽  
Vol 203 (3) ◽  
pp. 603-608 ◽  
Author(s):  
Thanonchat Imsombut ◽  
Yaowalak Srisuwan ◽  
Prasong Srihanam ◽  
Yodthong Baimark
Keyword(s):  
Silk Fibroin ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method

scholarly journals Preparation of Polysaccharide-Based Microspheres by a Water-in-Oil Emulsion Solvent Diffusion Method for Drug Carriers

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Yodthong Baimark ◽  
Yaowalak Srisuwan
Keyword(s):  
Electron Microscopy ◽  
Drug Loading ◽  
Drug Carriers ◽  
Water Soluble ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method ◽  
Scanning Electron

Polysaccharide-based microspheres of chitosan, starch, and alginate were prepared by the water-in-oil emulsion solvent diffusion method for use as drug carriers. Blue dextran was used as a water-soluble biomacromolecular drug model. Scanning electron microscopy showed sizes of the resultant microspheres that were approximately 100 μm or less. They were spherical in shape with a rough surface and good dispersibility. Microsphere matrices were shown as a sponge. Drug loading efficiencies of all the microspheres were higher than 80%, which suggested that this method has potential to prepare polysaccharide-based microspheres containing a biomacromolecular drug model for drug delivery applications.

scholarly journals Studying the effect of variables on baclofen floating microsponge

2019 ◽  
Vol 10 (3) ◽  
pp. 1300-1306
Author(s):  
Faten Q. Ibraheem ◽  
Anmar A. Abdelrazzaq
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Diffusion Method ◽  
In Vitro Drug Release ◽  
Aqueous Emulsion ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Stirring Time ◽  
Emulsion Solvent Diffusion Method

The aim of the present work was to develop a microsponge delivery system of baclofen to control its release and thereby reducing dosing frequency and enhancing patient compliance. The microsponge was produced by oil in oil emulsion solvent diffusion method. The effects of drug/polymer ratio, stirring time and type of Eudragit polymer on the physical characteristics of microsponges were investigated. The prepared microsponges was characterized for production yield (PY), loading efficiency (LD), particle size, surface morphology, and in vitro drug release. The results showed that the microsponge formula with Eudragit RS100 had optimum physical properties with PY % equal to 97 %, and LD % equal to 81% and controlled drug release (75% of drug release in 8 hours) when compared with other formulas and pure BFN. Therefore, the non-‎aqueous emulsion solvent diffusion method is a promising method to produce baclofen microsponges.‎

scholarly journals Studying the effect of variables on Acyclovir microsponge

2018 ◽  
pp. 66-76
Author(s):  
Noor Yousif Fareed ◽  
Hanan Jalal Kassab
Keyword(s):  
Drug Release ◽  
Production Yield ◽  
Diffusion Method ◽  
In Vitro Drug Release ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Loading Efficiency ◽  
Internal Phase ◽  
Emulsion Solvent Diffusion Method

The aim of the present investigation was to develop a microsponge delivery system of acyclovir to control its release when applied topically thereby reducing dosing frequency and enhancement patient compliance. The microsponges were produced by the oil in oil emulsion solvent diffusion method. The effect of different formulation and process variables such as internal phase volume, polymer type, drug-polymer ratio, stirring speed and stirring duration on microsponge production yield, loading efficiency, particle size and in-vitro drug release was evaluated. The result showed that the microsponge F2 prepared from Eudrajet RS polymer had optimum physical properties regarding the loading efficiency of 99.71_+ 0.7% and production yield which was 85%. Also, F2 showed 66% drug release within 8 hours. Accordingly, the oil in oil emulsion solvent diffusion method is an effective technique to formulate microsponges with maximum production yield and loading efficiency for acyclovir.

scholarly journals PREPARATION, CHARACTERIZATION AND EVALUATION OF POLY (LACTIDE –CO –GLYCOLIDE) MICROSPHERES FOR THE CONTROLLED RELEASE OF ZIDOVUDINE

2017 ◽  
Vol 9 (12) ◽  
pp. 70 ◽  
Author(s):  
Seema Kohli ◽  
Abhisek Pal ◽  
Suchit Jain
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Double Emulsion ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Average Particle ◽  
Plga Microspheres ◽  
Good Reproducibility ◽  
Solvent Diffusion ◽  
Emulsion Solvent Diffusion Method

Objective: The purpose of this research work was to develop and evaluate microspheres appropriate for controlled release of zidovudine (AZT).Methods: The AZT loaded polylactide-co-glycolide (PLGA) microspheres were prepared by W/O/O double emulsion solvent diffusion method. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). The influence of formulation factors (drug: polymer ratio, stirring speed, the concentration of surfactant) on particle size encapsulation efficiency and in vitro release characteristics of the microspheres was investigated. Release kinetics was studied and stability study was performed as per ICH guidelines.Results: Scanning electron microscopy (SEM) images show good reproducibility of microspheres from different batches. The average particle size was in the range of 216-306 μm. The drug-loaded microspheres showed 74.42±5.08% entrapment efficiency. The cumulative percentage released in phosphate Buffer solution (PBS) buffer was found to be 55.32±5.89 to 74.42±5.08 %. The highest regressions (0.981) were obtained for zero order kinetics followed by Higuchi (0.968) and first order (0.803).Conclusion: Microsphere prepared by double emulsion solvent diffusion method was investigated and the results revealed that 216-306 μm microsphere was successfully encapsulated in a polymer. FT-IR analysis, entrapment efficiency and SEM Studies revealed the good reproducibility from batch to batch. The microspheres were of an appropriate size and suitable for oral administration. Thus the current investigation show promising results of PLGA microspheres as a matrix for drug delivery and merit for In vivo studies for scale up the technology.

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