scholarly journals Destination Memory in Mild Alzheimer’s Disease

2013 ◽  
Vol 26 (3) ◽  
pp. 215-216 ◽  
Author(s):  
Mohamad El Haj ◽  
Virginie Postal ◽  
Didier Le Gall ◽  
Philippe Allain
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Destination Memory

Destination memory in Alzheimer’s Disease: When I imagine telling Ronald Reagan about Paris

Cortex ◽  
2013 ◽  
Vol 49 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Mohamad El Haj ◽  
Virginie Postal ◽  
Philippe Allain
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ronald Reagan ◽  
Destination Memory

Emotion and Destination Memory in Alzheimer’s Disease

2015 ◽  
Vol 12 (8) ◽  
pp. 796-801 ◽  
Author(s):  
Mohamad El Haj ◽  
Stephane Raffard ◽  
Pascal Antoine ◽  
Marie-Christine Gely-Nargeot
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Destination Memory

scholarly journals Cognitive Theory of Mind Influences Destination Memory: Evidence from Normal Aging and Alzheimer’s Disease

2019 ◽  
Vol 34 (8) ◽  
pp. 1409-1417 ◽  
Author(s):  
Mohamad El Haj ◽  
Philippe Allain ◽  
Ahmed A Moustafa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Theory Of Mind ◽  
Beneficial Effect ◽  
Cognitive Theory ◽  
Normal Aging ◽  
Future Research ◽  
Destination Memory ◽  
Social Abilities ◽  
Individual Profiles

AbstractObjectiveTheory of mind and destination memory are social abilities that require processing the attributes of interlocutors. Empirical research has demonstrated a relationship between performance on both abilities in normal aging and Alzheimer’s disease (AD). We therefore investigated whether processing attributes of interlocutors would result in better destination memory in AD.MethodsTwenty-six mild AD participants and 28 controls were tested on two occasions. On the first one, participants had to tell proverbs to celebrities’ faces. Following that, they decided whether they previously told that proverb to that celebrity or not. The same procedures were repeated on the second occasion; however, after telling the proverbs, participants had to introspect about what the celebrities might think about the proverbs (e.g., “what do you think that the celebrities would think about the proverbs?”).ResultsGroup comparisons showed a beneficial effect of introspection on destination memory in controls (Z = −2.57, p < .05) but not in AD participants (Z = −1.05, p = .29). However, analyzes of individual profiles demonstrated that 15 AD participants demonstrated better destination memory after introspection.ConclusionsOur findings show a beneficial effect of introspection on destination memory in normal aging, and at least in some mild AD cases. Future research should investigate the influence of social cognition on memory in AD and how introspection may provide a potential treatment for AD.

Destination Memory and Cognitive Theory of Mind in Alzheimer’s Disease

2015 ◽  
Vol 48 (2) ◽  
pp. 529-536 ◽  
Author(s):  
Mohamad El Haj ◽  
Marie-Christine Gély-Nargeot ◽  
Stéphane Raffard
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Theory Of Mind ◽  
Cognitive Theory ◽  
Destination Memory

scholarly journals “Forget to Whom You Have Told This Proverb”: Directed Forgetting of Destination Memory in Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Mohamad El Haj ◽  
Marie-Charlotte Gandolphe ◽  
Philippe Allain ◽  
Luciano Fasotti ◽  
Pascal Antoine
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Irrelevant Information ◽  
Directed Forgetting ◽  
The Other ◽  
Elderly Subjects ◽  
Destination Memory ◽  
Healthy Elderly ◽  
Inhibitory Deficits ◽  
Healthy Elderly Subjects

Destination memory is the ability to remember the receiver of transmitted information. By means of a destination memory directed forgetting task, we investigated whether participants with Alzheimer’s Disease (AD) were able to suppress irrelevant information in destination memory. Twenty-six AD participants and 30 healthy elderly subjects were asked to tell 10 different proverbs to 10 different celebrities (List 1). Afterwards, half of the participants were instructed to forget the destinations (i.e., the celebrities) whereas the other half were asked to keep them in mind. After telling 10 other proverbs to 10 other celebrities (List 2), participants were asked to read numbers aloud. Subsequently, all the participants were asked to remember the destinations of List 1 and List 2, regardless of the forget or remember instructions. The results show similar destination memory in AD participants who were asked to forget the destinations of List 1 and those who were asked to retain them. These findings are attributed to inhibitory deficits, by which AD participants have difficulties to suppress irrelevant information in destination memory.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Formation of paired helical filaments in Alzheimer's disease

1984 ◽  
Vol 42 ◽  
pp. 302-303
Author(s):  
J. Metuzals ◽  
D. F. Clapin ◽  
V. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Normal Brain ◽  
Protein Assemblies ◽  
Electron Microscopic ◽  
Helical Symmetry ◽  
Structural Levels

Information on the conformation of paired helical filaments (PHF) and the neurofilamentous (NF) network is essential for an understanding of the mechanisms involved in the formation of the primary lesions of Alzheimer's disease (AD): tangles and plaques. The structural and chemical relationships between the NF and the PHF have to be clarified in order to discover the etiological factors of this disease. We are investigating by stereo electron microscopic and biochemical techniques frontal lobe biopsies from patients with AD and squid giant axon preparations. The helical nature of the lesion in AD is related to pathological alterations of basic properties of the nervous system due to the helical symmetry that exists at all hierarchic structural levels in the normal brain. Because of this helical symmetry of NF protein assemblies and PHF, the employment of structure reconstruction techniques to determine the conformation, particularly the handedness of these structures, is most promising. Figs. 1-3 are frontal lobe biopsies.

Computer-aided methods for 3-D visualization of serial sections and thick biological specimens

1992 ◽  
Vol 50 (2) ◽  
pp. 1060-1061
Author(s):  
Mark Ellisman ◽  
Maryann Martone ◽  
Gabriel Soto ◽  
Eleizer Masliah ◽  
David Hessler ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Three Dimensional ◽  
Neuritic Plaque ◽  
Dimensional Structure ◽  
Data Sets ◽  
Molecular Physiology ◽  
Research Activities ◽  
Computer Aided ◽  
Dimensional Reconstruction

Structurally-oriented biologists examine cells, tissues, organelles and macromolecules in order to gain insight into cellular and molecular physiology by relating structure to function. The understanding of these structures can be greatly enhanced by the use of techniques for the visualization and quantitative analysis of three-dimensional structure. Three projects from current research activities will be presented in order to illustrate both the present capabilities of computer aided techniques as well as their limitations and future possibilities.The first project concerns the three-dimensional reconstruction of the neuritic plaques found in the brains of patients with Alzheimer's disease. We have developed a software package “Synu” for investigation of 3D data sets which has been used in conjunction with laser confocal light microscopy to study the structure of the neuritic plaque. Tissue sections of autopsy samples from patients with Alzheimer's disease were double-labeled for tau, a cytoskeletal marker for abnormal neurites, and synaptophysin, a marker of presynaptic terminals.

Liquid crystalline ordering of paired helical filaments in neurofibrillary tangles of Alzheimer's disease

1986 ◽  
Vol 44 ◽  
pp. 348-349
Author(s):  
D.F. Clapin ◽  
V.J.A. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Liquid Crystalline ◽  
Amyloid Fibrils ◽  
Geometric Analysis ◽  
Paired Helical Filaments ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Regular Spacing

Alzheimer's disease is characterized by the accumulation of abnormal filamentous proteins. The most important of these are amyloid fibrils and paired helical filaments (PHF). PHF are located intraneuronally forming bundles called neurofibrillary tangles. The designation of these structures as "tangles" is appropriate at the light microscopic level. However, localized domains within individual tangles appear to demonstrate a regular spacing which may indicate a liquid crystalline phase. The purpose of this paper is to present a statistical geometric analysis of PHF packing.

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