scholarly journals Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Stepanka Pruhova ◽  
Petra Dusatkova ◽  
Pavel J. Kraml ◽  
Michal Kulich ◽  
Zdena Prochazkova ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Macrovascular Complications ◽  
Family Status ◽  
Dominant Form ◽  
Media Thickness ◽  
Mutation Carriers ◽  
Mild Hyperglycemia ◽  
Autosomal Dominant Form

Aim.GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY.Methods.Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained.Results.The mean CIMT was 0.707 ± 0.215 mm (mean ± SD) in GCK mutation carriers and 0.690 ± 0.180 mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049 mm (P=0.19). No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL);P<0.0001) and glycated hemoglobin HbA1c(GCK-MODY 6.9% ± 1.0%, 52 mmol/mol ± 10; controls 5.7% ± 0.4%, 39 mmol/mol ± 3;P<0.0001). The frequency of myocardial infarction and ischemic stroke did not differ between groups.Conclusion.Our data indicate that the persistent hyperglycemia in GCK-MODY is associated with a low risk of developing diabetic macrovascular complications.

scholarly journals Effect of Sesame Lignan Supplementation on Carotid Intima-Media Thickness, Serum Lipid Profile, Serum VEGF, VCAM-1, ICAM-1 and vWF Levels in Cardiovascular Disease Patients

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Marzieh Mokhber ◽  
Ali Keshavarz ◽  
Farzad Shidfar ◽  
Abbas Hadji Akhundi ◽  
Hamidreza Pouraliakbar ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Levels ◽  
Serum Lipid Profile ◽  
Controlled Clinical Trial ◽  
Media Thickness ◽  
Sesame Lignans

Background: Atherosclerosis is a chronic inflammatory disease of the vascular wall which can alter the whole vascular system of both the aorta and coronary arteries. Sesame seeds are one of the richest sources of dietary lignans which exhibit diverse functions and valuable effects such as anti-hypertensive, anti-inflammatory, and anti-oxidative activities. Objectives: In this study, the Effect of sesame lignans on carotid intima-media thickness (CIMT), serum lipid profile, and serum levels of VEGF, VCAM-1, ICAM-1 and vWF were evaluated in cardiovascular (CVD) patients. Methods: In this double-blind, randomized, placebo-controlled clinical trial, thirty-six CVD patients who were candidates for angiography participated for 10 weeks. The subjects were asked to use 500 mg/day sesame lignans (lignan group, n = 19) or placebo (placebo group (starch), n = 17). The CIMT was measured by ultrasound and fasting blood samples were taken before and after the intervention. Results: Sesame lignans supplementation showed a significant decrease in both left and right CIMT, serum lipid profile, fasting blood glucose, and ICAM-1 serum levels compared to baseline and placebo (P < 0.05). Conclusions: These findings indicate that sesame lignans may contribute to the reduction of CIMT and prevent future cardiovascular events and so may be considered as a complementary therapeutic approach in CVD

scholarly journals Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
B. N. Okeahialam ◽  
S. A. Muoneme ◽  
H. O. Kolade-Yunusa
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Threshold Level ◽  
Carotid Intima Media Thickness ◽  
Postprandial Blood Glucose ◽  
Atherosclerotic Vascular Disease ◽  
Media Thickness ◽  
Significant Difference ◽  
Post Hoc

Background/Aims. Carotid intima media thickness (CIMT) tracks atherosclerotic vascular disease. Hypertension and diabetes chiefly contribute to atherosclerosis with 75% of symptomatic cardiovascular disease cases having dysglycaemia even in normal cases. Hypothesising that postprandial hyperglycaemia contributes to cardiovascular morbidity, we sought to determine if any relationship existed between glycaemic profile in nondiabetic hypertensives and atherosclerosis.Methods. In a study of CIMT in nondiabetic, statin-naïve hypertensives, we evaluated fasting blood glucose (FBG) and 2-hour postprandial sugar (2hPPBG) in the patients and compared them with the CIMT. CIMT was measured on both sides, 1 cm proximal to the carotid bulb using a 7.5 mHz transducer of ALOKA SSD-3500 ultrasound machine.Results. The subjects with complete data were 86 (63 F). The mean (SD) of CIMT was 0.89 (0.15) mm, FBG 4.8 (0.097) mmol/L, and 2hPPBG 6.5 (1.81) mmol/L. There was no significant correlation between FBG and 2hPPBG with CIMT. Blood pressure had no bearing on this. When blood glucose data were divided into quartiles and post hoc multiple comparison was done, there was significant difference in CIMT for the different ranges. This was not so for 2hPPBG.Conclusion. Though expected from other studies, we did not show any significant correlation between FBG and 2hPPBG status and CIMT. This may be our pattern as the degree of excursion of 2hPPBG was low. There may be a threshold level above which PPBG starts to impact CIMT.

scholarly journals Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis

2018 ◽  
Vol 50 (2) ◽  
pp. 452-459 ◽  
Author(s):  
Yu-Qing Huang ◽  
Jie Li ◽  
Cheng Huang ◽  
Ying-Qing Feng
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Multiple Linear Regression Analysis ◽  
Control Group ◽  
Media Thickness ◽  
Potential Biomarker

Background/Aims: Atherosclerosis is a serious disease that increases the risk of myocardial infarction and ischemic stroke. Previous studies have demonstrated that microRNA (miR)-29c could play significant roles in atherosclerosis via regulating inflammatory processes. However, the relationship between miR-29c and carotid intima-media thickness (CIMT) remains unknown. This study investigated associations between miR-29c and atherosclerosis and tested whether plasma miR-29c levels could be used to detect atherosclerosis. Methods: Plasma miR-29c levels were estimated by quantitative real-time PCR, and CIMT was measured by carotid ultrasound. Associations between miR-29c and CIMT were assessed by Spearman’s correlation coefficient and multiple linear regression analyses. Results: In total, 170 participants were divided into the study (CIMT ≥0.9 mm) and control (CIMT < 0.9 mm) groups. The study group showed higher C-reactive protein (CRP) and miR-29c relative expression levels compared with the control group. CIMT was positively correlated with miR-29c (r=0.659, p< 0.001) and CRP (r=0.447, p< 0.001), and miR-29c levels were also correlated with CRP (r=0.512, p< 0.001). Furthermore, multiple linear regression analysis showed that CIMT was significantly correlated with miR-29c (β=0.573, 95% confidence interval [CI]: 0.315-0.839; p< 0.001) and CRP (β=0.439, 95%CI: 0.186–0.825; p< 0.001). After age, body mass index, systolic blood pressure, total cholesterol and fasting blood-glucose were adjusted for, CIMT was still closely associated with miR-29c (β=0.529, 95%CI: 0.354–0.812; p< 0.001) and CRP (β=0.417, 95%CI: 0.198–0.724; p< 0.001). Evaluating CRP and miR-29c together (AUC=0.900, p< 0.001) achieved a better prognostic value for atherosclerosis than miR-29c (AUC=0.870, p< 0.001) or CRP (AUC=0.722, p< 0.001) alone. Conclusion: Increased miR-29c was closely associated with CIMT and may serve as a biomarker for identifying atherosclerotic patients.

Correlation of Serum Sclerostin Levels with Carotid Intima Media Thickness in Chronic Kidney Disease Hemodialysis

2020 ◽  
Vol 6 (1) ◽  
pp. 18-26
Author(s):  
Adhi Permana ◽  
Ian Effendi ◽  
Taufik Indrajaya
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Ultrasound Examination ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
The Mean ◽  
Sclerostin Level ◽  
Hemodialysis Duration

Chronic kidney disease is associated with a high mortality rate, especially cardiovascular disease associated with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing the occurrence of vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The aim of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing hemodialysis. In this cross section, the concentration of sclerostin was measured by examination of enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are declared high if above 162 pg / ml there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis duration is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.

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