scholarly journals Hierarchical Structures and Shaped Particles of Bioactive Glass and ItsIn VitroBioactivity

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
U. Boonyang ◽  
F. Li ◽  
A. Stein
Keyword(s):  
Body Temperature ◽  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Body Fluid ◽  
Colloidal Crystals ◽  
Hierarchical Structures ◽  
The Other ◽  
Bioactive Glasses ◽  
Ordered Macroporous

In this study, bioactive glass particles with controllable structure and porosity were prepared using dual-templating methods. Block copolymers used as one template component produced mesopores in the calcined samples. Polymer colloidal crystals as the other template component yielded either three-dimensionally ordered macroporous (3DOM) products or shaped bioactive glass nanoparticles. Thein vitrobioactivity of these bioactive glasses was studied by soaking the samples in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time and monitoring the formation of bone-like apatite on the surface of the bioactive glass. A considerable bioactivity was found that all of bioactive glass samples have the ability to induce the formation of an apatite layer on its surface when in contact with SBF. The development of bone-like apatite is faster for 3DOM bioactive glasses than for nanoparticles.

scholarly journals The Atomic-Scale Interaction of Bioactive Glasses with Simulated Body Fluid

2005 ◽  
Vol 480-481 ◽  
pp. 21-26 ◽  
Author(s):  
L.J. Skipper ◽  
F.E. Sowrey ◽  
D.M. Pickup ◽  
R.J. Newport ◽  
K.O. Drake ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Sol Gel ◽  
Atomic Scale ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Edge Structure ◽  
X Ray ◽  
X Ray Absorption

The formation of a carbonate-containing hydroxyapatite, HCAp, layer on bioactive calcium silicate sol-gel glass of the formula (CaO)0.3(SiO2)0.7 has been studied in-vitro in Simulated Body Fluid (SBF). Extended X-ray Absorption Fine Structure (EXAFS), X-ray Absorption Near Edge Structure (XANES), X-ray diffraction (XRD), and solid state nuclear magnetic resonance (NMR) measurements have been performed with results showing the formation of a significantly amorphous HCAp layer after less than 5 hours in solution.

Growth of Hydroxyapatite on Strontium Oxide Modified Bioactive Glass

2015 ◽  
Vol 1107 ◽  
pp. 397-402
Author(s):  
H.J.M. Ridzwan ◽  
N.H. Jamil ◽  
S.A. Syamsyir ◽  
W.A.W. Razali
Keyword(s):  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Body Fluid ◽  
Sol Gel ◽  
Amorphous State ◽  
Strontium Oxide ◽  
Bioactive Glasses ◽  
Xrd Pattern ◽  
Gel Method ◽  
Sol Gel Method

The bioactive glasses of SiO2-CaO-P2O5-SrO system have been prepared by a quick alkali mediated sol-gel method. The prepared bioactive glass of 1, 3, 5 wt% of SrO (coded: SR1, SR3, SR5, respectively) were characterized by SEM, XRD and FTIR. XRD pattern of all glasses calcined at 700°C in air confirmed that the calcined bioactive glass generally existed in amorphous state. The samples were immersed in simulated body fluid (SBF) to investigate the presence of hydroxyapatite (HA). All bioactive glass samples can induce the formation of hydroxyapatite (HA) as verified by SEM and XRD.

scholarly journals Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4834
Author(s):  
Laura Aalto-Setälä ◽  
Peter Uppstu ◽  
Polina Sinitsyna ◽  
Nina C. Lindfors ◽  
Leena Hupa
Keyword(s):  
Phase Composition ◽  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Surgical Procedures ◽  
Continuous Flow ◽  
Body Fluid ◽  
Glass Composition ◽  
Ion Release ◽  
High Tendency

The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.

scholarly journals Flexible organic–inorganic hybrid bioceramic for bone tissue regeneration

2020 ◽  
Vol 10 (04) ◽  
pp. 2050013
Author(s):  
Jing Chen ◽  
Xingmei Zhang ◽  
Beibei Li ◽  
Yawei Yang
Keyword(s):  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Tissue Regeneration ◽  
Body Fluid ◽  
Bone Tissue Regeneration ◽  
Osteoblast Cell ◽  
Butylene Succinate ◽  
Inorganic Hybrid ◽  
Cell Biocompatibility

Development of novel biomaterials for bone regeneration is based on the sufficient bone-bonding ability, bioactivity and biocompatibility. In this study, novel flexible poly(butylene succinate)/polydimethysiloxane-modified bioactive glass/nano-hydroxyapatite (PBSu/PDMS-BG/nHA) hybrid bioceramic with various nHA concentration on the in vitro bone-like hydroxyapatite (HA) formation, biomineralization activity and osteoblast cell biocompatibility were investigated. The rapid precipitation of HA on the hybrid bioceramic surfaces was found after being immersed in simulated body fluid (SBF) for seven days. Results show that the amount of HA deposition increased with the increase of nHA concentration. The optimized PBSu/PDMS-BG/nHA hybrid bioceramic exhibited good flexibility, high biomineralization activity and good osteoblast cell biocompatibility.

scholarly journals Nghiên cứu tính chất vật liệu thủy tinh y sinh 45S tổng hợp từ nguyên liệu chính cát trắng

2017 ◽  
Vol 33 (2) ◽  
Author(s):  
Bùi Xuân Vương
Keyword(s):  
Simulated Body Fluid ◽  
Cell Viability ◽  
Bioactive Glass ◽  
Body Fluid ◽  
In Vitro Bioactivity ◽  
Melting Method ◽  
Good Cell ◽  
Glass Powders

A bioactive glass 46S6 with composition 46% SiO2 - 24% CaO - 24% Na2O - 6% P2O5 (wt%) was elaborated by melting method. ‘‘In vitro’’ bioactivity of bio-glass was evaluated by soaking of glass-powders in a simulated body fluid (SBF) at different times. The obtained results highlighted the bioactivity of the bio-glass by the formation of a bioactive hydroxyapatite (HA) layer on its surface. Experiments ''in vitro'' in the presence of cells confirmed the non-toxicity and the good cell viability on this bio-glass.

In Vitro Bioactivity of Composite of Nanophase Titania/Bioactive Glass-Ceramic in Simulated Body Fluid

2005 ◽  
Vol 288-289 ◽  
pp. 171-174
Author(s):  
Hui Wang ◽  
Bang Cheng Yang ◽  
Qi Feng Yu ◽  
Dayi Wu ◽  
Xing Dong Zhang
Keyword(s):  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Glass Ceramic ◽  
Body Fluid ◽  
Mechanical Analysis ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
X Ray ◽  
Biomechanical Compatibility

Titania ceramics is lack of bone-bonding ability even if it has excellent biocompatibility. Recently, it is even found that the nanophase titania ceramics could enhance the proliferation of osteoblasts. If the bone-bonding ability of this material is improved, it would be a potential bone replacement material. Bioactive glass-ceramic (BGC) is provided with the best bioactivity in biomaterials. In this study, the apatite formation ability and the mechanic properties of titania ceramic were investigated by the accession of BGC. Four samples: TiO2 ceramic, TiO2 +10%BGC, TiO2 +20%BGC and BGC were prepared respectively. These ceramics were exposed to a simulated body fluid (SBF) for 7, 14 and 21d. Scanning electron microscopy (SEM), energy dispersive X-ray detector (EDX) and thin film X-ray diffraction (TF-XRD) results showed that the apatite formation of the ceramics was improved by adding BGC into nanophase titania ceramic. The mechanical analysis showed the biomechanical compatibility was also improved by adding BGC into nanophase titania ceramic.

In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles

2005 ◽  
Vol 284-286 ◽  
pp. 655-658 ◽  
Author(s):  
Kai Zhang ◽  
Newell R. Washburn ◽  
Joseph M. Antonucci ◽  
Carl G. Simon
Keyword(s):  
Body Fluid ◽  
Colloidal Crystal ◽  
Sol Gel ◽  
Molar Fraction ◽  
Bioactive Glasses ◽  
Templating Method ◽  
Sol Gel Process ◽  
Colloidal Crystal Templating ◽  
Ordered Macroporous

Three dimensionally ordered macroporous sol-gel bioactive glasses (3DOM-BGs)are a type of biomaterial that is both bioactive and resorbable. In this study, 80 % SiO2 – 20 % CaO (molar fraction) 3DOM-BG particles were prepared using a colloidal crystal templating method via a sol-gel process. The as-prepared 3DOM-BG particles can quickly convert to a calcium-deficient, bone-like apatite after soaking in a simulated body fluid (SBF). MC3T3-E1 osteoblastic cells were cultured in the presence of 3DOM-BG particles. Preliminary results from cell studies showed that 3DOM-BG particles are not cytotoxic and are compatible with MC3T3-E1 osteoblast-like cells in vitro.

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