scholarly journals Inflammatory Myofibroblastic Tumor of the Nasal Septum

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Yuri Okumura ◽  
Kazuhiro Nomura ◽  
Takeshi Oshima ◽  
Atsuko Kasajima ◽  
Takahiro Suzuki ◽  
...  
Keyword(s):  
Nasal Septum ◽  
Inflammatory Myofibroblastic Tumor ◽  
Clinical Presentation ◽  
Smooth Muscle Actin ◽  
Imaging Studies ◽  
Posterior Edge ◽  
Juvenile Angiofibroma ◽  
Anaplastic Lymphoma ◽  
Spindle Cells ◽  
One Year

We report an extremely rare case of inflammatory myofibroblastic tumor of the posterior edge of the nasal septum. An 11-year-old boy presented with frequent epistaxis and nasal obstruction persisting for one year. Based on the clinical presentation and imaging studies, juvenile angiofibroma was suspected, but angiography suggested the possibility of another type of tumor. Transnasal endoscopic surgery found that the tumor protruded into the nasopharynx from the posterior end of the nasal septum. Histological examination identified spindle cells with immunoreaction for vimentin, smooth muscle actin, and anaplastic lymphoma kinase (ALK), but not for desmin and cytokeratin. This is a report of inflammatory myofibroblastic tumor mimicking juvenile angiofibroma. This case suggests that angiography is helpful in the differential diagnosis of epipharyngeal tumor in adolescence.

Intraocular Inflammatory Myofibroblastic Tumor With ALK Overexpression

2004 ◽  
Vol 128 (1) ◽  
pp. e5-e7
Author(s):  
Dennis P. O'Malley ◽  
Christopher Poulos ◽  
Magdalena Czader ◽  
Warren G. Sanger ◽  
Attilio Orazi
Keyword(s):  
Tumor Cells ◽  
Inflammatory Myofibroblastic Tumor ◽  
Plasma Cells ◽  
Smooth Muscle Actin ◽  
Chromosome 2 ◽  
Muscle Actin ◽  
Anaplastic Lymphoma ◽  
Spindle Cells ◽  
Multiple Copies

Abstract We report a case of an intraocular inflammatory myofibroblastic tumor nearly filling the vitreous cavity of the eye of a 50-year-old man. The tumor was composed of a mixture of spindle cells and mixed inflammatory elements, including numerous plasma cells. The differential diagnosis included inflammatory pseudotumor and neoplastic mimics of this condition. Further investigation with immunohistochemistry revealed the mass to be composed of myofibroblasts, positive for smooth muscle actin stains and with weak anaplastic lymphoma kinase (ALK) expression in some tumor cells. Evaluation by fluorescence in situ hybridization revealed the tumor cells to have multiple copies of chromosome 2 and ALK but no rearrangement of the ALK gene. The authors propose that multiple copies of the ALK gene may be involved in inflammatory myofibroblastic tumor tumorigenesis, in addition to ALK gene rearrangements.

Inflammatory Myofibroblastic Tumor of the Liver

2006 ◽  
Vol 130 (10) ◽  
pp. 1548-1551
Author(s):  
Garron J. Solomon ◽  
Milan M. Kinkhabwala ◽  
Mohammed Akhtar
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Clinical Presentation ◽  
Smooth Muscle Actin ◽  
Quadrant Pain ◽  
Laboratory Findings ◽  
Spindle Cells ◽  
Resected Liver ◽  
Normocytic Normochromic Anemia ◽  
Normochromic Anemia ◽  
Liver Specimen

Abstract We report a case of hepatic inflammatory myofibroblastic tumor in a 26-year-old African American man who presented with right upper quadrant pain, weight loss, and fatigue during the previous year. Hepatomegaly was found on physical examination. Laboratory findings were significant for mild normocytic, normochromic anemia and elevated erythrocyte sedimentation rate. Imaging studies showed 2 contiguous masses suspicious for malignancy. A left partial hepatectomy was performed; the preoperative differential diagnosis was for angiosarcoma and hepatocellular carcinoma. The resected liver specimen showed 2 contiguous, firm, tan-white nodules that microscopically represented a proliferation of spindled myofibroblast cells set in an inflammatory and collagenized background. The spindle cells were strongly reactive for smooth muscle actin but negative for ALK-1. The morphologic and immunophenotypic findings, coupled with the clinical presentation, were consistent with an inflammatory myofibroblastic tumor of the liver.

scholarly journals Primary nasal meningioma- a case report

2017 ◽  
Vol 7 (1) ◽  
pp. 1127-1129
Author(s):  
A Ghosh ◽  
G Ghartimagar ◽  
S Thapa ◽  
MK Shrestha ◽  
OP Talwar
Keyword(s):  
Case Report ◽  
Nasal Cavity ◽  
Nasal Septum ◽  
Clinical Presentation ◽  
Sinonasal Tract ◽  
Nasal Stuffiness ◽  
One Year

Extracranial meningiomas may be subdivided into primary and secondary types based on absence or presence of intracranial attachments respectively. Primary sinonasal tract meningiomas are rare with unknown etiopathology and non-specific clinical presentation. Of these PEMs only 11.5% are in the nasal cavity and nasal septum. To our knowledge less than 50 cases of PEM of nasal cavity have been reported in the literature. We report a case of a 22 years old male who presented with epistaxis and increasing nasal stuffiness for the last one year.

scholarly journals Inflammatory myofibroblastic tumor of the pancreas in a dog

2019 ◽  
Vol 31 (6) ◽  
pp. 879-882
Author(s):  
Mariarita Romanucci ◽  
Sabrina V. P. Defourny ◽  
Marcella Massimini ◽  
Laura Bongiovanni ◽  
Giovanni Aste ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Distress Syndrome ◽  
Plasma Cells ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Variable Number ◽  
Postmortem Examination ◽  
Muscle Actin ◽  
Coagulative Necrosis ◽  
Spindle Cells

A large, ill-defined, firm, multinodular mass involving the pancreas was confirmed on postmortem examination of a 5-y-old, male Rottweiler that died following acute respiratory distress syndrome, after a period of anorexia and lethargy. Histologically, the mass consisted of plump spindle cells admixed with a variable number of macrophages, lymphocytes, plasma cells, and neutrophils. Foci of coagulative necrosis and hemorrhage were also observed. Spindle cells strongly reacted to antibodies against vimentin, α–smooth muscle actin, and calponin, whereas desmin was expressed only mildly and focally. Pan-cytokeratin, KIT, glial fibrillary acidic protein, and S100 protein were nonreactive. Variable numbers of MAC 387–positive cells, CD3+ lymphocytes, and numerous blood vessels were also detected throughout the mass. Histologic and IHC findings were consistent with a diagnosis of inflammatory myofibroblastic tumor of the pancreas.

Osteonecrosis of Interphalangeal Joint of Thumb Two Months after Rattlesnake Bite

Hand Surgery ◽  
2015 ◽  
Vol 20 (02) ◽  
pp. 330-332 ◽  
Author(s):  
Patrick Bonasso ◽  
Brandon Lucke-Wold ◽  
Glen Jacob
Keyword(s):  
Clinical Presentation ◽  
Operative Management ◽  
Definitive Diagnosis ◽  
Interphalangeal Joint ◽  
Review Of Literature ◽  
Imaging Studies ◽  
Unique Challenge ◽  
X Ray ◽  
One Year ◽  
Pathology Review

This case report details the osteonecrosis of the interphalangeal (IP) joint of the thumb two months after a rattlesnake bite. It describes the clinical presentation, imaging studies, histological review, pathology review, and review of literature. Our patient was a fifty-one year-old male who obtained a poisonous snakebite to the thumb. While in the hospital for acute treatment, a blood blister was debrided. He was seen two weeks after discharge for further debridement of epidermolysis. Patient presented one month later with a hand x-ray demonstrating bony erosions, and a bone scan showing active changes in the IP joint of his right thumb. He was taken to the OR for further debridement and definitive diagnosis. Pathology results confirmed osteonecrosis with negative bone cultures. The clinical presentation, diagnosis, and operative management of osteonecrosis offer a unique challenge, especially in a patient presenting with osteonecrosis from a poisonous snakebite.

scholarly journals Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report

2016 ◽  
Vol 9 (2) ◽  
pp. 464-469 ◽  
Author(s):  
Toshiki Etani ◽  
Taku Naiki ◽  
Takashi Nagai ◽  
Keitaro Iida ◽  
Ryosuke Ando ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Inflammatory Myofibroblastic Tumor ◽  
Plasma Cells ◽  
Smooth Muscle Actin ◽  
Vascular Endothelial ◽  
Inflammatory Infiltration ◽  
Anaplastic Lymphoma ◽  
Resected Tumor ◽  
Muscle Invasion ◽  
Endothelial Growth Factor

An inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by inflammatory infiltration of plasma cells, lymphocytes, and eosinophils. IMTs rarely occur in the urinary bladder. It is important to distinguish this tumor from other malignant spindle cell tumors. Herein, we report a patient with an IMT showing muscle invasion, who underwent a transurethral resection of the bladder tumor and, at a later date, partial cystectomy. The resected tumor specimen revealed a proliferation of spindle-shaped cells on a background of plasma cells and lymphocytes. Immunohistochemical staining showed the tumor to be positive for anaplastic lymphoma kinase (ALK), smooth muscle actin, and vascular endothelial growth factor (VEGF). Such histopathological findings were indicative of an IMT, suggesting the use of inhibitors of ALK and VEGF as pharmacotherapy.

scholarly journals An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Sanjivini V. Jacob ◽  
John D. Reith ◽  
Angerika Y. Kojima ◽  
William D. Williams ◽  
Chen Liu ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Smooth Muscle Actin ◽  
Portal Tract ◽  
Fish Analysis ◽  
Anaplastic Lymphoma ◽  
Alk Inhibitor ◽  
Spindle Cell Proliferation ◽  
History Of ◽  
Subcutaneous Tissues ◽  
Systemic Manifestations

Systemic inflammatory myofibroblastic tumor is an exceedingly rare entity. A 45-year-old Hispanic female presented with a 6-month history of left-sided thigh pain, low back pain, and generalized weakness. PET/CT scan revealed abnormal activity in the liver, adrenal gland, and pancreas. MRI of the abdomen demonstrated two 6-7 cm masses in the liver. MRI of the lumbar spine demonstrated lesions in the L2 to L4 spinous processes, paraspinal muscles, and subcutaneous tissues, as well as an 8 mm enhancing intradural lesion at T11, all thought to be metastatic disease. A biopsy of the liver showed portal tract expansion by a spindle cell proliferation rich in inflammation. Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1). Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver. FISH analysis of these lesions demonstrated an ALK (2p23) gene rearrangement. The patient was successfully treated with an ALK-inhibitor, Crizotinib, and is now in complete remission. We present the first reported case, to our knowledge, of inflammatory myofibroblastic tumor with systemic manifestations and ALK translocation. This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.

scholarly journals Unusual Case of Inflammatory Myofibroblastic Tumor in Maxilla

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Jaana Rautava ◽  
Tero Soukka ◽  
Esko Peltonen ◽  
Petri Nurmenniemi ◽  
Markku Kallajoki ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Unusual Case ◽  
Root Resorption ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Clinical Manifestations ◽  
Anaplastic Lymphoma ◽  
First Case ◽  
Rare Lesion ◽  
Children And Young Adults

Inflammatory myofibroblastic tumor (IMT) is a rare lesion found mostly in children and young adults and originates from the lung, abdominopelvic region, and retroperitoneum. Clinical manifestations of IMT or imaging are nonspecific and diagnosis is based on histopathological and immunohistochemical findings. Minority of all IMTs will metastasize. IMT in the oral cavity is an extreme rarity and this is a first case report of IMT in maxilla causing delayed tooth eruption and multiple cervical root resorption with an 11-year-old child. The IMT reported here was positive for smooth muscle actin, vimentin, and anaplastic lymphoma kinase (ALK1) with immunohistochemistry. Only three IMTs of the jaws have been reported so far and none of them had delayed root eruption and tooth resorption. This unusual case of IMT in a child was also ALK1- positive supporting neoplastic origin of her tumor. The case presented here underscores the importance of histopathological examination of the tissue found in any root resorption especially in the case of multiple resorptions.

Intrasellar Rhabdomyosarcoma: Case Report

Neurosurgery ◽  
2001 ◽  
Vol 48 (3) ◽  
pp. 677-680 ◽  
Author(s):  
Kazunori Arita ◽  
Kazuhiko Sugiyama ◽  
Atushi Tominaga ◽  
Fumiyuki Yamasaki
Keyword(s):  
Clinical Presentation ◽  
Smooth Muscle Actin ◽  
Visual Disturbance ◽  
Total Removal ◽  
Spindle Cells ◽  
Abducent Nerve Palsy ◽  
Undifferentiated Cells ◽  
Sellar Tumor ◽  
Local Radiation ◽  
Abducent Nerve

Abstract OBJECTIVE AND IMPORTANCE There has been only one reported case of an intrasellar rhabdomyosarcoma, the origin of which was in the paranasal sinus. The authors encountered a patient with an intrasellar rhabdomyosarcoma with no evidence of tumor at any additional sites. CLINICAL PRESENTATION A 28-year-old otherwise healthy man complaining of headache exhibited left abducent nerve palsy and left visual disturbance. The patient was diagnosed as having a sellar tumor invading the left cavernous sinus. INTERVENTION Near total removal of the tumor was achieved via a transsphenoidal approach. Histologically, the tumor was composed of small, round-to-elongated undifferentiated cells and large spindle cells with myoblastic features. Immunohistochemically, tumor cells were positive for antibodies against desmin, myoglobin, and α-smooth muscle actin. The tumor was identified as an embryonal rhabdomyosarcoma on the basis of the above pathological findings. Systemic investigation, including the nasal and paranasal regions, failed to detect any additional tumors. Postoperative local radiation therapy and chemotherapy with the use of ifosfamide, etoposide, and vincristine brought about complete initial remission. CONCLUSION Rhabdomyosarcoma should be considered in the differential diagnosis of a primary intrasellar neoplasm.

scholarly journals Voluminous Omental Inflammatory Myofibroblastic Tumor in an Elderly Man: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Pasquale Cianci ◽  
Antonio Ambrosi ◽  
Alberto Fersini ◽  
Nicola Tartaglia ◽  
Vincenzo Lizzi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Myofibroblastic Tumor ◽  
Plasma Cells ◽  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Abdominal Distension ◽  
Greater Omentum ◽  
Anaplastic Lymphoma ◽  
Mesenchymal Neoplasm ◽  
Spindle Cell Proliferation

Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm of intermediate biologic potential, with uncertain etiology. This tumor occurs primarily in the lung, but the tumor may affect any organ system. A 75-year-old male was evaluated for voluminous palpable high abdominal mass with continuous and moderately abdominal pain, associated with abdominal distension for the last two months. Abdominal computed tomography showed a large (32×29×15 cm) heterogeneously enhanced mass with well-defined margins. At surgery, the mass originated from the greater omentum was completely excised. Histologically the tumor was a mesenchymal neoplasm in smooth muscle differentiation and was characterized by spindle-cell proliferation with lymphocytes, plasma cells, and rare eosinophils. Immunohistochemically, the tumor cells were positive for vimentin and smooth muscle actin and negative for anaplastic lymphoma kinase. Complete surgical resection of IMTs remains the mainstay of treatment associated with a low rate of recurrence. Final diagnosis should be based on histopathological and immunohistochemical findings. Appropriate awareness should be exercised by surgeons to abdominal IMTs in combination with constitutional symptoms, abnormal hematologic findings, and radiological definition, to avoid misdiagnosed.

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