scholarly journals Synthesis and Biological Activity of 2,5-Bisubstituted Derivatives of 1,3,4-Thiadiazol-2,5-dithiol

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
T. S. Zhivotova ◽  
R. E. Bakirova ◽  
S. D. Fazylov ◽  
S. K. Kabieva ◽  
T. V. Kryazheva
Keyword(s):  
Biological Activity ◽  
Acrylic Acid ◽  
Carboxylic Acids ◽  
Biological Properties ◽  
Secondary Amines ◽  
Derivatives Of

By reaction of 1,3,4-thiadiazol-2,5-dithiol with different organohalogens, chlorides of carboxylic acids, acrylic acid derivatives, alkaloids, and secondary amines, various derivatives of 2,5-bi-substituted 1,3,4-thiadiazole were synthesized, and biological properties of some of them were studied.

scholarly journals FLAVONOID COMPOUNDS FROM ARTEMISIA GLABELLA KAR. ET. KIR., SYNTHESIS ON THEIR BASIS AND BIOLOGICAL ACTIVITY

2018 ◽  
pp. 215-222
Author(s):  
Габиден (Gabiden) Маратович (Maratovich) Байсаров (Baysarov) ◽  
Айдана (Аjdana) Рахманиякызы (Rakhmaniyakyzy) Жуматаева (Zhumatayeva) ◽  
Гулим (Gulim) Кенесбековна (Kenesbekovna) Мукушева (Mukusheva) ◽  
Эльвира (El'vira) Эдуардовна (Eduardovna) Шульц (Shul'ts) ◽  
Роза (Roza) Батталовна (Battalovna) Сейдахметова (Seydakhmetova) ◽  
...  
Keyword(s):  
Biological Activity ◽  
Raw Materials ◽  
Hepatoprotective Activity ◽  
Biologically Active ◽  
Secondary Amines ◽  
Moderate Activity ◽  
Amino Derivatives ◽  
Anti Inflammatory ◽  
Derivatives Of

As a result of complex chemical processing of medicinal raw materials of Artemisia glabella Kar. et Kir., including CO2 extraction and lactones isolation, we have investigated the chemical composition of flavonoids to select the biologically active ones and carry out modifications on their basis. Two flavonoids pectolinaringenin and cirsilineol have been isolated by partition chromatography from the secondary raw materials of Artemisia glabella Kar. et. Kir. and identified. To obtain new biologically active compounds, we have synthesized new amino derivatives of cirsilineol by the Mannich reaction with secondary amines (piperidine and N-methylpiperazine) in isopropanol with the presence of dimethylaminopyridine. In proton NMR spectrum of the synthesized compounds there are proton signals of the initial cirsilineol fragment; however, there is no N-8 proton signal, besides other signals typical for amines’ benzene ring have been observed at 1.53–3.90 ppm. It means that reaction occurred at the C-8 position of carbon in ring A. The synthesized compounds have been studied for various types of biological activity typical for this class, including hepatoprotective and anti-inflammatory activities. Amino derivatives of cirsilineol exhibit a moderate activity against HepG2 cell line, while cirsilineol at a dose of 5 mg/ml expresses a pronounced hepatoprotective activity. Moreover, all samples at a dose of 25 mg/kg show poor anti-inflammatory effects on the model of acute exudative reaction in vivo.

The synthesis and biological activity of derivatives of ?-(3-indolyl)acrylic acid

1979 ◽  
Vol 13 (5) ◽  
pp. 507-511
Author(s):  
V. P. Shamshin ◽  
V. P. Zhestkov ◽  
A. I. Ermakov ◽  
V. G. Voronin ◽  
Yu. M. Rabotinikov ◽  
...  
Keyword(s):  
Biological Activity ◽  
Acrylic Acid ◽  
Derivatives Of

Functional derivatives of thiophene. XIX. Synthesis and biological activity of some esters of 2-benzoylaminothiophene-3-carboxylic acids

1980 ◽  
Vol 14 (12) ◽  
pp. 861-863
Author(s):  
I. A. Kharizomenova ◽  
A. N. Grinev ◽  
N. V. Samsonova ◽  
N. V. Kaplina ◽  
M. V. Kapustina ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids ◽  
Functional Derivatives ◽  
Derivatives Of

Synthesis and Biological Activity of Mono- and Dibromo Derivatives of 2-Amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic Acids

2018 ◽  
Vol 88 (7) ◽  
pp. 1397-1401
Author(s):  
M. V. Dmitriev ◽  
D. V. Ivanov ◽  
N. M. Igidov ◽  
R. R. Makhmudov ◽  
V. V. Novikova ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids ◽  
Derivatives Of

ChemInform Abstract: FUNCTIONAL DERIVATIVES OF THIOPHENE. XIX. SYNTHESIS AND BIOLOGICAL ACTIVITY OF ESTERS OF 2-BENZOYLAMINOTHIOPHENE-3-CARBOXYLIC ACIDS

1981 ◽  
Vol 12 (21) ◽  
Author(s):  
I. A. KHARIZOMENOVA ◽  
A. N. GRINEV ◽  
N. V. SAMSONOVA ◽  
N. V. KAPLINA ◽  
M. V. KAPUSTINA ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids ◽  
Functional Derivatives ◽  
Derivatives Of

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Synthesis and Biological Activity of 28-Amide Derivatives of 23-Hydroxy Betulinic Acid as Antitumor Agent Candidates

2013 ◽  
Vol 9 (7) ◽  
pp. 920-925 ◽  
Author(s):  
Yi Bi ◽  
Jinyi Xu ◽  
Fei Sun ◽  
Xiaoming Wu ◽  
Wencai Ye ◽  
...  
Keyword(s):  
Biological Activity ◽  
Betulinic Acid ◽  
Antitumor Agent ◽  
Amide Derivatives ◽  
Derivatives Of
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